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Advances in Liver Transplantation: New Frontiers in Organ Regeneration and Immunomodulation

Posted in Artificial Intelligence - General, Artificial Intelligence Applications in Health Care, Artificial Intelligence in Health Care - Tools & Innovations, combination immunotherapies., Diagnostic Immunology, Human Immune System in Health and in Disease, Immuno-Oncology & Genomics, Immunodiagnostics, Immunology, Immunotherapy, Liver & Digestive Diseases Research, Population Health Management, Population Health Management, Genetics & Pharmaceutical, Population Health Management, Nutrition and Phytochemistry, Stem Cells for Regenerative Medicine, Uncategorized, tagged , , , , on June 6, 2025| Leave a Comment »

Advances in Liver Transplantation: New Frontiers in Organ Regeneration and Immunomodulation

Curator: Dr. Sudipta Saha, Ph. D.

 

Recent research in the field of liver transplantation has been marked by significant advancements in organ preservation, immune tolerance, and regenerative medicine. Efforts have been made to address the critical shortage of donor organs and reduce long-term complications associated with immunosuppressive therapy.

Normothermic machine perfusion (NMP) techniques have been employed to preserve and assess donor livers outside the body. This method has allowed marginal or extended criteria livers to be reconditioned, increasing the usable donor pool. The viability of these organs has been improved through real-time functional monitoring during perfusion.

Immunological tolerance has been targeted through cell-based therapies and gene editing strategies. Regulatory T-cell therapies and tolerogenic dendritic cells have been investigated to reduce the reliance on lifelong immunosuppression. CRISPR-based gene editing is also being explored to modify donor tissues before transplantation to evade host immune responses.

In parallel, liver organoids and bioengineered tissue scaffolds have been studied for their potential in partial transplantation or functional support in acute liver failure. Although clinical application remains at an early stage, these developments have suggested future directions for transplant alternatives or bridge-to-transplant therapies.

Artificial intelligence has been integrated into transplant decision-making, predicting post-transplant outcomes and optimizing donor-recipient matching. These models are being trained on large datasets to improve prognostic accuracy.

Ethical concerns surrounding organ allocation equity and experimental treatments continue to be actively discussed. However, these advancements have collectively pushed the boundaries of transplant medicine toward safer, more personalized, and more sustainable outcomes.

References:

https://pubmed.ncbi.nlm.nih.gov/29670285

https://pubmed.ncbi.nlm.nih.gov/32976865

https://pubmed.ncbi.nlm.nih.gov/32546694

https://pubmed.ncbi.nlm.nih.gov/31954498

https://jyoungpharm.org/6365/

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Mesentery: Designated As a New Organ

Posted in Cell Biology, Cytoskeleton, Developmental biology, Disease Biology, Evidence-based decision-making, Uncategorized, tagged , , , , , on January 6, 2017| Leave a Comment »

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

Researchers have classified a brand-new organ inside human body. Known as the mesentery, the new organ is found in our digestive systems, and was long thought to be made up of fragmented, separate structures. But recent research has shown that it’s actually one, continuous organ. The evidence for the organ’s reclassification is now published in The Lancet Gastroenterology & Hepatology. Although we now know about the structure of this new organ, its function is still poorly understood, and studying it could be the key to better understanding and treatment of abdominal and digestive disease.

mesentery

J Calvin Coffey, a researcher from the University Hospital Limerick in Ireland, who first discovered that the mesentery was an organ. In 2012, Coffey and his colleagues showed through detailed microscopic examinations that the mesentery is actually a continuous structure. Over the past four years, they’ve gathered further evidence that the mesentery should actually be classified as its own distinct organ, and the latest paper makes it official. Mesentery is a double fold of peritoneum – the lining of the abdominal cavity – that holds our intestine to the wall of our abdomen. It was described by the Italian polymath Leanardo da Vinci in 1508, but it has been ignored throughout the centuries, until now. Although there are generally considered to be five organs in the human body, there are in fact now 79, including the mesentery. The heart, brain, liver, lungs and kidneys are the vital organs, but there are another 74 that play a role in keeping us healthy. The distinctive anatomical and functional features of mesentery have been revealed that justify designation of the mesentery as an organ. Accordingly, the mesentery should be subjected to the same investigatory focus that is applied to other organs and systems. This provides a platform from which to direct future scientific investigation of the human mesentery in health and disease.

References:

http://www.thelancet.com/journals/langas/article/PIIS2468-1253(16)30026-7/abstract

http://www.sciencealert.com/it-s-official-a-brand-new-human-organ-has-been-classified

http://www.bbc.com/news/health-38506708

http://www.independent.co.uk/news/science/new-organ-mesentery-found-human-body-digestive-system-classified-abdominal-grays-anatomy-a7507396.html

https://in.news.yahoo.com/scientists-discover-human-organ-064207997.html

https://en.wikipedia.org/wiki/Mesentery

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