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Posts Tagged ‘Moonshot’


Cancer initiatives

Larry H. Bernstein, MD, FCAP, Curator

LPBI

 

Updated 4/12/2019

AACR 2016: Biden Calls for Overhauling Cancer Research Incentives

http://www.genengnews.com/gen-news-highlights/aacr-2016-biden-calls-for-overhauling-cancer-research-incentives/81252636/

 

The first priority cited by the vice president was data sharing. Biden defended the concept as essential to advancing the process of cancer research and countered a January 21 New England Journal of Medicine editorial in which editor-in-chief Jeffrey Drazen, M.D., contended that data sharing could breed data “parasites.”

Four days later, Dr. Drazen clarified NEJM’s position by adding that with “appropriate systems” in place, “we will require a commitment from authors to make available the data that underlie the reported results of their work within 6 months after we publish them.”

Other priorities Biden said should serve as the basis of new incentives:

  • Involve patients in clinical trial design—Raising awareness of trials, and allowing patients to participate in how they are designed and conducted, could help address the difficulty of recruiting patients for studies. Only 4% of cancer patients are involved in a trial, he said.
  • “Let scientists do science”—Biden contrasted unfavorably NIH’s roughly 1-year process for decisions on grants to that of the Prostate Cancer Foundation, which limits grant applications to 10 pages and decides on those funding requests within 30 days: “Why is it that it takes multiple submissions and more than a year to get an answer from us?” Biden said.
  • Encourage grants from younger researchers—Biden decried the current professional system under which younger researchers are sidetracked for years doing administrative work in labs before they can pursue their own research grants: “It’s like asking Derek Jeter to take several years off to sell bonds to build Yankee Stadium,” the VP quipped.
  • Measure progress by outcomes—Rather than the quantity of research papers generated by grants, Biden said, “what you propose and how it affects patients, it seems to me, should be the basis of whether you continue to get the grant.”
  • Promote open-access publication of results—Biden criticized academic publishing’s reliance on paid-subscription journals that block content behind paywalls and which own data for up to a year. He contrasted that system with the Bill and Melinda Gates Foundation’s stipulation that the research it funds be published in an open-access journal and be freely available once published.
  • Reward verification—Research that verifies results through replication should be encouraged, Biden said, which acknowledging that few people now get such funding.

Biden recalled how following Beau’s diagnosis with cancer, he and his wife Jill Biden, Ed.D., who introduced the VP at the AACR event, “had access to the best doctors in the world.”

“The more we talked to them, the more we understood that we are on the cusp of a real inflection point in the fight against cancer.”

Updated 4/12/2019

Pediatric Cancer Initiatives

Data Sharing for Pediatric Cancers: President Trump Announces Pledge to Fight Childhood Cancer Will Involve Genomic Data Sharing Effort

In the journal Science, Drs. Olena Morozova Vaske ( and David Haussler University of California, Santa Cruz) recently wrote an editorial entitled “Data Sharing for Pediatric Cancers“, in which they discuss the implications of President Trump’s intentions to increase funding for pediatric cancers with a corresponding effort for genomic data sharing.  Also discussed is the current efforts on pediatric genomic data sharing as well as some opinions on coordinating these efforts on a world-wide scale to benefit the patients, researchers, and clinicians.

The article is found below as it is a very good read on the state of data sharing in the pediatric cancer field and offers some very good insights in designing such a worldwide system to handle this data sharing, including allowing patients governance over their own data.

Last month, in a conference call held by the U.S. Department of Health and Human Services and National Institutes of Health (NIH), it was revealed that a large focus of President Trump’s pledge to fund childhood cancer research will be genomic data sharing. Although the United States has only 5% of the world’s pediatric cancer cases, it has disproportionately more resources and access to genomic information compared to low-income countries. We hope that the spotlight on genomic data sharing in the United States will galvanize the world’s pediatric cancer community to elevate genomic data sharing to a level where its full potential can finally be realized.

Pediatric cancers are rare, affecting 50 to 200 children per million a year worldwide. Thus, with 16 different major types and many subtypes, no cancer center encounters large cohorts of patients with the same diagnosis. To advance their understanding of particular cancer subtypes, pediatric oncologists must have access to data from similar cases at other centers. Because subtypes of pediatric cancer are rare, assembling large cohorts is a limiting factor in clinical trials as well. Here, too, data sharing is the first critical step.

Typically, pediatric cancers don’t have the number of mutations that make immunotherapies effective, and only a few subtypes have recurrent mutations that can be used to develop gene-targeted therapies. However, the abnormal expression level of genes gives a vivid picture of genetic misregulation, and just sharing this information would be a huge step forward. Using gene expression and mutation data, analysis of genetic misregulation in different pediatric cancer subtypes could point the way to new treatments.

A major challenge in genomic data sharing is the patient’s young age, which frequently precludes an opportunity for informed consent. Compounding this, the rarity of subtypes requires the aggregation of patients from multiple jurisdictions, raising barriers to assembling large representative data sets. A greater percentage of children than adults with cancer participate in research studies, and children often participate in multiple studies. However, this means that data collected on individual children may be found at multiple institutions, creating difficulties if there are no standards for data sharing.

To enable effective sharing of genomic and clinical data, the Global Alliance for Genomics and Health has developed the Key Implications for Data Sharing (KIDS) framework for pediatric genomics. The recommendations include involving children in the data-sharing decision-making process and imposing an ethical obligation on data generators to provide children and parents with the opportunity to share genomic and clinical information with researchers. Although KIDS guidelines are not legally binding, they could inform policy development worldwide.

To advance the sharing culture, along with the NIH, pediatric cancer foundations such as the St. Baldrick’s Foundation and Alex’s Lemonade Stand Foundation have incorporated genomic data-sharing requirements into their grants processes. Researchers and clinicians around the world have created dozens of pediatric cancer genomic databases and portals, but pulling these together into a larger network is problematic, especially for patients with data at more than one institution, as patient identifiers are stripped from shared data. However, initiatives like the Children’s Oncology Group’s Project Every Child and the European Network for Cancer Research in Children and Adolescents’ Unified Patient Identity may resolve this issue.

We urge the creators of pediatric cancer genomic resources to collaborate and build a real-time federated data-sharing system, and hope that the new U.S. initiative will inspire other countries to link databases rather than just create new siloed regional resources. The great advances in information technology and life sciences in the last decades have given us a new opportunity to save our children from the scourge of cancer. We must resolve to use them.

Source: Olena Morozova Vaske and David Haussler.  Science; 363(6432): 1125 (2019). Data sharing for pediatric cancers. 

NIH-NCI Initiative: International collaboration to create new cancer models to accelerate research

LIVE 1:45 pm – 3:10 pm 4/25/2016 Forum Opening, A War or Moonshot: Where Do We Stand? Creating a Disruptive Cancer Pipeline @2016 World Medical Innovation Forum: CANCER, April 25-27, 2016, Westin Hotel, Boston

Will President Obama’ s Cancer Immunotherapy Colloquium (dubbed Moonshot) mean Government is Fully Behind the War on Cancer or have we heard this before?

Exome Aggregation Consortium (ExAC), generated the largest catalogue so far of variation in human protein-coding regions: Sequence data of 60,000 people, NOW is a publicly accessible database

Healthcare conglomeration to access Big Data and lower costs

 

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Will President Obama’ s Cancer Immunotherapy Colloquium (dubbed Moonshot) mean Government is Fully Behind the War on Cancer or have we heard this before?

 

UPDATED on 12/13/2016

Greg Simon, White House Cancer Moonshot Task Force: Interview Q&A

Dec 12, 2016 | AnnouncementsQ&ASpeaker spotlights |

The following is an interview recently conducted by PMWC with Greg Simon, Executive Director at the White House Cancer Moonshot Task Force. The discussion focused on the future of the Cancer Moonshot with the upcoming change of administration.

A status update on the Cancer Moonshot will be presented at the upcoming Precision Medicine World Conference (PMWC) 2017 Silicon Valley. To registerclick here.

http://www.pmwcintl.com/greg-simon-qa/

 

SOURCE:

From: Tal Behar <talb=pmwcintl.com@mail61.atl161.mcsv.net> on behalf of Tal Behar <talb@pmwcintl.com>

Reply-To: Tal Behar <talb@pmwcintl.com>

Date: Tuesday, December 13, 2016 at 1:40 PM

To: Aviva Lev-Ari <AvivaLev-Ari@alum.berkeley.edu>

Subject: PMWC News – Late Breaking Interview – The White House Cancer Moonshot in Limbo

 

 

Reporter: Stephen J. Williams, Ph.D

potusmoonshotannouncementsotus

President Obama announces a “Moonshot” Program to create collaborations aimed at developing immunotherapies to cure cancer by 2020 at his last State of the Union Address. Vice President Biden will lead the effort.

 

From Cancer Letters

  • Obama Announces Moonshot to Cure Cancer
  • When Moonshots Collide
  • Soon-Shiong Says FDA & NCI are Onboard For His Moonshot; Feds Deny Involvement

Obama Announces Moonshot to Cure Cancer

President Barack Obama announced a moonshot aimed at curing cancer, a project to be led by Vice President Joe Biden.

The United States can do “so much more,” Obama said in his seventh and final State of the Union address Jan. 12. “Last year, Vice President Biden said that with a new moonshot, America can cure cancer. Last month, he worked with this Congress to give scientists at the National Institutes of Health the strongest resources they’ve had over a decade.

“Tonight, I’m announcing a new national effort to get it done. And because he’s gone to the mat for all of us, on so many issues over the past 40 years, I’m putting Joe in charge of mission control. For the loved ones we’ve all lost, for the family we can still save—let’s make America the country that cures cancer once and for all.”

  When Moonshots Collide

Did Patrick Soon-Shiong attempt to scoop President Barack Obama’s State of the Union address?

Several days before Obama announced the federal government’s moonshot to cure cancer, Soon-Shiong put out a draft press release, claiming that the White House, NIH, FDA and pharmaceutical companies have united in “Cancer MoonShot 2020,” an immunotherapy clinical trials program he devised.

Soon-Shiong, founder and CEO of NantWorks and the Chan Soon-Shiong Institute of Molecular Medicine, ultimately announced his moonshot on Jan. 11, a day before Obama announced his.

Conversation with The Cancer Letter

Soon-Shiong Says FDA & NCI are Onboard For His Moonshot; Feds Deny Involvement

Government agencies said the biotechnology billionaire Patrick Soon-Shiong had overstated the extent of their involvement in “Cancer MoonShot 2020,” the immunotherapy clinical trials program he put together.

In an in-depth conversation with Matthew Bin Han Ong, a reporter with The Cancer Letter, Soon-Shiong said that while his program doesn’t seek federal funds, it has the support of NCI and FDA officials.

Soon-Shiong said he and Vice President Joe Biden met to discuss their interlocking missions and are now pursuing them.

 

From the AACR website

AACR Thanks President Obama and Vice President Biden for Their Strong Commitment to Cancer Research and Biomedical Science in State of the Union Address

1/12/2016

PHILADELPHIA — The American Association for Cancer Research (AACR) applauds and commends President Obama and Vice President Biden for their dedication in the fight against cancer discussed during tonight’s State of the Union address.

The AACR looks forward to working with the administration and Congress to make faster progress against cancer so that we might achieve the goal that Vice President Biden outlined during his speech in the Rose Garden Oct. 21, 2015, specifically that now is the time to make an “absolute national commitment to end cancer as we know it today.”

“We have indeed reached an inflection point, where the number of discoveries that are being made at such an accelerated pace are saving lives and bringing enormous hope for cancer patients, even those with advanced disease,” said AACR President José Baselga, MD, PhD, physician-in-chief and chief medical officer at Memorial Sloan Kettering Cancer Center. “Now is the time for a major new initiative in cancer science that supports and builds upon our basic science foundation while translating these exciting scientific discoveries into improved treatments for cancer patients, such as in the areas of genomics, precision medicine, and immuno-oncology. Tonight’s State of the Union address underscores the importance of collaborations if we are to achieve the vision that President Obama has outlined.”

To that end, on Jan. 8, a group of 15 AACR members, led by Baselga and comprising a number of AACR Board Members, and other AACR leaders from nine states and 10 of the top cancer centers and medical institutions in the U.S., met with Vice President Biden’s senior staff to discuss the state of cancer research, as well as Vice President Biden’s commitment to leading in this important issue.

From Philly.com

Biden to open effort to fight cancer Friday at Penn

 

011316_Biden-SOTU

US Vice President Biden will meet with University of Pennsylvania researchers to discuss the new Moonshot program to eliminate cancer. Photo from http://www.philly.com

 

Jonathan Tamari

Posted: Wednesday, January 13, 2016, 4:14 PM

image: http://media.philly.com/designimages/partnerIcon-Inquirer-2014.jpg

WASHINGTON – Vice President Biden will launch his effort to find a cure for cancer Friday in Philadelphia, with a visit to Penn’s Abramson Cancer Center at the school’s Perelman School of Medicine.

Biden announced the visit in an online post Tuesday night, when the call to cure the disease was one of the highlights of President Obama’s State of the Union speech.

“It’s personal for me. But it’s also personal for nearly every American, and millions of people around the world,” said Biden’s post on Medium. The vice president’s son Beau died of brain cancer at the age of 46 last year.

Biden compared the effort to President Kennedy’s call to go to the moon.

“From my own personal experience, I’ve learned that research and therapies are on the cusp of incredible breakthroughs,” Biden wrote. “The goal of this initiative — this “Moonshot” — is to seize this moment.”
Read more at http://www.philly.com/philly/blogs/capitolinq/Biden-to-open-effort-to-fight-cancer-Friday-at-Penn.html#sQFbeebwSDM17S0d.99

 

Biden to tour labs, meet cancer researchers at Penn

 

Vice President Biden is scheduled to spend part of Friday afternoon at the University of Pennsylvania’s Abramson Cancer Center, the first stop on his quest for the United States to cure cancer. President Obama announced the new “Moon Shot” mission during his State of the Union address Tuesday night, comparing it with John F. Kennedy’s 1961 declaration to Congress that the nation would land a man on the moon by the end of the decade.Biden’s 3 p.m. visit includes a tour of laboratories and a roundtable discussion with researchers at the Smilow Center for Translational Research and the Perelman Center for Advanced Medicine, both 3400 Civic Center Blvd. The events are not open to the public but are likely to cause some disruption.

In an internal e-mail Thursday afternoon, Garry Scheib, CEO of the Hospital of the University of Pennsylvania, told employees that parts of the building would be emptied for security reasons from 11 a.m. through evening. “In addition, the Secret Service will temporarily close roadways near our campus to allow for secure transport of the Vice President,” Scheib wrote.

– Don Sapatkin
Read more at http://www.philly.com/philly/health/20160115_Biden_to_visit_Penn_cancer_center_Friday_afternoon.html#vCpr4Hfu2AGYLSoX.99

 

Billionaire pulls together drugmakers, IBX for cancer collaboration

A billionaire medical entrepreneur has pulled together several drugmakers and Philadelphia-based Independence Blue Cross to speed development of what researchers hope could be a powerful weapon against cancers – potent combinations of new drugs that harness the body’s immune system.

So-called immunotherapies help disease-fighting cells attack tumors. Yet researchers believe they may work best when two, three, or more of the drugs are used together – overwhelming a tumor’s cellular defenses with attacks from all sides.

The group – called the National Immunotherapy Coalition – brought together by Patrick Soon-Shiong calls itself Moon Shot 2020. The name spun out of conversations Soon-Shiong had last year with Vice President Biden, whose son Beau died of cancer in May. In his October announcement that he was not running for president, Biden suggested a project of moon-shot proportions would be needed to defeat cancer.

A controversial figure in oncology research circles because of his self-promotion, Soon-Shiong made his fortune by inventing the cancer drug Abraxane in the early 1990s. California-based Amgen and New Jersey-based Celgene have joined the effort. Early reports suggested Pfizer, Merck, and GlaxoSmithKline might participate, but other reports indicated they had not as of Monday.

Independence Blue Cross said in a statement Monday that it entered into an agreement with NantHealth, one of Soon-Shiong’s companies, to cover next-generation whole genome sequencing, which is a test designed to detect gene mutations that may serve as markers to help doctors choose cancer treatment.

Independence said its agreement with NantHealth involves a “very specific and complex lab study” related to certain types of cancer. The test will be covered for members with “specific conditions including rare cancers, tumors in children, metastatic cancer of unknown primary, primary brain cancer, triple negative breast cancer, and metastatic cancer where conventional therapies have been exhausted and patients remain candidates for further therapy. Coverage for the testing will be available to eligible members of Independence commercial plans in March 2016.”

As for the National Immunotherapy Coalition, Independence said members referred by their oncologist for participation in one of the approved Moon Shot 2020 clinical trials will be eligible for coverage for the routine patient care costs related to the trial. The coverage includes all routine services required for the patient – such as blood tests, supportive medications, and surgical interventions.

“Independence Blue Cross is committed to bringing state-of-the-art advances in oncology to our members and making care accessible and affordable,” Daniel J. Hilferty, president and CEO, Independence Blue Cross, said in the statement. “Decisions around cancer care are complex and personal. We’re focused on supporting Independence members and their oncologists by offering coverage for this innovative approach to treating cancer. Whole genome sequencing is one more option to help inform a personalized, effective treatment plan.”
Read more at http://www.philly.com/philly/business/20160112_Billionaire_pulls_together_drugmakers__IBX_for_cancer_collaboration.html#XuXeFCydClgRsX0W.99

 

This is a Great Announcement But What is the History of the Government and THE WAR on CANCER? (Have we heard this before?)

 

The War on Cancer (launced by US President Nixon in the early 1970’s) has been discussed on this site from a historical perspective

2013 Perspective on “War on Cancer” on December 23, 1971

 

as well as the further needs the cancer field needs from this governmental effort

War on Cancer Needs to Refocus to Stay Ahead of Disease Says Cancer Expert

World facing cancer ‘tidal wave’, warns WHO

 

A summation of these efforts would say we have achieved great results in reducing the burden of cancer (through smoking cessation, early screening programs, better education, as well as therapeutic advances) however as the worldwide populace ages we are, and will see, a “rising tidal wave” of cancer incidence across the globe, and cancer researchers are feeling we are at an important precipice on this war, one which could be lost.

And the program which both President Obama and Vice President Biden are suggesting, the power would be a massive collaboration between government, academia, industry, and patient advocacy will certainly produce positive results.

However these efforts have been ongoing as with the University of Pennsylvania-Novartis deal to work together on CAR-T therapies for leukemias as well as other cancers

New Facility Poised to Accelerate the Research and Development of Personalized Cellular Cancer Therapies

 

as well as other academic-industry partnerships in immuno-oncology.

There have been other such announcements in recent years (mainly to draw in research $ or assist in forming academia-industry partnerships) such as:

NCI sets goal of eliminating suffering and death due to cancer by 2015.

 

In 2003 then NCI president Dr. Andrew C. von Eschenbach announced, after discussions with leaders in the field, that

“I have proposed a challenge goal for the field of cancer research- to eliminate suffering and death due to cancer by 2015. I issued this challenge because I believe we are at a ‘strategic inflection’ in oncology…”

Later in early decade of 2010 another program began to help make a push to recoup some of the government research $ lost to budgetary constraints on the NIH

STAND UP TO CANCER

stand-up-2-cancer

This program has met much success in raising money, awareness, and clinical trial enrollment (following shows current stats from the organization site)

Founded: May 28, 2008
Funds Pledged since inception: Over $370 Million
Number of scientists participating in SU2C-funded research: Over 1000
Clinical Trails funded by SU2C planned, initiated or completed: Over 160
Patients enrolled in SU2C supported Clinical Trials: Over 6,000 patients
Number of institutions joining in SU2C’s collaborative mission: 129

However, although it has grown the cancer research world encompasses a greater number than they can provide for.

 

In short, there has been no government effort much like Nixon’s War on Cancer, which took an obscure disease at the time and not only put it in the limelight but probably the most powerful result was the creation of the National Cancer Institute, thereby developing a framework to promote cancer research for the next century. President Obama should be applauded for this effort yet the real test for the Moonshot program will be to create, much like the NCI did, a self-perpetuating system by which continued further advancement can be made.

 

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