DISCOVER BRIGHAM | NOVEMBER 7, 2019, 10AM – 6PM
Reporter: Aviva Lev-Ari, PhD, RN
#DISCOVERBRIGHAM
@pharma_BI
@AVIVA1950
Aviva Lev-Ari, PhD, RN will be attending and will cover presentations in real time
ABOUT BRIGHAM RESEARCH
Speakers
http://www.discoverbrigham.org/speakers/
AGENDA
http://www.discoverbrigham.org/agenda/
ASK A QUESTION WITH SLI.DO!
DO YOU WANT TO SUBMIT A QUESTION TO A SPEAKER OF A SESSION? YOU CAN DO IT THROUGH SLI.DO!
1. GO TO THE WEB ADDRESS: SLIDO.COM
2. ENTER THE EVENT CODE: DB19. THEN HIT JOIN!
3. PICK THE SESSION YOU WANT TO ASK A QUESTION. THEN ASK YOUR QUESTION!
4. YOUR QUESTION WILL BE REVIEWED AND MAY BE FORWARDED TO THE CHAIR TO ASK THE SPEAKER(S).
IT WORKS ON ANY DEVICE, YOU DO NOT NEED TO INSTALL ANYTHING!
Registration will open at 9:00 AM and will be located throughout the hospital including
- Schlager Atrium (formerly known as Cabot Atrium, 45 Francis Street Lobby),
- Schuster Lobby (75 Francis Street Entrance),
- Shapiro Cardiovascular Center (70 Francis Street Entrance), and the
- Hale Building for Transformative Medicine (HBTM) 1st Floor (60 Fenwood Road).
Click here for directions to these locations.
NAVIGATING THE BRIGHAM IS EASIER THAN EVER
Need directions to a clinic, conference room, public space, or help assisting someone who looks lost?
Try our browser-based wayfinding tool and mobile app, BWH Maps,
which provides real-time location tracking and directions in the hospital.
Look for BWH Maps on the Apple App Store and Google Play Store,
or visit maps.brighamandwomens.org.
FROM 60 FENWOOD ROAD:
Enter at 60 Fenwood Rd lobby entrance.
STAIRS:
Take the lobby staircase to the 2nd floor. Walk past the balcony overlooking the atrium and take the stairs on the left (Stair 2) to the 3rd floor. Once on the 3rd floor, exit the stairwell and take a right. The room is to your right through the double glass door, straight ahead.
ELEVATOR:
Take S Elevator to 3rd floor. Take a right out of the elevator. The room is past the stairwell, on your right through the double glass doors.
FROM 60 FENWOOD ROAD:
Enter at 60 Fenwood Rd lobby entrance.
STAIRS:
Take the lobby staircase to the 2nd floor. The conference room will be on your right near the display monitor.
ELEVATOR:
Enter at 60 Fenwood Rd main entrance and take the S Elevator to the 2nd floor. Once you exit the elevator, take a right and walk past the balcony overlooking the atrium and the conference room will be straight ahead near the display monitor.
FROM 70 FRANCIS STREET:
The Zinner Breakout Room is located in the Carl J. and Ruth Shapiro Cardiovascular Center at 70 Francis Street, Boston, MA. Upon entering the building at the street level, walk straight towards the escalators in the rear of the building. The Zinner Conference Center is located on your right; the Breakout room is through the large doors on the left.
FROM 70 FRANCIS STREET:
The Zinner Boardroom is located in the Carl J. and Ruth Shapiro Cardiovascular Center at 70 Francis Street, Boston, MA. Upon entering the building at the street level, walk straight towards the escalator, keeping to the left side of the building. The Conference Center is located on your right; the Boardroom is through the large doors on the back wall.
FROM 45 FRANCIS STREET:
Coming from 45 Francis Street lobby, walk towards the Main Pike (2nd floor hallway). Then take left on the Main Pike, 2nd door on right.
AGENDA
10:00 AM – 11:00 AM
Opening remarks
Elizabeth G. Nabel, MD, President Brigham Health, Prof. Medicine @HarvardMed
- 8th event since 2012
- show casing amazing research
- Open to the Public: Patients, Families to educate
- 90 Posters
- Health equity perspective as DNA of the Brigham
- Learn a new idea, meet someone new, create a new idea
Keynote Introduction
David Bates, MD @DBatesSafety
KEYNOTE
INVENTING AND PREDICTING A NEW ERA OF HEALTH WITH AI AND TECHQUITY
KYU RHEE, MD, MPP, VICE PRESIDENT & CHIEF HEALTH OFFICER, IBM CORPORATION & IBM WATSON HEALTH
BORNSTEIN FAMILY AMPHITHEATER
MAIN PIKE, 45 FRANCIS STREET LOBBY
- Partnership BWH & IBM WATSON
- Big data of claims from providers to payers
- Waiting rookms in Healthcare delivery
- Government: ACA
- AI Spring is here, no more Winter for AI
- Health disparities, salaries, sexual orientation – improving health of populations
- Science & Security
- Red Hat – data security – big data statoscope
- Healthcare Culture & Technology Culture: IBM & Amazon hire healthcare professionals
- Cost: Burnout, managing population health,
- Reduce physicians burnout
- Culture Tech – Competition by IBM’s Project Debater
1:00 – 1:50 PM
CLINICAL TRANSLATION OF DISCOVERIES GENERATED IN ENGINEERING IN MEDICINE
ZINNER BREAKOUT ROOM
FROM 70 FRANCIS STREET:
The Zinner Breakout Room is located in the Carl J. and Ruth Shapiro Cardiovascular Center at 70 Francis Street, Boston, MA. Upon entering the building at the street level, walk straight towards the escalators in the rear of the building. The Zinner Conference Center is located on your right; the Breakout room is through the large doors on the left.
- Microbiome – Bacteria and Fungus therapies – computational tools for applications on microbiome
- Diagnostics
- Microbiome in early childhood
- temporal variability during adulthood
- host disease bacteriptherapeutics: C-Diff
- Bugs as drugs
- Gnotobiotic mice model for c-Diff in mice
- MDSINE – Microbial dynamin model interaction model
- cancer microbiome: Bacteria causing cancer, cancer changing the bacteria environment
Jeff Karp BENG PhD @MrJeffKarp
- tissue based patch to seal open foramane ovale. Project remained in Academic settings however
- GLUE component was commercialized
- bioinspiration from living organs in Nature, slugs
- Viscose secretions
- Hydrophobic secretions and snails and sand castle worms
1:00 – 1:50 PM
CAR T CELLS:
ENGINEERING IMMUNE CELLS TO TREAT CANCER
MARSHALL A. WOLF CONFERENCE ROOM
2:00 – 2:50 PM
TRANSFORMING MEDICINE THROUGH PREVENTIVE GENOMICS
MARSHALL A. WOLF CONFERENCE ROOM
3:00 – 3:50 PM
HOME HOSPITAL AND THE BRIGHAM EXPERIENCE
ZINNER BREAKOUT ROOM
4:00 – 5:00 PM
TURNING “DARK MATTER” OF THE GENOME INTO RNA DRUGS
ZINNER BREAKOUT ROOM
Anna Krichevsky, PhD HMS Initiative for RNA Medicine
- paradox of organismal complexity and # protein encoding genes
- Human genome, 70% Transcriptome Non-coding RNA only 2% encode proteins
- Non-coding RNA small, long, multifunctional
- biogenesis of offending RNAs can be drugged
- RNA novel therapies: RNA as a Drug,
- Indications: Brain Tumors and AD: MicroRNA (miRNA)the smallest Glioblastoma – only 4 drugs FDA approved in 25 years miRNA – 10b inhibition kills gliomacells miR-132 most neuroprotective RNA
- Cardiovascular
Paul Anderson, MD, PhD
- ALS and FTD – Fronto Temporal Dimensia
- Riluzone 1970 – anti Anti-glutamateric
- Edarabone 2017 drugs approved – anti-oxidative
- Andogenesis role in Motor protection from Stress Cytoplasmatic tRNA – ANdiogenin (ANG) production
- 20 amino acids
- 5″-tiRNAs assemble G-quadruples – G4
- point mutationin ANG (mANG) reduce its RNanase
- G4-containing DNA analogs of 5″-tiRNA (Ala)
Marc Feinberg, MD
- Cardiovascular: CAD, Insulin resistence – Vascular inflammation
- Impaired angiogenesis: post MI repair CHF
- MiRNA therapeutics for Atherosclerosis – miR-181b: Aortic ECs Athero (mice) CAD (Human)
- miRNA _ Liposomes injected in the vessel wall – reduction of inflammation in vessel – microRNA Group
- monocyte – How can we increase or amintain mir-181b expression in endothelial cells?
- LncRNA Therapeutics for vascular Senescence and Atherosclerosis – no effect on leucocyte accumulation no difference in inflammation
- DNA-dependent protein kinase (DNA-PK)
- Does Loss SNHG12 triggers vascular senescence in the vessel wall
Clemens Scherzer, MD
- The Protein RNA Brain
- Dopamin p
- BRAINCODE: 64% RNA: mRNA, ncRNA,
- cell-type-spacific putative enhancer RNAs (eRNAs)
- eRNAs indicate active genetic switches
- central dogma in Biology: DNA, non-coding RNA, Protein
- Top 10 Markers
- Neuropsychiatric Disease: Parkinson: How do genetic variants function in specific brain cells: neurons, microglia, astrocytes
- genetic variants of neuropsychiatric diseases over-localize to active eRNA sites in dopamine neurons
- enhancers RNA – ADHD,
- enhacers RNA – schizoprania, bipolar, addiction – antopsychotic Vlporic acid
- BRAINCODE Project: BWH MGH HMS
OPIOID AND PAIN INNOVATIONS AT BRIGHAM HEALTH
MARSHALL A. WOLF CONFERENCE ROOM
5:00 – 6:00 PM
AWARDS & RECEPTION
HALE CAFÉ ATRIUM
SPECIAL PHOTO-OP TO CELEBRATE YOU!
WE WILL TAKE A GROUP PHOTO DURING THE RECEPTION AND AWARDS CEREMONY TO CELEBRATE YOU, OUR INNOVATORS!
THE PHOTO WILL BE DISPLAYED AT THE BRIGHAM IN THE HALE BUILDING. WE HOPE YOU CAN JOIN US IN CELEBRATING YOUR ACHIEVEMENTS.
SOURCE
2012pharmaceutical
sjwilliamspa
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