Posts Tagged ‘Mediterranean’

Antioxidant Potential of “Maltese Mushroom” (Cynomorium coccineum)

Reporter: Larry H. Bernstein, MD, FCAP


Evaluation of Antioxidant Potential of “Maltese Mushroom” (Cynomorium coccineum) by Means of Multiple Chemical and Biological Assays

Zucca P , Rosa A ,  Tuberoso CIG , Piras A ,  Rinaldi AC , Sanjust E , et al.   Nutrients 2013, 5(1), 149-161; doi:10.3390/nu5010149  (just published by Libertas)


Cynomorium coccineum is an edible, non-photosynthetic plant widespread along the coasts of the Mediterranean Sea.

The medicinal properties of Maltese mushroom  have been kept in high regard since ancient times.

We evaluated the antioxidant potential of fresh specimens of C. coccineum picked in Sardinia, Italy.

Both aqueous and methanolic extracts were tested by using multiple assay systems (DPPH, FRAP, TEAC, ORAC-PYR).

Total phenolics and flavonoids were also determined.

Gallic acid and cyanidin 3-O-glucoside were identified as the main constituents and measured.

Both extracts showed antioxidant capacities; ORAC-PYR assay gave the highest antioxidant value in both cases.

The methanolic extract was further investigated with in vitro biological models of lipid oxidation;

  • it showed a significant activity in preventing cholesterol degradation and
  • exerted protection against Cu2+-mediated degradation of the liposomal unsaturated fatty acids.

Results of the present study demonstrate that

  • the extracts of C. coccineum show a significant total antioxidant power and also
  • exert an in vitro protective effect in different bio-assays of oxidative stress.

Therefore, Maltese mushroom can be considered a valuable source of antioxidants and phytochemicals

  • useful in the preparation of nutraceuticals and functional foods.

Keywords: plant-based foods; antioxidant; nutraceuticals; Cynomorium coccineum; fungus melitensis; Maltese mushroom

Cynomorium coccineum

Cynomorium coccineum (Photo credit: Alastair Rae)

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Reporter: Aviva Lev-Ari, PhD, RN

What’s Up with the Mediterranean Diet?

Why Heart Doctors Love It


Most of us have heard about the Mediterranean diet, which has generated interest from both the media and the medical community as the gold standard in healthy eating. But what’s all the fuss about – is this diet really worth all the attention?

The answer is yes, according toMurray Mittleman, MD, DrPH, a physician in the CardioVascular Institute at Beth Israel Deaconess Medical Center, Director of the Master’s in Public Health program at Harvard Medical School, and Director of cardiovascular epidemiological research at BIDMC.

“The Mediterranean diet is a very healthy eating style that has been shown to improve cardiovascular risk factors – even for patients with established heart disorders,” Mittleman says.

What is the Mediterranean Diet?

While most healthy diets include produce, whole grains, and fish, the Mediterranean diet and lifestyle offer subtle differences that may reduce the risk for heart disease, while making it easier to stick to healthy eating habits.

According to the American Heart Association, traditional Mediterranean diets have the following characteristics in common:

  • High consumption of fruits, vegetables, beans, nuts and grains
  • Use of olive oil rather than saturated fats like butter, lard, and cottonseed, palm and coconut oils
  • Low to moderate consumption of dairy, eggs, fish and poultry
  • Very little red meat
  • Wine in low-to-moderate amounts

The Diet’s “Discovery”

Originating from the culture and traditional foods found in the area bordering the Mediterranean Sea, this diet first drew the attention of the American scientist Ancel Keys, who was stationed in Italy during World War II. Keys became convinced that middle-aged American men were experiencing heart attacks due to their diets and lifestyles. After conducting studies in the U.S., he began to work with researchers overseas in the first cross-cultural comparison of males and heart attack risk in what is known as the Seven Countries Study.

Starting in 1958, the Seven Countries Study followed 11,579 men, 40 to 59 years of age, in four regions of the world (United States, Northern Europe, Southern Europe and Japan). This study found that men in Southern Europe were far less likely to experience coronary deaths than those in the U.S. and Northern Europe. The study also began to identify the eating pattern known as the Mediterranean diet and its protective benefits.

Since then, “additional research has continued to show the beneficial effects of the diet,” says Mittleman. “The Lyon Diet Heart Study, conducted in the 1990s in France, showed that those who followed the Mediterranean Diet for three years had significantly fewer additional heart attacks and a 76 percent reduction in cardiovascular deaths compared to the control group.”

How Does it Work?

Murray A. Mittleman, MD, DrPH

The Mediterranean diet is a combination of many healthy choices that work together to promote good health, according to Mittleman.

“There is a low intake of refined carbs and very little processed food, which is an important distinction that also lowers fat and salt content,” he explains. “There is more variety in fruit and vegetable consumption, and portions are smaller than those commonly found in the U.S.”

Understanding how and why the Mediterranean diet works involves looking at each of the components that make up this particular style of eating.

Healthy Fats

The Mediterranean diet does not focus on limiting total fat consumption, but it does avoid the use of saturated fats and hydrogenated oils (trans fats), which both contribute to heart disease.

Most of the fat calories in a Mediterranean diet come from “good” or monounsaturated fats, mainly from olive oil and also from nuts.

“These plant-based fats don’t raise blood cholesterol levels the way saturated fat does,” says Mittleman. “In fact, monounsaturated fats actually help reduce LDL cholesterol levels when used in place of saturated or trans fats.”

Monounsaturated fats such as olive, canola, sesame, sunflower and corn oils contain alpha-linolenic acid, a type of omega-3 fatty acid from plant sources. Omega-3 fatty acids lower triglycerides, moderate blood pressure, decrease blood clotting and improve the health of your blood vessels.

Light Protein Sources

Fish is frequently on the menu of the Mediterranean diet, and red meat is rarely served. Light in calories, fish is a beneficial substitute for meat-heavy Western cuisine, which is higher in unhealthy saturated fat. In addition, fish such as mackerel, lake trout, herring, sardines, albacore tuna and salmon are rich sources of omega-3 fatty acids.

Other plant-based protein sources, such as beans and nuts, also predominate in this style of eating. These vegetable protein sources are also light on saturated fat, helping to keep cholesterol and blood pressure in check.

Plenty of Produce

A wide variety of fruits and vegetables play an important role in the Mediterranean diet, and include fresh salads, greens sautéed in garlic and olive oil, soups, and vegetarian pasta dishes.

Fruits, such as melon, often serve as dessert, rather than the sweetened, high-fat concoctions that Western-style dining offers. Baked sweets are generally reserved for holidays or special occasions. Fresh produce provides phytonutrients that prevent and repair damage to cells and protect blood vessels. In addition, the added fiber in the diet slows the release of glucose in the blood stream, which is an important way to help prevent or control diabetes.

A Little Wine

Kenneth J. Mukamal, MD, MPH

The Mediterranean diet typically includes a small amount of wine. While red wine has antioxidant properties, the amount, frequency and style of enjoying wine is what makes this an important part of Mediterranean dining, according toDr. Kenneth J. Mukamal, an internist and cardiovascular researcher at BIDMC.

Mukamel served as lead researcher in a BIDMC study that linked the heart benefits of alcohol to the frequency of drinking. The study, which investigated 38,000 men over a 12-year period, was published in the New England Journal of Medicine in January 2003.

“The study confirmed that people who have one drink a day have the lowest rate of heart disease compared with non-drinkers or heavy drinkers,” says Mukamal. “It doesn’t seem to be the type of alcohol that matters; it’s the frequency. Individuals who drink a little bit three to-seven days a week are at lowest risk. There’s also evidence that alcohol consumed with meals — which is typical in the Mediterranean diet — is safest, providing a more gradual increase in blood alcohol levels.”

How much alcohol is appropriate? The American Heart Association recommends up to one drink a day for women and one to two drinks a day for men. Examples of one drink include 4 ounces of wine, 12 ounces of beer, or 1.5 ounces of distilled spirits (80 proof).

Mukamal cautions that for some people, such as those who have or are at risk for breast cancer or hepatitis C, regular consumption of alcohol may not be advisable.

“It’s a complex mixture of potential risks and benefits, so it’s always worth a discussion with your doctor to be sure that drinking small amounts of alcohol is right for your situation,” he says.

Taking the Mediterranean Route

The incidence of heart disease and deaths in Mediterranean countries is lower than in the United States, but such statistics may not be entirely dependent upon diet. The Mediterranean diet is part of a lifestyle in which exercise, such as walking, is frequent. Families and friends gather to enjoy meals and each other’s company. And the pace of living seems less frenetic than elsewhere.

But you don’t have to go to Rome to live as the Romans do. With some planning and attention to diet and lifestyle, you can bring the flavor and health benefits of the Mediterranean into your own life.

The changes aren’t as severe as you might think. Here are some steps that can get you moving in the right direction:

  • Take a half-hour walk each day.
  • Use olive oil instead of butter or margarine.
  • Increase servings of fresh veggies and fruits – aim for at least seven per day.
  • Eat fish and poultry and minimize or eliminate red meat.
  • Aim for several meatless meals each week, incorporating legumes as a protein source when possible.
  • Use fresh herbs and spices to flavor food instead of salt.
  • Avoid foods that are processed, high in fat, or contain trans or saturated fat.
  • Have a small glass of wine with dinner, if your doctor agrees.
  • Invite your family and friends to join you!

“The Mediterranean diet is very sustainable and livable,” says Mittleman. “There’s a lot of variety for your palate and it’s easy to maintain. The heart-health benefits will pay you back for a lifetime.”

Above content provided by the CardioVascular Institute at Beth Israel Deaconess Medical Center. For advice about your medical care, consult your doctor.

Posted October 2012


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