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Posts Tagged ‘FASEB Journal’


Research Presentations

Larry H. Bernstein, MD, FCAP, Curator

LPBI

Harvard Citation Style: Introduction

Referencing or citing your sources is an important part of academic writing. It lets you acknowledge the ideas or words of others if you use them in your work and helps avoid plagiarism.

Referencing also demonstrates that you’ve read relevant backgound literature and you can provide authority for statements you make in your assignments.

The Harvard citation style can vary in minor features such as punctuation, capitalisation, abbreviations, and the use of italics.

There are two components to referencing: in-text citations in your paper and the reference list at the end of your paper.

The in-text citation:

Harvard is an ‘author/date’ system, so your in-text citation consists of author(s) and year of publication.

In-text citation of a book (the same format applies for a journal article)

If you quote directly from an author or to cite a specific idea or piece of information from the source you need to include the page number of the quote in your in-text citation.

The reference list:

All in-text citations should be listed in the reference list at the end of your document. The reference list should include details representing all the works you cite in your document and it should be in alphabetical order by author.

Reference list entry for a book

Reference list entry for a journal

Reference list entries contain all the information that someone needs to follow up your source. Reference lists in Harvard are arranged alphabetically by author.

The overarching principle in referencing or citing is that readers should be able to follow your sources if they are interested in finding out more about a topic and that you should acknowledge other authors whose ideas or information you have used.

Two or more works cited at one point in the text

If two or more works by different authors or authoring bodies are cited at one point in the text, use a semi-colon to separate them:

(Larsen 2000; Malinowski 1999)

The authors should be listed in alphabetical order.

 

Two or three authors or authoring bodies

When citing a work by two or three authors or authoring bodies, cite the names in the order in which they appear on the title page:

(Malinowski, Miller & Gupta 1995)

What is RefWorks? 

RefWorks is an online research management, writing and collaboration tool. It is designed to help researchers easily gather, manage, store and share all types of information, as well as generate citations and bibliographies.

Why should you use RefWorks?

  • One “click” and you can generate bibliographies in any citation style format. (APA, AMA, MLA and more!)
  • Allows you to create & organize your own personal database of references.
  • Import your references directly from databases, journals or the library catalog and avoid emailing or the need to save to a USB flashdrive.
  • Makes collaboration easier during group projects allowing you to share your RefWorks folder of references.

    New Users: Getting Started!
  • Go to Himmelfarb Library’s Homepage  
  • Under Accounts Click RefWorks  
  • Select “Sign up for an Individual Account” and complete the new user information form.
  • You will receive an email from RefWorks confirming your login username and password

RefWorks

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Write-N-Cite is a RefWorks tool that allows you to cite and imbed footnotes from your references in a Microsoft Word document. It automatically formats both the in-text citations and creates your bibliography from your references.

Note: You will need the  Group Code  for GWUMC to use Write-N-Cite off-campus.  
How to download Write-N-Cite:

write-in-cite_refworks_2.0

http://lgimages.s3.amazonaws.com/data/imagemanager/19521/write-in-cite_refworks_2.0.jpg

What is a DOI? A DOI (digital object identifier) is a unique alphanumeric string assigned by a registration agency (the International DOI Foundation) to identify content and provide a persistent link to its location on the internet.  Used for both print and electronic sources.

If a DOI (Digital Object Identifier) is not visible in either the article or the database, search Cross/Ref DOI Lookup using the article author and title.

Quick tutorial video put together by APA.

Writing a bibliography doesn’t have to be a confusing process!

For a good reference on APA Style go to the APA Citation Style Guide.

Produced by J.W. England Library, University of the Sciences in Philadelphia

Detailed instructions on formatting, text rules, and documentation. Find out how to set up your research paper from this web site.

A Manual for Writers of Research Papers, Theses, and Dissertations, Eighth Edition by Kate L. Turabian; Wayne C. Booth (Revised by); Gregory G. Colomb (Revised by); University of Chicago Press Staff (Revised by); Joseph M. Williams (Revised by)

Call Number: LB2369 .2013

ISBN: 0226816389

Publication Date: 2013-03-28

Available: Print (Himmelfarb Library)

From research to manuscript : a guide to scientific writing 2nd ed. by Katz, Michael Jay

Call Number: T11 .K345 2009

ISBN: 1402094663

Available: Print (Himmelfarb Library

http://libguides.gwumc.edu/c.php?g=27798&p=170464

What is GRC?

Origin, Purpose and Commitment of the Conferences

The Gordon Research Conferences were initiated by Dr. Neil E. Gordon, of the Johns Hopkins University, who recognized in the late 1920s the difficulty in establishing good, direct communication between scientists, whether working in the same subject area or in interdisciplinary research. The Gordon Research Conferences promote discussions and the free exchange of ideas at the research frontiers of the biological, chemical and physical sciences. Scientists with common professional interests come together for a full week of intense discussion and examination of the most advanced aspects of their field. These Conferences provide a valuable means of disseminating information and ideas in a way that cannot be achieved through the usual channels of communication – publications and presentations at large scientific meetings.

Admission Qualifications

Each Conference operates relatively autonomously with each Conference Chair being completely responsible for the content and conduct of the meeting as well as the selection of discussion leaders, speakers and attendees. The primary criteria for attendance at a Conference are scientific accomplishment and, implicitly, the commitment to participate actively and meaningfully in the discussions. Gordon Research Conferences will not discriminate against any individual based on that person’s race, color, national origin, gender, gender identity or expression, sexual orientation, age, religion, disability, genetic information or any other characteristic protected by law.

Conference Format

Normally, lectures are held in the morning and evening. Almost all Gordon Research Conferences begin on a Sunday evening and run through Thursday evening. Afternoons are available for informal participation in discussion, reading or recreation, as individuals desire.

The Board of Trustees of the Gordon Research Conferences established the Alexander M. Cruickshank Lectures to honor the many years of service to the organization by the former director, Dr. A.M. Cruickshank. Typically, there will be one such lectureship annually for each of the principal subdisciplines of the Conferences, namely the Biological, Chemical, and Physical sciences.

2015 Lecturers

  • Karl Deisseroth, Amygdala in Health & Disease
  • David M. Sabatini, Lysosomal Diseases
  • Laura Kiessling, Carbohydrates
  • Gerbrand Ceder, Physical Metallurgy
  • Liang Fu, Superconductivity

2014 Lecturers

  • Kristi S. Anseth, Signal Transduction by Engineered Extracellular Matrices
  • Eric Gouaux, Ligand Recognition and Molecular Gating
  • Claudia Felser, Solid State Chemistry
  • Gregory C. Fu, Stereochemistry
  • Joanna Aizenberg, Biointerface Science

2013 Lecturers

  • Erin Schuman, Dendrites: Molecules, Structure & Function
  • Carolyn Bertozzi, High Throughput Chemistry & Chemical Biology
  • Immanuel Bloch, Atomic Physics

2012 Lecturers

  • Bonnie Bassler, Microbial Stress Response
  • Angela M. Belcher, Renewable Energy: Solar Fuels
  • Naomi Halas, Noble Metal Nanoparticles

2011 Lecturers

  • Erick Carreira, Organic Reactions & Processes
  • Sandra Louise Schmid, Cell-Cell Fusion
  • Paul Weiss, Clusters, Nanocrystals & Nanostructures

2010 Lecturers

  • Stanislas Dehaene, Neurobiology of Cognition
  • Jorge Galan, Microbial Toxins and Pathogenicity
  • Chad Mirkin, Noble Metal Nanoparticles
  • Alanna Schepartz, Biopolymers

The FASEB Journal

The FASEB Journal ranks among the top biology journals in the world.* This monthly journal publishes peer-reviewed, multidisciplinary original research articles, as well as editorials, reviews, and news of the life sciences. As disciplines in the life sciences continue to overlap, readers are drawn to The FASEB Journal for its interdisciplinary coverage. Specifically, The FASEB Journal is a preferred venue for the latest research reports and reviews of epigenetics, iRNA mechanics, histone acetylation, nitric oxide signaling, eicosanoid biochemistry, angiogenesis, tumor suppressor genes, apoptosis, cytoskeletal function, and human stem cell research.

Influence

The FASEB Journal was recognized as one of the Top 100 Most Influential Journals of the past century in Biology and Medicine by the Special Library Association’s Biomedical and Life Sciences Division. Further, it has been covered by major news outlets including The Chicago Tribune, ABC News, Scientific American, and The New York Times.

The FASEB Journal Website

Breakthroughs in Bioscience

This series brings forth essays that illustrate recent breakthroughs in biomedical research and their importance to society. It also highlights the important role animal models play in biomedical research and discovery. Hard copies of the Breakthroughs in Bioscience series are available upon request. Please include the desired article, quantity and purpose for the publication’s use with your inquiry. Hover mouse over each article to view a brief description.

http://www.faseb.org/Policy-and-Government-Affairs/Publications/Breakthroughs-and-Horizons-in-Bioscience.aspx

The Human Microbiome: Your Own Personal Ecosystem

human microbiome breakthroughs

http://www.faseb.org/portals/2/images/opa/human%20microbiome%20breakthroughs%20cover.png

The Future of Individualized Medicine

Individualized Medicine Breakthroughs

http://www.faseb.org/portals/2/images/opa/Individualized%20Medicine%20Breakthroughs%20cover.png

Nanomedicine: A Targeted Approach

nanoparticle targeted approach horizons

http://www.faseb.org/portals/2/images/opa/nanoparticle%20targeted%20approach%20horizons%20cover.png

Optogenetics: Illuminating the Brain
Listen to the Podcast

http://www.faseb.org/portals/2/images/opa/horizons%20illuminating%20the%20brain%20cover.jpg

Other Publications and Reports

Physician Scientists: Assessing the Workforce by Howard H. Garrison and Anne M. Deschamps, PhD

FASEB’s “Make Your Voice Heard” webinar YouTube video and presentation

Energizing & Investing in the Future of Science: NIH Summer Research Program Immerses High School Students, Undergraduates, and Teachers in Science by Jennifer Hobin and Anne Deschamps

Stimulating Science Education: NIH Summer Research Program Engages Students and Teachers in Science by Jennifer A. Hobin

What’s happening to the new investigator? The FASEB Journal by Howard Garrison and Robert Palazzo

Gaining, Training and Retaining Physician Scientists Should Be a National Priority Op Ed by Bruce R. Bistrian

Foreign postdocs: the changing face of biomedical science in the U.S. by Howard Garrison, Andrea Stith and Susan Gerbi

Research Equipment and Resource Requirements of NIH-Supported Investigators: An Assessment of Current Conditions and Recommendations for Future Funding and Programs by Tamara Zemlo, Howard Garrison, et al.

In an Era of Scientific Opportunity, Are There Opportunities for Biomedical Scientists? by Howard H. Garrison, Susan Gerbi, and Paul Kincade

The Physician-Scientist: Career Issues and Challenges at the Year 2000 The FASEB Journal 2000;14:221-230 by Tamara Zemlo, Howard Garrison, Nicola Partridge and Timothy Ley

A Profile of the Members of FASEB Societies: NIH Awards, Degrees, and Institutional Affiliations, 1999 By Howard Garrison, Siddhartha Lahiri and David Stephens

The Report of the FASEB Consensus Conference on Graduate Education

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Stanford Study Finds miRNA-320a a Broad Regulator of Glycolysis, Potential Drug Target

 Reporter: Aviva Lev-Ari, PhD, RN

A study by Stanford researchers has found that microRNA-320a appears to regulate glycolysis in response to oxidative stress in several biological systems, including lung cancer and wasting of disused muscle.

The Stanford team was initially interested in better understanding the wasting of diaphragm muscles due to mechanical ventilation, but expanded its study to look at lung cancer and an experimental in vitro model of oxidative stress, as well as the similarity of pathogenic glycolytic pathways across these biological systems.

The group profiled miRNA and protein expression in samples from human diaphragm muscles under mechanical ventilation to identify miRNAs associated with the glycolytic rate-limiting enzyme phosphofructokinase, or PFKm, without which glycolysis is reduced.

The group initially identified 28 miRNAs that were significantly downregulated and three that were upregulated in the ventilated human diaphragm samples. Using predictive software, the group pinpointed miR-320a as being potentially involved in the regulation PFKm.

To validate miR-320a, the researchers looked at all three experimental systems — samples of diaphragm tissue, lung cancer, and an in vitro cell model under oxidative stress. In all three, miR-320a was down-regulated in the samples versus the control.

The group also confirmed that miR-320a influences PFKm in each system, and further demonstrated that miR-320a knockdown increased lactate levels in vitro; and thathigher miR-320a levels reduced lactate levels in in vivo mouse experiments.

The group wrote that the study shows for the first time that glycolytic activity “is increased in diaphragm tissue that is noncontractile as a result of full mechanical ventilator support.” The results also confirmed that glycolysis up-regulation, or the Warburg effect, is present in lung adenocarcinoma, and that both otherwise divergent disorders are in fact linked by the influence of miR-320a.

The finding has implications for cancer treatment, as well as more effective treatment for dysfunctional diaphragm muscles following breathing support using a ventilator, according to the team, which published the study online in the FASEB Journal earlier this month.

Glycolysis is the process of converting sugar into energy, and is implicated in the growth of some cancers through a process called the Warburg effect. To the Stanford team, the Warburg effect seen in lung adenocarcinoma “appears to closely mimic” that of dysfunctional human diaphragm tissue after mechanical ventilation therapy, a condition called ventilator-induced diaphragm dysfunction, or VIDD.

The Stanford researchers claim that their study shows that these very divergent biological systems share the same glycolysis regulatory apparatus involving miR-320a, which the authors believe they are the first to identify.

Additionally, “miR-320 regulation of glycolysis may represent a general mechanism underlying other clinical diseases that are associated with changes in energy supply,” the researchers wrote, such as cardiac ischemia, to insulin resistance.

In cancer specifically, down-regulation of miR-320a has been previously reported in a number of malignancies, the group reported. Coupled with the fact that the Warburg effect is thought to be important in many cancers, and the results of the group’s study in adenocarcinoma, this suggests that miR-320a “may be directly related” to the development of cancer, and that the associated glycolysis may be a potential drug target.

FASEB J. 2012 Jul 5. [Epub ahead of print]

Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems.

Tang HLee MSharpe OSalamone LNoonan EJHoang CDLevine SRobinson WHShrager JB.

Source

*Division of Thoracic Surgery, Department of Cardiothoracic Surgery.

Abstract

Glycolysis is the initial step of glucose catabolism and is up-regulated in cancer cells (the Warburg Effect). Such shifts toward a glycolytic phenotype have not been explored widely in other biological systems, and the molecular mechanisms underlying the shifts remain unknown. With proteomics, we observed increased glycolysis in disused human diaphragm muscle. In disused muscle, lung cancer, and H(2)O(2)-treated myotubes, we show up-regulation of the rate-limiting glycolytic enzyme muscle-type phosphofructokinase (PFKm, >2 fold, P<0.05) and accumulation of lactate (>150%, P<0.05). Using microRNA profiling, we identify miR-320a as a regulator of PFKm expression. Reduced miR-320a levels (to ∼50% of control, P<0.05) are associated with the increased PFKm in each of these diverse systems. Manipulation of miR-320a levels both in vitro and in vivo alters PFKm and lactate levels in the expected directions. Further, miR-320a appears to regulate oxidative stress-induced PFKm expression, and reduced miR-320a allows greater induction of glycolysis in response to H(2)O(2) treatment. We show that this microRNA-mediated regulation occurs through PFKm’s 3′ untranslated region and that Ets proteins are involved in the regulation of PFKm via miR-320a. These findings suggest that oxidative stress-responsive microRNA-320a may regulate glycolysis broadly within nature.-Tang, H., Lee, M., Sharpe, O., Salamone, L., Noonan, E. J., Hoang, C. D., Levine, S., Robinson, W. H., Shrager, J. B. Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems.

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