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Posts Tagged ‘polyphenols’


Metabolomics: its Applications in Food and Nutrition Research

Reporter and Curator: Sudipta Saha, Ph.D.

 

Metabolomics is a relatively new field of “omics” research concerned with the high-throughput identification and quantification of small molecule (<1500 Da) metabolites in the metabolome. The metabolome is formally defined as the collection of all small molecule metabolites or chemicals that can be found in a cell, organ or organism. These small molecules can include a range of endogenous and exogenous chemical entities such as peptides, amino acids, nucleic acids, carbohydrates, organic acids, vitamins, polyphenols, alkaloids, minerals and just about any other chemical that can be used, ingested or synthesized by a given cell or organism.

Metabolomics is ideally positioned to be used in many areas of food science and nutrition research including food component analysis, food quality/authenticity assessment, food consumption monitoring and physiological monitoring in food intervention studies. However, the potential impact of metabolomics is still limited by two factors: (1) technology and (2) databases. In terms of instrumentation, it is clear that significant improvements need to be made to make metabolite detection and quantification technology more robust, automated and comprehensive. While promising advances have been made, current techniques are only capable of detecting perhaps 1/10th of the relevant metabolome. This expanded breadth and depth of coverage is particularly important in food and nutrition studies.

Many more reference spectral or chromatographic databases on metabolites, food components and phytochemicals need to be developed and made public. It is only through these databases that nutritionally relevant compounds can be routinely identified or quantified. Indeed a comprehensive effort, similar to that undertaken to annotate the human metabolome, needs to be made to complete and annotate the “food metabolome”. Similar efforts also need to be directed towards creating publicly accessible, comprehensive nutritional phenotype databases that include quantitative metabolomic (and other omic) data collected from diet-challenge or food intervention experiments. While these kinds of endeavours may take years to complete and cost millions of dollars, hopefully the food science community (and its funding agencies) will find a way of coordinating its activities to complete these efforts. Indeed, having public resource like a food metabolome database or a nutritional phenotype database could be as valuable to food scientists as GenBank has been to molecular biologists.

Source References:

http://www.sciencedirect.com/science/article/pii/S0924224408000770

http://www.sciencedirect.com/science/article/pii/B9780123945983000010

http://www.sciencedirect.com/science/article/pii/S092422440900226X

http://www.sciencedirect.com/science/article/pii/S1359644605036093

http://www.sciencedirect.com/science/article/pii/B9780080885049000520

http://www.sciencedirect.com/science/article/pii/B9780123744135000051

Other articles related to this topic were published on this Open Access Online Scientific Journal, including the following:

Ca2+ signaling: transcriptional control

Larry H. Bernstein, MD, FCAP, Reporter, RN 03/06/2013

https://pharmaceuticalintelligence.com/2013/03/06/ca2-signaling-transcriptional-control/

Harnessing Personalized Medicine for Cancer Management, Prospects of Prevention and Cure: Opinions of Cancer Scientific Leaders @ http://pharmaceuticalintelligence.com

Aviva Lev-Ari, PhD, RN 01/12/2013

https://pharmaceuticalintelligence.com/2013/01/12/harnessing-personalized-medicine-for-cancer-management-prospects-of-prevention-and-cure-opinions-of-cancer-scientific-leaders-httppharmaceuticalintelligence-com/

Breakthrough Digestive Disorders Research: Conditions affecting the Gastrointestinal Tract.

Aviva Lev-Ari, PhD, RN 12/12/2012

https://pharmaceuticalintelligence.com/2012/12/12/breakthrough-digestive-disorders-research-conditions-affecting-the-gastrointestinal-tract/

A Second Look at the Transthyretin Nutrition Inflammatory Conundrum

Larry H. Bernstein, MD, FCAP, Reporter, RN 12/03/2012

https://pharmaceuticalintelligence.com/2012/12/03/a-second-look-at-the-transthyretin-nutrition-inflammatory-conundrum/

Metabolic drivers in aggressive brain tumors

Prabodh Kandala, PhD, RN 11/11/2012

https://pharmaceuticalintelligence.com/2012/11/11/metabolic-drivers-in-aggressive-brain-tumors/

Metabolite Identification Combining Genetic and Metabolic Information: Genetic association links unknown metabolites to functionally related genes

Aviva Lev-Ari, PhD, RN 10/22/2012

https://pharmaceuticalintelligence.com/2012/10/22/metabolite-identification-combining-genetic-and-metabolic-information-genetic-association-links-unknown-metabolites-to-functionally-related-genes/

Advances in Separations Technology for the “OMICs” and Clarification of Therapeutic Targets

Larry H. Bernstein, MD, FCAP, Reporter, RN 10/22/2012

https://pharmaceuticalintelligence.com/2012/10/22/advances-in-separations-technology-for-the-omics-and-clarification-of-therapeutic-targets/

Expanding the Genetic Alphabet and linking the genome to the metabolome

Larry H. Bernstein, MD, FCAP, Reporter, RN 09/24/2012

https://pharmaceuticalintelligence.com/2012/09/24/expanding-the-genetic-alphabet-and-linking-the-genome-to-the-metabolome/

Therapeutic Targets for Diabetes and Related Metabolic Disorders

Aviva Lev-Ari, PhD, RN 08/20/2012

https://pharmaceuticalintelligence.com/2012/08/20/therapeutic-targets-for-diabetes-and-related-metabolic-disorders/

The Automated Second Opinion Generator

Larry H. Bernstein, MD, FCAP, Reporter, RN 08/13/2012

https://pharmaceuticalintelligence.com/2012/08/13/the-automated-second-opinion-generator/

 

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