Feeds:
Posts
Comments

Posts Tagged ‘Oregon State University’


Reporter: Aviva Lev-Ari, PhD, RN

Dr. Pnina Abir-Am, Resident Scholar

http://paulingblog.wordpress.com/2012/11/21/dr-pnina-abir-am-resident-scholar/

https://pharmaceuticalintelligence.com/contributors-biographies/pnina-g-abir-am-phd-historian-of-molecular-biology/

Posted on November 21, 2012 by scarc

Pnina Abir-Am

Dr. Pnina Abir-Am, historian of science at Brandeis University’s Women’s Studies Research Center, is the first individual to complete a term as Resident Scholar in the OSU Libraries for the 2012-13 school year.  An accomplished scholar, Abir-Am has authored and edited a number of noteworthy publications, including the influential book Uneasy Careers and Intimate Lives: Women in Science, 1789-1989 (Rutgers University Press, 1987, 1989) co-edited with Dorinda Outram.

Abir-Am traveled across the country to conduct research in support of another book, DNA at 50: A Revisionist History of the Discovery of DNA Structure, scheduled for publication in 2013.  Delving into the Pauling Papers, the Jack Dunitz Papers, theDavid and Clara Shoemaker Papers and the History of Science Oral History Collection, Abir-Am sought “to better explain Pauling’s failure with solving the structure of DNA by examining in greater detail his deployment of a group known as ‘Pauling’s boys.’”

In her Resident Scholar presentation, Abir-Am argued – as have many others – that Pauling was ideally positioned to solve the DNA structure, given his great successes in protein research from 1936-1951 and culminating in his elucidation of the alpha-helix.  The question then, is why did he fail to discover the double helix?  Why did he lose the “race” to James Watson and Francis Crick?

The reasons for the failure are manifold, and Abir-Am acknowledges many that have been pointed out by other researchers.  For one, Pauling was very casual in his approach, believing protein structures to be of more importance than DNA.  He also underestimated the research being conducted by certain of his peers, including Erwin Chargaff, J.T. Randall and Rosalind Franklin.

In particular, Abir-Am argues that Pauling disregarded the work being conducted at Kings College, London, believing that physicists like J.T. Randall and Maurice Wilkins could not be expected to solve a complex biological structure like DNA, as their training left them ill-equipped for the task.  By the time Pauling did get serious about the DNA structure, he was too far behind the competition, using poor quality data and rushing a structure to print. Indeed, in the end, Pauling’s attitude toward DNA could be summed up as “too little too late,” a situation further reinforced by the political problems – culminating in the revoking of his passport – that he faced throughout 1952.

Abir-Am sheds new perspective by focusing on the social structure surrounding Pauling at Caltech during the early 1950s. In examining the story from this perspective, Abir-Am wonders what “Pauling’s boys” – understudies, peers and other colleagues including Alexander Rich, Robert Corey, Eddie Hughes, Verner Schomaker, Jerry Donohue, David Harker and Pauling’s second-born son, Peter – could have done to render Pauling’s attempt at DNA more successful.

Abir-Am posits that “the boys” could have done plenty: collect x-ray crystallographic data, collaborate on model building, make calculations, serve as delegates at conferences and even collect intelligence on rivals.  To some extent all of this did occur, but never to the point where Pauling shied away from his manifestly wrong triple-helical structure.

In thinking about what could have gone differently, Abir-Am offers three possible conjectures as to why “the boys,” all hugely talented, didn’t steer Pauling down a more productive path:

  1. They did voice their objections but Pauling ignored them since, after the success of the alpha-helix, he was no longer seeking advice;
  2. Long accustomed to accepting Pauling’s ways, “the boys” lost the ability to criticize his work;
  3. Pauling did not inform “the boys” of his interest in DNA because he wanted to surprise them.

By the conclusion of her stay, Abir-Am was still wrestling with these questions and evaluating her conjectures.  An entire chapter of her DNA book will be devoted to Pauling’s failed structure – we’ll be very excited to read it!

Update

After seeing this post, Dr. Abir-Am asked that we add some comments of her own, which are included here.

My initial reaction to OSU-SCARC’s (Oregon State University, Special Collections and Archive Research Center) Paulingblog’s entry of 11-21-12, reporting on my lecture “‘Pauling’s Boys’ and the Mystery of DNA Sructure” was “Wow, they did a better job than I might have done on my own!” Indeed, OSU-SCARC’s Program for Resident Scholars is a scholar’s paradise: a spacious reading room flooded by sunlight provides a superb “room with a view” of gorgeous Oregon trees. State of the art equipment scans archival documents straight into your flash drive. Rare, as well as recent, books that scholars might need to complement one’s ongoing archival research, line the reading room’s walls forming tasteful panels. The entrance is flanked by two glass cases for archival exhibits that rotate periodically and give the foyer a museum look.

But above all, SCARC is a paradise because of its angelic people, all eager to help resident scholars make the best of their precious stay. I was amazed at how readily the SCARC personnel not only guided me through the maze of archival documents in their care, but also helped me in preparing essential visuals. By displaying photomontages of Pauling and his associates, I was better able to convey his enigmatic predicament, as a leading molecular structurist who missed the solution of DNA structure, even though he was surrounded by many gifted and loyal associates, or “boys” in his era’s jargon. Along these lines, a slide of attendees at the Pasadena international conference on “Protein and Nucleic Acid Structure” which Pauling organized in September 1953, captured by photo 2 above, (click for enlargement) distinguished between “boys” from rival groups by color circles around their heads. These graphical devices were critical for my new argument that the outcome of competition over DNA structure was a matter of group rather than individual action.

Having spent considerable time in many archives on both sides of the Atlantic ocean, I have to conclude that OSU-SCARC, situated in the remote splendor of the Pacific Northwest, provides greater scholar-friendly opportunities than anything I have seen, including my prior favorite CCAC. (Churchill College Archive Center in Cambridge, UK) I now count SCARC scholars among my cherished colleagues and consider their work to be a valuable resource for my own chapter on Pauling & Co.’s effort with DNA structure. Last but not least, SCARC’s interest in this chapter, as well as in my forthcoming book DNA at 50 proved invigorating in propelling me toward a speedier revision of both chapter and book.

The Paulingblog’s Photo 2 conveys the civilized environment of OSU Libraries’ Willamette Lecture Room. For the sake of completeness, I wish to remind future applicants that the environment outside OSU’s library can also become a much cherished memory, especially the wild rapids of the McKenzie River which we survived during the Labor Day weekend preceding my 9-5-12 talk. Hopefully, the treasures I left untouched, whether in the archive or in the nearby Oregonian wild nature (e.g. Upper Klamath – I signed a petition to open it for rafting – Crater Lake, Sunset Bay) will soon cheer additional beneficiaries of SCARC’s Program for Resident Scholars.

$2 Million for Crick Medal $6 Million for Crick’s Letter to his Son

Francis Crick’s Nobel Prize medal for the discovery of the structure of DNA sold for 4 times its estimated value.

By Edyta Zielinska | April 12, 2013

A number of Francis Crick’s possessions were sold at auction this week in New York, including his Nobel Prize medal, which raked in $2.27 million. It was the first time a Nobel Prize medal was had ever been sold at auction, according to LiveScience.

Auctioning began on the medal at $280,000, but within a minute or so, bidding had exceeded the $1 million mark. In the end, the winner was Jack Wang, CEO of a Chinese biomedical firm that’s working on organ regeneration and devices that claim to work by activating electromagnetic fields in the body, according to Nature.

Suprisingly, however, the medal wasn’t the priciest of Crick’s possessions: a letter to his 12-year old son garnering $6 million. Crick’s family says they intend to donate at least 20 percent of the proceeds from the sale to the Francis Crick Institute, which is expected to open in London in 2015. “It’s a win for science,” Kindra Crick, Crick’s granddaughter and an artist living in Portland, Oregon, told Nature. (You can view a number of the auction items on a slideshow at LiveScience.)

Correction (April 12): This story has been updated from its original version to correct Francis Crick’s name.The Scientist regrets the error.

Auction of Crick’s 23-carat-gold medallion was awarded for the 1962 Nobel Prize

In NATURE, On 02 April 2013 Corrected 05 April 2013 Ewen Callaway wrote an article about Crick’s family stands to gain more than a million dollars after his Nobel medal and other memorabilia go to the auction block next week in New York. The 23-carat-gold medallion was awarded for the 1962 Nobel Prize in Physiology or Medicine, which Crick shared with Watson and Maurice Wilkins for their work on determining the molecular structure of DNA and its role in heredity. Crick put the medal in a family trust in 1990.

Crick’s letter to his Son

Callaway writes:
Start quote
One day before this sale, auctioneer Christie’s will sell the seven-page, handwritten letter that Crick sent to his 12-year-old son Michael in 1953 describing the structure of DNA. “Jim Watson and I have probably made a most important discovery,” begins the letter, which includes a sketch of the double-helical structure and Crick’s inference on how the molecule replicates. “You can understand that we are very excited.”
End quote
SOURCE for Crick’s Letter to his son:

Other articles related to these topics appeared on this Open Source Online Scientific Journal, including the following:

Paradigm Shift in Human Genomics – Predictive Biomarkers and Personalized Medicine – Part 1

Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2013/01/13/paradigm-shift-in-human-genomics-predictive-biomarkers-and-personalized-medicine-part-1/

Interview with the co-discoverer of the structure of DNA: Watson on The Double Helix and his changing view of Rosalind Franklin

Aviva Lev-Ari, PhD. RN

https://pharmaceuticalintelligence.com/2012/11/09/interview-with-the-co-discoverer-of-the-structure-of-dna-watson-on-the-double-helix-and-his-changing-view-of-rosalind-franklin/

2013 Genomics: The Era Beyond the Sequencing of the Human Genome: Francis Collins, Craig Venter, Eric Lander, et al.

Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2013/02/11/2013-genomics-the-era-beyond-the-sequencing-human-genome-francis-collins-craig-venter-eric-lander-et-al/

Harnessing Personalized Medicine for Cancer Management, Prospects of Prevention and Cure: Opinions of Cancer Scientific Leaders @ http://pharmaceuticalintelligence.com

Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2013/01/12/harnessing-personalized-medicine-for-cancer-management-prospects-of-prevention-and-cure-opinions-of-cancer-scientific-leaders-httppharmaceuticalintelligence-com/

The “Cancer establishments” examined by James Watson, co-discoverer of DNA w/Crick, 4/1953

Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2013/01/09/the-cancer-establishments-examined-by-james-watson-co-discover-of-dna-wcrick-41953/

DNA Structure and Oligonucleotides

Larry H Bernstein, MD, FACP

https://pharmaceuticalintelligence.com/2013/02/15/dna-structure-and-oligonucleotides/

CRACKING THE CODE OF HUMAN LIFE: Milestones along the Way – Part IIA

Larry H Bernstein, MD, FACP

https://pharmaceuticalintelligence.com/2013/02/12/cracking-the-code-of-human-life-milestones-along-the-way/

CRACKING THE CODE OF HUMAN LIFE: The Birth of BioInformatics and Computational Genomics – Part IIB

Larry H Bernstein, MD, FACP

https://pharmaceuticalintelligence.com/2013/02/13/cracking-the-code-of-human-life-the-birth-of-bioinformatics-and-computational-genomics/

CRACKING THE CODE OF HUMAN LIFE: Recent Advances in Genomic Analysis and Disease – Part IIC

Larry H. Bernstein, MD, FACP

https://pharmaceuticalintelligence.com/2013/02/14/cracking-the-code-of-human-life-recent-advances-in-genomic-analysis-and-disease/

The Initiation and Growth of Molecular Biology and Genomics – Part I

Larry H Bernstein, MD, FACP

https://pharmaceuticalintelligence.com/2013/02/08/the-initiation-and-growth-of-molecular-biology-and-genomics/

John Randall’s MRC Research Unit and Rosalind Franklin’s role at Kings College

Larry H Bernstein, MD, FACP

https://pharmaceuticalintelligence.com/2013/04/05/john-randalls-mrc-research-unit-and-rosalind-franklins-role-at-kings-college/

Expanding the Genetic Alphabet and linking the genome to the metabolome

Larry Bernstein, MD, FACP

https://pharmaceuticalintelligence.com/2012/09/24/expanding-the-genetic-alphabet-and-linking-the-genome-to-the-metabolome/

Read Full Post »


Reporter: Aviva Lev-Ari, PhD, RN

Simulations Show Young Surgeons Face Special Concerns With Operating Room Distractions

Article Date: 03 Dec 2012 – 1:00 PST

A study has found that young, less-experienced surgeons made major surgical mistakes almost half the time during a “simulated” gall bladder removal when they were distracted by noises, questions, conversation or other commotion in the operating room.

In this analysis, eight out of 18, or 44 percent of surgical residents made serious errors, particularly when they were being tested in the afternoon. By comparison, only one surgeon made a mistake when there were no distractions.

Exercises such as this in what scientists call “human factors engineering” show not just that humans are fallible – we already know that – but work to identify why they make mistakes, what approaches or systems can contribute to the errors, and hopefully find ways to improve performance.

The analysis is especially important when the major mistake can be fatal.

This study, published in Archives of Surgery, was done by researchers from Oregon State University and the Oregon Health and Science University, in the first collaboration between their respective industrial engineering and general surgery faculty.

“This research clearly shows that at least with younger surgeons, distractions in the operating room can hurt you,” said Robin Feuerbacher, an assistant professor in Energy Systems Engineering at OSU-Cascades and lead author on the study. “The problem appears significant, but it may be that we can develop better ways to address the concern and help train surgeons how to deal with distractions.”

The findings do not necessarily apply to older surgeons, Feuerbacher said, and human factors research suggests that more experienced people can better perform tasks despite interruptions. But if surgery is similar to other fields of human performance, he said, older and more experienced surgeons are probably not immune to distractions and interruptions, especially under conditions of high workload or fatigue. Some of those issues will be analyzed in continued research, he said.

This study was done with second-, third- and research-year surgical residents, who are still working to perfect their surgical skills. Months were spent observing real operating room conditions so that the nature of interruptions would be realistic, although in this study the distractions were a little more frequent than usually found.

Based on these real-life scenarios, the researchers used a virtual reality simulator of a laparoscopic cholecystectomy – removing a gall bladder with minimally invasive instruments and techniques. It’s not easy, and takes significant skill and concentration.

While the young surgeons, ages 27 to 35, were trying to perform this delicate task, a cell phone would ring, followed later by a metal tray clanging to the floor. Questions would be posed about problems developing with a previous surgical patient – a necessary conversation – and someone off to the side would decide this was a great time to talk about politics, a not-so-necessary, but fairly realistic distraction.

When all this happened, the results weren’t good. Major errors, defined as things like damage to internal organs, ducts and arteries, some of which could lead to fatality, happened with regularity. 

Interrupting questions caused the most problems, followed by sidebar conversations. And for some reason, participants facing disruptions did much worse in the afternoons, even though conventional fatigue did not appear to be an issue.

“We’ve presented these findings at a surgical conference and many experienced surgeons didn’t seem too surprised by the results,” Feuerbacher said. “It appears working through interruptions is something you learn how to deal with, and in the beginning you might not deal with them very well.” 

SOURCE:

http://www.medicalnewstoday.com/releases/253456.php

 

Events that should never occur in surgery (“never events“) happen at least 4,000 times a year in the U.S. according to research from Johns Hopkins University.

 

The findings, published in Surgery, is the first of its kind to reveal the true extent of the prevalence of “never events” in hospitals through analysis of national malpractice claims. They observed that over 80,000 “never events” occurred between 1990 and 2010.

They estimate that at least 39 times a week a surgeon leaves foreign objects inside their patients, which includes stuff like towels or sponges. In addition surgeons performing the wrong surgery or operating on the wrong body part occurs around 20 times a week.

Marty Makary, M.D., M.P.H., an associate professor of surgery at the Johns Hopkins University School of Medicine, said:

“There are mistakes in health care that are not preventable. Infection rates will likely never get down to zero even if everyone does everything right, for example. But the events we’ve estimated are totally preventable. This study highlights that we are nowhere near where we should be and there’s a lot of work to be done.”

The researchers believe that this finding could help ensure that better systems are developed to prevent these “never events” which should never happen. 

The study examined data from the National Practitioner Data Bank which handles medical malpractice claims to calculate the total number of wrong-site-, wrong-patient and wrong-procedure surgeries.

Over 20 years. they found more than 9,744 paid malpractice claims which cost over $1.3 billion. Of whom 6.6% died, while 32.9% were permanently injured and 59.2% were temporarily injured. 

Around 4,044 never events occur annually in the U.S., according to estimates made by the research team who analyzed the rates of malpractice claims due to adverse surgical events. 

Many safety procedures have been implemented in medical centers to avoid never events, such as timeouts in the operating rooms to check if surgical plans match what the patient wants. In addition to this, an effective way of avoiding surgeries that are performed on the wrong body part is using ink to mark the site of the surgery. In order to prevent human error, Makary notes that electronic bar codes should be implemented to count sponges, towels and other surgical instruments before and after surgery. 

It is a requirement that all hospitals report the number of judgments or claims to the NPDB. Makary did note, however, that these figures could be low because sometimes items left behind after surgery are never discovered. 

Most of these events occurred among patients in their late 40s, surgeons of the same age group accounted for more than one third of the cases. More than half (62%) of the surgeons responsible for never events were found to be involved in more than one incident. 

Makary comments the importance of reporting never events to the public. He stresses that by doing so, patients will have more information about where to go for surgery as well as putting pressure on hospitals to maintain their quality of care. Hospitals should report any never events to the Join Commission, however this is often overlooked and more enforcement is necessary. 

Written by Joseph Nordqvist 
Copyright: Medical News Today 

SOURCE:

http://www.medicalnewstoday.com/articles/254426.php

 

Read Full Post »