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Posts Tagged ‘chemical approaches to modulate TF function’


Profiling Transcription Factors (TFs) in Single Cell of Tumors: TF as drivers of Tumorigenesis – Therapeutic Target for Drug Discovery

Reporter: Aviva Lev-Ari, PhD, RN

 

Trends Cancer. 2015 Sep 1;1(1):53-65.

Targeting Transcription Factors in Cancer

Author information

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Abstract

Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be highly effective in treating particular malignancies, as highlighted by the clinical efficacy of agents that target nuclear hormone receptors. In this review we discuss recent advances in our understanding of TFs as drug targets in oncology, with an emphasis on the emerging chemical approaches to modulate TF function. The remarkable diversity and potency of TFs as drivers of cell transformation justifies a continued pursuit of TFs as therapeutic targets for drug discovery.

PMID:
26645049
PMCID:
PMC4669894
[Available on 2016-09-01]
DOI:
10.1016/j.trecan.2015.07.001

Article will be available on September 1, 2016

SOURCE

http://www.ncbi.nlm.nih.gov/pubmed/26645049

Transcription factors in tumors

Profiling transcription factors in single cell

Tumor cells often have aberrant transcription factor expression profiles. The aberration could have its origin at the genomic or transcriptomic level. The potency of transcription factors as drivers of tumorigenesis makes it an attractive therapeutic target for drug discovery.

Read the review

Accurate detection of low frequency transcription factors is a major challenge, especially when one starts from a single cell.

What are the challenges associated with single cell analysis? How can you successfully detect low frequency transcripts from a single cell?

Find out more about single cell analysis

SOURCE

From: Marcus W Feldman <mfeldman@stanford.edu>

Date: Tuesday, July 19, 2016 at 10:08 AM

To: Aviva Lev-Ari <AvivaLev-Ari@alum.berkeley.edu>

Subject: Fwd: Profiling transcription factors in single cell

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