Profiling Transcription Factors (TFs) in Single Cell of Tumors: TF as drivers of Tumorigenesis – Therapeutic Target for Drug Discovery
Reporter: Aviva Lev-Ari, PhD, RN
Targeting Transcription Factors in Cancer
- 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be highly effective in treating particular malignancies, as highlighted by the clinical efficacy of agents that target nuclear hormone receptors. In this review we discuss recent advances in our understanding of TFs as drug targets in oncology, with an emphasis on the emerging chemical approaches to modulate TF function. The remarkable diversity and potency of TFs as drivers of cell transformation justifies a continued pursuit of TFs as therapeutic targets for drug discovery.
From: Marcus W Feldman <email@example.com>
Date: Tuesday, July 19, 2016 at 10:08 AM
To: Aviva Lev-Ari <AvivaLev-Ari@alum.berkeley.edu>
Subject: Fwd: Profiling transcription factors in single cell