Series E: Patient-Centered Medicine
Series Content Consultant: Larry H Bernstein, MD, FCAP
Volume One:
The VOICES of Patients, Hospitals CEOs, Health Care Providers, Caregivers and Families: Personal Experience with Critical Care and Invasive Medical Procedures
2017
On Amazon.com since 10/16/2017
https://www.amazon.com/dp/B076HGB6MZ
Product details
- File Size: 9053 KB
- Print Length: 824 pages
- Publisher: Leaders in Pharmaceutical Business Intelligence; 1 edition (October 16, 2017)
- Publication Date: October 16, 2017
- Sold by: Amazon Digital Services LLC
- Language: English
- ASIN: B076HGB6MZ
- Text-to-Speech: Enabled
- X-Ray: Not Enabled
- Word Wise: Not Enabled
- Lending: Enabled
Enhanced Typesetting: Not Enabled
Author, Curator and Editor
Larry H Bernstein, MD, FCAP
Chief Scientific Officer
Leaders in Pharmaceutical Business Intelligence, Northampton, MA
and
Contributing Editor and Author
Gail S. Thornton, PhD(c)
Leaders in Pharmaceutical Business Intelligence, New Jersey
Image Source: Courtesy of Google Images
Editor-in-Chief BioMed e-Series of e-Books
Leaders in Pharmaceutical Business Intelligence, Boston
avivalev-ari@alum.berkeley.edu
BioMedical e-Books e-Series:
Cardiovascular, Genomics, Cancer, BioMed, Patient-centered Medicine
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- The VOICES of Patients, Hospitals CEOs, Health Care Providers, Caregivers and Families: Personal Experience with Critical Care and Invasive Medical Procedures … E: Patient-Centered Medicine Book 1) Kindle Edition — On Amazon.com since 10/16/2017
Other e-Books in the BioMedicine e-Series
Series A: e-Books on Cardiovascular Diseases
Content Consultant: Justin D Pearlman, MD, PhD, FACC
Volume One: Perspectives on Nitric Oxide
Sr. Editor: Larry Bernstein, MD, FCAP, Editor: Aviral Vatsa, PhD and Content Consultant: Stephen J Williams, PhD
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B00DINFFYC
Volume Two: Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation
Curators: Justin D Pearlman, MD, PhD, FACC, Larry H Bernstein, MD, FCAP and
Aviva Lev-Ari, PhD, RN
- Causes
- Risks and Biomarkers
- Therapeutic Implication
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B018Q5MCN8
Volume Three: Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics
Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
- Causes
- Risks and Biomarkers
- Therapeutic Implications
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B018PNHJ84
Volume Four: Regenerative and Translational Medicine: The Therapeutics Promise for Cardiovascular Diseases
Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
- Causes
- Risks and Biomarkers
- Therapeutic Implications
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B019UM909A
Volume Five: Pharmaco-Therapies of Cardiovascular Diseases
Volume Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
Work-in-Progress
Volume Six: Interventional Cardiology and Cardiac Surgery for Disease Diagnosis and Guidance of Treatment
Volume Curators: Justin D Pearlman, MD, PhD, FACC and Aviva Lev-Ari, PhD, RN
Work-in-Progress
In addition to the Seven Volumes of SERIES A: Cardiovascular Diseases, Not included in SERIES A is a Four Volume Series by Dr. Pearlman, Editor, on Cardiovascular Diseases, positioned as Academic Textbooks for Training Residents in Cardiology and Texts for CEU Courses in Cardiology [Hardcover, Softcover, e-Books].
- CVD 1: Causes of Cardiovascular Diseases
- CVD 2: Risk Assessment of Cardiovascular Diseases
- CVD 3: Management of Cardiovascular Diseases
- CVD 4: Volume Seven: Cardiac Imaging
Series B: e-Books on Genomics & Medicine
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One: Genomics Orientations for Personalized Medicine
Sr. Editor: Stephen J Williams, PhD
Editors: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B018DHBUO6
Volume Two: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS & BioInformatics, Simulations and the Genome Ontology
Editors: TBA
Work-in-Progress
INACTIVE – Volume Three: Institutional Leadership in Genomics
Editors: Aviva Lev-Ari, PhD, RN and TBA
Series C: e-Books on Cancer & Oncology
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One: Cancer Biology & Genomics for Disease Diagnosis
Sr. Editor: Stephen J Williams, PhD, Editors: Ritu Saxena, PhD, Tilda Barliya, PhD
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B013RVYR2K
Volume Two: Cancer Therapies: Metabolic, Genomics, Interventional, Immunotherapy and Nanotechnology in Therapy Delivery
Authors, Curators and Editors:
Larry H Bernstein, MD, FCAP and Stephen J Williams, PhD
Guest Authors:
Dror Nir, PhD and Tilda Barliya, PhD, Demet Sag, PhD, Ziv Raviv, PhD and
Aviva Lev-Ari, PhD, RN
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B071VQ6YYK
INACTIVE – Volume Three: Cancer Patients’ Resources on Therapies
Sr. Editor: TBA
Series D: Metabolomics and BioMedicine, The Immune System, Infectious Diseases and Therapeutic Implications
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One: Metabolic Genomics and Pharmaceutics
Author, Curator and Editor: Larry H Bernstein, MD, FCAP
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B012BB0ZF0
Volume Two & Volume Three
- The Immune System, Stress Signaling, Infectious Diseases and Therapeutic Implications: VOLUME 2: Infectious Diseases and Therapeutics and VOLUME 3: The Immune System and Therapeutics (Series D: BioMedicine & Immunology) Kindle Edition
VOLUME 2: Infectious Diseases and Therapeutics
Author, Curator and Editor: Sudipta Saha, PhD
VOLUME 3: The Immune System and Therapeutics
Author, Curator and Editor: Larry H Bernstein, MD, FCAP
Available on Kindle Store @ Amazon.com
https://www.amazon.com/dp/B075CXHY1B
Series E: Patient-centered Medicine
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One: The VOICES of Patients, Hospitals CEOs, Health Care Providers, Caregivers and Families: Personal Experience with Critical Care and Invasive Medical Procedures
Author, Curator and Editor: Larry H Bernstein, MD, FCAP and Co-Editor: Gail Thornton, Msc, PhD(c)
Available on Amazon.com since 10/16/2017
https://www.amazon.com/dp/B076HGB6MZ
Volume Two: Medical Scientific Discoveries for the 21st Century & Interviews with Scientific Leaders
Author, Curator and Editor: Larry H Bernstein, MD, FCAP
Scheduled for publication 10/2017
Volume Three: Milestones in Physiology & Discoveries in Medicine and Genomics
Author, Curator and Editor: Larry H Bernstein, MD, FCAP
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B019VH97LU
Volume Four: Medical 3D BioPrinting – The Revolution in Medicine
Editors: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
Scheduled for publication in 2017
This e-Book is a comprehensive review of recent Original Research on The VOICES of Patients, HealthCare Providers, Care Givers and Families: Personal Experience with Critical Care and Invasive Medical Procedures written by Experts, Authors, Writers. The results of Original Research are gaining value added for the e-Reader by the Methodology of Curation. The e-Book’s articles have been published on the Open Access Online Scientific Journal, since April 2012. All new articles on this subject, will continue to be incorporated, as published with periodical updates.
Open Access Online Journal
http://www.pharmaceuticalIntelligence.com
is a scientific, medical and business, multi-expert authoring environment for information syndication in several domains of Life Sciences, Medicine, Pharmaceutical and Healthcare Industries, BioMedicine, Medical Technologies & Devices. Scientific critical interpretations and original articles are written by PhDs, MDs, MD/PhDs, PharmDs, Technical MBAs as Experts, Authors, Writers (EAWs) on an Equity Sharing basis.
Our DOMAINS in Scientific Media
I. Pharmaceutical: Biologics, Small Molecules, Diagnostics
II. Life Sciences: Genomics and Cancer Biology
III. Patient-centered Medicine: Focus on #1: Cardiovascular, #2: Cancer, #3: Physiology: Metabolomics, Immunology
IV. Biomedicine, BioTech, and MedTech (Medical Devices)
V. HealthCare: Patient-centered Medicine and Personalized/Precision Medicine
LIST of VIDEOS
Cancer, Pain and Palliative Care
Importance of Pain Management
Introduction to Management of Breakthrough Pain
My survival story — what I learned from having cancer | Martin Inderbitzin | TEDxZurich
https://www.youtube.com/watch?v=M5QBH3wDrQY
List of Contributors & Contributors’ Biographies
Chapter 2, 3.1, 3.2, 3.3, 3.4, 4.2, 5.1.1, 5.1.2, 5.2.1, 5.2.2, 5.2.3, 5.3.2, 5.5.1 – 5.5.7, 5.5.9, 5.5.10, 5.6.1, 5.6.4, 5.6.5, 6.1, 6.2, 6.3 – 6.6, 7.2
Gail S Thornton, MA, PhD(c)
2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 5.4.3, 5.6.6, 5.7.1, 8.2
1.1, 4.1, 5.1.2, 5.5.8, 6.1, 6.2,
1.2, 1.3, 5.4.1, 5.4.2,
1.4
5.6.2,
5.6.3
7.1
Guest Author: Ferez Nallaseth, PhD
8.1
Guest Author: Itzhak Brook MD, MSc, Department of Pediatrics, Georgetown University School of Medicine Washington DC
1.5
Guest Author: Clifford Thornton
8.3
Preface
Aviva Lev-Ari, PhD, RN
This volume is the first in a four-volumes e-Series on Patient-Centered Medicine. There are narratives by Patients and there are accounts by Health Care Providers. This volume is unique in the body of existing literature on the subject matter, in the exposition effort to incorporate in tandem, the VOICES of Patients on their Personal Experience with Critical Care and Invasive Medical Procedures. We provide the Personal views of Hospitals CEOs, Health Care Providers, Caregivers and Families in conjunction with the voices of the Patients.
This Volume represents PRIMARY RESEARCH attained by two methodologies:
One, Personal Interviews conducted by the volume Co-Editor, Gail S. Thornton, with Patients and their families facing the diagnosis of a serious medical (not Terminal) illness requiring a major surgery. Ms. Thornton conducted interviews with Hospitals CEOs and other leaders of several Health Care Providers in the US and in other countries.
The other, Personal Accounts and Testimonies of Patients written by themselves. Some are MDs diagnosed with Cancer, had undergone invasive surgeries as an organ excision, some underwent Open Heart Surgery.
Larry H. Bernstein, MD, FCAP
This volume is divided into three parts: perceptions of care, the voice of cancer survivors, and the voice of open heart surgery survivors. This is quite difficult because of variation in patients’ ages, outlooks, chronicity and type of condition, and adverse effects of treatments. The best that we can do is look at a small number of narratives.
Volume Introduction
Larry H. Bernstein, MD, FCAP
Perceptions of care are determined by a number of important factors that are dependent on the individual and on the physician, and on the treatment conditions. The individual factors include, but are not limited to patient social status, linguistic factors, cognitive skills and level of education, and communication skills of the care providers. The facilities can be a factor not easily ranked, although that is always a matter for debate. The voices of cancer survivors are presented for both cancer and cardiovascular surgery. These are quite variable and are highly dependent on the specialty treatment organization.
Abbreviated electronic Table of Contents (eTOCs)
Part One: Perceptions of Care
Chapter 1: Personal Accounts
1.1 Personal Tale of JL’s Whole Genome Sequencing
1.2 Live Notes from @AACR’s #cbi16 Meeting on Precision Medicine: 5:10PM Big Idea A survivor’s Story
1.3 Live Notes from @AACR’s #cbi16 Meeting on Precision Medicine: Success Story and Dr. Stephan Grupp
1.4 Supportive Treatments: Hold the Mind Strong During Cancer
1.5 Finding My Voice: A Laryngectomee’s Story
Chapter 2: Articles on Perception of Care
2.1 Delivery of Care – External Sources – Intentionally are Left as References in Live Links.
- Track, trigger and teamwork: Communication of deterioration in acute medical and surgical wards Article
Intensive and Critical Care Nursing, Volume 26, Issue 1, Pages 10-17
Donohue, L.A.; Endacott, R.
Cited by Scopus (19) - Communication interaction in ICU-Patient and staff experiences and perceptions Article
Intensive and Critical Care Nursing, Volume 22, Issue 3, Pages 167-180
Magnus, V.S.; Turkington, L.
Cited by Scopus (39) - Nursing care in a high-technological environment: Experiences of critical care nurses Article
Intensive and Critical Care Nursing, Volume 31, Issue 2, Pages 116-123
Tunlind, A.; Granstrom, J.; Engstrom, A. - Knowledge, attitudes and barriers towards prevention of pressure ulcers in intensive care units: A descriptive cross-sectional study Article
Intensive and Critical Care Nursing, Volume 26, Issue 6, Pages 335-342
Strand, T.; Lindgren, M. - Rehabilitation during mechanical ventilation: Review of the recent literature Review article
Intensive and Critical Care Nursing, Volume 31, Issue 3, Pages 125-132
Ntoumenopoulos, G. - Reducing risk for ventilator associated pneumonia through nursing sensitive interventions Article
Intensive and Critical Care Nursing, Volume 29, Issue 5, Pages 261-265
Micik, S.; Besic, N.; Johnson, N.; Han, M.; Hamlyn, S.; Ball, H. - The lived experiences of adult intensive care patients who were conscious during mechanical ventilation: A phenomenological-hermeneutic study Article
Intensive and Critical Care Nursing, Volume 28, Issue 1, Pages 6-15
Karlsson, V.; Bergbom, I.; Forsberg, A. - Families’experiences of their interactions with staff in an Australian intensive care unit (ICU): A qualitative study Article
Intensive and Critical Care Nursing, Volume 31, Issue 1, Pages 51-63
Wong, P.; Liamputtong, P.; Koch, S.; Rawson, H. - Experiences of critically ill patients in the ICU Article
Intensive and Critical Care Nursing, Volume 24, Issue 5, Pages 300-313
Hofhuis, J.G.M.; Spronk, P.E.; van Stel, H.F.; Schrijvers, A.J.P.; Rommes, J.H.; Bakker, J.
Cited by Scopus (54)
2.2 Hospital CEO: A New Standard in Health Care – Farrer Park Hospital, Singapore’s First Fully Integrated Healthcare/Hospitality Complex
2.3 Drug Discovery for Cancer Cure: Value for Patients – Turning Advances in Science: A Case Study of a Leading Global Pharmaceutical Company – Astellas Pharma Inc.
2.4 Hospital CEO: A Rich Tradition of Patient-Focused Care — Richmond University Medical Center, New York’s Leader in Health Care and Medical Education
2.5 Hospital CEO: University Children’s Hospital Zurich (Universitäts-Kinderspital Zürich), Switzerland – A Prominent Center of Pediatric Research and Medicine
2.6 Hospital CEO: Swiss Paraplegic Centre, Nottwil, Switzerland – A World-Class Clinic for Spinal Cord Injuries
2.7 Institute Director: The Rutgers Global Health Institute, part of Rutgers Biomedical and Health Sciences, Rutgers University, New Brunswick, New Jersey – A New Venture Designed to Improve Health and Wellness Globally
2.9 The Future of Hospitals – How Medical Care and Technology Work Together to Advance Patient Care
Part Two: The Voice of Cancer Survivors
Chapter 3: A Diagnosis called “CANCER”
3.1 Cancer Companion Diagnostics
3.3 Liquid Biopsy Assay May Predict Drug Resistance
3.4 Pharmacogenomic Biomarkers for Personalized Cancer Treatment
Chapter 4: Patients Experience with Invasive Surgery and Minimally Invasive Surgery
4.1 Personalized Medicine: Cancer Cell Biology and Minimally Invasive Surgery (MIS)
4.2 Cardiotoxicity and Cardiomyopathy Related to Drugs Adverse Effects
Chapter 5: Cancer Types – Patients Experience
5.1 Thyroid Cancer
5.1.1 Experience with Thyroid Cancer
5.2 Brain Surgery
5.2.1 A Cousin’s Experience with a Pituitary Acromegaly
5.2.2 Loss of Normal Growth Regulation
5.2.3 Glioma, Glioblastoma and Neurooncology
5.3 Breast Cancer
5.3.1 Faces of Breast Cancer – Find Your Story, Join the Conversation
By TARA PARKER-POPE –
5.3.2 An Emotional and Thoughtful Decision Over BRAC1 and Surgery
5.4 Ovarian Cancer
5.4.1 A Curated History of the Science Behind the Ovarian Cancer β-Blocker Trial
5.4.2 Good and Bad News Reported for Ovarian Cancer Therapy
5.4.3 Almudena’s Story: A Life of Hope, Rejuvenation and Strength
5.5 Hematological Malignancies
5.5.1 Hematological Malignancy Diagnostics
5.5.2 Hematological Cancer Classification
5.5.3 Chemotherapy in AML
5.5.4 Update on Chronic Myeloid Leukemia
5.5.5 Rituximab for a variety of B-cell malignancies
5.5.6 T cell-mediated immune responses & signaling pathways activated by TLRs
5.5.7 Gene expression and adaptive immune resistance mechanisms in lymphoma
5.5.9 Management of Follicular Lymphoma
5.5.10 Gene Expression and Adaptive Immune Resistance Mechanisms in Lymphoma
5.6 Other Types of Cancer
5.6.1 Lung Cancer Therapy
5.6.2 Non-small Cell Lung Cancer drugs – where does the Future lie?
5.6.3 Colon Cancer
5.6.4 GERD and esophageal adenocarcinoma
5.6.5 Melanoma
5.6.6 Adenocarcinoma of the Duodenum – Nathalie’s Story: A Health Journey With A Happy Ending
5.7 Organ Transplantation
5.7.1 Marcela’s Story: A Liver Transplant Gives the Gift of Life
Chapter 6: Contributing Factors to A Compromised Patient’s Wellbeing
6.1 Nutrition: Articles of Note @PharmaceuticalIntelligence.com
6.2 Epigenetics, Environment and Cancer: Articles of Note @PharmaceuticalIntelligence.com
6.3 The relationship of stress hypermetabolism to essential protein needs
6.4 Cancer Drug-Resistance Mechanism
6.5 Biochemistry and Dysmetabolism of Aging and Serious Illness
6.6 Experience of and Alleviation of Pain
Chapter 7: Metabolomics & Vitamins
7.1 Metabolomics: its applications in food and nutrition research
7.2 Neutraceuticals
Part Three: The Voice of Open Heart Surgery Survivors
Chapter 8: Cardiac Surgery
8.2 Triple-bypass operation at age 69 – Ralph’s Story: An Entertainer at Heart
8.3 A Fantastic Vessel-Clearing Innovation on The vessel-clearing device, U.S. Patent No. 8,663,209
This e-Book has the following three parts:
- Part One: Perceptions of Care
- Part Two: The Voice of Cancer Survivors
- Part Three: The Voice of Open Heart Surgery Survivors
Part One
Perceptions of Care
Introduction
Larry H. Bernstein, MD, FCAP
The perception of care is importantly a personal matter. On the one hand, a young person who has undergone a series of procedures with unsatisfied relief, young or old, goes through a defined series of stages described in Death and Dying. In the early stages of healing the outlook may be good. The perceptions that are most vivid are related to comprehension of the seriousness of the illness, the satisfaction of the attention provided by the caregiver, and the immediate surroundings. Complications may ensue during the course of treatment, and a series of complications can be demoralizing. A not often recognized factor is the personal contact with family and friends, which can make a huge difference in the experience. Even when the contact is not at the bedside, daily and weekly phone contact is supportive. An undesirable feature of current situations is directly related to facilities management, crowding, nurse/patient ratio, the amount of time required for electronic health records review in competition with real time caring for patients.
Three-part ‘Cancer: Emperor of All Maladies’ documentary to debut in late March 2015.
The oncology “community” is apparently jumping at the chance to show support for documentary filmmaker Ken Burns‘ latest PBS project — a 6-hour film examining the history of cancer.
Genentech, Bristol-Myers Squibb, Siemens, Cancer Treatment Centers of America, the American Cancer Society, the Leukemia and Lymphoma Society, and the American Association for Cancer Research — have either helped bankroll or support the production and/or the publicity effort around the film, titled “Cancer: the Emperor of All Maladies.”
And in the run-up to the scheduled airing in late March, a number of those supporters are organizing pre-screening events — starting today with a special half-hour program hosted by Katie Couric, the global news anchor for Yahoo! News and a Stand Up To Cancer (SU2C) co-founder. The Couric program will be available at CancerFilms.org and will be broadcast later by about 30 PBS affiliate stations.
The documentary itself is based on the 2010 Pulitzer prize-winning book “The Emperor of All Maladies: A Biography of Cancer” by Siddhartha Mukherjee, MD, PhD.
The Entertainment Industry Foundation (EIF) and its SU2C initiative and WETA-TV, the Washington, D.C., PBS station, spearheaded the production and are coordinating outreach efforts.
EIF obtained the television and film rights for Mukherjee’s book soon after its publication (and prior to its Pulitzer) at the urging of the late producer Laura Ziskin, one of SU2C’s co-founders, who read the book when she was undergoing treatment for metastatic breast cancer. EIF then persuaded Burns to produce a documentary based on it.
Chapter 1: Personal Accounts
1.1 Personal Tale of JL’s Whole Genome Sequencing
Reporter: Aviva Lev-Ari, PhD, RN
1.2 Live Notes from @AACR’s #cbi16 Meeting on Precision Medicine: 5:10PM Big Idea A survivor’s Story
Reporter: Stephen J. Williams, Ph.D.
1.3 Live Notes from @AACR’s #cbi16 Meeting on Precision Medicine: Success Story and Dr. Stephan Grupp
Reporter: Stephen J. Williams, Ph.D
1.4 Supportive Treatments: Hold the Mind Strong During Cancer
Author: Demet Sag, PhD
1.5 Finding My Voice: A Laryngectomee’s Story
Guest Author: Itzhak Brook MD, MSc, Department of Pediatrics, Georgetown University School of Medicine Washington DC
Chapter 2: Articles on Perception of Care
Introduction
Larry H. Bernstein, MD, FCAP
In the first chapter there were examples of patient experiences in receiving care. This second portion gets to the driving factors in an institution that make a difference. There are changes in shifts, and there are nurse, dietitians, physician assistants, perhaps hospitalist and specialist physicians all involved in the patient’s care. Then there are visiting hours, family, and next of kin. These interactions are discussed here.
2.1 Delivery of Care – External Sources – Intentionally are Left as References in Live Links.
- Track, trigger and teamwork: Communication of deterioration in acute medical and surgical wards Article
Intensive and Critical Care Nursing, Volume 26, Issue 1, Pages 10-17
Donohue, L.A.; Endacott, R.
Cited by Scopus (19) - Communication interaction in ICU-Patient and staff experiences and perceptions Article
Intensive and Critical Care Nursing, Volume 22, Issue 3, Pages 167-180
Magnus, V.S.; Turkington, L.
Cited by Scopus (39) - Nursing care in a high-technological environment: Experiences of critical care nurses Article
Intensive and Critical Care Nursing, Volume 31, Issue 2, Pages 116-123
Tunlind, A.; Granstrom, J.; Engstrom, A. - Knowledge, attitudes and barriers towards prevention of pressure ulcers in intensive care units: A descriptive cross-sectional study Article
Intensive and Critical Care Nursing, Volume 26, Issue 6, Pages 335-342
Strand, T.; Lindgren, M. - Rehabilitation during mechanical ventilation: Review of the recent literature Review article
Intensive and Critical Care Nursing, Volume 31, Issue 3, Pages 125-132
Ntoumenopoulos, G. - Reducing risk for ventilator associated pneumonia through nursing sensitive interventions Article
Intensive and Critical Care Nursing, Volume 29, Issue 5, Pages 261-265
Micik, S.; Besic, N.; Johnson, N.; Han, M.; Hamlyn, S.; Ball, H. - The lived experiences of adult intensive care patients who were conscious during mechanical ventilation: A phenomenological-hermeneutic study Article
Intensive and Critical Care Nursing, Volume 28, Issue 1, Pages 6-15
Karlsson, V.; Bergbom, I.; Forsberg, A. - Families’experiences of their interactions with staff in an Australian intensive care unit (ICU): A qualitative study Article
Intensive and Critical Care Nursing, Volume 31, Issue 1, Pages 51-63
Wong, P.; Liamputtong, P.; Koch, S.; Rawson, H. - Experiences of critically ill patients in the ICU Article
Intensive and Critical Care Nursing, Volume 24, Issue 5, Pages 300-313
Hofhuis, J.G.M.; Spronk, P.E.; van Stel, H.F.; Schrijvers, A.J.P.; Rommes, J.H.; Bakker, J.
Cited by Scopus (54)
2.2 Hospital CEO: A New Standard in Health Care – Farrer Park Hospital, Singapore’s First Fully Integrated Healthcare/Hospitality Complex
Author: Gail S. Thornton, M.A.
2.3 Drug Discovery for Cancer Cure: Value for Patients – Turning Advances in Science: A Case Study of a Leading Global Pharmaceutical Company – Astellas Pharma Inc.
Author: Gail S. Thornton, M.A.
2.4 Hospital CEO: A Rich Tradition of Patient-Focused Care — Richmond University Medical Center, New York’s Leader in Health Care and Medical Education
Author: Gail S. Thornton, M.A.
2.5 Hospital CEO: University Children’s Hospital Zurich (Universitäts-Kinderspital Zürich), Switzerland – A Prominent Center of Pediatric Research and Medicine
Author: Gail S. Thornton, M.A.
2.6 Hospital CEO: Swiss Paraplegic Centre, Nottwil, Switzerland – A World-Class Clinic for Spinal Cord Injuries
Author: Gail S. Thornton, M.A.
2.7 Institute Director: The Rutgers Global Health Institute, part of Rutgers Biomedical and Health Sciences, Rutgers University, New Brunswick, New Jersey – A New Venture Designed to Improve Health and Wellness Globally
Author: Gail S. Thornton, M.A.
2.8 Center’s Provost & CSO: City of Hope, Duarte, California – Combining Science with Soul to Create Miracles at a Comprehensive Cancer Center designated by the National Cancer Institute – An Interview with the Provost and Chief Scientific Officer of City of Hope, Steven T. Rosen, M.D.
Author: Gail S. Thornton, M.A.
2.9 The Future of Hospitals – How Medical Care and Technology Work Together to Advance Patient Care
Curator: Gail S. Thornton, M.A.
Summary
Larry H. Bernstein, MD, FCAP
I have tried to give a two sided perspective on the patient perspective and on the interactions that can be attended to for improving patient care and the perception of care in a complex environment in which nurses, physicians and hospital staff are attending to the patient’s needs, whether it is the emergency department, intensive care unit, clinic, operating room, cath lab, or other location in the healthcare setting.
Part Two:
The Voice of Cancer Survivors
Introduction
Larry H. Bernstein, MD, FCAP
Cancer survival is a difficult matter. Medicine a century ago was focused on infectious disease. There were recurrences of war, famine and pestilence. There is a new model of war on a global stage, at the same time trying to limit nuclear deployment. The same problems that have historically derailed the progress of an equitable society have not gone away. With the development of antibiotics and vaccines, the contribution of infectious disease has been reduced, lifespan is increased for some, not all. There is shortened lifespan in impoverished societies and in wealthy societies associated with wasted human resources, greed and despair. Cancer is a disease of young and old, and it is organ specific, age specific, and linked to chronic disease with impaired T-cell immunity. The problem we are confronted with is that there is variability in the behavior of different cancers, some of which is related to transcription and suppression, and mutations. There was no knowledge of signaling pathways a century ago. Now mutation and mutagenesis in the course of the disease is a challenge to developing effective therapies, whether by chemo- or by immunological means. Single treatment modalities are the exception, not the rule.
The expression RAP physician refers to a group of physicians who the patient might not see – radiologists, anesthesiologists, and pathologists. Radiology has subspecialty in diagnostics and in radiotherapy. Anesthesiology is closely aligned with effective surgery. Cardiology also has developed an interventionist specialty that now rivals surgery. The pathologist has a crucial role in the diagnostic process that has continued to expand for decades. The only limitation it has is availability and skilled application of optical, genomic, proteomic, and lipidomic diagnostic methods.
If we put this matter aside, then we again have to think about when enough is enough. The prognosis of a cancer depends on the diagnosis or cancer type, the anaplasticity, the tumor size, migration to regional lymph nodes, and distant metastasis, which lends credence to staging, and add to that the matching of these elements with a personalized treatment. This last piece is in its infancy.
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Chapter 3: A Diagnosis called “CANCER”
3.1 Cancer Companion Diagnostics
Curator: Larry H. Bernstein, MD, FCAP
3.2 lncRNAs in Human Cancers
Curator: Larry H. Bernstein, MD, FCAP
3.3 Liquid Biopsy Assay May Predict Drug Resistance
Curator: Larry H. Bernstein, MD, FCAP
3.4 Pharmacogenomic Biomarkers for Personalized Cancer Treatment
Curator: Larry H Bernstein, MD, FCAP
Chapter 4: Patients Experience with Invasive Surgery and Minimally Invasive Surgery
4.1 Personalized Medicine: Cancer Cell Biology and Minimally Invasive Surgery (MIS)
Curator: Aviva Lev-Ari, PhD, RN
4.2 Cardiotoxicity and Cardiomyopathy Related to Drugs Adverse Effects
Curator: Larry H Bernstein, MD, FCAP
Chapter 5: Cancer Types – Patients Experience
5.1 Thyroid Cancer
5.1.1 Experience with Thyroid Cancer
Author: Larry H. Bernstein, MD, FCAP
Author and Illustration Curator: Larry H Bernstein, MD, FCAP and Curator: Aviva Lev-Ari, PhD, RN
5.2 Brain Surgery
5.2.1 A Cousin’s Experience with a Pituitary Acromegaly
Author: Larry H. Bernstein, MD, FCAP
5.2.2 Loss of Normal Growth Regulation
Curator: Larry H. Bernstein, MD, FCAP
5.2.3 Glioma, Glioblastoma and Neurooncology
Curator: Larry H. Bernstein, MD, FCAP
5.3 Breast Cancer
5.3.1 Faces of Breast Cancer – Find Your Story, Join the Conversation
By TARA PARKER-POPE –
Multiple attempts by e-Book Co-Editor, Gail Thornton were made in September and October 2017 to connect to Tara Parker-Pope for permission to reprint in this volume the transcript of the Audio. All attempts have failed. The e-Reader is encouraged to click on the links provided here.
5.3.2 An Emotional and Thoughtful Decision Over BRAC1 and Surgery
Curator: Larry H. Bernstein, MD, FCAP
5.4 Ovarian Cancer
5.4.1 A Curated History of the Science Behind the Ovarian Cancer β-Blocker Trial
Curator: Stephen J. Williams, Ph.D.
5.4.2 Good and Bad News Reported for Ovarian Cancer Therapy
Reporter and Curator: Stephen J. Williams, Ph.D.
5.4.3 Almudena’s Story: A Life of Hope, Rejuvenation and Strength
Author: Gail S. Thornton, M.A.
5.5 Hematological Malignancies
5.5.1 Hematological Malignancy Diagnostics
Author and Curator: Larry H. Bernstein, MD, FCAP
5.5.2 Hematological Cancer Classification
Author and Curator: Larry H. Bernstein, MD, FCAP
5.5.3 Chemotherapy in AML
Curator: Larry H. Bernstein, MD, FCAP
5.5.4 Update on Chronic Myeloid Leukemia
Curator: Larry H Bernstein, MD, FCAP
5.5.5 Rituximab for a variety of B-cell malignancies
Curator: Larry H Bernstein, MD, FCAP
5.5.6 T cell-mediated immune responses & signaling pathways activated by TLRs
Curator: Larry H. Bernstein, MD, FCAP
5.5.7 Gene expression and adaptive immune resistance mechanisms in lymphoma
Curator: Larry H Bernstein, MD, FCAP
Curator: Aviva Lev-Ari, PhD, RN
July 6, 2012 NY Times reports on a new approach based on DNA and RNA sequencing and a cancer drug for kidney cancer to bring REMISSION to Adultacute lymphoblastic leukemia (ALL).
On the lower left corner of this page – Watch the VIDEO
Dr. Lukas Wartman, is a Cancer Researcher specializing in Leukemia. He suspected he had Leukemia, the very disease he had devoted his medical career to studying.
After years of treatment and two relapses of ALL, he has exhaused all conventional approaches to his disease. At Washington University in St. Louis, his colleagues in the lab, decoded Dr. Wartman’s genetic information by genome sequencing techniques t determine the genetic cause of his ALL. The team found an overactive gne, FLT3 on Chromosome 13. The gene was treated with pfizer’s Suntinib drug for advanced kidney cancer.
Blood samples free of ALL found in days after using the drug. As results were very promising, Pfizer, the drug’s maker who has turned down Dr. Wartman’s request for the drug under their compassionate use program, though he explained that his entire salary was only enough to pay for 7 1/2 months of Sutent (Suntinib). While he does not know why Pfizer gave him the drug finally, he suspects it was the plea of his Nurse Practitioner, Stephanie Bauer, NP.
I recommend the reader to click on the links and follow the reactions of the public to this article in The New York Times.
5.5.9 Management of Follicular Lymphoma
Curator: Larry H. Bernstein, MD, FCAP
5.5.10 Gene Expression and Adaptive Immune Resistance Mechanisms in Lymphoma
Curator: Larry H. Bernstein, MD, FCAP
5.6 Other Types of Cancer
5.6.1 Lung Cancer Therapy
Curator: Larry H. Bernstein, MD, FCAP
5.6.2 Non-small Cell Lung Cancer drugs – where does the Future lie?
Curator: Ritu Saxena, Ph.D.
5.6.3 Colon Cancer
Author/Editor: Tilda Barliya PhD
5.6.4 GERD and esophageal adenocarcinoma
Curator: Larry H Bernstein, MD, FCAP
5.6.5 Melanoma
Curator: Larry H. Bernstein, MD, FCAP
5.6.6 Adenocarcinoma of the Duodenum
Nathalie’s Story: A Health Journey With A Happy Ending
Author: Gail S. Thornton, M.A.
5.7 Organ Transplantation
5.7.1 Marcela’s Story: A Liver Transplant Gives the Gift of Life
Author: Gail S. Thornton, M.A.
Chapter 6: Contributing Factors to A Compromised Patient’s Wellbeing
6.1 Nutrition: Articles of Note @PharmaceuticalIntelligence.com
Author and Curator: Larry H. Bernstein, MD, FCAP and Curator: Aviva Lev-Ari, PhD, RN
6.2 Epigenetics, Environment and Cancer: Articles of Note @PharmaceuticalIntelligence.com
Author and Curator: Larry H. Bernstein, MD, FCAP and Curator: Aviva Lev-Ari, PhD, RN
6.3 The relationship of stress hypermetabolism to essential protein needs
Curator: Larry H. Bernstein, MD, FCAP
6.4 Cancer Drug-Resistance Mechanism
Curator: Larry H. Bernstein, MD, FCAP
6.5 Biochemistry and Dysmetabolism of Aging and Serious Illness
Curator: Larry H. Bernstein, MD, FCAP
6.6 Experience of and Alleviation of Pain
Curator: Larry H. Bernstein, MD, FCAP
Chapter 7: Metabolomics & Vitamins
7.1 Metabolomics: its applications in food and nutrition research
Reporter and Curator: Sudipta Saha, Ph.D.
7.2 Neutraceuticals
Author and Curator: Larry H Bernstein, MD, FCAP
Summary
Larry H. Bernstein, MD, FCAP
This chapter has covered a very large selection of cancers, the progression of different types, and the expected long term survivals. The topics of great concern are pharmacotherapy and immunotherapy, which is best when based on an extablished protocol, preferably personalized. This chapter also is concerned with what is now recognized as alternative medicine. This might be based on a chemical extraction from a plant therapy that has been known for centuries. This also refers to food-based supplements. This has created a large effort to develop neutraceuticals. This requires a much greater foundation in metabolic discovery than we have today.
Part Three:
The Voice of Open Heart Surgery Survivors
Chapter 8: Cardiac Surgery
8.1 A Patient’s Perspective: On Open Heart Surgery from Diagnosis and Intervention to Recovery – A New Day, a New Lease and Unfolding Questions!
Guest Author: Ferez S. Nallaseth, Ph.D.
8.2 Triple-bypass operation at age 69 – Ralph’s Story: An Entertainer at Heart
Author: Gail S. Thornton, M.A.
8.3 A Fantastic Vessel-Clearing Innovation on The vessel-clearing device, U.S. Patent No. 8,663,209
Guest Author: Clifford Thornton
Cardiac Patient comment to this article included
Volume Summary
Larry H. Bernstein, MD, FCAP
This volume of contributions has focused on the patient’s response to treatment, the expected response to pharmacotherapy, immunotherapy, and radiation therapy. The discussion also entails the difficulties in going beyond diagnosis to a grasp of long term survival. In examining the patient perspective, the patient and the physician have to be in concert with realistic expectations of toxicities, exacerbations, and the possibility of a decline into cachexia.
Epilogue
Larry H. Bernstein, MD, FCAP
Individual experiences with cancer, heart disease, and debilitation
I must conclude this volume with the observation that it is true in medicine and healthcare that the patient comes first. This calls for a respect for the patient’s best concerns. In the United States (USA), this might be an unusual statement given the great diversity we have as a people. Nevertheless, integration of communities takes time, economic disparities separate individuals and communities within communities, and there are religious and cultural values that divide one person from another. In this respect, families matter, and families may be divided.
There is a range of individual, social and chronic conditions that engage all of us. On the one hand there is the end of life experience. We grow old, but how do we grow old? In the case of cancer, we see that it inflicts pain and suffering at any age. The death of a child is experienced by the parents. Cancer requires some combination of surgery, postoperative chemo- or immunotherapy with local radiation. The chance of recurrence is not small, so the question is always when and how it will be reasserted.
The situation with heart disease is not quite the same. We might like to just be lost in the night, but we don’t have choices. We are also faced with combined chronic systemic conditions, and the heart, kidneys, brain, and lungs are fed by a vascular system. Consequently, it raises the likelihood of multisystem failure. In this situation the possibilities are unclear. The patient with end stage renal disease may go on dialysis in clinic or terminally at home.
The situation is most impressive at the patient end of the process. I still remember a woman of color who had experienced emotional distress and ended several marriages in divorce before she entered the “metropolitan” hospital in my medical school years and was found to have a sudden increase in blood pressure related to a rare adrenaline secreting adenoma of the Organ of Zuckerkandl. She had no visitors during her hospital experience. That was also a time when schizophrenia was not understood, and it also brought shame to a family.
Then there are myths to dispel. When a young woman got pregnant, it was a personal and a family crisis. This is still a situation today that has been highlighted by a juncture disclosed in a presidential contestant interview about whether an abortion, considered a moral issue by the church, is punishable. It also was stated that it would necessitate a return of “back-alley” abortions. It reminded me of the autopsy I performed as a resident on a woman who had pyelonephritis leading to end stage kidney disease. I am a triplet with a sister two years older than myself, and I only learned late in life that my mother had had an aborted pregnancy to alleviate the strain it would place on the family, my father earning a meager living. There is no easy way to conclude this than to say that to the patient, medicine is highly personal.
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