Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Discussion Leader:

Anna Barker, Ph.D.
Director, Transformative Healthcare Knowledge Networks;
Co-Director, Complex Adaptive Systems Initiative:
Professor, School of Life Sciences, Arizona State University

World of Biomarkers following NIH Career – Molecular based Medicine

get all the facts right straight then distort them

Speakers:

Roy Perlis, MGH, Bipolar Specialty, Prof of Psychiatry

Specialist in Schizophrenia, Autism

• Complexity – overlapping diseases, genomics discovery
• Psychiatry Genomics – Susceptibility, variance explained by common variation, intervention studies for susceptibility
• depression is hereditary
• 2000 schizophrenics genome,
• phenotype models is only partially indicative of help if you are on Klonopin, is this enough for the diagnosis
• CRISPR — HOW to use it — not discovered yet for psychiatry disorder — it may be the solution, though

Joe Vockley

COO, Inova Health System

CSO, Inova Translational Medicine Institute

• Preeclempsia – preterm Birth is a complex disease many factor can cause it, 12% of birth are Preterm birth
• 10,000 genome vs full term birth, clinical phenotypes,
• model 81% predictive — triage screening based on markers – genomics to follow phenotyping.
• Genomics — indicative — not fully used from diagnostics to therapy
• ancestor data (familial info) of the 10,000 in the cohort was done filter variant
• whole genome sequencing, reimbursement does not support  to path to therapy based on genomics

Robert Plenge, M.D., Ph.D.   @rplenge
Vice President and Worldwide Head Genetics and Pharmacogenomics
Merck Research Laboratories – Specialist RA

ex- Pharmacogenetics at MGH

• sample size 100,000 genomes completely sequenced  – PM is at present in Oncology – use Genetics to discover diagnostics markers, clinical diagnosis, protocols – worst in cancer
• genetic effect are important component requires big cohort to identify large effect
• dysfunctional variant
• Proteomic predictors, in drug discovery not sufficient, marker of disease  it is helpful