Reported by: Dr. Venkat S. Karra, Ph.D.
NEW EVIDENCE FOR POLYOMAVIRUS BK ROLE IN PROSTATE CANCER
Prostate cancer is the leading cause of cancer morbidity and the third greatest cause of cancer death among men in developed countries.
English: Two-panel drawing shows normal male reproductive and urinary anatomy and benign prostatic hyperplasia (BPH). Panel on the left shows the normal prostate and flow of urine from the bladder through the urethra. Panel on the right shows an enlarged prostate pressing on the bladder and urethra, blocking the flow of urine. (Photo credit: Wikipedia)
A major question in cancer research has been whether virus infection plays a role in cancers of the genitourinary tract.
Now there seem to be a new evidence suggesting human polyomavirus BK is involved in maintaining and enhancing an environment suitable for prostate cancer growth. The research results were published in the August Journal of Virology, and the authors hope that these findings could lead to preventive and/or therapeutic prostate cancer vaccines.
(G. Sais, S. Wyler, T. Hudolin, I. Banzola, C. Mengus, L. Bubendorf, P.J. Wild, H.H. Hirsch, T. Sulser, G.C. Spagnoli, and M. Provanzano, 2012. Differential patterns of large tumor antigen-specific immune responsiveness in patients with BK polyomavirus-positive prostate cancer or benign prostatic hyperplasia. J. Virol. 86:8461-8471.)
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A new vaccine for prevention of prostate cancer will be very useful and will lower the cost of diagnosis and treatment of prostate cancer.
I have reservations. I can’t imagine a virus as cause. BPH is common with aging, and then we find prostate cancer commonly as a postoperative finding unrelated to death. Could the virus be an innocent bystander. Wait and see.
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Open Journals vs. Subscription-based « Pharmaceutical Intelligenceâ, very compelling plus the blog post ended up being a good read.
Many thanks,Annette