Posts Tagged ‘Ticells’

Thymus vs Bone Marrow, Two Cell Types in Human Immunology: B- and T-cell differences

Reporter: Larry H. Bernstein, MD, FCAP

Differences Between B-Cells and T-Cells


Aryal Sagar

Although mature lymphocytes all look pretty much alike, they are extraordinarily diverse in their functions. The most abundant lymphocytes are:

B lymphocytes (often simply called B cells) and
T lymphocytes (likewise called T cells)

Differences between B-Cells and T-Cells






1 Name B lymphocytes T lymphocytes
2 Origin Bone Marrow Thymus
3 Position Outside Lymph Node Interior of Lymph Node
4 Membranereceptor BCR (= immunoglobulin) for antigen TCR for antigen
5 Connections B-cells can connect to antigens right on the surface of the invading virus or bacteria. T-cells can only connect to virus antigens on the outside of infected cells.
6 Tissue Distribution Germinal centres of lymph nodes, spleen, gut, respiratory tract; also subcapsular and medullary cords of lymph nodes Parafollicular areas of cortex innodes, periarteriolar in spleen
7 Life Span Life span is short Life span is long
8 Surface Antibodies Surface Antibodies present Absence of surface antibodies
9 Secretion They secrete antibodies They secrete Lymphokines
10 Function В-cells form humoral or antibody-mediated immune system (AMI). T-cells form cell-mediated immune system (CMI).
11 Blood 20% of lymphocytes 80% of lymphocytes; CD4 > CD8
12 Formation They form plasma cells and memory cells. They form killer, helper and suppressor cells.
13 Movement to Infection Site Plasma cells do not move to the site of infection. Lymphoblasts move to the site of infection.
14 Function Plasma cells do not react against transplants and cancer cells. Killer cells react against transplants and cancer cells.
15 Function Plasma cells have no inhibitory effect on immune system. Suppressor cells inhibit immune system.
16 Function They defend against viruses and bacteria that enter the blood and lymph. They defend against pathogens including protists and fungi that enter the cells.
Differences Between B-Cells and T-Cells

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