Thymus vs Bone Marrow, Two Cell Types in Human Immunology: B- and T-cell differences
Reporter: Larry H. Bernstein, MD, FCAP
Differences Between B-Cells and T-Cells
http://www.microbiologyinfo.com/differences-between-b-cells-and-t-cells/
Aryal Sagar
Although mature lymphocytes all look pretty much alike, they are extraordinarily diverse in their functions. The most abundant lymphocytes are:
B lymphocytes (often simply called B cells) and
T lymphocytes (likewise called T cells)
S.N. |
Properties |
B-Cells |
T-Cells |
| 1 | Name | B lymphocytes | T lymphocytes |
| 2 | Origin | Bone Marrow | Thymus |
| 3 | Position | Outside Lymph Node | Interior of Lymph Node |
| 4 | Membranereceptor | BCR (= immunoglobulin) for antigen | TCR for antigen |
| 5 | Connections | B-cells can connect to antigens right on the surface of the invading virus or bacteria. | T-cells can only connect to virus antigens on the outside of infected cells. |
| 6 | Tissue Distribution | Germinal centres of lymph nodes, spleen, gut, respiratory tract; also subcapsular and medullary cords of lymph nodes | Parafollicular areas of cortex innodes, periarteriolar in spleen |
| 7 | Life Span | Life span is short | Life span is long |
| 8 | Surface Antibodies | Surface Antibodies present | Absence of surface antibodies |
| 9 | Secretion | They secrete antibodies | They secrete Lymphokines |
| 10 | Function | В-cells form humoral or antibody-mediated immune system (AMI). | T-cells form cell-mediated immune system (CMI). |
| 11 | Blood | 20% of lymphocytes | 80% of lymphocytes; CD4 > CD8 |
| 12 | Formation | They form plasma cells and memory cells. | They form killer, helper and suppressor cells. |
| 13 | Movement to Infection Site | Plasma cells do not move to the site of infection. | Lymphoblasts move to the site of infection. |
| 14 | Function | Plasma cells do not react against transplants and cancer cells. | Killer cells react against transplants and cancer cells. |
| 15 | Function | Plasma cells have no inhibitory effect on immune system. | Suppressor cells inhibit immune system. |
| 16 | Function | They defend against viruses and bacteria that enter the blood and lymph. | They defend against pathogens including protists and fungi that enter the cells. |
Differences Between B-Cells and T-Cells
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