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Lesson 1 AND 2 Cell Signaling & Motility: Lessons, Curations and Articles of reference as supplemental information: #TUBiol3373

Posted in Academic Publishing, Biological Networks, Cell Biology, Cell Biology, Signaling & Cell Circuits, tagged #TUBiol3373, Cell Motility, cell signaling, Content Curation, DNA, macromolecule detection, RNA on January 29, 2019| Leave a Comment »

Lesson 1 & 2 Cell Signaling & Motility: Lessons, Curations and Articles of reference as supplemental information: #TUBiol3373

Curator: Stephen J. Williams, Ph.D.

UPDATED 2/05/2019

UPDATED 1/27/2020

Syllabus for Cell Signaling & Motility for 2020

CELL SIGNALING AND MOTILITY (BIOL 3373)

SPRING 2020

Lectures:

Monday 5:00 PM – 8:00 PM

Biology Life Sciences, Room 342

Instructor:

Antonio Giordano, M.D., Ph.D.

Co-Instructor:

Stephen J. Williams, PhD

email: sjwilliamspa@comcast.net or tug83586@temple.edu

on Twitter @StephenJWillia2

Office hours: Biology Life Sciences Building, Room 431.

Friday: 12:00 noon – 2:00 PM. By appointment

(Phone: 215-2049520, or email: giordano@temple.edu).

Prerequisite:

BIO 3096, Cell Structure and Function (Minimum Grade of C- | May not be taken concurrently).

Description:

The communication among cells is essential for the regulation of the development of an organism and for the control of its physiology and homeostasis. Aberrant cellular signaling events are often associated with human pathological conditions, such as cancer, neurological disorders, cardiovascular diseases and so on. The full characterization of cell signaling systems may provide useful insights into the pathogenesis of several human maladies.

Text:

Molecular Biology of the Cell 6th Edition, Alberts et al. Garland Science. This textbook is available at the Temple Bookstore.

Grading:

The final grade will be based on the score of four examinations that include both group and individuals assignment. Each exam accounts for 25% of the final grade. There will be no make-up tests during the course. If you have a documented medical excuse and you contact me as soon as possible after the emergency, I will arrange a make-up exam. Complaints regarding the grading will not be considered later than two weeks after the test is returned.

Blackboard:

Announcements will be readily posted on Blackboard. It is your responsibility to check Blackboard periodically.

Attendance: Lecture attendance is mandatory. In addition, punctuality is expected.

Disabilities: Students with documented disabilities who need particular accommodation should contact me privately as soon as possible.

Honesty and Civility:

Students must follow the Temple’s Code of Conduct (see http://www.temple.edu/assistance/udc/coc.htm). This Code of Conduct prohibits: 1. Academic dishonesty and impropriety, including plagiarism and cheating. 2. Interfering or attempting to interfere with or disrupting the conduct of classes or any other activity of the University.”

Academic Rights and Responsibilities:

The policy of the University that regulates Student and Faculty Academic Rights and Responsibilities (Policy # 03.70.02) is available at the following web link: http://policies.temple.edu/getdoc.asp?policy_no=03.70.02

This policy sets the parameters for freedom to learn and freedom to teach, which constitute the pillars of academia.

SCHEDULE

This schedule is a general outline, which may be eventually modified. Changes will be announced in advance. Please, always check Blackboard and your email.

Date	Topic
Jan 13	Introduction (course overview and discussion of syllabus). General concepts: Eukaryotic and prokaryotic cell; DNA, RNA and proteins: Protein synthesis
Jan 20	Martin Luther King, Jr. Day (no classes held)
Jan 27	DNA analysis, RNA analysis; Proteins analysis; Microscopy.
Feb 3	Signaling: general concepts; Introduction to G-proteins; signaling via G-proteins (1)
Feb 10	Exam 1: In class presentation (group assignment)
Feb 17	Signaling via G-proteins (2); tyrosine kinase receptors signaling; Ras-MAPK pathway.
Feb 24	Exam 2: In class presentation (group assignment)
March 2- 8	Spring break
Mar 9	Cytoskeleton: Intermediate filaments; actin
Mar 16	Cytoskeleton: actin binding proteins; microtubules
Mar 23	Cytoskeleton: microtubules
Mar 30	Exam 3: in class Multiple choice questions (individual assignment)
Apr 6	Extracellular matrix; cell adhesion; coordinated polarization.
Apr 13	Cell motility and Wnt Signal Signaling.
Apr 20	Medical consequences of aberrant signaling pathways; production of small molecules for protein kinases In cancer therapy.
	Study days
May 4	Exam 4: In class presentation (group assignment)

Below is Powerpoint presentations for Lesson 1 and Lesson 2. Please check for UPDATES on this page for additional supplemental information for these Lessons including articles from this Online Access Journal

cell signaling and motility 1 lesson

cell signaling and motility 2 lesson

The following articles and curations discuss about the new paradigm how we now envision DNA, in particular how we now understand that the important parts of the genome are not just the exons which code for proteins but also the intronic DNA, which contains all the regulatory elements such as promoters, lncDNA, miRNA sequences etc. These are good reads for your presentations.