Lesson 1 & 2 Cell Signaling & Motility: Lessons, Curations and Articles of reference as supplemental information: #TUBiol3373
Curator: Stephen J. Williams, Ph.D.
UPDATED 2/05/2019
Syllabus for Cell Signaling & Motility for 2019
CELL SIGNALING AND MOTILITY (BIOL 3373)
SPRING 2017
Lectures:
Monday 5:00 PM – 8:00 PM
Biology Life Sciences, Room 342
Instructor:
Antonio Giordano, M.D., Ph.D.
Office hours: Biology Life Sciences Building, Room 431.
Friday: 12:00 noon – 2:00 PM. By appointment
(Phone: 215-2049520, or email: giordano@temple.edu).
Prerequisite:
BIO 3096, Cell Structure and Function (Minimum Grade of C- | May not be taken concurrently).
Description:
The communication among cells is essential for the regulation of the development of an organism and for the control of its physiology and homeostasis. Aberrant cellular signaling events are often associated with human pathological conditions, such as cancer, neurological disorders, cardiovascular diseases and so on. The full characterization of cell signaling systems may provide useful insights into the pathogenesis of several human maladies.
Text:
Molecular Biology of the Cell 6th Edition, Alberts et al. Garland Science. This textbook is available at the Temple Bookstore.
Grading:
The final grade will be based on the score of four examinations that include both group and individuals assignment. Each exam accounts for 25% of the final grade. There will be no make-up tests during the course. If you have a documented medical excuse and you contact me as soon as possible after the emergency, I will arrange a make-up exam. Complaints regarding the grading will not be considered later than two weeks after the test is returned.
Blackboard:
Announcements will be readily posted on Blackboard. It is your responsibility to check Blackboard periodically.
Attendance: Lecture attendance is mandatory. In addition, punctuality is expected.
Disabilities: Students with documented disabilities who need particular accommodation should contact me privately as soon as possible.
Honesty and Civility:
Students must follow the Temple’s Code of Conduct (see http://www.temple.edu/assistance/udc/coc.htm). This Code of Conduct prohibits: 1. Academic dishonesty and impropriety, including plagiarism and cheating. 2. Interfering or attempting to interfere with or disrupting the conduct of classes or any other activity of the University.”
Academic Rights and Responsibilities:
The policy of the University that regulates Student and Faculty Academic Rights and Responsibilities (Policy # 03.70.02) is available at the following web link: http://policies.temple.edu/getdoc.asp?policy_no=03.70.02
This policy sets the parameters for freedom to learn and freedom to teach, which constitute the pillars of academia.
SCHEDULE
This schedule is a general outline, which may be eventually modified. Changes will be announced in advance. Please, always check Blackboard and your email.
| Date | Topic |
| Jan 14 | Introduction (course overview and discussion of syllabus). General concepts: Eukaryotic and prokaryotic cell; DNA, RNA and proteins: Protein synthesis |
| Jan 21 | Martin Luther King, Jr. Day (no classes held) |
| Jan 28 | DNA analysis, RNA analysis; Proteins analysis; Microscopy. |
| Feb 4 | Signaling: general concepts; Introduction to G-proteins; signaling via G-proteins (1) |
| Feb 11 | Exam 1: In class presentation (group assignment) |
| Feb 18 | Signaling via G-proteins (2); tyrosine kinase receptors signaling; Ras-MAPK pathway. |
| Feb 25 | Exam 2: In class presentation (group assignment) |
| March 4- 10 | Spring break |
| Mar 11
|
Cytoskeleton: Intermediate filaments; actin |
| Mar 18 | Cytoskeleton: actin binding proteins; microtubules |
| Mar 25
|
Cytoskeleton: microtubules |
| April 1
|
Exam 3: in class Multiple choice questions (individual assignment) |
| Apr 8 | Extracellular matrix; cell adhesion; coordinated polarization. |
| Apr 15 | Cell motility and Wnt Signal Signaling. |
| Apr 22 | Medical consequences of aberrant signaling pathways; production of small molecules for protein kinases In cancer therapy. |
| Study days | |
| May 6 | Exam 4: In class presentation (group assignment) |
Below is Powerpoint presentations for Lesson 1 and Lesson 2. Please check for UPDATES on this page for additional supplemental information for these Lessons including articles from this Online Access Journal
cell signaling and motility 1 lesson
cell signaling and motility 2 lesson
The following articles and curations discuss about the new paradigm how we now envision DNA, in particular how we now understand that the important parts of the genome are not just the exons which code for proteins but also the intronic DNA, which contains all the regulatory elements such as promoters, lnDNA, miRNA sequences etc. These are good reads for your presentations.
The Search for the Genetic Code
Junk DNA codes for valuable miRNAs
And on How the Cell Creates Diversity post the Genetic Code by Use of Post Translational Modifications to Bring Diversity to Protein Structure/Function
Expanding the Genetic Alphabet and Linking the Genome to the Metabolome
Synthetic Biology: On Advanced Genome Interpretation for Gene Variants and Pathways: What is the Genetic Base of Atherosclerosis and Loss of Arterial Elasticity with Aging
Also there is a link to a Blood article using FISH to detect gene amplifications after Gleevec resistance onset here
Novel Mechanisms of Resistance to Novel Agents
Other Articles related to the #TUBiol3373 course include:
Lesson 9 Cell Signaling: Curations and Articles of reference as supplemental information for lecture section on WNTs: #TUBioll3373
Curation of selected topics and articles on Role of G-Protein Coupled Receptors in Chronic Disease as supplemental information for #TUBiol3373
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