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Mitochondria and Cardiovascular Disease: A Tribute to Richard Bing

Posted in Cardiovascular Pharmacogenomics, Cell Biology, Signaling & Cell Circuits, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Frontiers in Cardiology and Cardiovascular Disorders, Origins of Cardiovascular Disease, Pharmaceutical Industry Competitive Intelligence, Pharmacotherapy of Cardiovascular Disease, tagged Bing, Cardiovascular disease, health, Heart disease, Heart Failure, International Society for Heart Research, Sundance Film Festival, Vienna on April 14, 2013| 6 Comments »

Mitochondria and Cardiovascular Disease

Curator: Larry H Bernstein, MD, FACP

This article is the FIRST in a four-article Series covering the topic of the Roles of the Mitochondria in Cardiovascular Diseases. They include the following;

Mitochondria and Cardiovascular Disease: A Tribute to Richard Bing, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/chapter-5-mitochondria-and-cardiovascular-disease/

Mitochondrial Metabolism and Cardiac Function, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/mitochondrial-metabolism-and-cardiac-function/

Mitochondrial Dysfunction and Cardiac Disorders, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/mitochondrial-dysfunction-and-cardiac-disorders/

Reversal of Cardiac mitochondrial dysfunction, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/reversal-of-cardiac-mitochondrial-dysfunction/

Richard Bing was one of the founders of IACS. He was the first president of the International Study Group for Research in Cardiac Metabolism 1969 – 1973.

Then he was elected as Lifetime President of that organization which became the International Society for Heart Research. In 2001 he was recipient of the first of the Academy’s most prestigious Medals of Merit. On October 12, Richard J. Bing, an APS member since 1942, celebrated his 100th birthday and his scientific colleagues acknowledged the milestone in editorials published in several journals.

A movie documentary was chosen to be aired

at the Sundance Film Festival. It is still available on YouTube.com http://www.youtube.com/watch?v=EewKOQhdvHM

Richard Bing published over 500 peer reviewed articles on topics ranging from cardiac metabolism in congestive heart failure to echocardiographic studies of the posterior left ventricular wall in experimental myocardial infarction. He was the first to define the physiology of congenital heart disease (Helen Taussig

and Richard Bing, Blue Baby operation, patent foramen ovale, ductus arteriosus, veno-arterial mixing) by threading a catheter into the heart.

In addition to his scientific contributions, Richard Bing wrote more than 200 compositions of music including

the Missa (Chanted Mass) which was performed in the Cathedral of Saint Stefans in Vienna, Austria on October 30, 1993.

Bing also wrote a number of non-medical books including a novel and several short stories.

1. Cheng, T. O. Happy 100th Birthday to Dr. Richard John Bing, Int J Cardiol 137(2): 87-101, 2009.

2. Taegtmeyer, H. Richard Bing at 100: Reflections on a Lion in Winter. J Mol Cell Cardiol 47(5): 562-4, 2009.

3. Taegtmeyer, H. A Lion at Rest: Richard Bing dies at 101. Circ Res. 2011;108:9-11.

http://dx.doi.org./10.1161/CIRCRESAHA.110.237099

Print ISSN: 0009-7330. Online ISSN: 1524-4571 http://circres.ahajournals.org/content/108/1/9

This discussion is another in a series discussing

mitochondrial metabolism,
energetics
regulatory function, and dysfunction,
the process leading to apoptosis
a larger effect on disease.

Recall with regard to mitochondrial oxidation-reduction reactions and repair that there are

organ specific differences in the rates of organelle mutation errors and in the rates of repair.

Consider also the effect of

iron-binding in the function of the cell,
Ca2+ binding in the creation of the mechanical work.

The protein content of the cell is determined by

the balance between protein synthesis and protein degradation.

At constant intracellular protein concentration, i.e. at steady state,

rates of protein synthesis and degradation are equal.

The Ubiquitin-Mediated Proteolytic Pathway is involved in

complete destruction of its protein substrates, but
in limited proteolysis and posttranslational processing
it generates biologically active peptides or fragments.

It is essential for the system that ubiquitin recycles. This function is carried out by

ubiquitin C-terminal hydrolases (isopeptidases).

Although turnover of protein results in energy dissipation, regulation

at the level of protein degradation effectively controls protein levels.

In the mechanisms controlling macroautophagy,

protein phosphorylation plays an important role.

Activation of a signal transduction pathway accompanies inhibition of macroautophagy.

Components of this pathway include

a heterotrimeric Gi3-protein,
phosphatidylinositol 3-kinase
p70S6 kinase.

Autophagy, or mitophagy in mitochondria, is a process

central to consider in cardiac dysfunction –

either acute coronary syndrome, or chronic congestive heart failure.

Clues to heart disease in unexpected places, Temple researchers discover (eurekalert.org)
Statins prevent cardiovascular disease, but safer alternatives available (foodconsumer.org)
selenium and Q10 reduces mortality from cardiovascular disease (healthlift.wordpress.com)

References

Mitochondrial dynamics and cardiovascular diseases Ritu Saxena
http://pharmaceuticalintelligence.com/2012/11/14/mitochondrial-dynamics-and-cardiovascular-diseases/

Mitochondrial Damage and Repair under Oxidative Stress larryhbern
http://pharmaceuticalintelligence.com/2012/10/28/mitochondrial-damage-and-repair-under-oxidative-stress/

Mitochondria: Origin from oxygen free environment, role in aerobic glycolysis, metabolic adaptation larryhbern
http://pharmaceuticalintelligence.com/2012/09/26/mitochondria-origin-from-oxygen-free-environment-role-in-aerobic-glycolysis-metabolic-adaptation/

Ca2+ signaling: transcriptional control larryhbern
http://pharmaceuticalintelligence.com/2013/03/06/ca2-signaling-transcriptional-control/

MIT Scientists on Proteomics: All the Proteins in the Mitochondrial Matrix identified Aviva Lev-Ari
http://pharmaceuticalintelligence.com/2013/02/03/mit-scientists-on-proteomics-all-the-proteins-in-the-mitochondrial-matrix-identified/

Nitric Oxide has a ubiquitous role in the regulation of glycolysis -with a concomitant influence on mitochondrial function larryhbern
http://pharmaceuticalintelligence.com/2012/09/16/nitric-oxide-has-a-ubiquitous-role-in-the-regulation-of-glycolysis-with-a-concomitant-influence-on-mitochondrial-function/

Ubiquinin-Proteosome pathway, autophagy, the mitochondrion, proteolysis and cell apoptosis larryhbern
http://pharmaceuticalintelligence.com/2013/02/14/ubiquinin-proteosome-pathway-autophagy-the-mitochondrion-proteolysis-and-cell-apoptosis-reconsidered/

Low Bioavailability of Nitric Oxide due to Misbalance in Cell Free Hemoglobin in Sickle Cell Disease – A Computational Model Anamika Sarkar
http://pharmaceuticalintelligence.com/2012/11/09/low-bioavailability-of-nitric-oxide-due-to-misbalance-in-cell-free-hemoglobin-in-sickle-cell-disease-a-computational-model/

The rationale and use of inhaled NO in Pulmonary Artery Hypertension and Right Sided Heart Failure larryhbern
http://pharmaceuticalintelligence.com/2012/08/20/the-rationale-and-use-of-inhaled-no-in-pulmonary-artery-hypertension-and-right-sided-heart-failure/

Mitochondria and Cardiovascular Disease: A Tribute to Richard Bing, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/chapter-5-mitochondria-and-cardiovascular-disease/

Mitochondrial Metabolism and Cardiac Function, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/mitochondrial-metabolism-and-cardiac-function/

Mitochondrial Dysfunction and Cardiac Disorders, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/mitochondrial-dysfunction-and-cardiac-disorders/

Reversal of Cardiac mitochondrial dysfunction, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/reversal-of-cardiac-mitochondrial-dysfunction/

Sulfur-Deficiciency and Hyperhomocysteinemia (pharmaceuticalintelligence.com)
Mitochondrial metabolism and cardiac function (pharmaceuticalintelligence.com)
Macrophage Migration Inhibitory Factor Inhibition Is Deleterious for High-Fat Diet-Induced Cardiac Dysfunction (plosone.org)
L-carnitine significantly improves patient outcomes following heart attack (eurekalert.org)
Mitochondrial Disorders Overview (geneticamedicala.wordpress.com)
An Appraisal of Human Mitochondrial DNA Instability: New Insights into the Role of Non-Canonical DNA Structures and Sequence Motifs (plosone.org)
Cardiotoxicity and Cardiomyopathy Related to Drugs Adverse Effects (pharmaceuticalintelligence.com)
Lp(a) Gene Variant Association (pharmaceuticalintelligence.com)
Predicting Drug Toxicity for Acute Cardiac Events (pharmaceuticalintelligence.com)
Amyloidosis with Cardiomyopathy (pharmaceuticalintelligence.com)

Related Pharmaceutical Intelligence articles to follow

Occurrence of the term signal transduction in papers since 1977. These figures were extracted through an analysis of the papers contained within the MEDLINE database. (Photo credit: Wikipedia)