Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Mitochondria and Cardiovascular Disease

Curator: Larry H Bernstein, MD, FACP

This article is the FIRST in a four-article Series covering the topic of the Roles of the Mitochondria in Cardiovascular Diseases. They include the following;

• Mitochondria and Cardiovascular Disease: A Tribute to Richard Bing, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/chapter-5-mitochondria-and-cardiovascular-disease/

• Mitochondrial Metabolism and Cardiac Function, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/mitochondrial-metabolism-and-cardiac-function/

• Mitochondrial Dysfunction and Cardiac Disorders, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/mitochondrial-dysfunction-and-cardiac-disorders/

• Reversal of Cardiac mitochondrial dysfunction, Larry H Bernstein, MD, FACP

http://pharmaceuticalintelligence.com/2013/04/14/reversal-of-cardiac-mitochondrial-dysfunction/

Related articles

• Clues to heart disease in unexpected places, Temple researchers discover (eurekalert.org)
• Statins prevent cardiovascular disease, but safer alternatives available (foodconsumer.org)
• selenium and Q10 reduces mortality from cardiovascular disease (healthlift.wordpress.com)

 References

Mitochondrial dynamics and cardiovascular diseases    Ritu Saxena
http://pharmaceuticalintelligence.com/2012/11/14/mitochondrial-dynamics-and-cardiovascular-diseases/

Mitochondrial Damage and Repair under Oxidative Stress   larryhbern
http://pharmaceuticalintelligence.com/2012/10/28/mitochondrial-damage-and-repair-under-oxidative-stress/

Mitochondria: Origin from oxygen free environment, role in aerobic glycolysis, metabolic adaptation   larryhbern
http://pharmaceuticalintelligence.com/2012/09/26/mitochondria-origin-from-oxygen-free-environment-role-in-aerobic-glycolysis-metabolic-adaptation/

Ca2+ signaling: transcriptional control     larryhbern
http://pharmaceuticalintelligence.com/2013/03/06/ca2-signaling-transcriptional-control/

MIT Scientists on Proteomics: All the Proteins in the Mitochondrial Matrix identified  Aviva Lev-Ari
http://pharmaceuticalintelligence.com/2013/02/03/mit-scientists-on-proteomics-all-the-proteins-in-the-mitochondrial-matrix-identified/

Nitric Oxide has a ubiquitous role in the regulation of glycolysis -with a concomitant influence on mitochondrial function    larryhbern
http://pharmaceuticalintelligence.com/2012/09/16/nitric-oxide-has-a-ubiquitous-role-in-the-regulation-of-glycolysis-with-a-concomitant-influence-on-mitochondrial-function/

Ubiquinin-Proteosome pathway, autophagy, the mitochondrion, proteolysis and cell apoptosis  larryhbern
http://pharmaceuticalintelligence.com/2013/02/14/ubiquinin-proteosome-pathway-autophagy-the-mitochondrion-proteolysis-and-cell-apoptosis-reconsidered/

Low Bioavailability of Nitric Oxide due to Misbalance in Cell Free Hemoglobin in Sickle Cell Disease – A Computational Model   Anamika Sarkar
http://pharmaceuticalintelligence.com/2012/11/09/low-bioavailability-of-nitric-oxide-due-to-misbalance-in-cell-free-hemoglobin-in-sickle-cell-disease-a-computational-model/

The rationale and use of inhaled NO in Pulmonary Artery Hypertension and Right Sided Heart Failure    larryhbern
http://pharmaceuticalintelligence.com/2012/08/20/the-rationale-and-use-of-inhaled-no-in-pulmonary-artery-hypertension-and-right-sided-heart-failure/

Related articles

• Sulfur-Deficiciency and Hyperhomocysteinemia (pharmaceuticalintelligence.com)
• Mitochondrial metabolism and cardiac function (pharmaceuticalintelligence.com)
• Macrophage Migration Inhibitory Factor Inhibition Is Deleterious for High-Fat Diet-Induced Cardiac Dysfunction (plosone.org)
• L-carnitine significantly improves patient outcomes following heart attack (eurekalert.org)
• Mitochondrial Disorders Overview (geneticamedicala.wordpress.com)
• An Appraisal of Human Mitochondrial DNA Instability: New Insights into the Role of Non-Canonical DNA Structures and Sequence Motifs (plosone.org)
• Cardiotoxicity and Cardiomyopathy Related to Drugs Adverse Effects (pharmaceuticalintelligence.com)
• Lp(a) Gene Variant Association (pharmaceuticalintelligence.com)
• Predicting Drug Toxicity for Acute Cardiac Events (pharmaceuticalintelligence.com)
• Amyloidosis with Cardiomyopathy (pharmaceuticalintelligence.com)

Related Pharmaceutical Intelligence articles to follow

Occurrence of the term signal transduction in papers since 1977. These figures were extracted through an analysis of the papers contained within the MEDLINE database. (Photo credit: Wikipedia)

Overview of signal transduction pathways involved in apoptosis, also known as “programmed cell death”. (Photo credit: Wikipedia)

English: I (John Schmidt) made this diagram. (Photo credit: Wikipedia)