Real Time Conference Coverage: Advancing Precision Medicine Conference,Morning Session Track 1 October 3 2025
Reporter: Stephen J. Williams, PhD
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using the following meeting hashtags
#AdvancingPM #precisionmedicine #WINSYMPO2025
Agenda Track 1: WIN Symposium
WIN SYMPOSIUM
Co-Chairs
8:40 – 9:00
Welcome and Introduction
Dr. El-Diery welcomes all to this joint symposium with Advancing Precision Medicine and the Win Consortium, which he is currently the head of. More in the WIN Consortium: (Worldwide Innovation Network Consortium in Precision Oncology). The WIN Network is involved in setting up internationalclinical tumor board collaboration
Source: https://winconsortium.org/
WIN was formed on the premise that we can accomplish more together than each organization can achieve working alone. We aim to improve cancer patients’ survival and quality of life. View WIN’s history and unique attributes:
Clinical trials, projects and publications
WIN members collaboratively design and carry out global studies designed to achieve breakthroughs for patients worldwide. Our distinguished Scientific Advisory Board oversees WIN studies. Current trials include:
- 01
Identification of a central network hub of key prognostic genes based on correlation between transcriptomics and survival in patients with metastatic solid tumors - 02
Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments - 03
SPRING – Landmark Lung Cancer Tri-Therapy Clinical Trial - 04
WINTHER: the WIN Consortium’s first global personalized medicine clinical trial, published in Nature Medicine
View a summary of the WIN Consortium here:
Click to access Brochure_WIN_v24.0_2025_08_13__.pdf
They guide WIN’s strategic, operational, and scientific direction.
Nigel Russell, Founder and CEO, Advancing Precision Medicine
Christopher P. Molineaux, President & Chief Executive Officer, Life Science Pennsylvania
As president & CEO of Life Sciences Pennsylvania, Christopher Molineaux serves as the chief advocate and spokesman for the life sciences industry that calls Pennsylvania home. Molineaux oversees the strategic direction for the association, assuring Life Sciences Pennsylvania continues to be the catalyst that makes Pennsylvania the top location for life sciences companies.
Molineaux brings to Life Sciences Pennsylvania more than 25 years of experience in the bio-pharmaceutical and health care industries, with front-line experience in developing and executing strategies to navigate a shifting economic and political environment.
9:00-9:40
Keynote Lecture – WIN Consortium
Targeting the Achilles’ Heel of Cancer: Synthetic Lethality and Hypoxia in Precision Oncology
William Kaelin was born in New York City. He studied chemistry and mathematics at Duke University in Durham, North Carolina, and received his doctor of medicine degree there in 1982. He then did his residency at Johns Hopkins University in Baltimore, Maryland. In 2002 he became a professor at Harvard Medical School in Cambridge, Massachusetts.
Work
Animals need oxygen for the conversion of food into useful energy. The importance of oxygen has been understood for centuries, but how cells adapt to changes in levels of oxygen has long been unknown. William Kaelin, Peter Ratcliffe, and Gregg Semenza discovered how cells can sense and adapt to changing oxygen availability. During the 1990s they identified a molecular machinery that regulates the activity of genes in response to varying levels of oxygen. The discoveries may lead to new treatments of anemia, cancer and many other diseases.
TRACK 1 204BC
WIN SYMPOSIUM
MULTI-OMICS
9:40 – 10:40
SESSION 1
From Base Pairs To Better Care:
AI and Omics in Precision Oncology
9:40-10:00
Multi-Omic Profiling and Clinical Decision Support in Precision Oncology
David Spetzler, PhD, MBA, MS, President, Caris Life Sciences
10:00-10:20
Integrating Omics and AI for Next-Gen Precision Oncology
Keith T. Flaherty, MD, FAACR, Director of Clinical Research, Massachusetts General Cancer Center; Professor of Medicine, Harvard Medical School;
President-Elect: 2025-2026, American Association for Cancer Research (AACR)
10:20-10:40
Real-World Data and AI in Precision Oncology: Making Data Work for Patients – Q&A
MODERATOR: Jeff Elton, PhD, Vice Chairman, Founding CEO
ConcertAI
PANELISTS: David Spetzler, PhD, MBA, MS, President, Caris Life Sciences
Keith T. Flaherty, MD, FAACR, Director of Clinical Research, Massachusetts General Cancer Center; Professor of Medicine, Harvard Medical School;
President-Elect: 2025-2026, American Association for Cancer Research (AACR)
0:40 – 11:10
Break and Exhibits
TRACK 1 204BC
TRACK 2 204A
WIN SYMPOSIUM
MULTI-OMICS
11:10 – 1:10
SESSION 2
The Evolution of Precision Oncology:
Integrating MRD, AI, and Beyond
11:10-12:00
Precision Cancer Consortium
Shruti Mathur, MS, Pharma Diagnostic Strategy Leader, Global Product Strategy (GPS), Genentech
Daryl Pritchard, PhD, Interim President, Personalized Medicine Coalition
Keith T. Flaherty, MD, FAACR, Director of Clinical Research, Massachusetts General Cancer Center; Professor of Medicine, Harvard Medical School;
President-Elect: 2025-2026, American Association for Cancer Research (AACR)
SESSION 3
The Shifting Landscape:
Tumor Plasticity and Resistance
12:00-12:20
Mathematical and Evolutionary Modeling in Precision Radiation Oncology
Jacob Scott, MD, DPhil, Professor and Staff Physician-Scientist, CWRU School of Medicine and Cleveland Clinic
12:20-12:40
Plasticity and Persistence: The Role of EMT in Cancer Progression and Therapy Resistance
Sendurai A. Mani, PhD, Professor of Pathology and Laboratory Medicine, Brown University; Associate Director of Translational Oncology, Brown University Legorreta Cancer Center
12:40-1:00
Targeting Molecularly Defined Subsets: Challenges in Translational Oncology
Benedito A. Carneiro, MD, MS, Director, Clinical Research
Director, Cancer Drug Development; Associate Director, Division of Hematology/Oncology
Legorreta Cancer Center, Brown University Health
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