LIVE 4:50 pm – 5:55 pm Early Detection and Prevention of Cancer & Innovation Break: Announcing the C³ Prize from Astellas Oncology and the World Medical Innovation Forum @2016 World Medical Innovation Forum: CANCER, April 25-27, 2016, Westin Hotel, Boston
2016 World Medical Innovation Forum: CANCER, April 25-27, 2016,
Partners HealthCare, Boston, at the Westin Hotel, Boston
ANNOUNCEMENT
Leaders in Pharmaceutical Business intelligence (LPBI) Group
will cover in Real Time using Social Media this Event on
CANCER Innovations
Aviva Lev-Ari, PhD, RN, Founder LPBI Group & Editor-in-Chief
http://pharmaceuticalintelligence.com
Streaming LIVE @Westin in Boston
Novartis Ballroom
Early Detection and Prevention of Cancer
The prevention of cancer and the development of new strategies to detect cancer precursors and early-stage malignancies when treatment may be most effective – clinically and financially — are critical research goals. Our panel of experts reviews powerful imaging modalities, single-cell analysis of the tumor microenvironment and next-generation cancer models. Circulating tumor DNA testing to monitor response to treatment and emergence of cancer resistance—with the objective of early cancer diagnosis before symptoms appear—will also be detailed.
- New technology – Liquid biopsy?
- detection via Imaging or individual cells what analytics to use
- diagnostics – clinical useful
- NGS is molecular diagnostics is transformative and the next revolution in early detection
- prevention using imaging – pap smear – 70 years to capture by imaging is done
- Upper Gi endoscopy OCT and Lower GI colonoscopy – fecal genomics
- Data generated from OCT and from Genomics
- MGH and BWH 1/2 Billion data points in the systems of LABS alone
- Data science – to detect disease
- Anemias, RBC – all CBC data model 120 days vs Iron defficient anemia — PREDICTED diagnosis of anemia 3 months in advance and offer treatment in early diagnostics
- Data Scientists is huge, finding the skilled scientists
- FUTURE — 15 years down the road, genetics, environmental
- Public Health Education population to get them into screening and into prevention
- focus on tumor and therapy
- NGS – early molecular
- NGS – Polimorphism – epidemiological
- Microbiome role to characterize the microbial ecosystem and Cancer
- How to make colonoscopy more effective
- screening for populations
- polips adenomas — leads to cancer
- Upper GI esophageal is increasing – GERD common lesion few develop cancer from displacia – sampling when there is descplacia high grade OCT is used – displastics
- colonorectal is declining
- molecular imaging of over expression of enzyme in desplesia
- FDA approved and CMS reimbursed – diagnostics on polips
- Data to help understand Cancer and other diseases – what patient population to target for prevention
- Using Drugs for Prevention: Aspirin, Statin,
- Who is likely to develop Cancer ????????
- developing with MGH diagnostics for early tumor using Liquid Biopsy for early detections
- biopsy for COPD –>>> cancerization, abnormality in nasal swab
- As tumor develops genomics instability – apply same technology in the Pharmaceutical industry
- Side effects are for all however the drugs benefits some and not all — Who to be targeted fro therapy
- circulated Tumor cells resistance to treatment for a better combination
- obtaining the tissue do HPV on tissue proper vaccine adjuvent therapy to bring prevention
- sensors
- Can I be cure? Pharma – manifestation of disease
- collaboration among pharma could bring a revolution in treatment
- Imaging
- digitization in Pathology, interoperability, intra center cancer, inter-center cancer
- tumor segmentation
- IBM and Watson – Oncology specific DB
- imaging, pathology and molecular data – infrastructure is not yet ready
- diagnostics based on data – radiation and chemo budgets will shrinks
- all Pharma: R&D goes to gene mutations, stop the signal transduction, pathways identified via genomics
- Metabolic Profiling of Tumors
- sequencing – select alterations in circulating DNA, small tissue samples, biopsies in retrospective developed into cancer
- BRCA and Prostate cancer, stroma cells are predictive of behavior of tumor, need to use retrospective data
- data integration: Clinical, OMICS, tissue and organism,
- training scientists in new technologies
Novartis Ballroom
By 2030, the global cancer burden is expected to grow to 22.2MillionCancer cases
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