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Eric Topol, M.D., Gary & Mary West Endowed Chair of Innovative Medicine, Scripps Research, Executive VP, Scripps Research, Ex-Chairman of Cardiovascular Medicine at Cleveland Clinic and Founder of the Cleveland Clinic Lerner College of Medicine

Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

Eric Topol, M.D. is professor of genomics and holds the Scripps endowed chair in innovative medicine. He is the director of the Scripps Translational Science Institute in La Jolla, California. Previously, he led the Cleveland Clinic to its #1 ranking in heart care, started a new medical school, and led key discoveries in heart disease.

Professor of Genomics
Department of Molecular and Experimental Medicine
California Campus
Laboratory Website
etopol@scripps.edu
(858) 554-5708

Scripps Research Joint Appointments

Director, Scripps Translational Science Institute
Faculty, Graduate Program

Other Joint Appointments

Chief Academic Officer, Scripps Health
Senior Consultant, Scripps Clinic, Division of Cardiovascular Diseases

Research Focus

My research is on indvidualized medicine, using the genome and digital technologies to understand each person at the biologic, physiologic granular level to determine appropriate therapies and prevention. An example is the use of pharmacogenomics and our research on clopidogrel (Plavix). By determining the reasons for why such a large proportion of people do not respond to this medication, we can use alternative treatment strategies to prevent blood clots.

 

Education

M.D., University of Rochester, New York, 1979
B.A., Biomedicine, University of Virginia, Charlottesville, 1975

Professional Experience

University of Virginia, B.A. With Highest Distinction, 1975
University of Rochester, M.D. With Honor, 1979
University of California, San Francisco, Internal Medicine Residency, 1979-1982
Johns Hopkins, Cardiology Fellowship, 1982-1985
University of Michigan, Professor with Tenure, Department of Internal Medicine, 1985-1991
Cleveland Clinic, Chairman of the Department of Cardiovascular Medicine, 1991-2006
Cleveland Clinic, Chief Academic Officer, 2000-2005
Cleveland Clinic Lerner College of Medicine,Founder and Provost
Case Western Reserve University, Professor of Genetics,2003-2006

Awards & Professional Activities

Elected to Institute of Medicine, National Academy of Sciences
Simon Dack Award, American College of Cardiology
American Heart Association, Top 10 Research Advances (2001, 2004)
Top 10 Most Cited Researchers in Medicine, Institute for Scientific Information
Doctor of the Decade, Thompson Scientific Award

Selected References

Goetz L, Bethel K, Topol EJ. Rebooting cancer tissue handling in the sequencing era. JAMA 309: in press, 2013

Harper AR, Topol EJPharmacogenomics in clinical practice and drug developmentNature Biotechnology, 2012 Nov;30(11):1117-24. [PMID: 23138311]

Komatireddy R, Topol EJ. Medicine Unplugged: The Future of Laboratory Medicine. Clin Chem. 2012 Oct 15. [PMID: 23071365]

Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, Ren B, Fu X-D, Topol EJ, Rosenfeld MG, Frazer KA. 9p21 DNAvariants associated with coronary artery disease impair interferon-c signalling response. Nature470(7333):264-268, 2011. [PMID 21307941]

Bloss CS, Schork NJ, Topol EJEffect of Direct-to-Consumer Genomewide Profiling to Assess Disease RiskNew England Journal of Medicine 364(6):524-534, 2011. [PMID 21226570]

Topol EJ, Schork NJ. Catapulting clopidogrel pharmacogenomics forward. Nature Medicine 17(1):40-41, 2011. [PMID 21217678]

Rosenberg S, et al, Topol EJ; PREDICT Investigators. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assesing coronary artery disease in nondiabetic patients. Annals of Internal Medicine153(7):425-434, 2010. [PMID 20921541]

Topol, EJ. Transforming Medicine via Digital Innovation. Science Translational Medicine 2(16):16cm4, 2010. [PMID 20371472]

http://creativedestructionofmedicine.com/?p=3

The wireless future of medicine

http://www.ted.com/talks/eric_topol_the_wireless_future_of_medicine

FinanciaPost‘s Digital revolution in antiquated health-care industry a major operation

Listen to Dr. Topol’s podcast interview with Knowledge@Wharton

In his new book, The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care, Eric Topol argues that medicine is set to undergo its biggest shakeup in history, pushed by demanding consumers and the availability of game-changing technology. Topol — a cardiologist, director of the Scripps Translational Science Institute and co-founder of the West Wireless Health Institute in La Jolla, Calif. — was recently interviewed for Knowledge@Wharton by C. William Hanson, III, a professor of anesthesiology and critical care, and director, surgical intensive care, at the Hospital of the University of Pennsylvania. Hanson’s latest book is titled, Smart Medicine: How the Changing Role of Doctors Will Revolutionize Health Care, published in 2011.

Below is an edited transcript of the conversation.

William Hanson: I thought it might be worthwhile to quickly give you a sense of who I am and where I’m coming from [in this interview]. I’m an anesthesiologist and an intensivist, primarily a surgical intensivist, and serve as chief medical information officer at Penn. So I have some interests that will skew in that direction.

I love the title of your book. There are many people on both sides of this question. Some would say that the creative destruction of medicine is a pretty scary concept, and I think there would be plenty of us who would agree that something drastic needs to happen. You’re obviously in the latter category.

Eric Topol: I’m in the [group that feels] something drastic needs to happen. I think it can happen, it will happen and I’m hoping that we can help facilitate or catalyze that.

Hanson: You have been in a prominent role in terms of questioning traditional medical concepts. Maybe you could describe for the audience what your personal practice is and some of the issues in which you have engaged the traditional medical establishment in the past.

Topol: What I’ve done to try to change medicine in many different ways [includes] research on how to come up with better therapies. These were in large trials, as large as 40,000 patients with heart attacks, but also in [other] ways, such as starting a new medical school with a very innovative curriculum and challenging a drug safety issue which was really important for the public. So I’ve had different experiences over the years.

But what was changing for me was that four or five years ago, we recognized we had this new emerging capability of digitizing human beings, which we’ve never had before. Everybody is used to digitizing books, movies and newspapers, whatever. But when you digitize human beings by knowing the sequence of their DNA, all their physiologic metrics, like their vital signs, their anatomy [and so forth], this comes together as a unique kairos — this supreme opportune moment in medicine.

Hanson: That’s a nice lead in. I want to return to that digitization because it is something I’m dealing with in our IT systems, as I’m sure you are — what to do with the digitized information, how much of it to keep, how to analyze it. But I wanted to come back to your book title and to one of the gentlemen who endorsed the book, Clayton Christensen. He has written a couple of books as you know, including The Innovator’s Dilemma and The Innovator’s Prescription.

Topol: He has written three books on innovation and is renowned for his insights and leadership in [that] space. But there’s a little bit of a difference between us.

Hanson: Maybe you could elaborate on that.

Topol: Yes. I look to him as one of the real guiding lights of innovation. He’s not a physician. In the book, Innovator’s Prescription, he worked with a young physician, Jason Hwang, who is now out at Stanford.

Hanson: Yes, I have met him.

Topol: The difference, though, is that I am coming at it from almost three decades in the medical profession, and I’m not calling for an innovation. He calls it disruptive innovation. I’m looking at a much more radical thing. This is like taking what Clayton has popularized [and making it much bigger] … in terms of how transformative this can be, this whole ability to digitize human beings.

Hanson: In his work, he has talked about the digitization of the music industry, for example, and the film industry. Recognizing that you’re dealing at a much deeper level with the medical side of things, [it has to do with] how products enter the market at the low end and disrupt and take over higher-end products. For me and you at academic medical centers, where we think we’re providing state of the art care, I wonder to what extent we are likely to be made irrelevant by radical disruptions of the kind you’re talking about. What do you think about that?

Topol: I think that the medical community has been incredibly resistant to change. That’s across not just academic medical centers, but the whole continuum of medicine, [including] practicing physicians. But there is a consumer-driven health care revolution out there where each individual has access to their smart phone, all their vital signs and relevant data. There’s an ability to tap into their DNA sequence and all of their genomics. And of course that’s superimposed on this digital infrastructure that each person has now with a social network, with broadband Internet access and pervasive connectivity.

The Atlantic’s
 Q&A with Dr. Topol

Destroying Medicine to Rebuild It: Eric Topol on Patients Using Data

The emergency announcement on the transcontinental flight was terse and urgent: “Is there a doctor on board?” A passenger in distress was feeling intense pressure in his chest.

Eric Topol strode down the aisle to examine the passenger to see if he was having a heart attack, a diagnosis that normally would be tough at 35,000 feet. But Topol was armed with a prototype device that can take a person’s electrocardiogram (ECG) using a smartphone. The director of the Scripps Translational Science Institute near San Diego, he had just demonstrated how it worked during a lecture in Washington, D.C.

“It’s a case that fits over your iPhone with two built-in sensors connected to an app,” says Topol, showing me the device, made by Oklahoma City-based AliveCor. “You put your fingers on the sensors, or put them up to your chest, and it works like an ECG that you read in real-time on your phone.”

Dr. Topol’s guest blog for ForbesThe Power of Digitizing Human Beings and his Q&A with SalonThe Coming Medical Revolution

Read Wired’s Q&A with Dr. Topol: Why Doctors Need to Embrace Their Digital Future Now

Slate featured the book on their blog “Future Tense”

And here for an interview on Keen On (Tech Crunch TV): Why the Entrepreneurial Opportunities are Limitless http://www.pbgtoolkit.com/docs_pbg/1331561497Doc6.jpg

“Keen On” http://www.pbgtoolkit.com/docs_pbg/1331915366topol.jpg

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