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Posts Tagged ‘Boston University’


The Biomedical Engineering Society (BMES) Boston Industry Chapter, Boston University Biomedical Engineering Department & Healthcare PioneersTM

Reporter: Aviva Lev-Ari, PhD, RN

present:

Medical Device Innovation – Logistics of Innovation and Case Studies 

Thursday, October 24th, 2013 5:30 – 9:00 PM

Boston University- LSEB B01, 24 Cummington Street, Boston, MA 02215

New Opportunity for Exhibitors – get a booth at this evening’s conference directly in the auditorium for just $100. Purchase Tickets below.

Medical device innovation is a bridge between formal biomedical engineering education and a professional career, while translating scientific research to market. As we all know, bringing medical devices from concept to commercialization can be difficult. The Biomedical Engineering Society (BMES) Boston Industry Chapter and the Healthcare PioneersTM group are presenting an evening Forum (with a live video broadcast option for registered members) to address key success factors and discuss case studies in medical device innovation. Here are few of the questions we will be addressing:

• Intellectual property and how to protect it

• Business development

• Engaging doctors in medical device innovation

Panel Speakers:

Ms. Karin Gregory, MPH, managing partner at Furman Gregory Deptula LLC, will share her experience of over 30 years in the healthcare industry in addressing tips and pitfalls in bringing medical innovation to market.

Dominic J. F. Tong, M.D. CEO and Principal at Del Mar Medical & Radiology Services.  Dr. Tong will talk about his experience as a medical director for multiple medical technology companies across the country, as well as about starting an academic spinoff in the field of medical imaging.

Gabriel Gruionu, PhD, co-owner and manager, Restore Surgical LLC and Medical Product Development. LLC. Dr. Gruionu will address the innovation social network in academia, how we can connect and align different key players for successful medical innovation inside and outside universities. He will illustrate his concepts with examples from three academic start-up companies from the US and Europe.

By sharing thoughtful process and best practices in presentation and question & answer formats, the speakers will provide insights into the wide range of issues any biomedical engineer should consider as they contribute as team members and leaders of new device and drug development programs.

When:  Thursday, October 24th

Time:    5:30 pm – 9:00 pm

Where:   Boston University- LSEB B01, 24 Cummington Street, Boston, MA 02215

Agenda:

5:30 – 6:00pm                     Registration/Networking/Refreshments

6:00 – 6:15 pm                    Opening Remarks, BMES and HCP Leadership Team

6:15 – 7:30 pm                    Panel: “Medical Device Innovation”

7:30 – 8:00 pm                    Question & Answer Segment

8:00- 9:00 pm                     Networking/Refreshments

 

For SPONSORSHIP OPPORTUNITIES please call (347) 903-4362

 

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Myocardial Strain and Segmental Synchrony: Age and Gender in Speckle-tracking-based Echocardiographic Study

Reporter: Aviva Lev-Ari, PhD, RN

  • Original Article

Age- and Sex-based Reference Limits and Clinical Correlates of Myocardial Strain and Synchrony: The Framingham Heart Study

  1. Susan Cheng1*,
  2. Martin G. Larson2,
  3. Elizabeth L. McCabe3,
  4. Ewa Osypiuk4,
  5. Birgitta T. Lehman4,
  6. Plamen Stanchev4,
  7. Jayashri Aragam5,
  8. Emelia J. Benjamin6,
  9. Scott D. Solomon7 and
  10. Ramachandran S. Vasan8

+Author Affiliations


  1. 1Framingham Heart Study, Framingham, MA; Brigham and Women’s Hospital, Boston, MA

  2. 2Framingham Heart Study, Framingham, MA; Boston University, Boston, MA

  3. 3Boston University, Boston, MA

  4. 4Framingham Heart Study, Framingham, MA

  5. 5Veterans Administration Hospital, West Roxbury, MA

  6. 6Framingham Heart Study, Framingham, MA; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA; Boston University School of Public Health, Boston, MA

  7. 7Brigham and Women’s Hospital, Boston, MA

  8. 8Framingham Heart Study, Framingham, MA; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA
  1. * Brigham and Women’s Hospital, 75 Francis Street, PBB-119 Boston, MA 02115scheng3@partners.org

Abstract

Background—There is rapidly growing interest in applying measures of myocardial strain and segmental synchrony in clinical investigations and in practice, but data are limited regarding their reference ranges in healthy individuals.

Methods and Results—We performed speckle-tracking-based echocardiographic measures of left ventricular (LV) myocardial strain and segmental synchrony in healthy Framingham Heart Study participants (n=738, mean age 63 years, 64% women) who were free of cardiovascular disease. Reference values (2.5th, 50th, 97.5th quantiles) were estimated using quantile regression. Age- and sex-based upper (97.5th quantile) limits were as follows:

  • 15.5% to -16.9% (women) and -14.5 to -15.4% (men) for longitudinal strain;
  • -21.9% to -24.3% (women) and -18.9% to -25.0% (men) for circumferential strain;
  • 114-158 msec (women) and 133-206 msec (men) for longitudinal segmental synchrony (SD of regional time-to-peak strains); and,
  • 204-224 msec (women) and 201-288 msec (men) for transverse segmental synchrony.

In multivariable analyses, women compared to men had

  • ~1.7% greater longitudinal strain,
  • ~2.2% greater transverse strain, and
  • ~3.2% greater circumferential strain (P<0.0001 for all).

Older age and higher diastolic blood pressure, even within the normal range, was associated with worse transverse segmental synchrony (P<0.001). Overall, clinical covariates contributed ≤12% of the variation in myocardial strain or synchrony in this healthy sample.

Conclusions—We estimated age- and sex-specific reference limits for echocardiographic measures of LV strain and synchrony in a healthy community-based sample, wherein clinical covariates contributed only a modest proportion of the variation. These data may facilitate interpretation of LV strain-based measures obtained in future clinical research and practice.

Key Words:

  • Received November 19, 2012.
  • Accepted July 18, 2013.

SOURCE

CIRCIMAGING.112.000627Published online before print August 5, 2013,doi: 10.1161/​CIRCIMAGING.112.000627

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