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Volume Seven is 2nd Edition of

Volume One

Title of Volume Seven:

Text Mining with Machine Learning, Book Glossary from Article’s WordClouds.

Title of Volume One:

Perspectives on Nitric Oxide in Disease Mechanisms

An Audio Book

Authors and Editors:

• Dr. Justin D. Pearlman, MD, PhD, FACC
• Aviva Lev-Ari, PhD, RN
• Arav Gandhi, aspiring cardiologist, producer of TTS, WordClouds, Glossaries and Audio e-Book, Volume 7

 

Volume Seven is the 2nd Edition of Volume One in the following e-Series:

Series A: Cardiovascular Diseases ($515)

https://www.amazon.com/gp/product/B07P981RCS?ref_=dbs_p_mng_rwt_ser_shvlr&storeType=ebooks

This e-Series consists of the following six volumes:

• Cardiovascular Diseases, Volume One: Perspectives on Nitric Oxide in Disease Mechanisms
• Volume Two: Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation
• Volume Three: Etiologies of Cardiovascular Diseases – Epigenetics, Genetics and Genomics
• Volume Four: Therapeutic Promise: Cardiovascular Diseases, Regenerative & Translational Medicine
• Volume Five: Pharmacological Agents in Treatment of Cardiovascular Diseases
• Volume Six: Interventional Cardiology for Disease Diagnosis and Cardiac Surgery for Condition Treatment

 

The NEW Volume Seven in the English Edition of Series A will include:

1. Access to Audio articles in Volume One
2. Glossary for Volume One
3. Editorials – Audio in the English language [also available as Part C in each Volume in Series A in the Spanish Edition]
4. Selection of five WordCloud images for each Chapter in the Volume

Cardiovascular Diseases, Volume One:

Perspectives on Nitric Oxide in Disease Mechanisms

 

Series A, Volume 1:

electronic Table of Contents (e-TOCs)

All articles are in Audio format

 

Chapter 1:

Nitric Oxide Basic Research

 

1.1 Discovery of Nitric Oxide

LISTEN to the Audio

1.1.1 Discovery of Nitric Oxide and its Role in Vascular Biology

Aviral Vatsa, PhD, MBBS

 

1.1.2 Nitric Oxide: The Nobel Prize in Physiology or Medicine

Aviva Lev-Ari, PhD, RN

1.2 Nitric Oxide Synthase(s)

1.2.1 Nitric Oxide: A Short Historic Perspective

Aviral Vatsa, PhD, MBBS

1.2.2 Nitric Oxide: Role in Cardiovascular Health and Disease

Aviral Vatsa, PhD, MBBS

1.3 Endothelial Blood Cell Interactions: Platelet, Leukocyte and Monocyte

1.3.1 Nitric Oxide: Chemistry and Function

Aviral Vatsa, PhD, MBBS

1.4 Signaling Pathways

1.4.1 Nitric Oxide Signaling Pathways

Aviral Vatsa, PhD, MBBS

1.4.2 Nitric Oxide has a Ubiquitous Role in the Regulation of Glycolysis – with a Concomitant Influence on Mitochondrial Function

Larry H. Bernstein, MD, FCAP

1.5 Oxidative Stress

1.5.1 Mitochondrial Damage and Repair under Oxidative Stress

Larry H. Bernstein, MD, FCAP

1.6 Oxygen and Nitrogen Reactive Species

1.6.1 Interaction of Nitric Oxide and Prostacyclin in Vascular Endothelium

Larry H Bernstein, MD, FCAP

1.6.2 Prostacyclin and Nitric Oxide: Adventures in vascular biology –  a tale of two mediators

Aviva Lev-Ari, PhD, RN

Chapter 2:

Nitric Oxide and Circulatory Diseases

 

Insert WordClouds after the Name of the Author of EACH article in all the Chapters that follows

 

2.1 Endothelial Dysruption and Denudation

2.1.1 Blood-vessels-generating Stem Cells Discovered

Ritu Saxena, PhD

2.1.2 Differential Distribution of Nitric Oxide – A 3-D Mathematical Model

Anamika Sarkar, PhD

2.1.3 Nitric Oxide Nutritional Remedies for Hypertension and Atherosclerosis. It’s 12AM: Do you know where your electrons are?

Meg Baker, PhD

2.2 Endothelin and ET Receptors

2.2.1 Statins’ Nonlipid Effects on Vascular Endothelium through eNOS Activation

Larry H Bernstein, MD, FCAP

2.2.2 Endothelial Function and Cardiovascular Disease

Larry H Bernstein, MD, FCAP

2.2.3 Endothelin Receptors in Cardiovascular Diseases: The Role of eNOS Stimulation: Observations on Intellectual Property Development for an Unrecognized Future Fast Acting Therapy for Patients at High Risk for Macrovascular Events

Aviva Lev-Ari, PhD, RN

Chapter 3:

Therapeutic Cardiovascular Targets

 

3.1 Nitric oxide and therapeutic Targets

3.1.1 Cardiovascular Disease (CVD) and the Role of Agent Alternatives in Endothelial Nitric Oxide Synthase (eNOS) Activation and Nitric Oxide Production

Aviva Lev-Ari, PhD, RN

3.1.2 Telling NO to Cardiac Risk

Stephen J Williams, PhD

3.1.3 Nitric Oxide and its Impact on Cardiothoracic Surgery

Tilda Barliya PhD

3.2 Therapeutic opportunities for Endothelial Progenitor Cells

3.2.1 Inhibition of ET-1, ETA and ETA-ETB, Induction of Nitric Oxide production, stimulation of eNOS and Treatment Regime with PPAR-gamma agonists (TZD): eEPCs Endogenous Augmentation for Cardiovascular Risk Reduction – A Bibliography

Aviva Lev-Ari, PhD, RN

3.2.2 Bystolic’s generic Nebivolol – Positive Effect on circulating Endothelial Progenitor Cells Endogenous Augmentation

Aviva Lev-Ari, PhD, RN

3.2.3 Positioning a Therapeutic Concept for Endogenous Augmentation of cEPCs — Therapeutic Indications for Macrovascular Disease: Coronary, Cerebrovascular and Peripheral

Aviva Lev-Ari, PhD, RN

3.2.4 Endothelial Dysfunction, Diminished Availability of cEPCs, Increasing CVD Risk for Macrovascular Disease – Therapeutic Potential of cEPCs

Aviva Lev-Ari, PhD, RN

3.3 Hypertension, Congestive Heart Failure and Endothelin Biomarker

3.3.1 Clinical Trials Results for Endothelin System: Pathophysiological Role in Chronic Heart Failure, Acute Coronary Syndromes and MI – Markers of Disease Severity or Genetic Determination?

Aviva Lev-Ari, PhD, RN

3.4 Hypotension and Shock: Cardiovascular Collapse

3.4.1 Nitric Oxide and Sepsis, Hemodynamic Collapse and the Search for Therapeutic Options

Larry H Bernstein, MD, FCAP

3.4.2 Sepsis, Multi-organ Dysfunction Syndrome, and Septic Shock: A Conundrum of Signaling Pathways Cascading Out of Control

Larry H Bernstein, MD, FCAP

3.5 Hemorrhagic and Thrombo-embolic Events

3.5.1 Nitric Oxide Function in Coagulation

Larry H Bernstein, MD, FCAP

 

Chapter 4:

Nitric Oxide and Neurodegenerative Diseases

 

4.1 Nitric Oxide Covalent Modifications: A Putative Therapeutic Target?

Stephen J. Williams, PhD

 

Chapter 5:

Bone Metabolism

 

5.1 Nitric Oxide in Bone Metabolism

Aviral Vatsa, PhD, MBBS

 

Chapter 6:

Nitric Oxide and Systemic Inflammatory Disease

 

6.1 Nitric Oxide and Immune Responses: Part 1

Aviral Vatsa, PhD, MBBS

6.2 Nitric Oxide and Immune Responses: Part 2

Aviral Vatsa, PhD, MBBS

6.3 Nitric Oxide Production in Systemic Sclerosis

Aviral Vatsa, PhD. MBBS

Chapter 7:

Nitric Oxide: Lung and Alveolar Gas Exchange

 

7.1 ’Lung on a Chip’

Ritu Saxena, Ph.D.

7.2 Low Bioavailability of Nitric Oxide due to Misbalance in Cell Free Hemoglobin in Sickle Cell Disease – A Computational Model

Anamika Sarkar, Ph.D.

7.3 The Rationale and Use of Inhaled Nitric Oxide in Pulmonary Artery Hypertension and Right Sided Heart Failure

Larry H Bernstein, MD, FCAP

7.4 Transposon-mediated Gene Therapy improves Pulmonary Hemodynamics and attenuates Right Ventricular Hypertrophy: eNOS gene therapy reduces Pulmonary vascular remodeling and Arterial wall hyperplasia

Aviva Lev-Ari, PhD, RN

 

 

Chapter 8:

Nitric Oxide and Kidney Dysfunction

 

8.1 Part I: The Amazing Structure and Adaptive Functioning of the Kidneys: Nitric Oxide

Larry H. Bernstein, MD, FCAP

8.2 Part II: Nitric Oxide and iNOS have Key Roles in Kidney Diseases

Larry H. Bernstein, MD, FCAP

8.3 Part III: The Molecular Biology of Renal Disorders: Nitric Oxide

Larry H. Bernstein, MD, FCAP

8.4 Part IV: New Insights on Nitric Oxide Donors

Larry H. Bernstein, MD, FCAP

8.5 The Essential Role of Nitric Oxide and Therapeutic Nitric Oxide Donor Targets in Renal Pharmacotherapy

Larry H. Bernstein, MD, FCAP

 

Chapter 9:

Nitric Oxide and Cancer

 

9.1 Crucial role of Nitric Oxide in Cancer

Ritu Saxena, Ph.D.

Glossary across all volumes in the Series A

Insert here Glossary for Volume 1

Editorials – Audio in the English language [also available as Part C in each Volume in Series A in the Spanish Edition]

Insert here Editorials for Volume 1

Selection of five WordCloud images for each Chapter in each Volume

Insert here selection of five WordClouds that are best representing the subject of  Volume 1

 

REPEAT same structure presented for Volume 1 for the following volumes in Series A:

• Volume Two: Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation