2016 BioIT World: Track 5 – April 5 – 7, 2016 Bioinformatics Computational Resources and Tools to Turn Big Data into Smart Data
Reporter: Aviva Lev-Ari, PhD, RN
Track 5 – April 5 – 7, 2016
Bioinformatics
Computational Resources and Tools to Turn Big Data into Smart Data
Track 5 assembles thought leaders who will present case studies using computational resources and tools that take data from multiple –omics sources, including microbiomics and metabolomics, and align it with clinical action. Turning big data into smart data can lead to real-time assistance in disease prevention, prognosis, diagnostics, and therapeutics. With the ever-increasing volume of information generated for curing or treating diseases and cancers, bioinformatics technologies, tools and techniques play a critical role in turning data into actionable knowledge to meet unstated and unmet medical needs.
Tuesday, April 5
7:00 am Workshop Registration and Morning Coffee
8:00 – 11:30 Recommended Morning Pre-Conference Workshops* Visualization for Biomedical Data Analysis: From the Basics to Applications
12:30 – 4:00 pm Recommended Afternoon Pre-Conference Workshops* iConquerMS™: A Patient-Centered Research Model
* Separate registration required
2:00 – 6:00 Main Conference Registration
4:00 PLENARY KEYNOTE SESSION
5:00 – 7:00 Welcome Reception in the Exhibit Hall with Poster Viewing
Wednesday, April 6
7:00 am Registration Open and Morning Coffee
8:00 PLENARY KEYNOTE SESSION
9:00 Benjamin Franklin Awards and Laureate Presentation
9:30 Best Practices Awards Program
9:45 Coffee Break in the Exhibit Hall with Poster Viewing
DATA MANAGEMENT, MODELING AND VALUE COMPARISON
10:50 Chairperson’s Opening Remarks
11:00 canvasXpress: A Highly Interactive JavaScript Library for Analytic Visualization of Genomics (and Other High Dimensional) Data
Isaac Neuhaus, Ph.D., Senior Principal Scientist, Bristol-Myers Squibb
This talk will describe how this package integrates with our R environment.
11:30 eTRIKS and tranSMART in IMI’s PreDiCT-TB: Data Management, Modeling and Comparison
Francisco Bonachela Capdevila, Ph.D., Postdoc Data Coordinator, Translational Informatics and External Innovation, Janssen Pharmaceutica
PreDiCT-TB is an IMI-funded project which takes a comprehensive model-based approach to fill the gaps in the current drug development pathway in tuberculosis. Preclinical information is propagated into the clinical stage in order to optimize drug selection at the clinical phase. In this context, we have developed a tranSMART-based solution that extracts PK-PD modeling data from studies at any in vitro, in vivo or clinical stage of the drug development chain.
12:00 pm Fusing Systems Biology & Predictive Analytics for Multi `Omic Data: Demo of the PATH Platform for Knowledge Generation
Scott Marshall, Ph.D., Managing Director, Biomarker and IVD Analytics, Precision for Medicine
The future of healthcare will be transformed by flexible frameworks designed to discover complex signals in rich datasets through the merger of predictive genomic analytics and systems biology that are designed to incorporate information about molecular and cellular systems across multi `omic data. PATH™ a secure, scalable, cloud-based solution for predictive genomic analytics serves as a knowledge generation platform for translational and clinical research.
12:30 Session Break
12:40 Luncheon Presentation I: Medical Evidence Is Becoming the Currency of Healthcare Transformation
John Piccone, Partner, Life Sciences Offering Leader, Watson Health, IBM
This session will share experiences applying IBM Watson Real World Evidence solutions to help researchers explore huge volumes of unstructured and structured content to discover insights and information and produce medical evidence. Examples include identifying unmet medical needs; demonstrating product value and differentiation for pharmaceuticals and medical devices; improving drug comparative effective studies; and competitive intelligence.
1:10 Luncheon Presentation II (Sponsorship Opportunity Available)
1:40 Session Break
NOVEL BIOINFORMATICS AND DATA ANALYSIS APPROACHES
1:50 Chairperson’s Remarks
Michael Liebman, Ph.D., Managing Director, IPQ Analytics, LLC
1:55 From Phenotype to Genotype: Using TranSMART for Managing Human Genetics Data
Andrew Hill, Science and Technology Lead, Research Business Technology, Pfizer
Genotype/phenotype analysis informs target identification, validation, mechanistic understanding, and precision medicine. Genetic variants and associated phenotype datasets are large, complex, and difficult to manage and access. The bioinformatics community needs to share information about both challenges and solutions. In this presentation we’ll describe our experience with using TranSMART as a repository for human genotype-phenotype data.
2:25 Presentation to be Announced
2:55 Increasing the Competitiveness of Pharma Companies: Real Time Search and Analytics Across Structured & Unstructured Data
Xavier Pornain, WW Vice President, Sales and Alliances, Sales, Sinequa
This presentation highlights how Sinequa’s platform helps leading pharma companies in the following areas: 1) Speed up submission of New Drug Applications to reduce costs for new drugs development; 2) Drive innovation, accelerate research and shorten Drug Time-to-Market; 3) Foster cooperation in R&D while respecting information governance and security; and 4) Optimize clinical trials and catalyze drug repositioning.
3:10 From Out that Shadow: Diagnosis, Discovery and Data Integration in Single-Cell Phenomics
Michael Stadnisky, Ph.D., CEO, FlowJo, LLC
The standardization, throughput, and content of single cell assays has brought flow cytometry and digital PCR into the mainstream. However, data analysis has remained in the shadows, relying on expert supervision and manual analysis, and rarely integrated into the life science data ecosystem. We show that an intuitive analysis platform can democratize diagnosis and discovery in single cell assays and significantly accelerate time to insight.
3:25 Refreshment Break in the Exhibit Hall with Poster Viewing
4:00 A New Rational Approach to Predict Regulatory SNPs and Therapeutic Targets in the Human Genome
Ernesto Prado Montes de Oca, Ph.D., Director & Principal Investigator, Personalized Medicine Laboratory (LAMPER), Medical and Pharmaceutical Biotechnology Unit, CIATEJ AC, CONACYT
Our algorithm performed 53% sensitivity and 84.6% specificity to detect functional rSNPs in the human genome. We demonstrate that our method is more sensitive and has better performance that is-rSNP and RegulomeDB. We also assessed the impact of homotypic redundancy using a novel approach called the homotypic redundancy weight factor (HWF). We can predict cell line-specific and ethnic-specific rSNPs in any disease and any gene(s) where enough genomic/epigenomic information is available.
4:30 From GWAS and Whole Genomes to Personalized Therapeutics: Non-Coding Variants for New Drugs
Leonard Lipovich, Ph.D., Associate Professor, Center for Molecular Medicine and Genetics, Wayne State University
Although two-thirds of human genes do not encode proteins, studies of significant human disease-associated genetic variants from exomes, Genome-Wide Association Studies, and whole-genome sequencing continue to emphasize protein-coding genes. However, coding genes are often far, and separated by recombination breakpoints from, these significant variants. Here, we identify candidate disease causative non-coding variants for wetlab validation and eventual therapeutic targeting. A list of co-authors appears on the Bio-IT Conference website alongside this abstract.
5:00 Sponsored Presentation (Opportunity Available)
5:30 – 6:30 Best of Show Awards Reception in the Exhibit Hall with Poster Viewing
Thursday, April 7
7:00 am Registration and Morning Coffee
8:00 PLENARY KEYNOTE SESSION PANEL
10:00 Coffee Break in the Exhibit Hall and Poster Competition Winners Announced
PATENT LAW AND MODELING RISKS/OPPORTUNITIES
10:30 Chairperson’s Opening Remarks
10:40 Dramatic Changes in US Patent Law: The Implications for Bioinformatics
John Conley, J.D., Ph.D., Professor, Law, University of North Carolina
Not too long ago, patents on software and software-based analytical methods–in medicine, finance, and business generally–were commonplace and concern about their effects was profound. Now, after a series of Supreme Court cases, those patents are facing legal extinction. This presentation will explain the recent developments in patent law and their legal, practical, and economic implications for the bioinformatics industry.
11:10 Building a Platform for Modeling Risk and Opportunities in Drug Development
Michael Liebman, Ph.D., Managing Director, IPQ Analytics, LLC
Sabrina Molinaro, Ph.D., Institute for Clinical Physiology, National Research Council, Italy
11:40 Sponsored Presentation (Opportunity Available)
12:10 pm Session Break
12:20 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own
1:20 Dessert Refreshment Break in the Exhibit Hall with Poster Viewing
MOLECULAR BIOTECHNOLOGY AND BIOINFORMATICS: INFORMATICS TOOL AND THERAPEUTIC APPLICATIONS
1:55 Chairperson’s Remarks
William Loging, Ph.D., Associate Professor of Genomics & Head, Production Bioinformatics, Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
2:00 A Discussion of the Three Types of Cancer Informatics Tools: Statistical, Dimensional, and Semantic, and a Commentary on Cancer Viewed as a Complex System
William Rice, M.D., Senior Vice President, Clinical Innovation, Central and West Texas Division, Hospital Corporation of America
For non-specialists, this talk will present three types of informatics tools that are used in cancer research. Statistical tools use correlative mathematics to infer relationships, dimensional tools use structural models of shapes and interactions to define physiology, and semantic approaches attempt to associate word position and context to define meaning. Parsing the topic of cancer informatics into these three general categories may help non-informaticists be better collaborators with computational modeling colleagues.
2:30 Talk Title to be Announced
Prahlad T. Ram, Ph.D., Associate Professor, Department of Systems Biology; Co-Director, Biostatistics, Bioinformatics and Systems Biology Program, The University of Texas MD Anderson Cancer Center
3:00 Molecular Impacts of Immune Modulating Drugs on Cancer Patients
William Loging, Ph.D., Associate Professor of Genomics & Head, Production Bioinformatics, Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
The area of Immuno-Oncology provides a novel strategy for cancer treatment by utilizing the patient’s Immune system to combat tumor growth. We investigated the impact of specific immune modulating drugs on patients with diagnosed tumors in order to understand the molecular changes that take place at the pathway level. These data are correlated to phenotypic effect and provide insights into the mechanism of immune system directed therapies for cancer.
3:30 Biosimilar Structural Comparability Assessment by NMR: From Small Proteins to Monoclonal Antibodies
Bostjan Japelj, Ph.D., Senior Scientist, Protein Biophysics and Bioinformatics, Sandoz Biopharmaceuticals
This talk will discuss 1) the insight on how to use NMR as a method to evaluate high order similarity between biosimilar and reference product on the market; 2) methods to evaluate degree of similarity between two NMR spectra of proteins shown by examples from three case studies; and 3) an update on the current state of the art NMR spectroscopy in biosimilar drug product formulations and associated challenges.
4:00 Conference Adjourns
SOURCE
http://www.bio-itworldexpo.com/bioinformatics/
From: Bio-IT World 2016 <kc@healthtech.com>
Date: Monday, November 30, 2015 at 11:00 AM
To: Aviva Lev-Ari <AvivaLev-Ari@alum.berkeley.edu>
Subject: Bioinformatics: Computational Resources & Tools to Turn Big Data into Smart Data
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