Dementia does not cause Depression, Depression is independent of Demensia Biomarkers
Reporter: Aviva Lev-Ari, PhD, RN
If the two Mental health conditions are independent, due to distinct etiologies —
What implications these research findings could have on Treatment of each of the diseases?
Depression in Elderly Not Related to Dementia Markers
Published: Jul 30, 2014
A New Risk Factor For Dementia: Depression Symptoms Linked To More Rapid Decline In Memory
Clinical-pathologic study of depressive symptoms and cognitive decline in old age
- Robert S. Wilson, PhD,
- Ana W. Capuano, PhD,
- Patricia A. Boyle, PhD,
- George M. Hoganson, MD,
- Loren P. Hizel, BA,
- Raj C. Shah, MD,
- Sukriti Nag, MD,
- Julie A. Schneider, MD,
- Steven E. Arnold, MD and
- David A. Bennett, MD
- Correspondence to Dr. Wilson: rwilson@rush.edu
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10.1212/WNL.0000000000000715Neurology
- Abstract
- Full Text (PDF)
- Also available:
- Data Supplement
ABSTRACT
Objective: To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia.
Methods: In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations included assessment of depressive symptoms (10-item Center for Epidemiological Studies Depression Scale) and cognitive function (battery of 17 performance tests). A total of 582 individuals died during follow-up and underwent a uniform neuropathologic examination to quantify β-amyloid plaques and tau tangle density in multiple brain regions and identify neocortical Lewy bodies, hippocampal sclerosis, and gross and microscopic cerebral infarcts.
Results: Level of depressive symptoms slightly increased during follow-up. Incident mild cognitive impairment (52.2%) was associated with higher level of depressive symptoms before the diagnosis but not with change in symptoms after the diagnosis; incident dementia (17.9%) was associated with higher symptom level before dementia onset and with more rapid decline in symptoms after dementia onset. None of the neuropathologic markers was related to level of depressive symptoms or change in symptoms over time. In a mixed-effects model adjusted for the neuropathologic markers, higher level of depressive symptoms averaged over evaluations was associated with more rapid global cognitive decline, accounting for 4.4% of the variability in decline not attributable to the neuropathologic markers. Depressive symptoms did not modify the association of the neuropathologic markers with cognitive decline.
Conclusion: In old age, depressive symptoms have an association with cognitive decline that is independent of the neuropathologic hallmarks of dementia.
- Received February 6, 2014.
- Accepted in final form May 17, 2014.
- © 2014 American Academy of Neurology
SOURCE
http://www.neurology.org/content/early/2014/07/30/WNL.0000000000000715.short
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