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Technion students have developed a smart tool for predicting the risk of atrial fibrillation – a heart disorder that can lead to critical situations

Reporter: Aviva Lev-Ari, PhD, RN

Atrial fibrillation risk prediction from the 12-lead electrocardiogram using digital biomarkers and deep representation learning 

Shany BitonSheina GendelmanAntônio H RibeiroGabriela MianaCarla MoreiraAntonio Luiz P RibeiroJoachim A Behar European Heart Journal – Digital Health, ztab071, https://doi.org/10.1093/ehjdh/ztab071 Published: 05 August 2021 Article history

Abstract

Aims

This study aims to assess whether information derived from the raw 12-lead electrocardiogram (ECG) combined with clinical information is predictive of atrial fibrillation (AF) development.Methods and results

We use a subset of the Telehealth Network of Minas Gerais (TNMG) database consisting of patients that had repeated 12-lead ECG measurements between 2010 and 2017 that is 1 130 404 recordings from 415 389 unique patients. Median and interquartile of age for the recordings were 58 (46–69) and 38% of the patients were males. Recordings were assigned to train-validation and test sets in an 80:20% split which was stratified by class, age and gender. A random forest classifier was trained to predict, for a given recording, the risk of AF development within 5 years. We use features obtained from different modalities, namely demographics, clinical information, engineered features, and features from deep representation learning. The best model performance on the test set was obtained for the model combining features from all modalities with an area under the receiver operating characteristic curve (AUROC) = 0.909 against the best single modality model which had an AUROC = 0.839.Conclusion

Our study has important clinical implications for AF management. It is the first study integrating feature engineering, deep learning, and Electronic medical record system (EMR) metadata to create a risk prediction tool for the management of patients at risk of AF. The best model that includes features from all modalities demonstrates that human knowledge in electrophysiology combined with deep learning outperforms any single modality approach. The high performance obtained suggest that structural changes in the 12-lead ECG are associated with existing or impending AF.

Graphical AbstractGraphical Abstract

A look at the experimental environment: digital markers (HRV and MOR), deep learning features (DNN), and clinical data (EMR) are combined in a model training to predict atrial fibrillation

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Keywords

Atrial fibrillationDeep learningRisk prediction Issue Section: Original Article

SOURCES

https://academic.oup.com/ehjdh/advance-article/doi/10.1093/ehjdh/ztab071/6342413?


The students trained a deep learning system (layered neural network) using more than a million ECG records of more than 400,000 patients, thus creating a mechanism to predict human chances of developing atrial fibrillation over a five-year period. They then combined the deep neural network with information. Clinical on the patient.This model was able to correctly predict the risk of developing atrial fibrillation in 60% of cases, while maintaining a high specificity rate of 95% (i.e. only 5% of the people identified as people at risk did not develop the disease

technion.ac.il/2021/10/תחזית-לב/?fbclid=IwAR3RO_5DFnctI9whAffvznEd3hrchfauy6LXZnglVd12cv1z4cfxkwn98Xk

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