Posts Tagged ‘Pain Therapy’

Outstanding Achievement in Anesthesiology

Curator: Larry H Bernstein, MD, FCAP


Thomas J. Rick, MD, for Outstanding Achievements in Anesthesiology and Pain Management

The International Association of HealthCare Professionals has carefully selected Thomas J. Rick, MD, to represent anesthesiology in their publication, The Leading Physicians of the World.  Dr. Rick’s selection is a significant representation of his enduring passion and complete dedication for the field of anesthesiology and pain management. He is considered to be among the best throughout his 19 years in practice.

A well versed and respected anesthesiologist and pain management physician practicing in Phoenix, Arizona, Dr. Rick features a track record of achievements that have marked his 19-year professional journey in his challenging specialty. In a relaxed and friendly setting with accommodating support staff, Dr. Rick receives his at Thomas J. Rick, MD PC, his well equipped private office where he deals with anesthetic and pain management services for patients undergoing surgeries. While he primarily devotes his time to his office in Phoenix, he additionally provides anesthesiology-related services to patients of the St. Joseph’s Hospital and Medical Center and Banner Good Samaritan Medical Center, also in Phoenix, Arizona.

Dr. Rick embraced a career in medicine upon completing his medical degree in 1994 at Hahnemann University Hospital. His postgraduate training led him to the University of Arizona and his continuing learning enhanced his certification in anesthesiology by the American Board of Anesthesiology. As an affirmation of his commitment to education and his desire to advance by adapting his practice to the latest discoveries and technologies in his field, Dr. Rick joined the American Society of Anesthesiology and the Arizona Society of Anesthesiology. An active man in his free time, passionate by tennis, fitness, and drums, he attributes his exceptional success to his availability, as well affordability and accessibility of service.

Stanford Medical School

Myer “Mike” Rosenthal

  • Ellis N. Cohen Award for Outstanding Achievement in Anesthesiology, Stanford University Department of Anesthesia (1980)
  • Jack R. Collins Memorial Award for Outstanding Leadership in Anesthesia Education, Dannemiller Society (1990)
  • Kaiser Award for Clinical Teaching, Stanford University School of Medicine (1991, 2004)
  • Board of Directors (President and Chairman of Board – 2001-2004), Foundation for Anesthesia Education and Research (2000 – 2009)
  • Director (President – 1997-1998), American Board of Anesthesiology (1986 – 1998)
  • Medical Director of Intensive and Intermediate Intensive Care Units, Stanford University Hospital (1975 – 1997)

Arthur Bert, MD

Senior staff anesthesiologist, Rhode Island Hospital

Arthur Bert, MD, has served as director of cardiac anesthesia (1986-2002) at Rhode Island Hospital and as director of pediatric cardiac anesthesia (1996-2005) at Hasbro Children’s Hospital. Bert continues to pursue his interests in adult and pediatric cardiovascular and thoracic anesthesia as a senior staff anesthesiologist. He is a clinical professor of surgery (anesthesiology) at the the Warren Alpert Medical School at Brown University. He also holds the position of director of experimental cardiac surgery, anesthesiology and cardiac imaging at the cardiac surgery research laboratories of Children’s Mercy Hospital, in Kansas City, MO, where he is part of a funded research team that is growing tissue-engineered heart valves. He is a consultant anesthesiologist at Women & Infants Hospital for neonatal anesthesia.


Bert graduated as president of Alpha Omega Alpha Medical Honor Society from Mount Sinai School of Medicine in New York City. He served as a resident in internal medicine at Beth Israel Deaconess Medical Center in Boston and was awarded the Dr. Nathan Sidel Prize for outstanding achievement. He completed his anesthesia residency and an adult cardiac anesthesia fellowship at Beth Israel Hospital in Boston, followed by a pediatric anesthesia fellowship at Children’s Hospital Boston.

Board Certification

Diplomate of the American Board of Anesthesiology (1985) and re-certified in 2008

Testamur of the National Board of Echocardiography in Perioperative Transesophageal Echocardiography (1998)

Diplomate (2006) and re-certified in 2007


Top Physicians, Rhode Island Monthly magazine (2000, 2002, 2004, 2006 and 2008)

Guide to America’s Top Physicians, Consumers’ Research Council of America, Washington, DC (2005, 2006)

Teaching Recognition Award, Brown Medical School (2005)

Dr. Charles A. Hill Award from the RI Medical Society (2006)


Applications of transesophageal echocardiography to intraoperative patient management

Techniques of reducing blood product transfusions during surgery

Cerebral function monitoring during general anesthesia

Research: Echocardiographic evaluation of tissue-engineered valve function

ASA Award for Excellence in Research

Henrik Kehlet, M.D., Ph.D.

The annual ASA Award for Excellence in Research recognizes an individual for outstanding achievement in research that has or is likely to have an important impact on the practice of anesthesiology.

The individual’s work must represent a body of original, mature and sustained contribution to the advancement of the science of anesthesiology. The nominee need not be a physician, an anesthesiologist or a member of ASA, but must be presently engaged in research related to anesthesiology, academically accomplished with peer-reviewed publications and funded research, and nominated in response to a call for nominations. The completed application must include the nominee’s current curriculum vitae, a letter of nomination and a seconding letter from two individuals with an understanding of the research contributions of the individual.

The 2014 Award for Excellence in Research was presented to Henrik Kehlet, M.D., Ph.D., at the ANESTHESIOLOGY™ 2014 annual meeting in New Orleans on Monday, October 13, 2014. Dr. Kehlet is a Professor at Rigshospitalet, Copenhagen University, Denmark.

Dr. Kehlet is known for his research and writing in surgical pathophysiology, surgical stress response and the transition from acute to chronic pain, among other topics.

Henrik Kehlet, M.D., Ph.D. is perhaps the most well-known surgeon among physician anesthesiologists around the world due to his substantial contributions toward the understanding of surgical pathophysiology. After Dr. Kehlet completed his medical studies and surgical residency at the University of Copenhagen, Denmark, he enrolled in a Ph.D. program within the same institution, authoring a thesis pertaining to the study of the hypothalamic-pituitary-adrenocortical function in glucocorticoid-treated surgical patients. Dr. Kehlet served as the Chief of Surgery and Professor of Surgery, Copenhagen University at Hvidovre University Hospital from 1989 to 2004. He was subsequently appointed as a Professor of Perioperative Therapy and Head of the Section for Surgical Pathophysiology at the Rigshospitalet in Copenhagen. Dr. Kehlet continues to be an extremely prolific writer, having authored more than 950 scientific articles covering topics of surgical pathophysiology, acute pain physiology and pharmacotherapy, surgical stress response, regional anesthesia and analgesia, perioperative immune function, fast-track surgery and the transition from acute to chronic pain.

Dr. Kehlet’s research led to the creation of the concept of fast-track surgery, or enhanced recovery after surgery (ERAS), with the aim of painless and safe surgeries. His work related to pain relief and surgical outcomes led to the multimodal analgesia approach of combining different analgesics for better pain control and fewer side effects that is widely used today. Dr. Kehlet also is credited with the concept of pre-emptive analgesia, or administering an analgesic prior to surgical injury in order to decrease the intensity and duration of postoperative pain. In addition to his many contributions to perioperative pain management, Dr. Kehlet is responsible for establishing the first nationwide hernia database in Denmark, with the purpose of optimizing outcomes and documenting different approaches to improve care.

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Reporter: Aviva Lev-Ari, PhD, RN




7:45 Registration and Continental Breakfast

8:30 Chairperson’s Opening Remarks

William K. Schmidt, Ph.D. (biography), President, NorthStar Consulting, LLC, VP Clinical & Regulatory, Arcion Therapeutics, VP Clinical Development, CrystalGenomics (CG Pharmaceuticals)

8:45 Pain, Addiction, Abuse and Psychiatric Co-morbidities
Dr. Medve will discuss managing critical interplays and putting the patient at the center of the treatment team.
The session will cover:

  • Addiction – what is it?
  • Animal models – can they predict human addiction?
  • Psychiatric illness vs pain vs addiction – how do these interplays work?
  • Opioids and the future of pain care
  • How best to manage patients in a complicated care system

Dr. Medve will also discuss Nektar’s recently Fast Tracked NCE opioid NKTR-181, which is designed to have a slow rate of entry into the brain to reduce the attractiveness of the molecule as a target of abuse and to reduce its CNS-mediated side effects.

Robert Medve, MD (biography), Vice President & Chief Medical Officer, Nektar Therapeutics

9:15 Allosteric Inhibitors of the NGF/TrkA Pathway: a Novel, Small Molecule Approach to Inhibiting Peripherally Mediated Pain
Nerve Growth Factor (NGF) plays a significant role in the generation and maintenance of the nociceptive pain associated with a variety of human diseases. Array Biopharma has used a structural biology driven approach to develop potent, highly selective small molecules that inhibit TrkA kinase activity through allosteric modulation. The efficacy of TrkA inhibitors in rodent models of peripheral pain will be detailed. Additionally, potential mechanistic differentiation from the anti-NGF strategy will be discussed as will in vivo efficacy and long term safety associated with their small molecule inhibitors.

Steven Andrews, Ph.D., Associate Director, Drug Discovery, Array BioPharma

9:45 New Models of Pain in Freely Moving Rodents
The pain field has been frustrated by the limitations of the current evoked nociception models that are used for screening or target discovery. Regeneron has been working on several non-evoked models of visceral pain and deep tissue pain that are providing some interesting mechanistic insights. Dr. LaCroix-Fralish’s in vivo pharmacology team is seeking to develop therapeutics for the treatment of pain and neurological disability. In this presentation, he will discuss his team’s efforts to develop new models for visceral and deep tissue pain.

Michael LaCroix-Fralish, Ph.D.,(biography) Staff Scientist, Pain Therapeutics Group, Regeneron Pharmaceuticals

10:15 Poster Viewing & Refreshment Break

10:45 TRPA1 as a Pain Target: Progress and Challenge
A gain of function mutation of TRPA1 has been linked to familial episodic pain syndrome in humans. This result, coupled with a growing preclinical literature, has made TRPA1 an attractive pain target. Dr. Chen will address several key biology and drug discovery issues, including physiological/pathological function of TRPA1, species difference, therapeutic profile and drug discovery strategies.

Jun X. Chen, Ph.D. (biography), Principal Research Scientist GPRD, Neuroscience, Abbott Laboratories

11:15 Gene Therapy to Control Intractable Pain in Cancer Patients: A New Paradigm?
A very high proportion (up to 85%) of terminal cancer patients suffer from severe pain; current therapies, principally opioids, are of limited use. Benitec Biopharma Ltd. is developing a gene therapy strategy to control pain in such patients using intrathecal delivery of lentiviral particles expressing shRNA constructs designed to inactivate the Protein Kinase C gamma gene (PKCg) in neurones of the spinal cord. Others have demonstrated the strategy works in neuropathic pain models in rats. Benitec has developed constructs that strongly inactivate PKCg in vitro; these particular shRNAs target sequences within PKCg that are absolutely conserved between rat and humans as well as pre-clinical test species (dogs and macaques), simplifying pre-clinical testing. These new constructs are being validated in rat pain models and protocols for pre-clinical testing are being developed. Benitec believes a gene therapy  approach for pain control in terminal cancer patients is warranted, the approach is relatively low risk and offers the prospect of a single treatment providing long term pain relief.

Peter French, Ph.D. (biography), Chief Executive Officer, Benitec Biopharma

11:45 Pain in Children: Challenges in Conducting Pediatric and Neonatal Pain Studies and Treating Pain in Children
This presentation will cover the following:

  • Developmental physiology and pharmacology, including enzyme maturation and drug metabolism
  • Pain measures: assessments from neonates through adolescents
  • Challenges in clinical study design, including: recruitment, use of placebo, blood volume restrictions and formulations
  • Current concepts in the treatment of pain in children

Ernest A. Kopecky Ph.D, MBA, VP Clinical Development, Head, Neuroscience TA, COLLEGIUM Pharmaceutical

12:15 Luncheon

1:30 Transition from Acute to Chronic Pain States

Tony L. Yaksh, Ph.D. (biography), Professor & Vice Chair for Research, Department of Anesthesiology and Professor of Pharmacology, University of California, San Diego

2:00 Minimizing Experimental Error in Analgesic Research by Reducing Placebo Response and Variability
The properly educated patient can be your greatest ally in producing a positive analgesic clinical trial. A significant portion of an analgesic investigation’s variability is produced secondary to cognitive gaps that the patient may have when interpreting the various protocol mandated scales and questions. All pharmaceutical companies spend a large amount of time perfecting their protocol and selecting/educating quality sites so that the efficacy of their drug can be statistically demonstrated. However, an equal amount of effort is rarely placed on patient education. This piece of the puzzle is the responsibility of the site and as such, we have developed educational materials to reduce placebo response and garner data that is as “true” as possible. This talk will discuss placebo response training and other ways to mitigate variability in analgesic clinical trials.

Neil Singla, MD (biography), Founder & Chief Scientific Officer, Lotus Clinical Research, LLC

2:30 Analgesic Potential of TRPA1 Antagonists
TRPA1 serves as a broad sensor for the detection of both endogenous and exogenous reactive chemicals. This presentation will review the rationale for targeting TRPA1 for the treatment of pain, including peri-operative, inflammatory, visceral and neuropathic conditions. In addition, recent progress on the clinical development of TRPA1 antagonists will be summarized, including data from Cubist and Hydra Bioscience’s clinical development programs.

Magdalene Moran, Ph.D. (biography), Vice President, Biology, Hydra Biosciences

3:00 Poster Viewing & Refreshment Break

3:30 Overview of Analgesic Efficacy and Safety of Tanezumab, a Monoclonal Antibody Targeting Nerve Growth Factor for Treatment of Chronic Pain
Nerve growth factor (NGF) has been increasingly implicated as a facilitator of pain in human diseases and related animal disease models. Monoclonal antibodies targeting NGF have shown compelling efficacy in relieving pain in a number of painful conditions. This presentation will review the current analgesic efficacy and safety profile of tanezumab, a monoclonal antibody in late-stage development for chronic pain.

Mark T. Brown, MD (biography), Executive Director, Clinical Program Leader for Osteoarthritis and Cancer Pain Studies, Pfizer Inc.

4:00 Conotoxins: Molecular Tools to Dissect Pain Pathways
Conotoxins are disulfide-rich peptides isolated from the venom of the predatory cone snail. Millions of years of natural selection fine-tuned this complex mixture of venom peptides to be highly potent and selective to various ion channels, transporters and GPCRs. In particular their subtype selectivity make them preferred tools for the study of receptors (e.g. ionchannels) involved in neuropathic pain. With ready access to sequencers we are now able to mine the transcriptome of the venom ducts, providing us with more sequence information than we can produce, certainly putting the pressure back on developing better synthetic methodologies. In this presentation, Dr. Muttenthaler will describe the discovery, synthesis and application of this class of compounds with a focus on the latest advancement in creating a diverse toolbox for neuroscientists.

Markus Muttenthaler, Ph.D. (biography), Departments of Chemistry and Cell Biology, The Scripps Research Institute

4:30 Making Investment Choices in Pain Management
In this presentation, Dr. Meltzer will walk the audience through some top line discussions of how Purdue Pharma is looking at the current and future marketplace of pain management and how that influences investment choices.

Brian Meltzer, MD(biography) Executive Director, R&D Innovation, Purdue Pharma

5:00 Cocktail Reception


8:15 Chairperson’s Opening Remarks

William K. Schmidt, Ph.D. (biography), President, NorthStar Consulting, LLC, VP Clinical & Regulatory, Arcion Therapeutics, VP Clinical Development, CrystalGenomics (CG Pharmaceuticals)

8:20 Addressing Acute and Persistent Pain at its Origins: Transcription Factor Decoys For Pain Prevention and Treatment
Adynxx Inc. is developing a transformative technology platform addressing pain at its molecular roots – preventing the development of pain following surgery or trauma and resolving established chronic pain syndromes. The Adynxx platform utilizes a proprietary form of oligonucleotide technology – small pieces of DNA that bind to transcription factors and inhibit their activity. Adynxx’s lead compound, AYX1, is designed to prevent acute post-surgical pain and the transition to persistent or chronic pain with a single intrathecal administration at the time of surgery. AYX1 acts by inhibiting the spinal cord activity of transcription factor EGR1, a powerful molecular switch whose function is critical in the establishment and maintenance of post-surgical or trauma-related pain. In this presentation, Dr. Manning will discuss the concept of transcription factor decoys, the preclinical data from several rodent models of post-surgical pain, mechanical hyperalgesia and functional recovery.  AYX1 entered clinical trials in Q2 2012 and data from Phase 1 safety and general development plans will be discussed.

Donald C. Manning, MD, Ph.D. (biography), Chief Medical Officer, Adynxx Inc.

8:50 Overview of Fulranumab, an Anti-NGF Antibody for Treatment of Chronic Pain
A variety of anti-NGF compounds are currently in development.  Fulranumab is a fully human anti-NGF antibody that shows promise in relief of a variety of pain models.  This presentation will review the clinical efficacy and safety profile that has been developed to date.

David Upmalis, MD, Senior Director and Compound Development Team Leader, fulranumab, Janssen Research Foundation

9:20 Selective A3 Adenosine Receptor Agonists for Chronic Neuropathic Pain
The clinical management of chronic neuropathic pain is limited by marginal effectiveness and unacceptable side effects of current analgesics such as opiates, gabapentanoid or drugs that modulate the noradrenergic/serotonergic pathway: novel analgesics are therefore needed. Dr. Salvemini’s findings identify therapeutic use of selective A3 adenosine receptor (A3AR) agonists in chronic neuropathic pain of distinct etiologies including chemotherapy-induced neuropathic pain caused by paclitaxel, oxaliplatin and bortezomib. In addition, A3AR agonists increase the potency and efficacy of morphine, gabapentin and amitriptyline. Her team’s findings provide the pharmacological rationale for therapeutic development of A3AR agonists, as novel analgesics for the management of chronic neuropathic pain.

Daniela Salvemini, Ph.D., Professor, Saint Louis University School of Medicine

9:50 Poster Viewing & Refreshment Break

10:15 Mechanisms and Novel Treatment of Neuropathic Pain

Allan Basbaum, Ph.D. (biography), Professor and Chair, Department of Anatomy, University of California, San Francisco

10:45 Panel Session: Treating Pain in the Clinic – the Physician’s Perspective on Unmet Need and the Challenges Facing Pain Drug Developers

Chair: William K. Schmidt, Ph.D. (biography), President, NorthStar Consulting, LLC, VP Clinical & Regulatory, Arcion Therapeutics, VP Clinical Development, CrystalGenomics (CG Pharmaceuticals)

Sean Mackey, MD, Ph.D. (biography), Chief, Division of Pain Management, Stanford University School of Medicine, Associate Professor of Anesthesiology, Director, Stanford Systems Neuroscience & Pain Lab

Lynn Webster, MD, (biographyMedical Director, CRI Lifetree, President-Elect, The American Academy of Pain Medicine

Michael S. Leong, MD, Clinic Chief, Stanford Pain Medicine Center, Clinical Associate Professor, Anesthesia, Stanford University

11:45 Neuroimaging Based Pain Detection: Findings and Applications
Dr. Mackey will cover recent advances in neuroimaging as an objective tool for the detection of pain. He will discuss recent data for both detection of acute and chronic pain, and potential applications.

Sean Mackey, MD, Ph.D. (biography), Chief, Division of Pain Management, Stanford University School of Medicine, Associate Professor of Anesthesiology, Director, Stanford Systems Neuroscience & Pain Lab

12:15 Luncheon

1:15 An NGF Inhibitor Update: Thoughts and Observations Regarding the Future of this Class of Pain Therapeutics
Dr. Lane will discuss results from Phase 2 and 3 studies that have come out in past months. She will also cover status of their development and what the FDA Arthritis Advisory Committee’s recent recommendation to lift the hold on NGF inhibitors in clinical development means for the future of this class of pain therapeutics.

Nancy E. Lane, MD (biography), Endowed Professor of Medicine and Rheumatology, Director, Musculoskeletal Diseases of Aging Research Group Director, Academic Geriatric Resource Program, Co-Director, Building Interdisciplinary Research Careers in Women’s Health (BIRCWH), Co-Director, Center for Translational Research in Osteoarthritis, UC Davis Health System

1:45 Panel Session: NGF Antagonists Back on Track: Clinical Development Challenges and Opportunities Moving Forward

Chair: William K. Schmidt, Ph.D. (biography), President, NorthStar Consulting, LLC, VP Clinical & Regulatory, Arcion Therapeutics, VP Clinical Development, CrystalGenomics (CG Pharmaceuticals)

Mark T. Brown, MD (biography), Executive Director, Clinical Program Leader for Osteoarthritis and Cancer Pain Studies, Pfizer Inc.

Nancy E. Lane, MD (biography), Endowed Professor of Medicine and Rheumatology, Director, Musculoskeletal Diseases of Aging Research Group Director, Academic Geriatric Resource Program, Co-Director, Building Interdisciplinary Research Careers in Women’s Health (BIRCWH), Co-Director, Center for Translational Research in Osteoarthritis, UC Davis Health System

David Upmalis, MD, Senior Director and Compound Development Team Leader, fulranumab, Janssen Research Foundation

Steven Andrews, Ph.D., Associate Director, Drug Discovery, Array Biopharma

2:45 End of Conference

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