Justin D. Pearlman, AB, MD, ME, PhD, MA, FACC
Justin D. Pearlman, MD, PhD, FACC – Scientific Expert & Key Opinion Leader on Cardiovascular Diseases, Cardiac Imaging & Complex Diagnosis in Cardiology: Senior Editor & Author
Research Gate list
- 4,225 citations
- 2,131 Total Research interest
- 5,054 reads of my work
Roles at Leaders in Pharmaceutical Business Intelligence (LPBI)
Medical 3D Printing LPBI’s M3DP Initiative:
- Product Concepts and Product Design, Cardiovascular and Vascular Applications
Cardiovascular Medical Devices Inventor
- Inventor Pages are Password Protected
Roles at LBPI’s BioMed e-Series
- e-SERIES A: Cardiovascular Diseases — Content Consultant
EDITORIAL
- Co-Curator, Volume Two with Larry H Bernstein and Aviva
- Co-Curator, Volume Five with Aviva
- Co-Curator, Volume Six with Aviva
- Editor, Hard Cover, CVD 1,2,3,4
Dr. Pearlman’s ResearchGate Milestone
>4,000 citations
RG Score of research quality > 95% of all researchers in ResearchGate
Prior Patents to joining LPBI:
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Method of and system for signa |
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Imaging apparatus and method with compensation for object motion |
Roles at our Open Access Scientific Online Journal http://pharmaceuticalintelligence.com
Research Categories OWNER
- Cardiovascular Pharmaceutical Genomics
[Ran core labs for international trials]
- Medical Imaging Technology, Image Processing/Computing, MRI – Investigator Initiated Research Category
[Taught at MIT Graduate level Applied Physics and EE]
[MRI – Designed, launched and operated Advanced Imaging Centers]
Expert, Author, Writer for the following Research Categories:
- Frontiers in Cardiology
- Medical Devices
- Statistical Methods for Research Evaluation (MLE, Akaike Info Crit, genomics)
- Computational Biology/Systems and Bioinformatics (ran supercomputer facility)
- Nitric Oxide in Health and Disease (case series of novel application testing)
- Clinical Trials (Core lab director, analysis center director, design&implement)
Additional Declared Strong Expertise:
- Bio Instrumentation in Experimental Life Sciences Research
- Biomarkers & Medical Diagnostics
- Genomic Testing: Methodology for Diagnosis
- Health Economics and Outcomes Research
- HealthCare IT
- Imaging-based Cancer Patient Management
- Nanotechnology for Drug Delivery
- Origins of Cardiovascular Disease
- Patient Experience: Personal Memories of Invasive Medical Intervention
Additional Declared Expertise:
- Alzheimer’s Disease: Etiology & Pharmacotherapy
- Cardiac & Vascular Repair Tools Subsegment: Medical Devices
- Stents & Tools
- Valves & Tools
- Pharmacotherapy of Cardiovascular Disease
- HTN
- Procedures
- Aortic Valve: TAVI, TAVI vs Open Heart Surgery
- Mitral Valve: Repair and Replacement
- Personalized Medicine & Genomic Research
- Stem Cells for Regenerative Medicine
- Technology Transfer: Biotech and Pharmaceutical
Justin D. Pearlman, MD, PhD, FACC
Personal Bio
jdpmdphd@gmail.com
C 617-894-6888
In 1985 I earned my ME at University of Virginia (Biomedical Engineering), and in 1986 the PhD, University of Virginia (Engineering, Applied Sciences). During 1983-1986, I was a Cardiology Fellow at University of Virginia. My Research Fellowships in 1985-1986 as NIH Senior Research Fellow was while at the Dept. of Medicine, Cardiology Division, University of Virginia. From VA I have continued for 1986-1988 as a Fellow in Noninvasive Imaging: Department of Medicine, Cardiac Unit at Massachusetts General Hospital in Boston, MA.
In the pursuit of my 2 degrees in biomedical engineering and applied sciences, I developed connections, facility, transferable skills and experience designing projects, garnering enthusiasm and team building that generated highly productive multidisciplinary collaborations. Specifically, I have worked productively with Anesthesiology, Emergency Medicine, Internal Medicine, Radiology, and Surgery, plus basic science departments including Biochemistry and Molecular Biology, Pharmacology and Toxicology, Mathematics, Statistics, Physiology and Biophysics, and Business as well as other Schools.
I recently made efforts to get approval for
o 23 patent claims, and now
o construction of my ClearECG(c) MRI invention is underway
o I am nearing completion of an Editorial Commission for a three volume theme of e-Books on Cardiovascular Causes, Diagnosis, and Management.
I have enjoyed a very rich experience sponsoring numerous PhD’s and MD’s in cardiovascular clinical excellence and efficiency, generating and fostering basic research and bench-to-bedside translational research. My breadth of experiences includes funding and directing a supercomputer facility, funding, designing and building advanced cardiovascular imaging centers, acting as chief of cardiology, vice-chair and chair, hiring, downsizing and remediating, program, team building, designing and providing training at advanced levels (including founding and teaching advanced coursework at MIT and Harvard).
I hold Leadership roles in Cardiology. All along, the career involved mentorship, Clinical, Faculty, Research, Clinical Research, Grant writing, and Administration in the capacities of Chief of Cardiology, Vice-Chair and Chair.
Justin D. Pearlman, MD ME PhD, FACC
Chief of Cardiology KMC
KMC is UCLA affiliate
Vice Chair of Medicine UCLA
Specialties:
- Internal Medicine,
- Cardiology,
- Cardiovascular Radiology,
- Image Processing,
- Computer Science,
- Electronic Records
Patents
1. JDPearlman “Imaging Apparatus and Method with Compensation for Object Motion”
U.S. Patent #5602891 – Awarded 2/11/97
2. JDPearlman “Multivariate Cardiac Monitor”
U.S. Patent #0025139 – Awarded 9//01
3. JDPearlman “Spatio-Temporal Reordered MRI” (pending)
4. JDPearlman “Real-Time Telepresence” (pending)
5. JDPearlman “Cardiovascular CT” (pending)
6. JDPearlman “12 Lead EKG during MRI or CT” (pending)
7. JDPearlman “Negative Contrast for CT” (pending)
8. JD Pearlman “MRI Imaging Method and Apparatus”
U.S. Patent #6121775 – Awarded 9/19/00
DEMOGRAPHIC INFORMATION
Name: Justin D. Pearlman, AB, MD, ME, PhD, MA, FACC
Address: 10505 Finchley Drive, Bakersfield CA 93311-3502
Cell 617-894-6888
e-mail: jdpmdphd@gmail.com
Place of Birth: Danbury, CT
EDUCATION AND TRAINING
Education:
1975 AB Harvard University (Mathematics) magna cum laude
1980 MD University of Connecticut
1985 ME University of Virginia (Biomedical Engineering)
1986 PhD University of Virginia (Engineering, Applied Sciences)
2003 MA Dartmouth College (honorary Master of the Arts)
Postdoctoral Training:
Internships and Residencies:
1980-1981 Intern in Medicine: University of California, Davis (Sacramento)
1981-1983 Resident in Medicine: University of California, Davis (Sacramento)
Clinical Fellowships:
1983-1986 Cardiology Fellow: University of Virginia
1986-1988 Fellow, Noninvasive Imaging: Department of Medicine, Cardiac Unit Massachusetts General Hospital
Research Fellowships:
1985-1986 NIH Senior Research Fellow: Dept. of Medicine, Cardiology Division, University of Virginia
Licensure and Certification:
1981-1983;2011 California Medical License (on voluntary hold when moved East)
1983 American Board of Internal Medicine, Board Certificate
1986 Massachusetts Medical License
11/6/91 American Board of Cardiology, Board Certificate
5/7/02 American Board of Cardiology, Board Certificate
4/17/12 American Board of Cardiology, Board Certificate
2001 New Hampshire Medical License
2010/11 Tennessee, Oklahoma, California Medical Licenses
Languages: English, Spanish, French, German, …
Part I
PROFESSIONAL APPOINTMENTS
Academic Appointments:
1988-1990 Instructor in Medicine, Harvard Medical School
1989-1990 Instructor, Health Sciences Technology, Massachusetts Institute of Technology
1990-2001 Associate Staff, Program in Health Sciences Technology, Harvard-Massachusetts Institute of Technology (Cambridge, MA)
1990-1992 Assistant Professor, Harvard Medical School (at Mass General Hospital)
1992-1993 Assistant Professor, Harvard Medical School (at Beth Israel Hospital)
1993-2001 Associate Professor, Harvard Medical School (Beth Israel Deaconess Med Ctr)
2001-2002 Visiting Professor, Dartmouth Medical School (Hanover, NH)
2002-2009 Professor of Medicine, Dartmouth Medical School (Hanover, NH)
2002-2009 Professor of Radiology, Dartmouth Medical School (Hanover, NH)
2009-2011 Comp Health/locum (Shawnee OK, Jackson TN)
2011-2013 Chief of Cardiology KMC, Visiting Professor UCLA (Bakersfield/LA CA)
2011-2012 Int. Chair of Medicine, KMC
2011-2013 Vice Chair of Medicine, UCLA (Bakersfield/LA CA)
Hospital Appointments:
1987-1992 Director, NMR Computing & Technologies: Massachusetts General Hospital (Boston, MA)
1988-1992 Clinical Assistant in Medicine: Massachusetts General Hospital (Boston, MA)
Director of Magnetic Resonance Imaging Technologies and Computing: Department of Radiology, Division of Magnetic Resonance Imaging, Beth Israel Hospital/Beth Israel Deaconess Medical Center (Boston, MA)
1992-2001 Associate Staff, Harvard-M.I.T. Health Science Technology Program (Cambridge, MA)
1992-1999 Staff Physician/Researcher: Departments of Radiology, Medicine, Beth Israel Deaconess Medical Center (Boston, MA)
2001-2009 Director of Advanced Cardiovascular Imaging, Dartmouth-Hitchcock Medical Center (Hanover/Lebanon NH); Echocardiography Attending; Nuclear Medicine Attending
Norris Cotton Cancer Center, Investigator Member, Director of Imaging Center
Director of the Dartmouth Advanced Imaging Center, Dartmouth Medical
School, Dartmouth-Hitchcock Medical Center (Hanover/Lebanon NH);
2009 Honored Member of Madison Registry of Who’s Who in the World Among Executives and Professionals.
2011 Chief Division of Cardiology KMC/UCLA Affiliate
Director of Cardiology Consultative Service,
Director of Cardiology Clinic Service,
Director of Cardiology Non-invasive Laboratory,
Director of Cardiology Quality Program
Int Chair of Medicine KMC
AWARDS AND HONORS
1971 John Harvard Scholar
1972-1975 Harvard College Scholarship for High Standing on the Dean’s List
1975 High Honors in Mathematics, Harvard University
1975 Rodgers Prize in Mathematics, Harvard University
- Invented Singularity Point Editing, basis for the solution to Fermat’s last theorem; and proved converse to Hopf Poincaré Index Theorem
1976-1980 Joseph Collins Scholarship for Marked Excellence in Scholastic and Extracurricular Activities
1986 Young Investigators Award (Finalist), American College of Cardiology
- Invented NMR method of P-31 of ischemic metabolism evaluation
1988-1993 F.I.R.S.T. Awardee, National Institutes of Health (R29 HL41287)
- Discovered liquid crystal behavior of atheroma lipid and developed methods to characterize triglyceride salting of the transition to solidification
1993- Listed in Best Physicians in America (both under Radiology and Cardiology)
- Proposed myocardial tagging, and invented statistical order imaging reconstructions including first known implementation of maximal intensity projection angiography
1996- Listed in Best Physicians in New England
1997- Listed in Best 2,000 Physicians in America (both under Radiology and Cardiology)
1997- Fellow, American College of Cardiology
1999- Listed in Best of Boston, Who’s Who in the World, Who’s Who among Professionals, Who’s Who among Administrators
2010- Marquis Who’s Who in America, Who’s Who in the World
SERVICE ASSIGNMENTS
Principal Hospital/Health Care System Clinical Service Responsibility:
1992-1999 Staff Physician, Radiology Beth Israel Deaconess Medical Center
1999-2001 Staff Physician, Cardiology Beth Israel Deaconess Medical Center
Director of Imaging, Harvard Angiogenesis Center; Director of Angiogenesis Imaging National Core Lab
2001-2009 Staff Cardiology Attending, Dartmouth Hitchcock Medical Center; Echocardiography Interpretations
2001-2009 Staff Radiology Attending, Dartmouth Hitchcock Medical Center; Nuclear Medicine and Magnetic Resonance Imaging Interpretations
2001-2009 Director of Advanced Cardiovascular Imaging, Dartmouth-Hitchcock Medical Center
2001-2009 Director of Advanced Imaging Center, Dartmouth-Hitchcock Medical Center
2011 Chief of Cardiology, Int Chair of Medicine, Kern Medical Center
2012 Vice Chair of Medicine, University California Los Angeles (UCLA)
MAJOR COMMITTEE ASSIGNMENTS
National and Regional:
1989 President, Northeast Chapter of Sigma (Computer Group)
1990 Lecturer and Editorial Assistant: Henry Goldberg Society (London, UK)
1992-1994 Member, Supervisory Board: 3rd International Conference on Visualization
1993 Member, Program Committee: Society for Magnetic Resonance
1995 Member, IEEE Symposium on Biomedical Visualization Program Committee
1996 Special Reviewer: National Institutes of Health, NHLBI
2002 Editorial Advisory Board, Bentham Science, Drug Design & Discovery
2005-2009 Grant committee reviewer: AHA, NIH, Hong Kong Council, Advanced Imaging Center Clinical Design & Development, Norris Cotton Cancer Center, Radiology Seed Project, Molecular Medicine, Masters and PhD Adviser/Supervisor, Thayer School of Engineering, Computer Science Research & Development.
2009-2011 Matryx Group, Hong Kong Council, Visual Solutions, Missive, Clear ECG.
2011-2013 CEO Council, STEMI Receiving Center Initiative.
Massachusetts General Hospital:
1990-1992 Member, Scientific Review Committee
1990-1992 Member, BRSG Grants and Interim Funding Committee
1990-1992 Member, Scientific Advisory Committee for MGH Imaging Center Director, Super Computer Procurement Committee
Beth Israel Hospital/BIDMC:
1992-1999 Member, Hospital Electronic Mail Task Force
1992-1999 Member, Hospital Electronic Data Security Task Force
1993-1999 Member, Radiologic Information System Committee
Member, Digital Radiographic Development Group
Dartmouth-Hitchcock Medical Center:
2001-2009 Director, Advanced Imaging Research Committee, Angiogenesis Research Center, Echocardiography Center, Nuclear Medicine Center
2002-2009 Norris Cotton Cancer Center Member, Advisor, Investigator
Kern Medical Center:
2011 Chief of Cardiology, Director of Clinical Services, Director of Quality Improvement,
2011 Int. Chair of Medicine,
- Chair’s Council,
- Medicine Staff,
- Rapid Medical Evaluation,
- Morbidity & Mortality Supervision,
- Oncology,
- Palliative Care,
- Pharmacology & Therapeutics.
MAJOR ADMINISTRATIVE RESPONSIBILITIES
1987-1992 Director: NMR Computing & Technologies (Mass. General Hospital)
1989-1992 Reader: Radiology/MRI (Mass. General Hospital)
1989-1992 Assistant Reader: Thallium scintigraphy and cardiac ultrasound (MGH)
1990-1992 Clinical Assistant in Medicine (Mass. General Hospital)
1990-1992 Consultant: Radiology/MRI (Mass. General Hospital)
1990-1992 Director, MRI Computing & Technologies (Mass. General Hospital)
1991-1992 Director of Cardiovascular MRI (Mass. General Hospital)
1992-1999 Director: Magnetic Resonance Imaging Technologies and Computing, Department of Radiology (Beth Israel Hospital)
1992-1999 Reader: MRI and X-Ray Angiography (Beth Israel Hospital)
1993-1997 Director, NMR Technologies and Computing (BIDMC)
Director, Visualization Laboratory (BIDMC)
Director of Core Lab, SCOR (NIH Program Project)
Director of Imaging, Harvard Angiogenesis Center
2001-2009 Director of Advanced Cardiovascular Imaging
2002-2009 Director of the Dartmouth Advanced Imaging Center
2011- Chief of Cardiology, Director QI, Int Chair of Medicine, Chair’s Counsel
2012- Vice Chair of Medicine, University California Los Angeles (UCLA)
PROFESSIONAL SOCIETY INVOLVEMENT
Memberships, Offices and Committee Assignments in Professional Societies:
1984- American College of Physicians (Member)
1984-1997 American College of Cardiology (Member)
1997- American College of Cardiology (Fellow)
1984- American Federation of Clinical Researchers (Member)
1985-1994 Society of Magnetic Resonance Imaging (Member: Member of Program Committee
1994-1996 Society for Magnetic Resonance (Member)
1996- International Society for Magnetic Resonance in Medicine (Member)
1993- North American Society for Cardiac Imaging (Member)
1993- Radiologic Society of North America (Member)
1996- The Institute of Electrical and Electronics Engineers (IEEE)–(Member)
The Society for Imaging Science and Technology (Member)
Society for Cardiovascular Magnetic Resonance
Society of Molecular Imaging
2007- American Society of Echocardiography
EDITORIAL BOARDS
1985- Reviewer, IEEE (Engineering Society)
1988- Reviewer, Circulation, Journal of the American College of Cardiology, Radiology
1997- Reviewer, Magnetic Resonance in Medicine, E-Medicine, Circulation
2011- Editor, E-Medicine, Web-MD
2012- Editor, Cardiovascular Diseases, Three Volume Series for Leaders in Pharmaceutical Business Intelligence BioMed e-Books Series
http://pharmaceuticalintelligence.com/biomed-e-books/
2012- Expert, Author, Writer http://PharmaceuticalIntelligence.com
Medical School Courses (for Medical/Dental/Graduate students)
1994-1997 Lecturer: Radiology Core Clerkship 550.1M “Real Time MRI”
Graduate Medical Courses/Seminars/Invited Teaching Presentations Lecturer:
1993 “Real-time MRI by Response-Modulated Excitation,” Montreal Heart Institute; Montreal, Quebec, June 17.
1993 “Clinical Value of Cardiovascular MRI,” Harvard University Physics Colloquium; Cambridge, MA, October 8.
1995 “Rapid System Virtual Prototyping,” Symposium, The Johns Hopkins University Applied Physics Laboratory; Laurel, MD, May 11.
1995 “3D Coronary Imaging,” Notre Dame Heart Institute, Montreal, Canada, June 21.
1995 “MRI of Cardiac Perfusion,” Notre Dame Heart Institute, Montreal, Canada, June 22.
1995 “3D Coronary Imaging,” St. Paul’s Teaching Hospital, Vancouver, B.C., August 24.
1995 “The Visualization Forum: New Technologies and Old Talents,” The Visualization Research Institute, “invitation only” workshop, Aspen, Colorado, October 12-14.
1995 “Object Oriented Visualization,“ Capstone Lecture, IEEE Symposium on Frontiers in Biomedical Visualization, BioMed Visualization ’95, Atlanta, Georgia, October 30.
1996 “Trends in Digital Image Manipulation with Special Emphasis on the Cardiovascular System,” Plenary Lecturer, 28th International Diagnostic Course – Imaging of the Heart and Chest, Davos, Switzerland, March 23-29.
1996 “Advances in Cardiac Evaluation,” Grand Rounds, Anesthesia Department, Beth Israel Hospital, Boston, MA, February 8.
1996 “Development of Techniques to Observe Collateral Blood Supply to the Heart,” Department of Computer Science, Simmons College, Boston, MA, September 25.
1997 “Collateral-specific imaging,” Grand Rounds, Cardiology Department, Beth Israel-Deaconess Medical Center, Boston, MA, February 20.
1997 “Influence of New Imaging Capabilities on Quality and Costs of Medical Care,” New England Society of College Chairmen, Boston, MA, April 26.
1997 “Advances in Virtual Colonoscopy,” GI Grand Rounds, Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, December 9.
1998 “Virtual Colonoscopy,” GI Pathophysiology Lecture Series, Beth Israel Deaconess Medical Center, Boston, MA, January 21.
1998 “MRI of Coronary Collaterals: A Guide to Predicting Infarcts?” Cardiovascular Research Seminar Series, St. Elizabeth’s Medical Center, Boston, MA, Feb 4.
1999 “MRI of Angiogenesis” Angiogenesis Meeting, MA, March 31
2000 “MRI in Clinical Trials” Chiron Meeting, San Francisco, CA, Jun 15
2001 “Gene Therapy of Angiogenesis” Society CVMR, Altanta GA, May 19.
2004 “Microvascular Assessment” Grand Rounds, DHMC, Lebanon NH, Mar 25.
2005 “Space-Time Fractals” Angiogenesis Research Center, DHMC, Lebanon NH
2005 “Microvascular Imaging” Vasculata Conference, Co-sponsored by Dartmouth Medical School, University of Washington and NAVBO, Lebanon NH July 20
2005 “4D Imaging of PFO” Cardiology Dept, DHMC, Lebanon NH
2005 “V-Mode MRI” Cardiology Dept, DHMC, Lebanon NH
2006 “Non-Invasive Assessment of Myocardial Oxygenation” Grand Rounds, DHMC, Lebanon NH
2006 Plenary Lecture “Data Path for Coronary CTA” IEEE 17th Annual Workshop 14-May-2006 Santa Fé, NM
2006-7 Advanced Image Computing – Course taught at Thayer School of Engineering
2007 Plenary Lecture, Advanced Cardiovascular Imaging. American College of Physicians, 26-Oct-07
2007 “MRI Microscopy” invited lecturer, Frontiers in Microscopy, Jackson Laboratory, Bar Harbor, ME
2010 “Computed Tomographic Angiography” DHMC, Lebanon, NH.
2011- Medical Education in Cardiovascular Consultative and Diagnostic Services, Medical Documentation, KMC, Bakersfield, CA.
2012- Biostatistics and Evidence Based Medicine, KMC, Bakersfield, CA.
2013- Research Opportunities and Methods, KMC, Bakersfield, CA.
Advisory and Supervisory Responsibilities in Clinical or Laboratory Setting
PhD Project Designer/Supervisor – Harvard, BU, MIT, HST, Dartmouth (Eight PhD Theses, two Masters Theses).
Teaching assignments:
“MRI physics” MGH/Harvard, Beth Israel/Harvard, HST, MIT, Dartmouth
“Advanced Imaging” Harvard, MIT, Dartmouth (Engineering School, Fellows, Attendings)
“Computer Science,” Beth Israel Deaconess Medical Center, Radiology Residents & Fellows (Visualization Laboratory): Fellows’ Computer Imaging Conference (weekly)
“Fast MRI,” Beth Israel Deaconess Medical Center, Radiology Residents & Fellows
“Cardiovascular MRI,” Dartmouth-Hitchcock Medical Center, Radiology Fellows and Residents, Cardiology Fellows
Leadership Roles
(organization of course, preparation of teaching materials, etc.)
1988-1991 Established and conducted course for Health Science and Technologies Program, Harvard/MIT-HST Program: HST.583 “Advanced Methos of Image Analysis for Medical Applications”
1991 Raised funds, designed, built and directed an advanced image processing facility at MGH
1992 Raised funds, designed, built and directed a supercomputer facility at MGH
1994 Raised funds, designed, built and directed an advanced imaging center at BIDMC
2002-2008 Raised funds, worked with Dean, Department Chairs, got buy in for new Advanced Imaging Center at Dartmouth, Supervised all aspects of development including designs, blueprints, successfully deployed high field MRI, micro CT, CTA, optical mammography, micro PET
Obtained support from Sun Microsystems and Hewlett-Packard and established Visualization Laboratory, which supports work by colleagues in Radiology, Anesthesiology, Cardiology, Neurology, Neurosurgery, and Pulmonary Medicine.
Director Advanced Cardiovascular Imaging Obtained equipment support, computer support, space commitments and established multi-department collaborations.
C. Regional, National, International Contributions
Invited Lecture Presentations
1992 “Visualization and Information Extraction from Multi-modality Multidimensional Medical Image Data,” Presented at the annual meeting of the IEEE Society; Boston, MA, November 23.
1993 “3D Coronary MRA,” Annual Meeting of the North American Society for Cardiac Imaging; San Antonio, TX, May 18-23.
1993 “Real-time MRI by Response-Modulated Excitation,” Montreal Heart Institute; Montreal, Quebec, June 17.
1993 “Clinical Value of Cardiovascular MRI,” Harvard University Physics Colloquium; Cambridge, MA, October 8.
1993 “The Changing Role of Visualization in Medicine,” Presented at the annual meeting of the IEEE Society, San Jose, CA, October 27.
1994 “Rapid System Virtual Prototyping (RSVP),” Presented at the Advanced Technology Conference of The Johns Hopkins University Applied Physics Laboratory; Laurel, MD,March 10
1994 “Three dimensional visualization of the coronary artery tree from standardized MRA,” XIth International Atherosclerosis Conference, Montreal, March 10 “Translucent reconstruction of 3D elastic subtraction CT angiography,”9th European Congress of Radiology – ECR‘95, Vienna, Austria, March 15.
1995 “3D Visualization of coronary arteries by MR,” presented at the CAG International Meeting, Fukuoka, Japan, April 21
1995 “3D MRA of coronary arteries,” American Roentgen Ray Society 95th Annual Scientific Meeting, Washington, D.C., May 2
1995 “Cardiology MRA and cardiac perfusion,” American Roentgen Ray Society 95th Annual Scientific Meeting, Washington, D.C., May 5
1995 “Rapid System Virtual Prototyping,” Symposium, The Johns Hopkins University Applied Physics Laboratory; Laurel, MD, May 11
1995 “3D Coronary Imaging,” Notre Dame Heart Institute, Montreal, Canada,June 21
1995 “MRI of Cardiac Perfusion,” Notre Dame Heart Institute, Montreal, Canada, June 22
1995 “3D Coronary Imaging,” St. Paul’s Teaching Hospital, Vancouver, B.C., August 24
1995 “The Visualization Forum: New Technologies and Old Talents,” The Visualization Research Institute, “invitation only” thinktank, Aspen,Colorado, October 12-14
1995 “Object Oriented Visualization,“ Capstone Lecture, IEEE Symposium on Frontiers in Biomedical Visualization, BioMed Visualization ’95, Atlanta, Georgia, October 30.
1996 “Trends in Digital Image Manipulation with Special Emphasis on the Cardiovascular System,” Plenary Lecturer, 28th International Diagnostic Course Imaging of the Heart and Chest, Davos, Switzerland, March 23-29.
1996 “Advances in Cardiac Evaluation,” Grand Rounds, Anesthesia Department, Beth Israel Hospital, Boston, MA, February 8.
1996 “Development of Techniques to Observe Collateral Blood Supply to the Heart,” Department of Computer Science, Simmons College, Boston, MA, September 25.
1997 “Collateral-specific imaging,” Grand Rounds, Cardiology Department, Beth Israel Deaconess Medical Center, Boston, MA, February 20.
1997 “Influence of New Imaging Capabilities on Quality and Costs of Medical Care,” New England Society of College Chairmen, Boston, MA, April 26.
1997 “Advances in Virtual Colonoscopy,” GI Grand Rounds, Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, December 9.
1998 “Virtual Colonoscopy,” GI Pathophysiology Lecture Series, Beth Israel Deaconess Medical Center, Boston, MA, January 21.
MRI of Coronary Collaterals: A Guide to Predicting Infarcts?” Cardiovascular Research Seminar Series, St. Elizabeth’s Medical Center, Boston, MA, Feb 4.
1999 “MRI of Angiogenesis” Angiogenesis Society Meeting, MA, March 31
2000 “MRI in Clinical Trials” Chiron Meeting, San Francisco, CA, Jun 15
2001 “Gene Therapy of Angiogenesis” Society CVMR, Altanta GA, May 19.
2002-2013 Cardiology Board Review Leader, Lectures on Valve Disease, MRI, HTN, Nitric Oxide, stress testing, angiogenesis.
2012-2013 Judge, UCLA research competition.
b. Professional Leadership Roles related to Teaching
Established and conducted course for Harvard – M.I.T. / Health Science and Technologies Program: HST.583 “Advanced Methods of Image Analysis for Medical Applications”
2001- Training Program for Advanced Imaging MRI, CT, Nuclear, Dartmouth
D. Clinical Activities:
1. Staff physician/researcher–Cardiovascular Imaging; Cardiology and Radiology
Areas of major focus: Cardiovascular imaging, image computing, low-invasive
imaging modalities (Echocardiography, Nuclear Medicine Imaging, Angiography, EBT); angiogenesis studies.
Sites: UCDMC, UVa, MassGen, BIDMC, DHMC, KMC/UCLA
Citations: Best Physicians in America, Best 2000 Physicians, Best of New England, Best of Boston
2. Clinical Program Development (e.g. new methods of clinical care, treatment, care delivery)
Missive© Meaningful Use EMR Quality, Billing and Efficiency Extender, Computed Colonography, CTA, MRA, Angiogenesis Imaging, Image-guided Procedures, National Core Laboratory for MRI Assessments of Ischemic Heart Disease, Elastic Match, Advanced Cardiovascular Imaging Center, Dartmouth Advanced Imaging Center, Microvascular imaging, Oxygenation Influx Rate (OIR), Oxygenation Consumption Rate (OCR), Diagnostic Cardiology Center, Horizontal Care Quality Improvement Initiative, Multidisciplenary Quality Assessment, Failsafe Service.
3. Director of Cardiology Clinical Services
Added new diagnostic services, perform transesophageal echocardiography, stress echocardiography, 2D/3D, MRI, CTA, nuclear imaging, and run clinics and hospital consult services.
4. Vice Chair KMC/UCLA
Perform administrative duties, remedial action design, assessments, supervision, quality improvement, training program oversight, morning report supervision, conferences supervision, program development, strategic planning, compliance.
Part II
A: Laboratory & Clinical Investigator Ladder
A. REPORT OF RESEARCH:
1. Major Research Interests:
a. Cardiovascular Imaging
b. Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI)
c. Evaluation of atherosclerotic plaque development; chemistry, physiology, NMR spectroscopy, and NMR microscopic imaging
d. Angiogenesis research
e. Mathematical modeling
2. Research Summary: 1993-1998
At Massachusetts General Hospital I developed the MRI Computing Facility, including procuring a Supercomputer as PI for an NIH Shared Instrumentation Grant, and supervised application development of the InstaScan echo-planar system for cardiac MRI. Moved to Beth Israel Hospital (1992) to pursue further my work in fast MRI, taking advantage of newer more advanced equipment installed at Beth Israel. There was no adequate image computing available, so obtained industry grants exceeding $300,000, and created a visualization laboratory. Under my direction, this facility has supported projects in Radiology, Anesthesia, Pulmonary Medicine, Neurology, Neuro-Surgery, as well as Cardiology. Combining MRI technology with advanced image processing, developed new software, in use at multiple hospitals.
Based on opportunity and the potential for a major patient benefits, focused much of my effort on imaging micro-vasculature, neo-vascularization, angiogenesis and, in particular, the development of collateralized myocardium. I invented two new techniques for that: (1) a high-resolution CT shadow imaging technique and (2) a novel collateral-sensitive MRI technique. A patent was awarded relating to the first, and a patent is pending on the second.
Performed a large number of studies documenting the accuracy and validity of the new diagnostic methods (published in Nature Medicine, Academic Radiology and Magnetic Resonance in Medicine), and then developed clinical applications. Patients who had severe coronary artery disease that could not be addressed by angioplasty or bypass surgery received major benefits.
The basic procedure is as follows: patients with angina despite bypass or other procedures receive growth factor (e.g., VEGF=Vascular Endothelial Growth Factor and bFGF=basic Fibroblast Growth Factor), using my collateral-sensitive MRI as the principal clinical guide to determine dose effects. The new MRI techniques I developed identify the collateralization response and predict outcome accurately. It was not known how much growth factor to give or by what route. With colleagues in the angiogenesis center, we performed multiple series of studies in a porcine model of chronic ischemia, and now we are in clinical trials. Within 4 weeks, substantive new vessel growth in the ischemic myocardium is evident by my MRI techniques. When the new vessel development covers the area at risk (defined by another MRI image series I employ), the target is met. Achieving that target results in substantive relief from angina, greatly improved exercise tolerance and, in a number of cases, improved wall thickening, wall motion, and normalized ejection fraction. Patients who had chest pain with minimal activity are now pain-free and back to full activity.
My laboratory has subsequently served as the Core Lab for a multi-center trials funded by Chiron Corporation, Mercke-Sharpe and Dome, Johnson and Johnson and others, and is a Core for the Cardiology S.C.O.R. Program Projects sponsored by the N.I.H.
3. Narrative Description of Research: 1997-99
The major focus of my work related to visualization and assessment of micro-circulation. A very strong motivation for this work is the recent development of growth factor treatments for coronary artery disease, with no clinical means of measuring their direct impact. I developed methods of visualizing and measuring micro-circulation in the lungs as well as for the heart. Neovascularization in mature adult tissues is a tightly regulated process that can occur in a number of conditions ranging from ischemic heart disease to cancer growth. The presence of collaterals in coronary circulation developing in response to progressive coronary artery occlusion has been correlated with improved myocardial function and overall clinical outcome. New technologies now offer the possibility of therapeutic stimulation of myocardial collaterals. However, there were no reliable noninvasive techniques capable of identifying and tracking collateral vessel development. Therefore I developed a new approach to collateral imaging that relies on magnetization preparation and spatial frequency reordering to distinguish collateral and normal circulation on the basis of geometric differences. The accuracy and reliability and its ability to track neovascularization over time was tested in 34 pigs instrumented with an Ameroid occluder. The spatial extent of in vivo MR-determined collateral-supplied myocardial territory correlated well with both ex vivo 3-D CT assessment (r=0.95), and with microsphere-determined distribution of collateral blood flow (r=0.86). Application of this technique produced successful assessment of collateral development in an ischemic porcine model of angiogenesis as well as in patients with coronary artery disease.
The problem of identifying newly developing vessels in the ischemic areas of the heart required detection of a very small target in a large field of view. Such a target can be identified if it sends up a “flare.” To set up such a flare for identification of sparse collateral vessels in a large field of view, I took advantage of the magnetic susceptibility of the MRI contrast agent gadolinium and the ability of echo planar imaging to eliminate T1 relaxivity differences so that T2* determined contrast. Gadolinium picks up a relatively large fraction of the magnetization that is applied during MRI. Uniformly distributed gadolinium in tissues enhances MR signal while heterogeneous distribution results in local magnetic field gradients between high and low susceptibility locations that rapidly scramble detectable signal. Application of T2* imaging produces geometry-dependent local field disturbances during bolus passage of magnetic susceptibility agent such as gadolinium which acts, in effect, like a black flare.
Localization of the susceptibility contrast “flare” to the collateral vessels zone within the myocardium is achieved by restricting T2* sensitivity to specific spatial frequencies. The pulse sequence has a transition from T2* weighting to T1 weighting, applying the T2* to differences on a scale of 1/16th the field of view or smaller (e.g. within the myocardium) while applying T1 weighting (susceptibility insensitive) to low frequency large events (e.g. the left ventricle).
Having developed the basic technique, I then set out to investigate critical features of the dark flash to show that a) LV filling with magnetic susceptibility contrast does not obscure myocardial signal, b) the dark flash is not due to wall motion, c) myocardial targeting work for a wide range of wall thickness, d) the extent of dark flash corresponds to the anatomical extent of intramyocardial neovascularization, and e) the method can identify and monitor developing collateral circulation in the heart. This provided pilot data for a grant I submitted to the NIH which was awarded as an RO1, with a score of 9.4%, $748,727 for the next 3 years.
I studied 80 pigs instrumented with Ameroid coronary occluders, in collaborations with Drs. Simons and Laham of Cardiology, and Dr. Sellke of Cardiovascular Surgery for optimization of treatment. In this model, the placement of a plastic-encased Ameroid ring around a proximal segment of a coronary artery leads to progressive coronary occlusion secondary to gradual fluid absorption by the Ameroid material. In all cases, the CS-MR images showed that the signal drop associated with left ventricular filling was minimal, did not suppress myocardial signal, and did not interfere with detection and localization of the dark flash. To demonstrate that the generation of dark flash was not due to the wall motion, I carried out ex vivo imaging of freshly excised hearts (no wall motion) triggered by an external timer 6 weeks after Ameroid implantation. In all cases the presence and extent of the collateral dark flash was similar in timing and extent to that seen during in vivo imaging in the same animals. This reproduction of the in vivo phenomenon excludes wall motion as a cause of collateral flash. Finally, analysis of variance of data from 44 studies (22 at 3 weeks and 22 at 6 weeks after Ameroid placement) showed that different wall thicknesses, ranging 0.8-1. cm, did not affect the detection of the flash (p=NS).
The ability to validate collateral-sensitive MRI was limited by the low resolution of the Principal alternative – microsphere distribution. Therefore, in addition to completing validation studies with microspheres, I developed a new test for collateral investigation based on high resolution CT. This new method is for ex vivo 3D assessment of collateral development. It requires selective cannulation of the coronary arteries, contrast injection, and a new form of digital subtraction. The result of this is a 3D data set reporting at 1 mm3 resolution what regions of the heart get contrast delivery beyond a coronary occlusion only when the distal artery is at low pressure and not when it is at high pressure. This work was validated against microspheres in a porcine model of collateral development, and published in Academic Radiology.
The new method of digital subtraction accounts for the fact that tissues are elastic, so they do not match exactly at different times. The idea is based on the way we perceive depth — binocular vision. In binocular vision, two different views (left eye, right eye) are compared. Data seen only in one view are thrown out (hold a finger in front of one eye, it appears transparent). Elastic subtraction mimics this, but keeps that which is present in only one view, and throws out what they have in common. I was awarded a U.S. patent for this on 2/11/97, and the international patent is pending. The new method allows comparison of imaging under different conditions select out the tissue supplied by collaterals. It is also useful for automated 3D angiography.
Contrast spiral CT images were obtained with and without saline infusion into the distal left circumflex while contrast was mechanically injected in the left anterior descending and in the right coronary arteries as I previously published (Nature Medicine, 1995–#28 on CV/Bibliography). 3-D reconstructions of the heart and of the collateral zone were computed and correlated with the MR-determined collateral zone size in the same hearts in vivo. There was an excellent agreement between both measurements with the overall correlation of 0.95.
Since then, my laboratory was selected as the Core laboratory for a series of studies sponsored by Chiron Corp., Biosense, and Genzyme to assess by MRI the impact of growth factors on patients with coronary artery disease. The initial results are very promising, as an alternative way to treat coronary artery disease, by an injection instead of bypass. I have completed 28 cases so far, with significant benefit evident. In addition, I have a core role in the Cardiology S.C.O.R., evaluating growth factor and other treatments, including laser.
4. Narrative Description of Research: 1999-2001
As a completion of prior work, my lab performed extensive “Receiver Operator Characteristic” studies on 30 different non-invasive measures of cardiac perfusion and growth factor response, determining that a new analytic method, “equitime” performed best. Also, we conducted clinical evaluations comparing the perfusion methods to results from nuclear medicine (MIBI and thallium), which indicate that our new rest MRI studies compare favorably to stress MIBI, with higher resolution and without requiring induction of stress in patients prone to angina. As Director of Imaging for the Harvard Angiogenesis Center, I continue to design studies and maintain the Core Laboratory for assessment of Angiogenesis, and continue to guide the development of new therapies for cardiac revascularization, including laser and angiogenic growth factor animal studies and clinical trials. Work has focused largely on advancements in quantitative imaging of angiogenesis. We provided the National Angiogenesis Imaging Core Lab for multiple pre-clinical and clinical trials of angiogenesis. I invented, developed and validated new methods of assessment, including SMART (Serial Motion Assessment by Reference Tracking), and EQUITIME (highest ROC method for identifying impaired blood delivery by rest MRI). My lab determined that myocardium at risk as identified by stress nuclear imaging could also be identified by rest MRI through detailed assessment of impaired blood arrival to the myocardium using EQUITIME. Rest study provides greater reproducibility than stress study, and is also safer in patients with inducible ischemia.
5. Narrative Description of Research: 2002-2005
Two major manufacturers of imaging equipment offered me new imaging equipment (MRI, CT, PET) if I would help them by directing the development of clinical applications and improvements. I determined that the best opportunity to pursue that offer, which required space and a high level of collegial collaboration between Radiology and Cardiology, would be at Dartmouth. I accepted an offer from Drs. Spiegel, Simons, and St. Germaine to move to Dartmouth as Director of Advanced Cardiovascular Imaging, where I am setting up a new Advanced Cardiovascular Imaging Center that will expand on the roles of quantitative cardiovascular imaging in angiogenesis assessment and in clinical cardiology. Subsequently I was asked also to Direct the Advanced Imaging Center for the Norris Cotton Cancer Center and the Thayer School of Engineering.
While developing perfusion-sensitive MRI for angiogenesis studies, we compared inversion recovery and saturation recovery repeat imaging to determine number of repeats possible ein a single session. We incidentally discovered retention of contrast in areas of infarction, which is now the basis of myocardial scar mapping.
I was recruited by Dartmouth to start the Dartmouth Advanced Imaging Center to serve as a magnet for cutting edge tertiary care. We established new imaging capabilities with distinct advantages unsurpassed in the nation. We focused the new Center on physiologic imaging, including microPET, 3T whole body MRI, and image-guided minimally invasive procedures. It is used now for evaluation of angiogenesis, dysplasia, remodeling, tracked (SMART) function, viability, diastolic relaxation, high accuracy lung cancer screening (angiogenic nodules), three-dimensional and functional evaluation of congenital heart abnormalities and repairs, metabolic imaging and tissue characterization. It will provide new methods for treatment including image-guided myocardial injections and three-dimensional image-guided interventional catheterization with concurrent non-invasive assessment of impact.
My goals included: 1) Provide new cardiovascular imaging methods to supplement non-diagnostic echocardiography and nuclear studies (the new imaging methods include CV-MRI and 64 slice CV-CT); 2) Create new clinical tools that will be the basis for primary referrals; 3) Develop image-guided minimal invasive treatments; 5) Develop screening studies (coronary artery disease, blood delivery, plaque stability; early lung cancer); 6) Develop a reputation for cutting-edge clinically relevant research in cardiovascular imaging; 7) Develop cross-modality validations and clinically valuable image fusions.
Primary focus of new initiatives: 1) micro-imaging, 2) molecular imaging. The former aims to identify microvascular changes associated positively with therapeutic coronary angiogenesis and negatively with new cancer therapies. This will foster major new initiatives working closely with Dr. Mark Israel and colleagues at the Norris Cotton Cancer Center. The latter aims to identify distribution of cell surface markers utilizing antibody tagged microspheres for T2*/T1 hybrid high frequency over-sampled MRI. While our initial focus is support of angiogenesis research, that will have broad applications in ischemia, heart failure, oncology, endocrine, and other areas.
6. Narrative Description of Research: 2006-2007
Served as Director of the Dartmouth Advanced Imaging Center. Authored the NIH grant that paid for the facility renovation, and the first phase is completed. Further facility development is planned to expand this new Center as a translational imaging facility. We have successfully installed a research whole body 3T MRI system (Philips Achieva). This has an attached animal facility and we are currently establishing protocols for the new system and expanding participation from researchers throughout the Dartmouth community. Arranged multiple sponsored industry contracts. Arranged for installation of an SGI PRISM Imaging Supercomputer, to be installed March 06, whole body EPR, 3D ultrasound, hybrid MRI – Near InfraRed imaging, microwave imaging, a robotic microscope for automated 3D histology, and adjacent 64 slice multidetector CT. In addition to promoting the success of the overall center, developed research programs addressing microvascular and nano-technology imaging. We have developed a novel contrast agent for quantitative molecular imaging by joint MRI and near infrared imaging. We have developed a new oxygen-sensitive MRI method that measures oxygenation recovery in the heart with no injections. Preliminary data show a clear difference between normals and patients with heart failure. The heart failure patients all exhibit markedly impaired oxygenation recovery each heartbeat, consistent with reversion to the fetal phenotype of increased sarcoplasmic reticulum/calcium loading and decreased mitochondrial efficiency. Also I am porting my “V-Mode MRI” to the new research system. The V-mode MRI enables real time measurement of velocities within any specified blood vessel. Our target application is initially evaluation of renal artery stenosis, which is seen in 30% of patients presenting for cardiac catheterization. In addition to using peak velocity to compute pressure gradient across stenosis, other derived flow parameters will provide means to examine microvascular disease to predict who will benefit from revascularization. The V-Mode MRI will later be applied to coronary artery disease for non-invasive measurement of pressure gradients across lesions, characterization of flow reserve, and microvascular disease. The new magnet will also serve to extend our work on measurements of neovascular development and collateral dependence.
7. Narrative Description of Research: 2007-2009
As principle investigator for application of angiogenesis imaging to early accurate detection of cancer, Directed the development of methods that classify pulmonary nodules as cancer or benign based on space-time fractal dimension of contrast arrival (a novel measurement of blood delivery pattern that distinguished cancerous nodules from benign with better than 95% sensitivity and specificity). For patients who should not receive contrast agents (creatinine clearance <60, risk of nephrogenic fibrosing dermopathy) we investigated the ability to make the early accurate diagnosis of lung cancer from inhalation of carbogen (95% oxygen, 5% carbondioxide). That also proved successful, and avoided the need for intravenous contrast agents. In addition, we discovered that coronary stenosis becomes evident during carbogen inhalation due to a distinct change in magnetic susceptibility from deoxyhemoglobin vs oxyhemoglobin. This identifies coronary disease without stress testing. Furthermore, we were able to develop from technique maps of oxygenation influx and extraction rates at 25 msec resolution throughout the cardiac cycle, fully non-invasively. In addition, this method quantifies the inhibition of mitochondria by increased calcium in the sarcoplasmic reticulum, that occurs with heart failure. In a series of 20 subjects, this appears much more reproducible a measure of heart failure status than NT-pro-BNP. A variant we developed from this new technique identifies microvascular impairment (cardiac syndrome X).
8. Narrative Description of Research: 2009-2013
Served as physician supervisor for new initiatives in establishing a multidisciplinary palliative care service, a horizontal care service, and a multi-facility quality improvement program. Developed and continue to expand meaningful use software and clinical integration tools under the CMS initiative. I serve as Chief Medical Officer for Matryx, All Clear Diagnostics, ClearSolutions™ and VisualSolutions. I designed and developed Missive© electronic record service tools. I completed a mini-Fellowship in GERIATRICS at UCLA and continue research and development work in geriatrics via the UCLA Geriatrics Scholar program. I supervise research by residents and serve as judge for UCLA research symposium. This included leadership skill training an a project which introduced to subspecialty clinics routine screening and referrals for geriatric issues (imbalance, hearing deficit, cognitive impairment, visual impairment, depression, polypharmacy, age-appropriate medication, social support inadequacy).
Developed research programs for heart failure diagnostics and developed a method to evaluate the calcium load impairment of myocardial metabolism (relating to the work by Dr. Roger J Hajjar on SERCA2a) by dynamic cardiac magnetic resonance imaging of oxygen uptake kinetics mapped to the myocardium (completely non-invasive, with validation porcine and human data). These distinguish heart failure (quantified delayed oxyhemoglobin conversion) from ischemic heart disease (regional more profound impairment) and enable quantitative assessment of the metabolic impediment imposed by SERCA2a deficient activity. I also have developed planning tools for optimal resynchronization, and have been commissioned to publish a three-volume cardiology e-textbook, including: Alternative Designs for the Human Artificial Heart: The Patients in Heart Failure Outcomes of Transplant (donor)/Implantation (artificial) and Monitoring Technologies for the Transplant/Implant Patient in the Community.
3. Research Funding Information:
1. 534120 (NSF #0083423): Mining Human Brain Data: Analysis, Classification, and Visualization (PI by transfer)
2. 534018 (NSF #0312629): ITR: A System for Data Integration and Pattern Discovery in Multimodal Spatio-Temporal Data: Lesion Analysis and Data Sharing (PI by transfer)
3. 534031 (NSF #0308229): DTA Management of Protected Information for Data Sharing and Collaboration (PI by transfer )
4. NIH Resource Development Grant: 10/02 0%
Title: Advanced Imaging Resource Development
Government funding supports renovations for the development of the Dartmouth Advanced Imaging Center
01: direct: $1,500,000
5. Principal Investigator: Doris Duke Clinical Innovation Award 02/05-05/06 20%
Title: “Early Cancer Detection by Imaging Angiogenesis”
01: direct 100,000, indirect 15,000, total 115,000
02: direct 100,000, indirect 15,000, total 115,000
PI: Justin D. Pearlman
This project validates and expands applications of hybrid T1/T2* neovascular imaging for MRI of Angiogenesis, a patented novel MRI method invented by the PI that identifies microvascular angiogenesis/neovascular development below resolution of x-ray angiography; No cost extension to accommodate move to Dartmouth.
6. Principal Investigator: FAMRI Award 07/02-06/05
Total $3,000,000
Principal Investigator: NIH 1R01 HL58072 01/15/98-12/31/02 40%
Title: “MRI of Coronary Collaterals”
01: direct 150,905, indirect 101,106, total 252,011
02: direct 147,748, indirect 98,991, total 246,739
03: direct 149,687, indirect 100,290, total 249,977
PI: Justin D. Pearlman
This project validates and expands applications of hybrid T1/T2* neovascular imaging for MRI of Angiogenesis, a patented novel MRI method invented by the PI that identifies microvascular angiogenesis/neovascular development below resolution of x-ray angiography; No cost extension to accommodate move to Dartmouth.
7. Core Director: NIH PPG: 5P50HL063609 04/01/00 – 03/31/03 15%
Title: “Endothelial Cell Signal in Cardiac Angiogenesis”
01: PI Michael Simons: direct $1,176,979; indirect $577,744; total $1,754,723
02: -change institutions
03: PI Robert Rosenberg direct $1,239,232; indirect $429,528; total $1,758,760
Human and Large Animal Imaging Core
PI of Core: Justin Pearlman, MD ME PhD
This project applies MRI to measure impaired blood supply and functional consequences in pre-clinical and clinical trials.
8. Co-investigator: NIH SCOR RO1HL56992 05/01/99–04/30/03 5%
Title: “MRI of Angiogenesis”
PI: Roger Laham, MD
Project Period, Direct: $490,000 Total: $813,000
This project applies MRI of Angiogenesis to study impact of therapeutic angiogenesis in specific populations. It aims to establish new therapeutic approaches to ischemic heart disease based on the promotion of angiogenesis.
9. Principal Investigator: Doris Duke Clinical Innovation Award 8/1/02-8/31/04 20%
Title: “Early Cancer Detection by Imaging Angiogenesis”
01: direct 100,000, indirect 15,000, total 115,000
02: direct 100,000, indirect 15,000, total 115,000
PI: Justin D. Pearlman
10. Principal Investigator: New York Cardiac Center 7/01/99 – 6/30/02 15%
Title:“Cardiovascular Volumetric Research Projects”
PI: Justin D. Pearlman
Project Period, Direct: Costs: $240,000 Total: $360,000 Current Year: $75,000
Translation research measuring receiver operator characteristics for clinical practice applications of volumetric and perfusion MRI – applying Fermi Function deconvolution transit time analysis vs. novel metrics
11. Principal Investigator: Chiron Corporation 12/01/97 – 11/30/98 10%
Title: “Coronary rFGF-2”
PI of Core: Justin D. Pearlman
Direct: $74,000 Total: $92,500
Develop protocols to evaluate novel angiogenesis therapies (pericardial vs. myocardial injection vs. laser)
12. Principal Investigator: NIH 5RO3HL55354 9/30/95 – 2/28/98 0%
Title:“Data Reduction from MRI Time Series”
PI: Justin D. Pearlman
Project Period, Direct: $99,519 Total: $166,197
Develop analytic theories for information extraction from large image datasets.
13. Principal Investigator: BIHRF Research Grant 3/01/96 – 2/28/98 5%
Radiologic Foundation–Beth Israel Deaconess Medical Center
Title:“Minimally Invasive Cardiac Revascularization Award”
PI: Justin D. Pearlman
Project Period, Direct $10,000, Total: $10,000
Development of CT method to identify spatial extent of collateral-dependent tissue.
14. Co-Investigator: NIH 1R01 HL53793 7/01/96 – 6/30/99 5%
Title:“Angiogenesis and Myocardial Ischemia”
PI: Michael Simons
Project Period, Direct: $492,899 Total: $813,283
Develop and apply applications of MRI to Angiogenesis Trials
15. Co-Investigator: Faer Grant/Anesth. Dept 4/96 – 4/98 30%
Title:“Virtual Reality Training Device for Fiberoptic Bronchoscopy”
PI: Shorten GD
Development of a 3D interactive virtual endoscopy system for training anesthesiologists
16. Co-Investigator: NIH/SCOR Grant 5P50HL063609#6 15%
L. Cantley, Principal Investigator 12/01/96 – 11/30/01
Project Period, Direct: $490,000 Total: $818,303
Title:“Role of Tyrosine Kinases and Phosphatases in Vascular Development and Signaling”
Applications of MRI to Angiogenesis Pre-Clinical Evaluations
17. Principal Investigator: NIH PPG : 2P01CA048729 (7/1/97-6/31/99) 10%
Thomas Brady, Principal Investigator
Project Period, Direct: $670,800 Total: $1,120,240
Computer and Technologies Core PI of Core: Justin Pearlman
Develop automated data handling and information extraction for cardiac function and perfusion
18. Principal Investigator: NIH PPG : 5P01CA048729 (7/1/99-6/31/01) 10%
Thomas Brady, Principal Investigator
Project Period, Direct: $690,870 Total: $1,153,757
Computer and Technologies Core PI of Core: Justin Pearlman
Provide analytic support for MRI studies modifying blood delivery
19. Principal Investigator: Whitacker Foundation 4/1/93-3/31/96 25%
“Real-time 3D NMR Velocity Measurement”
PI: Justin D. Pearlman
Project Period, Direct: $150,000 Total: $180,000
Invented technique called “Response-Modulated Excitation” that enables 1 mm diameter sampling at 128 points refreshed 64 times/second measuring blood velocities inside body, e.g., aorta, as MRI equivalent of Doppler ultrasound but with 3D freedom of volume selection without the air-water attenuation.
20. Principal Investigator: AHA Established Investigator 7/1/95-6/30/00 0%
“Multidimensional Imaging of Cardiovascular Pathophysiology: Focus on Atheroma”
Project Period, Direct: $323,500 Total: $323,500
Developed high resolution (10 micron) NMR imaging for tissue characterization of unstable plaque shape indices, structure and constituents
21. Principal Investigator: AHA Grant-in-Aid 7/1/95-6/30/98 25%
“MRI Measurement of Collateral-Dependent Ischemia”
Project Period, Direct: $120,000 Total: $132,000
Validated biplane real-time MRI measurements of extent and severity of infarct and ischemic territories
22. Principal Investigator: NIH First: 1R29HL041287 07/07/88-04/30/93 50%
Atheroma Detection using NMR PI: Justin Pearlman, MD ME PhD
Project Period, Direct: $150,000 Total: $250,501
NMR investigations of tissue character of atheromatous plaque, demonstrating thermotropic behaviors and importance of shape index, a marker of plaque stability; 10 micron resolution in vivo imaging of organ cultured human coronary arteries.
23. Principal Investigator: NIH: 1S10RR006519 06/02/91-06/01/92 0%
Parallel Superscalar Processing System PI: Justin Pearlman, MD ME PhD
Project Period, Direct: $300,000, Total $300,000
PI for shared instrument grant funding high-end instrumentation for NMR Research
24. Co-investigator: NIH: 5P50HL026215 09/29/87-09/29/89 25%
Specialized Center Of Research In Ischemic Heart Disease PI: Edgar Haber
Project Period, Direct: $780,000 Total: $1,302,605
Computer Core Lab – Visualization and Mathematical Modeling
25. Investigator: NIH: 5T32HL007208 06/01/86-05/31/87 100%
Title: “Multidisciplinary Research Training In Cardiology”
PI: Edgar Haber
Project Period, Direct: $481,542 Total: $804,178
Cardiovascular Imaging – Mathematical Modeling
26. Supervisor: KMC/UCLA Palliative Care Program ~2012-2015
Project funding ~300,000
Funding for development of a multidisciplinary palliative care program
Industry and other Grants:
Donations: >10 donation sources from private donors (grateful patients of Dr. Pearlman)
Philips: $1.5 million equipment discount; luminary site status for Dartmouth; engineering support
Medtronics: $50,000 budget for MRI of cardiac resynchronization
Genzyme: $60,000 core support for National Corelab MRI assessments (on-going). Biosense/Johnson & Johnson: $80,000 donated catheters 5/1/97
Nicomed Pharmaceuticals: $75,000 contrast agent evaluations10/01/96 – 11/1/97
Chiron Pharmaceuticals: $200,000 supplies 9/1/97
Hewlett-Packard: $250,000 donated 3D imaging hardware 10/01/97
Sun Microsystems, Inc.: $400,000 donated computer workstations 9/01/96; established MR Computing and Technologies Center at BIDMC
Sterling Drug Company: $54,421 contrast agent evaluations 12/01/93 – 11/30/94 (Examined ability of WIN59090 sprodiamide to to identify ischemia in a porcine model using dipyridamole MRI)
Silicon Graphics Instruments, Inc: $150,000 donated computer workstations 9/1/93; established MR Computer and Technologies Center at MGH
5. Patents:
1. JDPearlman “Imaging Apparatus and Method with Compensation for Object Motion”
U.S. Patent #5602891 – Awarded 2/11/97
2. JDPearlman “Multivariate Cardiac Monitor”
U.S. Patent #0025139 – Awarded 9//01
3. JDPearlman “Spatio-Temporal Reordered MRI” (pending)
4. JDPearlman “Real-Time Telepresence” (pending)
5. JDPearlman “Cardiovascular CT” (pending)
6. JDPearlman “12 Lead EKG during MRI or CT” (pending)
7. JDPearlman “Negative Contrast for CT” (pending)
8. JD Pearlman “MRI Imaging Method and Apparatus”
U.S. Patent #6121775 – Awarded 9/19/00
B. REPORT OF TEACHING:
1. Local Contributions
a. Medical School Courses (for Medical/Dental/Graduate students)
1994-1997 Lecturer: Radiology Core Clerkship 550.1M “Real Time MRI”
b. Graduate Medical Courses/Seminars/Invited Teaching Presentations Lecturer:
1993 “Real-time MRI by Response-Modulated Excitation,” Montreal Heart Institute; Montreal, Quebec, June 17.
1993 “Clinical Value of Cardiovascular MRI,” Harvard University Physics Colloquium; Cambridge, MA, October 8.
1995 “Rapid System Virtual Prototyping,” Symposium, The Johns Hopkins University Applied Physics Laboratory; Laurel, MD, May 11.
1995 “3D Coronary Imaging,” Notre Dame Heart Institute, Montreal, Canada, June 21.
1995 “MRI of Cardiac Perfusion,” Notre Dame Heart Institute, Montreal, Canada, June 22.
1995 “3D Coronary Imaging,” St. Paul’s Teaching Hospital, Vancouver, B.C., August 24.
1995 “The Visualization Forum: New Technologies and Old Talents,” The Visualization Research Institute, “invitation only” workshop, Aspen, Colorado, October 12-14.
1995 “Object Oriented Visualization,“ Capstone Lecture, IEEE Symposium on Frontiers in Biomedical Visualization, BioMed Visualization ’95, Atlanta, Georgia, October 30.
1996 “Trends in Digital Image Manipulation with Special Emphasis on the Cardiovascular System,” Plenary Lecturer, 28th International Diagnostic Course – Imaging of the Heart and Chest, Davos, Switzerland, March 23-29.
1996 “Advances in Cardiac Evaluation,” Grand Rounds, Anesthesia Department, Beth Israel Hospital, Boston, MA, February 8.
1996 “Development of Techniques to Observe Collateral Blood Supply to the Heart,” Department of Computer Science, Simmons College, Boston, MA, September 25.
1997 “Collateral-specific imaging,” Grand Rounds, Cardiology Department, Beth Israel-Deaconess Medical Center, Boston, MA, February 20.
1997 “Influence of New Imaging Capabilities on Quality and Costs of Medical Care,” New England Society of College Chairmen, Boston, MA, April 26.
1997 “Advances in Virtual Colonoscopy,” GI Grand Rounds, Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, December 9.
1998 “Virtual Colonoscopy,” GI Pathophysiology Lecture Series, Beth Israel Deaconess Medical Center, Boston, MA, January 21.
1998 “MRI of Coronary Collaterals: A Guide to Predicting Infarcts?” Cardiovascular Research Seminar Series, St. Elizabeth’s Medical Center, Boston, MA, Feb 4.
1999 “MRI of Angiogenesis” Angiogenesis Meeting, MA, March 31
2000 “MRI in Clinical Trials” Chiron Meeting, San Francisco, CA, Jun 15
2001 “Gene Therapy of Angiogenesis” Society CVMR, Altanta GA, May 19.
2004 “Microvascular Assessment” Grand Rounds, DHMC, Lebanon NH, Mar 25.
2005 “Space-Time Fractals” Angiogenesis Research Center, DHMC, Lebanon NH
2005 “Microvascular Imaging” Vasculata Conference, Co-sponsored by Dartmouth Medical School, University of Washington and NAVBO, Lebanon NH July 20
2005 “4D Imaging of PFO” Cardiology Dept, DHMC, Lebanon NH
2005 “V-Mode MRI” Cardiology Dept, DHMC, Lebanon NH
2006 “Non-Invasive Assessment of Myocardial Oxygenation” Grand Rounds, DHMC, Lebanon NH
2006 Plenary Lecture “Data Path for Coronary CTA” IEEE 17th Annual Workshop 14-May-2006 Santa Fé, NM
2006-7 Advanced Image Computing – Course taught at Thayer School of Engineering
2007 Plenary Lecture, Advanced Cardiovascular Imaging. American College of Physicians, 26-Oct-07
2007 “MRI Microscopy” invited lecturer, Frontiers in Microscopy, Jackson Laboratory, Bar Harbor, ME
2011 “Electrocardiography” Grand Rounds Lecture, UCLA/KMC
2012 “Pulmonary Hypertension” Grand Rounds Lecture, UCLA/KMC
2013 “MRI” Grand Rounds Lecture, UCLA/KMC
Advisory and Supervisory Responsibilities in Clinical or Laboratory Setting
(for medical or graduate students, residents or fellows)
PhD Advisor – Harvard, BU, MIT, HST (Five PhD Theses, 2 Masters Theses).
“Computer Science,” Beth Israel Deaconess Medical Center, Radiology Residents & Fellows (Visualization Laboratory): Fellows’ Computer Imaging Conference (weekly)
“Fast MRI,” Beth Israel Deaconess Medical Center, Radiology Residents & Fellows
2001- “Cardiovascular MRI,” Dartmouth-Hitchcock Medical Center, Radiology Fellows and Residents, Cardiology Fellows
d. Leadership Roles
(organization of course, preparation of teaching materials, etc.)
1988-1991 Established and conducted course for Health Science and Technologies Program, Harvard/MIT-HST Program: HST.583 “Advanced Methos of Image Analysis for Medical Applications”
Obtained support from Sun Microsystems and Hewlett-Packard and established Visualization Laboratory, which supports work by colleagues in Radiology, Anesthesiology, Cardiology, Neurology, Neurosurgery, and Pulmonary Medicine.
Director Advanced Cardiovascular Imaging Obtained equipment support, computer support, space commitments and established multi-department collaborations.
2. Regional, National, International Contributions
a. Invited Lecture Presentations
1992 “Visualization and Information Extraction from Multi-modality Multidimensional Medical Image Data,” Presented at the annual meeting of the IEEE Society; Boston, MA, November 23.
1993 “3D Coronary MRA,” Annual Meeting of the North American Society for Cardiac Imaging; San Antonio, TX, May 18-23.
1993 “Real-time MRI by Response-Modulated Excitation,” Montreal Heart Institute; Montreal, Quebec, June 17.
1993 “Clinical Value of Cardiovascular MRI,” Harvard University Physics Colloquium; Cambridge, MA, October 8.
1993 “The Changing Role of Visualization in Medicine,” Presented at the annual meeting of the IEEE Society, San Jose, CA, October 27.
1994 “Rapid System Virtual Prototyping (RSVP),” Presented at the Advanced Technology Conference of The Johns Hopkins University Applied Physics Laboratory; Laurel, MD,March 10
1994 “Three dimensional visualization of the coronary artery tree from standardized MRA,” XIth International Atherosclerosis Conference, Montreal,March 10 “Translucent reconstruction of 3D elastic subtraction CT angiography,”9th European Congress of Radiology -ECR‘95, Vienna, Austria, March 15.
1995 “3D Visualization of coronary arteries by MR,” presented at the CAG International Meeting, Fukuoka, Japan, April 21
1995 “3D MRA of coronary arteries,” American Roentgen Ray Society 95th Annual Scientific Meeting, Washington, D.C., May 2
1995 “Cardiology MRA and cardiac perfusion,” American Roentgen Ray Society 95th Annual Scientific Meeting, Washington, D.C., May 5
1995 “Rapid System Virtual Prototyping,” Symposium, The Johns Hopkins University Applied Physics Laboratory; Laurel, MD, May 11
1995 “3D Coronary Imaging,” Notre Dame Heart Institute, Montreal, Canada,June 21
1995 “MRI of Cardiac Perfusion,” Notre Dame Heart Institute, Montreal, Canada, June 22
1995 “3D Coronary Imaging,” St. Paul’s Teaching Hospital, Vancouver, B.C., August 24
1995 “The Visualization Forum: New Technologies and Old Talents,” The Visualization Research Institute, “invitation only” thinktank, Aspen,Colorado, October 12-14
1995 “Object Oriented Visualization,“ Capstone Lecture, IEEE Symposium on Frontiers in Biomedical Visualization, BioMed Visualization ’95, Atlanta, Georgia, October 30.
1996 “Trends in Digital Image Manipulation with Special Emphasis on the Cardiovascular System,” Plenary Lecturer, 28th International Diagnostic Course Imaging of the Heart and Chest, Davos, Switzerland, March 23-29.
1996 “Advances in Cardiac Evaluation,” Grand Rounds, Anesthesia Department, Beth Israel Hospital, Boston, MA, February 8.
1996 “Development of Techniques to Observe Collateral Blood Supply to the Heart,” Department of Computer Science, Simmons College, Boston, MA, September 25.
1997 “Collateral-specific imaging,” Grand Rounds, Cardiology Department, Beth Israel Deaconess Medical Center, Boston, MA, February 20.
1997 “Influence of New Imaging Capabilities on Quality and Costs of Medical Care,” New England Society of College Chairmen, Boston, MA, April 26.
1997 “Advances in Virtual Colonoscopy,” GI Grand Rounds, Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, December 9.
1998 “Virtual Colonoscopy,” GI Pathophysiology Lecture Series, Beth Israel Deaconess Medical Center, Boston, MA, January 21.
MRI of Coronary Collaterals: A Guide to Predicting Infarcts?” Cardiovascular Research Seminar Series, St. Elizabeth’s Medical Center, Boston, MA, Feb 4.
1999 “MRI of Angiogenesis” Angiogenesis Society Meeting, MA, March 31
2000 “MRI in Clinical Trials” Chiron Meeting, San Francisco, CA, Jun 15
2001 “Gene Therapy of Angiogenesis” Society CVMR, Altanta GA, May 19.
b. Professional Leadership Roles related to Teaching
Established and conducted course for Harvard – M.I.T. / Health Science and Technologies Program: HST.583 “Advanced Methods of Image Analysis for Medical Applications”
2001-2009 Training Program for Advanced Imaging MRI, CT, Nuclear, Dartmouth
2011-2013 Training Program for Diagnostic Cardiology, KMC/UCLA Affiliate
Part III: Bibliography
Original Reports:
- Pearlman JD. Chagas’ disease in California: no longer an endemic diagnosis. Am J Med 1983; 75(6):1057-60.
- Pearlman JD. Nuclear magnetic resonance spectral signatures of liquid crystals in human atheroma as basis for multi-dimensional digital imaging of atherosclerosis. PhD Dissertation, School of Engineering and Applied Science, University of Virginia, August 1986.
- Pearlman JD, Gibson RS. Doppler measurement of left atrial depressurization and mitral valve area in patients with suspected mitral stenosis: Validation of a new method. Am Heart J 1987; 113:868-73.
- Pearlman JD, Beller GA, Nygaard TW, Smucker ML, Rothbart RM, Gibson RS. Diagnosis of occult critical aortic stenosis with intravenous infusion of dobutamine. Am J Noninvas Cardiol 1987; 1:134-9.
- Zajicek J, Pearlman JD, Merickel MB, Ayers CR, Brookeman JR, Brown MF. High resolution proton NMR spectra of human arterial plaque. Biochem Biophys Res Comm 1987; 149(2): 437-42.
- Pearlman JD, Zajicek J, Carman CS, Merickel M, Ayers CR, Brookeman JR, Brown MF. High resolution 1H NMR spectral signature from human atheroma. Magn Reson Med 1988; 7(3); 262-79.
- Pearlman JD, Boucher CA. Diagnostic value for coronary artery disease of chest pain during dipyridamole-thallium stress testing. Am J Cardiol 1988; 61(1): 43-5.
- Pearlman JD, Triulzi MO, King ME, Newall J, Weyman AE. Limits of normal left ventricular dimensions in growth and development: analysis of dimensions and variance in the two-dimensional echocardiograms of 268 normal healthy subjects. JACC 1988; 12(6):1432-41.
- Kaul S, Pearlman JD, Touchstone DA, Esquival L. Prevalence and mechanisms of mitral regurgitation in the absence of intrinsic abnormalities of the mitral leaflets. Am Heart J 1989; 118(5 pt 1):963-72.
- Pearlman JD, Zajicek J, Merickel MB, Carman CS, Ayers CR, Brookeman JR, Brown MF. High-resolution H-1-NMR spectral signature from human atheroma. Magn. Reson. Med. 1988; 7(3):262-79.
- Pearlman JD, Hogan RD, Wiske PS, Franklin TD, Weyman AE. Echocardiographic definition of the left ventricular centroid. I. analysis of methods for centroid calculation from a single tomogram. J. Am. Coll. Cardiol. 1990; 16(4):986-92.
- Wiske PS, Pearlman JD, Hogan RD, Franklin TD, Weyman AE. Echocardiographic definition of the left ventricular centroid II: determination of the optimal centroid during systole in normal and infarcted l hearts. J. Am. Coll. Cardiol. 1990; 16(4): 993-9.
- Pearlman JD, Triulzi MO, King ME, Abascal VM, Newell J, Weyman AE. Left atrial dimensions in growth and development: normal limits for two-dimensional echocardiography. J. Am. Coll. Cardiol. 1990; 16(5): 1168-74.
- Pearlman JD, Hardy CJ, Cline HE. Continual NMR cardiography without gating: M-mode MR imaging. Radiology 1990; 175(2): 369-73.
- Pearlman JD, Leavitt M, Newell JB. A priori information in image analysis: assessment of intensity distribution for definition of shape and size of small vessels. IEEE Trans. Med. Imag. 1990; 9(4):461-5.
- Cline HE, Hardy CJ, Pearlman JD. FastMR cardiac profiling with two-dimensional selective pulses. J. Magn. Reson. Med. 1991; 17(2): 390-401.
- Hardy CJ, Pearlman JD, Moore JR, Roemer PB, Cline HE. Rapid NMR cardiography with a half- echo M-mode method. J. Comput. Assist. Tomogr. 1991; 15(5): 868-74.
- Pearlman JD, Southern JF, Ackerman JL. Nuclear magnetic resonance microscopy of atheroma in human coronary arteries. Angiology 1991; 42(9): 726-33.
- Lin JL, Wilber DJ, Du D, Pearlman JD, Ruskin JN, Garan H. Localization of breakthrough site of canine monomorphic ventricular tachycardia by pacemapping. A vectorial approach. Circulation 1991; 84:1319-32.
- Kwong KK, McKinstry RC, Chien D, Crawley AP, Pearlman JD, Rosen BR. CSF-suppressed quantitative single-shot diffusion imaging. Magn. Reson. Med. 1991; 21(1):157-63.
- Pearlman JD, Moore JR, Lizak MJ. Real-time NMR beam-directed velocity mapping: v-mode NMR. Circulation 1992; 86(5): 1433-8.
- Pearlman JD, Badimon JJ. Atherosclerotic plaque detection by nuclear magnetic resonance and radiolabeled autologous low-density lipoprotein. Am J Cardiac Imag 1992; 6(4): 325-32.
- Renshaw PF, Guimaraez AA, Fava H, Rosenbaum JF, Pearlman JD, Flood JG, Puopolo PR, Clancy K, Gonzalez RG. Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration. Am. J. Psychiat. 1992; 149(11): 1592-4.
- Edelman RR, Manning WJ, Pearlman JD, Li W. Human coronary arteries: projection angiograms reconstructed from breath-hold 2-dimensional MR images. Radiology 1993; 187(3): 719-22.
- Johnson LA, Pearlman JD, Miller CA, Young RI, Thulborn KR. MR quantification of cerebral ventricular volume using a semiautomated algorithm. Am. J. Neuroradiol. 1993; 14(6): 1373-8.
- Reese TR, Pearlman JD. NMR gradient response modeling to ensure excitation coherence. J. Magn. Reson. Imaging 1994; 4(4): 569-76.
- Rous C, Coatrieux JL, Dillenseger JL, Fishman EK, Loew M, Meinzer HP, Pearlman JD. Visualization in medicine: VIRTUAL reality or ACTUAL reality? IEEE Visualization, Siggraph, ISSN:1070-2385 1994; 396-399.
- Pearlman JD, Wieczorek TJ. Relaxivity corrected response modulated excitation (RME): a T2- corrected technique achieving specified magnetization patterns from an RF pulse and a time- varying magnetic field. Magn. Reson. Med. 1994; 32(3): 388-95.
- Pearlman JD, Edelman, RR. Ultrafast Magnetic Resonance Imaging: Segmented turboflash, echo-planar, and real-time nuclear magnetic resonance. Cardiac Imaging, Radiol. Clin. N. Am. 1994; 32(3):593-612.
- Pearlman JD, Raptopoulos VD, Kleefield J. 3-dimensional elastic subtraction spiral CT angiography. Radiology 1995; 197:143-4.
- Pearlman JD, Hibberd MG, Chuang ML, Harada K, Lopez JJ, Gladstone SR, Friedman M, Sellke FW, Simons M. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nat Med 1995; 1(10):1085-9.
- Harada K, Friedman M, Lopez JJ, Wang SY, Li J, Prasad PV, Pearlman JD, Edelman ER, Sellke FW, Simons M. Vascular endothelial growth factor administration in chronic myocardial ischemia. Am. J. Physiol.-Heart Circul. Physiol. 1996; 39(5.2):H1791-802.
- Raptopoulos V, Rosen MP, Kent KC, Kuestner LM, Sheiman RG, Pearlman JD. Sequential helical CT angiography of aortoiliac disease. Am. J. Roentgenol. 1996; 166(6): 1347-54.
- Sheiman RG, Raptopoulos V, Caruso P, Vrachliotis TG, Pearlman JD. Comparison of Tailored and Empriric Scan Delays for CT Angiography of the Abdomen. Am. J. Roentgenol. 1996; 167(3):725-9.
- Raptopoulos V, Schwartz RK, McNicholas MMJ, Movson J, Pearlman JD, Joffe N. Multiplanar helical CT enterography in patients with Crohn’s disease. Am. J. Roentgenol. 1997; 169(6):1545-50.
- Pearlman JD, Popitz M, Shorten GD. The development of a multimedia teaching program for fiberoptic intubation. J Clin. Monit. 1997; 13(5):287-91.
- Vrachliotis TG, Pearlman JD, Baltopoulos G, Vrachliotis G, Bellenis I, Tatsis G, Vlahos L, Raptopoulos V. Radiographic determination of total lung capacity in patients with pneumonectomy. J Thorac Imaging 1997; 12(3):212-14.
- Luboldt W, Stehling MK, Pearlman JD, Seemann R, Raptopoulos V. CT-subtraction angiography (CTSA). Results with an automated “elastic” subtraction algorithm. Radiologe 1997; 37(1):89-93.
- Lopez, JJ, Laham RJ, Stamler A, Pearlman JD, Bunting S, Kaplan A, Carrozza JP, Sellke FW, and Simons M, VEGF administration in chronic myocardial ischemia in pigs. Cardiovasc Res, 1998. 40(2): p. 272-81.
- Pearlman JD. Three- (and More) Dimensional Imaging of the Heart, Great Vessels, and Coronary Arteries. American Heart Association: Cardiovascular Radiology 1997; 5-8.
- Pearlman JD, Laham RJ, Simons M, Gladstone S, Raptopoulos V. Extent of myocardial collateralization: Determination with three-dimensional elastic-subtraction spiral CT. Acad Radiol 1997; 4(10):680-6.
- Katz, DB, Pearlman JD, Popitz M, and Shorten GD, The development of a multimedia teaching program for fiberoptic intubation. J Clin Monit, 1997. 13(5): 287-91.
- McNicholas MMJ, Raptopoulos VD, Schwartz RK, Sheiman RG, Zormpala A, Prassopoulos, PK, Ernest RD, Pearlman JD. Excretory-phase CT urography for opacification of the urinary collecting system. Am. J. Roentgenol. 1998; 170(5):1261-7.
- Sellke FW, Laham RJ, Edelman ER, Pearlman JD, Simons M. Therapeutic angiogenesis with basic fibroblast growth factor: Technique and early results. Ann. Thorac. Surg. 1998; 65(6):1540-1544.
- Lopez JJ, Laham RJ, Stamler A, Pearlman JD, Bunting S, Kaplan A, Carrozza JP, Sellke FW, Simons M. VEGF administration in chronic myocardial ischemia in pigs. Cardiovasc. Res. 1998; 40(2):272-81.
- Patel, MR, Blum A, Pearlman JD, Yousuf N, Ives JR, Saeteng S, Schomer DL, and Edelman RR, Echo-planar functional MR imaging of epilepsy with concurrent EEG monitoring. AJNR Am J Neuroradiol, 1999. 20(10): p. 1916-9.
- Laham, RJ, Sellke FW, Edelman ER, Pearlman JD, Ware JA, Brown DL, Gold JP, and Simons M, Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled trial. Circulation, 1999; 100(18): p. 1865-71.
- Laham RJ, Rezaee Mehrdad, Post M, Novicki Deborah, Sellke FW, Pearlman JD, Simons M, and Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces angiogenesis in a porcine model of chronic myocardial ischemia.Journal of Pharmacology Experimental Therapy 2000;292(2) 795-802.
- “http://www.informatik.uni-trier.de/~ley/db/indices/a-tree/h/Heiland:Marc.html” Marc Heiland, Justin D. Pearlman, “http://www.informatik.uni-trier.de/~ley/db/indices/a-tree/p/Post:Marc.html” Marc Post, “http://www.informatik.uni-trier.de/~ley/db/indices/a-tree/m/Meinzer:Hans=Peter.html” Hans-Peter Meinzer: Bewegungsverfolgung des schlagenden Herzens an hyperfein-getaggten, schichtverfolgenden CSPAMM Aufnahmen. “http://www.informatik.uni-trier.de/~ley/db/conf/bildmed/bildmed2000.html” \l “HeilandPPM00” Bildverarbeitung für die Medizin 2000: 282-286
- Sato K, Laham RJ, Pearlman JD, Novicki D, Sellke FW, Simons M, and Post MJ, Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. Ann Thorac Surg, 2000. 70(6): 2113-8.
- Pearlman JD, Laham RJ, and Simons M. Coronary Angiogenesis: Detection in vivo with MR imaging sensitive to collateral neocirculation- preliminary study in pigs. Radiology 2000; 214:801-807.
- Laham RJ, Chronos NA, Pike M, Leimbach ME, Udelson JE, Pearlman JD, Pettigrew RI, Whitehouse MJ, Yoshizawa C, and Simons M, Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a phase I open-label dose escalation study. J Am Coll Cardiol 2000. 36(7): 2132-9.
- Pearlman JD, Gertz ZM, Wu Y, Simons M, and Post MJ, Serial motion assessment by reference tracking (SMART): application to detection of local functional impact of chronic myocardial ischemia. J Comput Assist Tomogr 2001. 25(4): 558-62.
- Laham RJ, Simons M, Pearlman JD, Ho KK, Baim DS, Magnetic resonance imaging demonstrates improved regional systolic wall motion and thickening and myocardial perfusion of myocardial territories treated by laser myocardial revascularization, J Am Coll Cardiol. 2002 Jan 2;39(1):1-8.
- Pearlman JD, Laham RJ, Post M, Leiner T, Simons M, Medical imaging techniques in the evaluation of strategies for therapeutic angiogenesis, Curr Pharm Des. 2002;8(16):1467-96.
- Foote RS and Pearlman JD, B-type natriuretic peptide in heart failure. N Engl J Med, 12Dec2002. 347(24): p. 1976-8 (Ltr/reply).
- Foote RS, Pearlman JD, Siegel AH, and Yeo KT, 2004, Detection of Exercise-Induced Ischemia by Changes in B-type Natriuretic Peptides. J Am Coll Cardiol. 2004 Nov 16;44(10):1980-7.
- Baklanov, EDD, Thompson CA, Xu Y, Moodie KL, Gao L, Zarovnaya EL, and Pearlman JD. Novel double contrast MRI technique for intramyocardial detection of percutaneously transplanted autologous cells. Mag. Reson. Med. 2004 Dec;52(6):1438-42.
- Wang Y, Makedon F, Ford J, and Pearlman JD, A hybrid approach for selecting marker genes for phenotype classification using microarray gene expression data, Bioinformatics 2004 Dec 7 (epub ahead of print).
- Yuhang Wang, Fillia Makedon, and Pearlman JD. Machine Learning Models For Cancer Classification Using Loss of Heterozygosity Data Derived from SNP Arrays. 2005
- Jianfeng Qin, Thomas W. Chittenden TW, Ling Gao, Pearlman JD. Automated migration analysis based on cell texture: method & reliability. BMC Cell Biol, 2005. 6(1): p. 9.
- “http://www.informatik.uni-trier.de/~ley/db/indices/a-tree/w/Wang:Yuhang.html” Yuhang Wang, “http://www.informatik.uni-trier.de/~ley/db/indices/a-tree/m/Makedon:Fillia.html” Fillia Makedon, “http://www.informatik.uni-trier.de/~ley/db/indices/a-tree/f/Ford:James_C=.html” James C. Ford, Justin D. Pearlman: HykGene: a hybrid approach for selecting marker genes for phenotype classification using microarray gene expression data. “http://www.informatik.uni-trier.de/~ley/db/journals/bioinformatics/bioinformatics21.html” \l “WangMFP05” Bioinformatics 21(8): 1530-1537 (2005)
- Huang H, Ford J, Gao L, and Pearlman JD, Early Lung Cancer Detection Based on Registered Perfusion MRI, “javascript:AL_get(this,%20’jour’,%20’Oncol%20Rep.’);” Oncol Rep. 2006;15 Spec no.:1081-4.
- Li Shen, Wei Zheng, Ling Gao, Heng Huang, Fillia Makedon, Pearlman JD. Spatio-Temporal Modeling of Lung Images for Cancer Detection. “javascript:AL_get(this,%20’jour’,%20’Oncol%20Rep.’);” Oncol Rep. 2006;15 Spec no.:1085-9.
- Yuhang Wang, Makedon F, and Pearlman JD, Tumor Classification based on DNA Copy Number Aberrations Determined using SNP Arrays: Oncology Reports, 15:1057-1061, 2006.
- Helisch, A., S. Wagner, N. Khan, M. Drinane, S. Wolfram, M. Heil, T. Ziegelhoeffer, U. Brandt, J.D. Pearlman, H.M. Swartz, and W. Schaper, Impact of mouse strain differences in innate hindlimb collateral vasculature. Arterioscler Thromb Vasc Biol, 2006. 26(3): p. 520-6.
- Post, M.J., K. Sato, M. Murakami, J. Bao, D. Tirziu, J.D. Pearlman, and M. Simons, Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation. Am J Physiol Regul Integr Comp Physiol, 2006. 290(3): p. R494-500.
- Zhuang, Z.W., L. Gao, M. Murakami, J.D. Pearlman, T.J. Sackett, M. Simons, and E.D. de Muinck, Arteriogenesis: noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents. Radiology, 2006. 240(3): p. 698-707.
- Chittenden T.W.; J.A Sherman, A.E. Hall, A.A. Lanahan, J.D. Pearlman, J. H. Moore; S. Schwartz; F. Xiong; Jennit; Taylor JM, M. Simons; Transcriptional Profiling in Coronary Artery Disease: Indications for Novel Markers of Coronary Collateralization. Circulation (In Press)
- Li Shen, Wei Zheng, Ling Gao, Heng Huang, Fillia Makedon, and Justin Pearlman. Spatio-Temporal Modeling of Lung Images for Cancer Detection. International Journal of Oncology, Volume 15, 1085-1089, 2005.
- Heng Huang, Li Shen, James Ford, Ling Gao, Justin Pearlman. Early lung cancer detection based on registered perfusion MRI. International Journal of Oncology, Volume 15, 1080-1084, 2005.
- Heng Huang, Li Shen, Fillia Makedon, Bruce Hettleman, Justin Pearlman. “http://www.sciencedirect.com/science ” Cardiac Motion Analysis to Improve Pacing Site Selection in CRT, Academic Radiology, Elsevier Science, Volume 13, Issue 9, Pages 1124-1134, September 2006.
- Heng Huang, Li Shen, Fillia Makedon, Bruce Hettleman, Justin Pearlman. A Novel Surface Registration Algorithm with Biomedical Modeling Applications, IEEE Transactions on Information Technology in BioMedicine, accepted to appear, 2006.
- Li Shen, Wei Zheng, Ling Gao, Heng Huang, Fillia Makedon, and Justin Pearlman. Spatio-Temporal Modeling of Lung Images for Cancer Detection. “http://www.spandidos.com/OR.htm” Oncology Reports, Special Issue on Computational Analysis and Decision Support Systems in Oncology, 15:1085-1090, 2006.
Books, Book Chapters and Monographs:
- Genant HK, Pearlman JD. Nuclear magnetic resonance. In: Advancements in medical diagnosis. Merck, Sharp and Dohme (monograph), 1985.
- Pearlman JD, Miller D, Kantor HL. Nuclear magnetic resonance spectroscopy: current and future application for cardiovascular disease. In: Miller D, ed. Clinical cardiac imaging. New York: McGraw-Hill Book Company, 1988: (VIII) 127-45.
- Pearlman JD. NMR imaging and spectroscopy studies of the coronary arteries: I. Multidimensional imaging of atheromatous changes. In: Sideman S, Beyar R, eds. Image analyses and simulation of the cardiac system. London: Freund Publishing House, 1990:439-51. (Proceedings of the 5th Henry Goldberg Workshop on Analysis and Simulation of the Cardiac System.)
- Pearlman JD. NMR imaging and spectroscopy studies of the coronary arteries: II. 3-D reconstruction of in vivo coronary arteries. In: Sideman S, Beyar R (eds.). Image analysis and simulation of the cardiac system. London: Freund Publishing House, 1990:451-64. (Proceedings of the 5th Henry Goldberg Workshop on Analysis and Simulation of the Cardiac System.)
- Pearlman JD, Weyman AE. Tissue characterization with ultrasound. In: Weyman AE (ed.). Principals and practice of echocardiography. Malvern, PA: Lea & Febiger Company, 1991; (40).
- Pearlman JD, Edelman RR. Ultrafast magnetic resonance imaging: segmented turboFLASH, echo-planar, and real-time NMR. In: Radiologic Clinics of North America. Philadelphia: W. B. Saunders Company, 1994; 32:593-612.
- Pearlman JD, Gao L, Simons M. Magnetic Resonance Imaging of Angiogenesis. In: Fuster D, Chronos, eds. Cardiovascular Magnetic Resonance, Established and Emerging Applications. London and New Yorlk: Martin Dunitz Ltd, Taylor and Francis Group plc; 2003.
- Pearlman JD. Imaging Angiogenesis: A Guide for Clinical Management and Therapeutic Trials. In: Laham RJ, Baim DS, eds. Angiogenesis and Direct Myocardial Revascularization. Totowa, New Jersey: The Humana Press Inc; 2004.
- Pearlman JD. Coronary Artery Disease. IN: EMedicine “http://www.emedicine.com/radio/topic192.htm” http://www.emedicine.com/radio/topic192.htm ) Updated 7Oct2005. Eds: Hrudaya Nath, Bernard D Coombs, John D Newell, Jr, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE
- Pearlman JD, Kahn A, Tsapakos M. Colon Polyps. In: EMedicine ( “http://www.emedicine.com/radio/topic185.htm” http://www.emedicine.com/radio/topic185.htm ) Updated 7Mar2005. Eds: Pamela DiPiro, Bernard Coombs, A Dachman, R Krasny, E Lin. Published by eMedicine.com, Inc. Omaha, NE
- Masato Okada, “http://www.emedicine.com/cgi-bin/foxweb.exe/screen@d:/em/ga?book=med&authorid=5714&topicid=158” Justin D Pearlman. Aortitis. In: EMedicine ( “http://www.emedicine.com/med/topic158.htm” http://www.emedicine.com/med/topic158.htm ) Updated 12Nov05. Eds. Russell F Kelly, Francisco Talavera, PharmD, Ronald J Oudiz, Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE
- Pearlman JD. Coronary Artery Disease. IN: EMedicine ( “http://www.emedicine.com/radio/topic192.htm” http://www.emedicine.com/radio/topic192.htm ) Updated 27Oct2008. Eds: Hrudaya Nath, Bernard D Coombs, John D Newell, Jr, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE
Book Chapters as Editor:
- Walter A Tan, David J Moliterno. Unstable Angina. In: EMedicine “http://www.emedicine.com/med/topic2606.htm” http://www.emedicine.com/med/topic2606.htm ) Updated 24Aug2005. Eds: Justin D Pearlman; Francisco Talavera, PharmD,; Marschall S Runge; Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE
- Steven R Klepac, Evan J Samett. Cardiac MRI – Technical Aspects Primer In: EMedicine ( “http://www.emedicine.com/radio/topic866.htm” http://www.emedicine.com/radio/topic866.htm ) Updated 14Jul2005. Eds: Justin D Pearlman, Bernard D Coombs, Lawrence M Boxt, Robert M Krasny Charles S White. Published by eMedicine.com, Inc. Omaha, NE
- Vibhuti N Singh, Rakesh K Sharma, Navin C Nanda, Hanumanth K Reddy,Joel A Strom Aortic Regurgitation In: EMedicine ( “http://www.emedicine.com/radio/topic45.htm” http://www.emedicine.com/radio/topic45.htm ) Updated 4May2005. Eds: Justin D Pearlman, Bernard D Coombs, Robert M Steiner, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE
- Li Zhou, Spencer Rosero, James P Daubert,David Huang, Hongsheng Guo. Atrial Tachycardia. In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” http://www.emedicine.com/med/topic188.htm) updated 21Nov2004. Editors: Justin D Pearlman, Francisco Talavera, Brian Olshansky, Amer Suleman, Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- Allan H Andrews, Kent C Holtzmuller, Allen J Taylor. Cardiac Cirrhosis In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic275.htm” http://www.emedicine.com/med/topic275.htm ) updated 2Sept2004. Editors: Justin D Pearlman, Francisco Talavera, Ronald J Oudiz, Amer Suleman, MMichael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE.
- Julia Gates,George G Hartnell. Cardiac Tumors In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic66.htm” http://www.emedicine.com/radio/topic66.htm ) updated 29Jul2005. Editors: Justin D Pearlman, Bernard D Coombs, John D Newell Jr, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE.
- Haroon R Afridi, George G Hartnell. Cardiomyopathy, Dilated In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic128.htm” http://www.emedicine.com/radio/topic128.htm ) updated 10Feb2005. Editors: Justin D Pearlman, Bernard D Coombs, Michael R Rees, Robert M Krasny, Eugene C Lin. Published by eMedicine.com, Inc. Omaha, NE.
- Diwaker Agarwal, George G Hartnell. Cardiomyopathy, Hypertrophic In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic129.htm” http://www.emedicine.com/radio/topic129.htm ) updated 24Apr2003. Editors: Justin D Pearlman, Bernard D Coombs, Michael R Rees, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE.
- Elizabeth McGuigan. Cardiomyopathy, Restrictive In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic130.htm” http://www.emedicine.com/radio/topic130.htm ) updated 9Feb2005. Editors: Justin D Pearlman, Bernard D Coombs, Michael R Rees, Robert M Krasny, Eugene C Lin. Published by eMedicine.com, Inc. Omaha, NE.
- Craig T Basson, Carl J Vaughan. Carney Complex In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2941.htm” http://www.emedicine.com/med/topic2941.htm ) updated 10Jun2005. Editors: Justin D Pearlman, Francisco Talavera, Frank M Sheridan, Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE.
- John S To. Constrictive Pericarditis In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic191.htm” http://www.emedicine.com/radio/topic191.htm ) updated 26Aug2005. Editors: Justin D Pearlman, Bernard D Coombs, Robert M Steiner, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE.
- J Bayne Selby Jr, Michael Assey. Coronary Artery Calcification – CT In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic865.htm” http://www.emedicine.com/radio/topic865.htm ) updated 28Jan2004. Editors: Justin D Pearlman, Bernard D Coombs, John D Newell Jr, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE.
- Noel G. Boyle. Diagnostic Programmed Electrical Stimulation In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic865.htm” http://www.emedicine.com/radio/topic865.htm ). Editors: Justin D Pearlman, Francisco Talavera, Steven J Compton, Amer Suleman, Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- Vinod Patel, Paul James,Thomas Smith. Digitalis Toxicity In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic568.htm” http://www.emedicine.com/med/topic568.htm ) updated 3Aug2004. Editors: Justin D Pearlman, Francisco Talavera, Ronald J Oudiz, Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE.
- Leonard Ganz. Implantable Cardioverter/Defibrillators In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic3386.htm” http://www.emedicine.com/med/topic3386.htm ) updated 28Oct2004. Editors: Justin D Pearlman, Francisco Talavera, Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE.
- Wojciech Zareba, Spencer Rosero. Long QT Syndrome In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic1983.htm” http://www.emedicine.com/med/topic1983.htm ) updated 10Jun2005. Editors: Justin D Pearlman, Brian Olshansky, Amer Suleman, Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- Daniel M Beyerbach, Christopher Cadman. Lown-Ganong-Levine Syndrome In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2954.htm” http://www.emedicine.com/med/topic2954.htm ) updated 28Oct2004. Editors: Justin D Pearlman, Francisco Talavera, Frank M Sheridan, Amer Suleman, Leonard Ganz Published by eMedicine.com, Inc. Omaha, NE.
- Adam E Schussheim. Mitral Valve Prolapse In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic1484.htm” http://www.emedicine.com/med/topic1484.htm ) updated 21Nov2004. Editors: Justin D Pearlman, Francisco Talavera,Marschall S Runge, Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE.
- Vijai V Chauhan, Antonella Quattromani. Pacemaker Crosstalk In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2920.htm” http://www.emedicine.com/med/topic2920.htm ) updated 1Nov2005. Editors: Justin D Pearlman, Francisco Talavera, Brian Olshansky, Amer Suleman, Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- Noel G Boyle. Pacemaker-Mediated Tachycardia In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2918.htm” http://www.emedicine.com/med/topic2918.htm ). Editors: Justin D Pearlman, Francisco Talavera, Brian Olshansky, Amer Suleman, Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- William J Strimel, Susan Noe. Pericardial Effusion In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic1786.htm” http://www.emedicine.com/med/topic1786.htm ) updated 4May2005. Editors: Justin D Pearlman, Francisco Talavera, Ronald J Oudiz, Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE.
- Hongsheng Guo. Programmed Electrical Stimulation In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic3578.htm” http://www.emedicine.com/med/topic3578.htm ) updated 21Nov2005. Editors: Justin D Pearlman, Francisco Talavera, Brian Olshansky, Amer Suleman, Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- Mark L Greenberg, Arvind Chandrakantan. Radiofrequency Catheter Ablation In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” http://www.emedicine.com/med/topic2957.htm” http://www.emedicine.com/med/topic2957.htm ) updated 26Aug2005. Editors: Justin D Pearlman, Francisco Talavera, Brian Olshansky, Amer Suleman, Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- Adrian W Messerli, Alan D Forker. Sinus Node Dysfunction In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2132.htm” http://www.emedicine.com/med/topic2132.htm ) updated 2Jun2005. Editors: Justin D Pearlman, Francisco Talavera, Brian Olshansky, Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE.
- S Bruce Greenberg. Tetralogy of Fallot In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic685.htm” http://www.emedicine.com/radio/topic685.htm ) updated 27Oct2004. Editors: Justin D Pearlman, Bernard D Coombs, Michael R Rees, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE.
- Syed Nazeer, Abraham Kocheril, Saim Maqsood, Mateen A Awan, Jatin Dave. Torsade de Pointes In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2286.htm” http://www.emedicine.com/med/topic2286.htm ) updated 6Jul2005. Editors: Justin D Pearlman, Francisco Talavera, Brian Olshansky, Amer Suleman,Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- David Akinpelu, Sarath Reddy, Javier M Gonzalez. Treadmill and Pharmacologic Stress Testing In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2961.htm” http://www.emedicine.com/med/topic2961.htm ) updated 21Mar2003. Editors: Justin D Pearlman, Francisco Talavera, Ronald J Oudiz, Amer Suleman, Michael E Zevitz. Published by eMedicine.com, Inc. Omaha, NE.
- Vibhuti N Singh, Rakesh K Sharma, Hanumanth K Reddy, Navin C Nanda. Ventricular Septal Defect In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/radio/topic740.htm” http://www.emedicine.com/radio/topic740.htm ) updated 25Nov2004. Editors: Justin D Pearlman, Bernard D Coombs, John D Newell Jr, Robert M Krasny, Charles S White. Published by eMedicine.com, Inc. Omaha, NE.
- Steven J Compton. Ventricular Tachycardia In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2367.htm” http://www.emedicine.com/med/topic2367.htm ) updated 26Sept2005. Editors: Justin D Pearlman, Francisco Talavera, Brian Olshansky, Amer Suleman, Leonard Ganz. Published by eMedicine.com, Inc. Omaha, NE.
- Vibhuti N Singh, Kul B Aggarwal. Myocardial Infarct, Acute In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2367.htm” http://www.emedicine.com/med/topic2367.htm ) updated 6Mar2006. Editors: Justin D Pearlman, Bernard D Coombs, J Bayne Selby Jr, Robert M Krasny, James F Gruden. Published by eMedicine.com, Inc. Omaha, NE.
- Vibhuti N Singh, Joel A Strom. Ventricular Aneurysms In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2367.htm” http://www.emedicine.com/med/topic2367.htm ) updated 6Mar2006. Editors: Justin D Pearlman, Bernard D Coombs, J Bayne Selby Jr, Robert M Krasny, James F Gruden. Published by eMedicine.com, Inc. Omaha, NE.
- Vibhuti N Singh, Joel A Strom. Ventricular Aneurysms In: EMedicine ( “http://www.emedicine.com/med/topic188.htm” “http://www.emedicine.com/med/topic2367.htm” http://www.emedicine.com/med/topic2367.htm ) updated 30-Oct-2008. Editors: Justin D Pearlman, Bernard D Coombs, J Bayne Selby Jr, Robert M Krasny, James F Gruden. Published by eMedicine.com, Inc. Omaha, NE.
- Tamam N Mohamad, Hesham A Fakhri, John D Dingell, Juan M Bernal, Deepak Thatai John D Dingell. Cardiovascular Disease and Pregnancy. Emedicine. Authors working on revisions. Updated: Feb 10, 2012 Editors: Justin D Pearlman, MD, PhD, ME, MA, Francisco Talavera, PharmD, PhD, Ronald J Oudiz, MD, Amer Suleman, MD, Sidney C Smith Jr, MD
- Stanley S Wang, MD, JD, MPH. Metabolic Syndrome. Updated: Apr 1, 2013 Editors Justin D. Pearlman ME ME PhD MA, Francisco Talavera, PharmD PhD, Ronald J Oudiz, MD, FACP, FACC Amer Suleman, MD, Sidney C Smith Jr, MD
- Bhavik V Thakkar, MD, Adam E Schussheim, MD. Mitral Valve Prolapse. Updated: Apr 15, 2013. Specialty Editor Board Justin D Pearlman, MD, ME, PhD, FACC, MA, Francisco Talavera, PharmD, PhD, Marschall S Runge, MD, PhD, Amer Suleman, MD, Richard A Lange, MD
- Mark L. Greenberg MD, Arvind Chandrakantan, MD. Catheter Ablation. Updated April 12, 2013. Specialty Editor Board: Justin D Pearlman, MD, ME, PhD, FACC, MA Francisco Talavera, PharmD, PhD, Brian Olshansky, MD, Jeffrey N Rottman, MD
Other Material Presentations (multipage peer reviewed proceedings & abstracts):
- Chuang M, Pearlman JD. Accurate model-independent determination of cardiac volumes. Computer Applications to Assist Radiology. In: JM Boehme, AH Rowberg and NT Wolfman (eds.) Proceedings of S/CAR-94, Symposia Foundation, Carlsbad, CA, 1994; 141-6.
- Wieczorek TJ, Dolan RP, Pearlman JD. Interactive control of excitation for real time magnetic resonance imaging. Computer Applications to Assist Radiology. In: JM Boehme, AH Rowberg and NT Wolfman (eds.) Proceedings of S/CAR-94, Symposia Foundation, Carlsbad, CA, 1994.
- ” Christian Roux, Jean-Louis Coatrieux, Jean-Louis Dillenseger, Elliot K. Fishman, Murray H. Loew, Hans-Peter Meinzer, Justin D. Pearlman: Visualization in Medicine: VIRTUAL Reality or ACTUAL Reality? (Panel). “http://www.informatik.unitrier.de/~ley/db/conf/visualization/visualization1994.html” \l “RouxCDFLMP94” IEEE Visualization 1994: 396-399
- Nahum D. Gershon, Richard Mark Friedhoff, John Gass, Robert Langridge, Hans-Peter Meinzer, Justin D. Pearlman: Is visualization REALLY necessary?: the role of visualization in science, engineering, and medicine. “http://www.informatik.unitrier.de/~ley/db/conf/siggraph/siggraph1994.html” \l “GershonFGLMP94” SIGGRAPH 1994: 499-500
- Pearlman JD, Chuang ML. Rapid determination of ejection fraction. presented at the First World Congress on Computational Medicine, Public Health and Biotechnology, Univ. of Texas, CHPC, Austin, TX, April 1994.
- Pearlman JD, Chuang M, Schulz RA, Geil G. Computer segmentation of complex 3D structures for holographic visualization. Computer Applications to Assist Radiology, Proceedings of S/CAR-94, JM Boehme, AH Rowberg and NT Wolfman (eds.)1994, 775-6, Symposia Foundation, Carlsbad, CA.
- Pearlman JD, Gazit Y. Accurate Quantitation of Atheroma Inside Arterial Walls by 1H-NMR In: Woodford FP, Davignon J, Sniderman A, eds. Atherosclerosis X: Proceedings of the 10th International Symposium on Atherosclerosis (Montreal, Canada, October 9-14, 1994). Elsevier 1995; 1066:1008-17.
- Pearlman JD. Three- and Four-Dimensional Visualization of the Coronary Artery Tree from Standardized Magnetic Resonance Angiography by Interactive Computer Tools and Volumetric Holography. In: Woodford FP, Davignon J, Sniderman A, eds. Atherosclerosis X: Proceedings of the 10th International Symposium on Atherosclerosis (Montreal, Canada, October 9-14, 1994). Elsevier 1995; 1002-7.
- Pearlman JD. Visualization in Medicine: Multidimensional Object Presentation Methods for Computer Displays and Volume Holography. Proc. of Biomedical Visualization 1995, IEEE Computer Society Press, Los Alamitos, CA 1996; 66-78.
- Pearlman JD and Yaseen ZS: Multiplexed space-time maps for time-series data visualization: application to 4-D cardiac imaging. SPIE, The International Society for Optical Engineering, Proceedings of Annual Meeting, San Jose, CA, January 26, 1998.
- Pearlman JD and Yaseen ZS: Time series visualization by multiple view reductive decomposition for rapid diagnostics. SPIE, The International Society for Optical Engineering, Proceedings of Annual Meeting, San Jose, CA, January 26, 1998.
- Pearlman JD and Yaseen ZS: Multiview reductive decomposition.” Proceedings of SPIE, The International Society for Optical Engineering: Visual Data Exploration and Analysis V. Annual Meeting at San Jose, CA, January 26, 1998; [3298-19]: 134-44.
- Pearlman JD and Sukhatme VV: High-resolution atheroma mixture-modeled MRI. Proceedings of SPIE, The International Society for Optical Engineering: Visual Data Exploration and Analysis V. Annual Meeting at San Jose, CA, January 26, 1998; [3298-28]:229-38.
- Pearlman JD and Sukhatme VV: Visually assisted identification of components in complex 1H-NMR data series: application to early detection and monitoring of atherosclerosis. SPIE, The International Society for Optical Engineering, Proceedings of Annual Meeting, San Jose, CA, January 27, 1998.
- Heiland M, Pearlman JD, Post M, and Meinzer H-P, Bewegungsverfolgung des schlagenden Herzens an hyperfein-getaggten, schichtverfolgenden CSPAMM Aufnahmen. Bildverarbeitung für die Medizin 2000: 282-286.
- Wu Y, Post MJ, Datta R, Gao L, and Pearlman JD. Identification of optimal parameters for first-pass cardiac MRI perfusion measurement by Receiver Operating Characteristic analysis, 73rd scientific session, New Orleans, LA, November 2000.
- Moodie, K. L., B. E. Arbuckle, R. T. Palac, Pearlman JD, L. Gao, J. E. Tomaszewski, S. A. Lewis and E. d. Muinck. Acute Myocardial Infarction in the Investigation of Autologous Cell Transplant to improve Left Venticular Function in Swine. In: 54th AALAS National Meeting; 2003; Seattle Washington: University of Missouri; 2003.
- Makedon, F., A. A. Tzika, L. Astrakas, Pearlman JD, Y. Wang, T. Steinberg, L. Shen, K. Chambers, and J. Ford, Fusing information for tracking tumors: International Journal of Molecular Medicine, 2003, v. 12, p. S77.
- Fillia Makedon, A. Aria Tzika, Loukas Astrakas, Justin Pearlman, Yuhang Wang, Tilmann Steinberg, Li Shen, Kristen Chambers, and James Ford. Fusing information for tracking tumors. In The 8th World Congress on Advances in Oncology and 6th International Symposium on Molecular Medicine, Hersonissos, Crete, Greece, October, 2003.
- Fillia Makedon, A. A. Tzika, L. Astrakas, Justin Pearlman, Yuhang Wang, Tilmann Steinberg, Li Shen, Kristen Chambers, James Ford. Fusing information for tracking tumors. The 8th World Congress on Advances in Oncology and 6th International Symposium on Molecular Medicine, October 16-18, 2003, Creta Maris Hotel, Hersonissos, Crete, Greece.
- Heng Huang, Pearlman JD, Li Shen, Ling Gao, Fillia S. Makedon. Three-Dimensional Analysis of Cardiac Magnetic Resonance Imaging Using Spherical Hamonics. Featured Poster. American College of Cardiology 53rd Annual Scientific Session, New Orleans, 9 Mar 2004.
- Fei Xiong, Tilmann Steinberg, Filia S. Makedon, Bruce D. Hettleman, Alan T. Kono, Pearlman JD. Secure Heart Failure Database Development and Data Sharing. Special Topics. American College of Cardiology 53rd Annual Scientific Session, New Orleans, 7 Mar 2004.
- Pearlman JD, L. Gao, et al. Trans-Esophageal Cardiac MRI: Initial Clinical Experience. 12th ISMRM Scientific Meeting and Exhibition, Kyoto, Japan, ISMRM. 2004.
- Makedon, F., C. B. Owen, C. Sudborough, S. Kapidakis, P. Gloor, C. Heckman, J. Ford, and Pearlman JD, 2004, The ethical dilemma of data sharing under risk: ETHICOMP 2004, p. 594-608, Syros, Greece, April 14-16, 2004.
- Zhifeng Wang, Y. X., James C. Ford, Fillia S. Makedon, Zhenwu Zhuang, Ling Gao, and Pearlman JD. An Adaptive Approach for Image Subtraction. 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California, September 1, 2004.
- Huang H, Makedon FS, Pearlman JD, Ford JC, Shen L, Wang Y, and Gao L. Efficient Similarity Retrieval Framework for Temporal Shape Sequences: A Case Study in Cardiac MR Images. 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California September 1, 2004.
- Fei Xiong, Kefei Cao, Zhifeng Wang, James Ford, Fillia Makedon, and Pearlman JD, An Extensible Framework for Sharing Clinical Guidelines and Services, 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California September 1, 2004.
- Yurong Xu, Zhifeng Wang, Fillia S. Makedon, and Pearlman JD, BP-Neural Network based- characterization of Electrographic Magnetohydrodynamic Signals in MR, 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California September 1, 2004.
- Heng Huang, Li Shen, Fillia S. Makedon, Ling Gao, and Justin Pearlman. Three-dimensional analysis of cardiac magnetic resonance imaging using spherical harmonics model. In ACC’04: Annual Scientific Session of the American College of Cardiology, New Orleans, March 7-10, 2004.
- Heng Huang, Fillia Makedon, Justin Pearlman, James Ford, Li Shen, Yuhang Wang, and Ling Gao. Efficient similarity retrieval framework for temporal shape sequences: A case study in cardiac MR images. In Proc. 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California, September 1, 2004.
- Heng Huang, Fillia Makedon, Justin Pearlman, James Ford, Li Shen, Yuhang Wang, and Ling Gao. “http://ieeexplore.ieee.org/xpl/absprintf.jsp?arnumber=1403914&page=FREE” Efficient similarity retrieval framework for temporal shape sequences: A case study in cardiac MR images. Proc. 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California, September 1, 2004.
- Li Shen, Ling Gao, Zhenwu Zhuang, Ebo DeMuinck, Fillia Makedon, Pearlman J. An Interactive 3D Visualization and Manipulation Tool for Effective Assessment of Angiogenesis and Arteriogenesis using Computed Tomographic Angiography. In: IS&T/SPIE 17th annual symposium Electronic Imaging: Science and Technology; 2005 1/16/-1/20/; San Jose, California, USA; 2005
- Huang H, Shen L, Ford JC, Makedon F, Gao L, and Pearlman JD, Functional Analysis of Cardiac MR Images using SPHARM Modeling, Proc. of SPIE Medical Imaging 2005: Image Processing, 2005 1/16/-1/20/; San Jose, California, USA; 2005
- Huang H, Shen L, Makedon F, Zhang S, Greenberg M, Gao L, and Pearlman JD, A Clustering-based Approach for Prediction of Cardiac Resynchronization Therapy, Proc. of the 20th Annual ACM Symposium on Applied Computing, Computer Applications in Health Care (CACH) track, SAC 2005 20th ACM Symposium on Applied Computing, Santa Fe, New Mexico, March 13-17, 2005.
- Li Shen, Wei Zheng, Ling Gao, Heng Huang, Fillia Makedon, Pearlman JD. Modeling Time-Intensity Profiles for Pulmonary Nodules in MR Images. In: The 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society; 2005; Shanghai, China: to be appear; 2005.
- Heng Huang, Li Shen, Rong Zhang, Fillia Makedon, Bruce Hettleman, Justin D. Pearlman: A Prediction Framework for Cardiac Resynchronization Therapy Via 4D Cardiac Motion Analysis. “http://www.informatik.uni-trier.de/~ley/db/conf/miccai/miccai2005-1.html” \l “HuangSZMHP05a” MICCAI 2005: 704-711
- Heng Huang, Li Shen, Fillia Makedon, Sheng Zhang, Mark Greenberg, Ling Gao, Justin D. Pearlman: A clustering-based approach for prediction of cardiac resynchronization therapy. “http://www.informatik.uni-trier.de/~ley/db/conf/sac/sac2005.html” \l “HuangSMZGGP05” SAC 2005: 260-266
- Heng Huang, Li Shen, James Ford, Fillia Makedon, Ling Gao, and Justin Pearlman. Functional analysis of cardiac MR images using spharm modeling. In SPIE Medical Imaging 2005: Image Processing, San Diego, California, February 12-17, 2005.
- Li Shen, Ling Gao, Zhenwu Zhuang, Ebo DeMuinck, Heng Huang, Fillia Makedon, and Justin Pearlman. An interactive 3d visualization and manipulation tool for effective assessment of angiogenesis and arteriogenesis using computed tomographic angiography. In SPIE Medical Imaging 2005: Visualization, Image-Guided Procedures, and Display, San Diego, California, February 12-17, 2005.
- Heng Huang, Li Shen, Fillia Makedon, Bruce Hettleman, Justin Pearlman. A Prediction Framework for Cardiac Resynchronization Therapy via 4D Cardiac Motion Analysis. MICCAI 2005: 8th International Conference on Medical Image Computing and Computer Assisted Intervention, Palm Springs, California, USA Oct 26-29, 2005.
- Heng Huang, Li Shen, Fillia Makedon, Bruce Hettleman, Justin Pearlman. Surface Alignment of 3D Spherical Harmonic Models: Application to Cardiac MRI Analysis. MICCAI 2005: 8th International Conference on Medical Image Computing and Computer Assisted Intervention, Palm Springs, California, USA Oct 26-29, 2005.
- Li Shen, Wei Zheng, Ling Gao, Heng Huang, Fillia Makedon, and Justin Pearlman. Modeling Time-Intensity Profiles for Pulmonary Nodules in MR Images. EMBS 2005: The 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Shanghai, China, September 1-4, 2005.
- Heng Huang, Li Shen, James Ford, and Ling Gao, Fillia Makedon, and Justin Pearlman. “Fast surface alignment of 3D spherical harmonic models”. CVPR 2005
- Heng Huang, Fei Xiong, Fillia Makedon, Li Shen, Bruce Hettleman, Justin Pearlman. K-means+ Method for Improving Gene Selection for Classification of Microarray Data. CSB 2005: IEEE Computational Systems Bioinformatics Conference, pp 110-111, Stanford, California, Aug 8-11, 2005.
- Li Shen, Ling Gao, Zhenwu Zhuang, Ebo DeMuinck, Heng Huang, Fillia Makedon, and Justin Pearlman. “http://www.cis.umassd.edu/~lshen/papers/shen_2005mi.pdf” An interactive 3D visualization and manipulation tool for effective assessment of angiogenesis and arteriogenesis using computed tomographic angiography. SPIE Medical Imaging 2005, San Diego, California, February 2005.
- Sheng Zhang, Weihong Wang, James Ford, Fillia Makedon, Justin D. Pearlman: Using Singular Value Decomposition Approximation for Collaborative Filtering. “http://www.informatik.uni-trier.de/~ley/db/conf/wecwis/cec2005.html” \l “ZhangWFMP05” CEC 2005: 257-264
- Heng Huang, Li Shen, James Ford, Fillia Makedon, Ling Gao, and Justin Pearlman. Functional analysis of cardiac MR images using SPHARM modeling. SPIE Medical Imaging 2005, San Diego, California, February 2005.
- Heng Huang, Li Shen, Rong Zhang, Fillia Makedon, Bruce Hettleman, Justin D. Pearlman: Surface Alignment of 3D Spherical Harmonic Models: Application to Cardiac MRI Analysis. “http://www.informatik.uni-trier.de/~ley/db/conf/miccai/miccai2005-1.html” \l “HuangSZMHP05” MICCAI 2005: 67-74.
- Fei Xiong, Heng Huang, James C. Ford, Fillia Makedon, Justin D. Pearlman: A New Test System for Stability Measurement of Marker Gene Selection in DNA Microarray Data Analysis. “http://www.informatik.uni-trier.de/~ley/db/conf/pci/pci2005.html” \l “XiongHFMP05” Panhellenic Conference on Informatics 2005: 437-447
- Heng Huang, Rong Zhang, Fei Xiong, Fillia Makedon, Li Shen, Bruce Hettleman, Justin D. Pearlman: K-means+ Method for Improving Gene Selection for Classification of Microarray Data. “http://www.informatik.uni-trier.de/~ley/db/conf/csb/csbw2005.html” \l “HuangZXMSHP05” CSB Workshops 2005: 110-111.
- Wei Zheng, Zhifeng Wang, Li Shen, Fillia Makedon, and Justin Pearlman. Measuring Blood Delivery to Solitary Pulmonary Nodule by Perfusion Magnetic Resonance Imaging. SPIE Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, San Diego, California, February 2006.
- Zhuang, Z. W., L. Gao, et al. (2006). “Arteriogenesis: noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents.” Radiology 240(3): 698-707.
- Chittenden, T. W., J. A. Sherman, et al. (2006). “Transcriptional profiling in coronary artery disease: indications for novel markers of coronary collateralization.” Circulation 114(17): 1811-20.
- Helisch, A., S. Wagner, et al. (2006). “Impact of mouse strain differences in innate hindlimb collateral vasculature.” Arterioscler Thromb Vasc Biol 26(3): 520-6.
- Huang, H., L. Shen, et al. (2006). “Early lung cancer detection based on registered perfusion MRI.” Oncol Rep 15 Spec no.: 1081-4.
- Huang, H., L. Shen, et al. (2006). “Cardiac motion analysis to improve pacing site selection in CRT.” Acad Radiol 13(9): 1124-34.
- Post, M. J., K. Sato, et al. (2006). “Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation.” Am J Physiol Regul Integr Comp Physiol 290(3): R494-500
- Shen, L., W. Zheng, et al. (2006). “Spatio-temporal modeling of lung images for cancer detection.” Oncol Rep 15 Spec no.: 1085-9
- Wang, Y., F. Makedon, et al. (2006). “Tumor classification based on DNA copy number aberrations determined using SNP arrays.” Oncol Rep 15 Spec no.: 1057-9.
- Huang, H., L. Shen, et al. (2007). “A novel surface registration algorithm with biomedical modeling applications.” IEEE Trans Inf Technol Biomed 11(4): 474-82.
- David Cevallos MD, Sam Ratnayake MD, Zeina Ali MS IV, Stephen Schale MS I, Justin D. Pearlman MD PhD. Impact of Diabetes in Pulmonary Coccidioidomycosis. UCLA Symposium 5-Jun-2012, Los Angeles CA
- A. Ohri MD, G. Petersen MD, I. Kalha MD, A. Heidari MD, S. Qaqish MD, L. Townsend, J. Singh, R. Zak, S. Schale, J.D. Pearlman MD PhD. Cost-Benefit Analysis of Colonoscopy, Sigmoidoscopy and Virtual CT Colonoscopy. UCLA Symposium 5-Jun-2012, Los Angeles CA
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I actually consider this amazing blog , âSAME SCIENTIFIC IMPACT: Scientific Publishing –
Open Journals vs. Subscription-based « Pharmaceutical Intelligenceâ, very compelling plus the blog post ended up being a good read.
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I actually consider this amazing blog , âSAME SCIENTIFIC IMPACT: Scientific Publishing –
Open Journals vs. Subscription-based « Pharmaceutical Intelligenceâ, very compelling plus the blog post ended up being a good read.
Many thanks,Annette
I actually consider this amazing blog , âSAME SCIENTIFIC IMPACT: Scientific Publishing –
Open Journals vs. Subscription-based « Pharmaceutical Intelligenceâ, very compelling plus the blog post ended up being a good read.
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Many thanks,Annette