Leaders in Pharmaceutical Business Intelligence (LPBI) Group

• Cell Biology and Cell Circuits
• Cancer Biology and Innovations in Cancer Therapy
• Biomarkers & Medical Diagnostics
• Disease Biology, Small Molecules in Development of Therapeutic Drugs
• Nanotechnology for Drug Delivery
• Scientist: Career Considerations

Ziv Raviv, PhD

Specialty: Cancer, Cell biology, Signal transduction, Biochemistry

zraviv06@gmail.com

Cell +972-545659106

(o)  +972-48710942

Personal Bio

Education

1993-1995	B.Sc.  Faculty of Life Science, Bar-Ilan University, Israel.
1995-1998	M.Sc. Department of Cell Biology and Histology, Sackler faculty of Medicine, Tel-Aviv University, Israel. Supervised by Prof. Ina Fabian. Research project: Antioxidant protective effect from oxidative stress-induced apoptosis by ascorbic acid.
1999-2003	PhD Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel. Supervised by Prof. Rony Seger. Research projects:A) Molecular and biochemical mechanisms of ERK5 signaling.B) Sub-cellular localization of ERK5 and ERK5 cascade components.

Professional Experience

2009-2011		Research Associate Scientist, National Institute for Biotechnology in the Negev, Department of Life Sciences, Ben-Gurion University, Israel.
2006-2009		Postdoctoral Research Fellow, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
2004-2006		Postdoctoral Research Fellow, Department of Pathology, Albert Einstein College of Medicine, Bronx NY, New York, USA.
2000-2003		Science teaching, Clore Science Museum, and the Dept. of Biological Regulation, Feinberg Graduate School, Weizmann Institute of Science, Rehovot, Israel.
1998-1999:		Research assistant in Biotech industry, Shiloov Medical Technologies Ltd. Research under GLP regulations: Development of methods for the detection of HIV antibodies in whole blood samples.

Other

2011-

Reviewer Cancer Letters and European Journal of Pharmacology.

Scientific and Laboratory Techniques Expertise:

• Industrial experience: working in R&D under GLP regulations in Shiloov Medical Technologies Ltd.
• Lab techniques: broad experience in various techniques:

Molecular biology: DNA/RNA purification, PCR, RT-PCR, plasmid construction, expression vectors etc.

Biochemistry and immunological methods: Immunoprecipitation, Western Blot, ELISA, recombinant protein expression and purification, protein separation and analysis by FPLC etc.

Tissue culture: Extensive and broad experience in mammalian tissue culture, including transient and stable transfection and infection, siRNA etc. Experience working with peripheral blood mononuclear cells (PBMC).

FACS: Operation and analysis.

Fluorescent and confocal microscopy.

Computers: Extensive experience and usage of various computer software and biological internet tools.

Scientific Writing Expertise:

Experience in recruiting money and writing of:

(i) Research grants – where the following grants were awarded:

2007-2009: Israel Cancer Association (ICA), at TAU.

2010-2013: The Leukemia & Lymphoma Society (LLS), at NIBN.

(ii) Reports – to research funds.

(iii) Scientific articles.

(iv) Clinical studies – Helsinki committee submissions.

Miscellaneous:

• I have gained much practice in science teaching, and students’ supervising in their research studies.
• I have excellent skills in oral presentations. My English practice is at the mother tongue level.
• I have the ability to lead projects independently and as part of a team.
• I am easily creating connections for collaborations, and maintaining many of them continuously.
• I gained management experience and practice in administrative scientific affairs including communications with intra- as well as extra- institutional entities (e.g., research funds, R&D authorities, ethical review board (Helsinki committee), etc.).

Publications

1) Raviv Z^1,2, Cohen S, and Reischer D. Jasmonates: Plant stress hormones consist with anti-cancer cell death activates. Cancer Chemother. Pharmacol, DOI 10.1007/s00280-012-2039-z, Nov., 2012.

2)  Raviv Z.^1,2, Zilberberg A., Cohen S., Reischer D., Horrix C., Berger M.,  Rosin-Arbesfeld R., and Flescher E.  Methyl jasmonate sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity by downregulation of survivin expression.  Br. J Pharmacol., 2011 Nov; 164(5):1433-44.

3)  Horrix C., Raviv Z., Flescher E., Voss C. and Berger M. R. Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells. Cell Mol Life Sci., 2010. 

4)  Zhong Y., Seunghee Y., Kalie E., Raviv Z., and Seger R.  Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. PLoS One, 2010, 

5)  Koren, I., Raviv, Z.¹, Shoshan-Barmatz, V. Down-regulation of voltage-dependent anion channel-1 expression by RNA interference prevents cancer cell growth in vivo. Cancer Biol Ther., 2010

6)  Shoshan-Barmatz V., De Pinto V., Zweckstetter M, Raviv Z.¹, Keinan N., Arbel N. VDAC, a multi-functional mitochondrial protein regulating cell life and death. Molecular Aspects of Medicine, 2010.

7)  Raviv Z. ¹, Kalie E., and Seger R. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. J Cell Sci., 2004.

8) Yao Z., Flash I., Raviv Z., Yung Y., Asscher Y., Pleban S., Seger R. Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1. Oncogene, 2001.

9)  Witenberg B., Kalir HH., Kravtsov V., Raviv Z., Fabian I. Vitamin C inhibits apoptosis induced by oxidative stress in HL-60 myeloid leukemia cells. Biochem Pharmacol., 1999.

10) Witenberg B., Kletter Y., Kalir HH., Raviv Z., Fenig E., Nagler A., Halperin D., Fabian I. Ascorbic acid inhibits apoptosis induced by X-irradiation in HL-60 myeloid leukemia cells. Radiat Res. 1999.

¹ Principle writing and editing.

² Corresponding author.

 

List of referees

1) Rony Seger, PhD, Professor and Head, Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel.

Tel: +972-89343602, Fax: +972-89344116

Email: rony.seger@weizmann.ac.il

2) Ilan Tzarfati, PhD, Professor and Chair, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel-Aviv 69978, Israel.

Tel:  +972-36407015, Fax: +972-36409160

Email: ilants@post.tau.ac.il

3) Ina Fabian, PhD, Professor emeritus, Department of Cell and Developmental Biology. Tel-Aviv University, Sackler Faculty of Medicine, Tel-Aviv 69978, Israel
Tel:  +972-36409628, Fax: +972-36407432
Email: inaf@post.tau.ac.il

4) Yosef Yarden, PhD, Professor, Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Tel: +972-89343974

Email: yosef.yarden@weizmann.ac.il
Secretary (Mrs. Lesley Braaf): +972-89344502, Fax (confidential): +972-89342488

5) Ron Apte, PhD, Professor and Chair, Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.

Tel: +972-86477258

E-mail: rapte@bgu.ac.il

6) Roni Ashkenasi, PhD, Independent Museums and Institutions Professional

Tel: +972-54-4471260

E-mail: ronibait@gmail.com