Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Roles at http://pharmaceuticalintelligence.com

Expert, Author, Writer for the following Research Categories:

Category OWNER: Tools for Regenerative medicine ( beyond stem cells)

•             EAW – Bio Instrumentation in Experimental Life Sciences Research
•             EAW – Biological Networks, Gene Regulation and Evolution
•             EAW – Biomarkers & Medical Diagnostics
•             EAW – Frontiers in Cardiology
•                Medical Devices
•                   Stents & Tools
•             EAW – Medical Devices R&D Investment
•             EAW – Metabolomics
•             EAW – Stem Cells for Regenerative Medicine
•             EAW – Technology Transfer: Biotech and Pharmaceutical

Affiliation: MGH/Center for Engineering in Medicine

EDUCATION

Postdoctoral                  Harvard Medical School.

                                      Center for Engineering in Medicine. Host: Martin L. Yarmush (2012-)

 

Regenerative medicine, BioMEMS.

 

Postdoctoral                           University of California, Berkeley

Bioengineering/Mechanical Engineering, Host: Boris Rubinsky. (2010-2011).

Theoretical and experimental systems to prevent muscle contraction during electroporation based treatments.

Ph.D.                             Hebrew University of Jerusalem, Israel.

Bioengineering. (2007-2010)

Thesis: A Study on Electro-Chemical Phenomena in and around Cells. Electrolysis and                       Electroporation.

 

Boris Rubinsky (Chair), Haim Rabinowitch, Michael Belkin.

Examination Fields: Numerical and experimental study on the effects of electric fields on the living cell, with applications to biotechnology, food engineering, medicine and energy.

B.Sc (cum laude)         Technion, Israel.

Biotechnology and Food Engineering. (2003-2007).

Major: Food Engineering.

     

        High School                 Hebrew University High School, Jerusalem, Israel (1997-2000).

Major: Physics and Computer Science

 

PUBLICATIONS

 

Journal Papers:

 

1       Golberg, A, M. Belkin and B. Rubinsky, “Irreversible Electroporation for Microbial Control of Drugs in Solution,” AAPS PharmSciTech, vol 10 (3), pp: 881-886, DOI: 10.1208/s12249-009-9277-3, 2009.

2       Golberg, A. and B. Rubinsky, “A statistical model for multidimensional irreversible electroporation cell death in tissue,” BioMedical Engineering OnLine, vol. 9:13, doi:10.1186/1475-925X-9-13, 2010

3       Golberg, A., H. D. Rabinowitch  and B. Rubinsky, “Galvanic apparent internal impedance: an intrinsic tissue property, ” Biochemical and biophysical research communications, vol. 389, pp. 168-171, 2009

4       Golberg A.,  H.D. Rabinowitch, and B. Rubinsky, “Zn/Cu- vegetative batteries, bioelectrical characterizations and primary cost analyses,” J. Renewable Sustainable Energy, doi:10.1063/1.3427222 2010, highlighted in Nature, 465,848, 2010, doi:10.1038/465848d.

5       Golberg, A. and B. Rubinsky, “The effect of electroporation type pulsed electric fields on DNA in aqueous solution,” Technology in Cancer Research and Treatment, vol. 9(4), pp 423-430, 2010.

6       Golberg, A,  Y. Fischer, M. Belkin and B. Rubinsky,” Intermittently Delivered Pulsed Electric Fields for Sterile Storage of Turbid Media,” IEEE Transactions on Plasma Science, vol. 38( 11), pp. 3211-3218, 2010.

7       Golberg,* A, S. Laufer*, H. D.Rabinowitch and B. Rubinsky, “In vivo non thermal irreversible electroporation impact on rat liver galvanic apparent internal resistance,” Phys. Med. Biol. vol. 56 (2011) 951-963, 2011. * Equal contribution.

8       Golberg, A, Rae C.S, Rubinsky B” Listeria monocytogenes cell wall constituents charge effect on irreversible electroporation threshold,” Biochimica et Biophysica Acta–Biomembranes, vol. 1818(3):689-94 2012 doi:10.1016/j.bbamem.2011.11.003 .

9       Golberg, A. and B. Rubinsky,” A numerical study towards electroporation based treatment planning considering  muscle contraction,” Technology in Cancer Research and Treatment, vol. 11(2):189-201, 2012.

10    Francois F, Rubinsky L, Golberg, A and B Rubinsky, ”Variable Electric Fields for High Throughput Electroporation   Protocol Design,”  Biotechnology and Bioengineering, vol. 109(8): 2168-2171, 2012,  Editor Spotlight Key Article

11    Golberg, A, ” Listeria monocytogenes growth control in milk by intermittently delivered pulsed

electric fields,” Proceedings of Bio and Food Electrotechnologies, pp 1-6, Italy,  2012.

12    Golberg, A, Linshiz,G, Hillson,N.J, M. Koudritsky, Chemodanov,A,  “Distributed marine biorefineries for developing economies”, IMECE2012-86051, pp 1-9, Proceeding of ASME Congress and Exhibition, 2012.

13    Linshiz G, Golberg, A, Konry T, Hillson N ,“Fusion of Biology, Computer Science and Engineering – in the quest to efficient and successful Synthetic Biology,” Perspectives in Biology and Medicine, 55(1) , 2013.

14    Golberg, A., Bei M., Sheridan R. and Yarmush M.L, “Regeneration and control of human fibroblast cell density by intermittently delivered pulsed electric fields,” Biotechnology and Bioengineering, vol. 110(6):1759-68,2013

15    Golberg, A, “Analytical model of local distribution of chemicals in tissues with first order rate metabolism kinetics,” Chemical Engineering Research Communications, vol. 201(1): 102-119, 2013.

16    Golberg, A and Yarmush M.L. “Nonthermal Irreversible electroporation: Fundamental, Applications, Challenges,” IEEE Transactions on Biomedical Engineering, vol. 60 (3):707-14, 2013

17    Golberg,A, Yarmush,M.L, Konry,T “Pico-liter immunosorbent droplet microfluidic platform for point-of-care tetanus diagnostics,”  Microchimica Acta, vol. 180 (9-10): 855-860, 2013.

18    Golberg,A “The Impact of Pulsed Electric Fields on Cells and Biomolecules, a Comment on ‘Lightning‐triggered electroporation and electrofusion as possible contributors to natural horizontal gene transfer by Tadej Kotnik’.” Physics of Live Reviews, vol 10 (3): 382-383, 2013.

19    Golberg, A, Vitkin,E, Linshiz,G, AhmaKhan,S, Hillson, N.J, Yakhini Z, Yarmush,M.L,” Proposed Design of Distributed Marine Biorefineries: Thermodynamics, Technology, and Sustainability Implications for Developing economies,” Biofuels, Bioproducts & Biorefining.  Accepted

20    Golberg, A, Broelsch, G.F, Bohr,S, Mihm, M.C, Austen, W.G, Albadawi,H, Watkins,M.T, Yarmush, M, “Non-Thermal, Pulsed Electric Field Cell Ablation: A Novel Tool for Regenerative Medicine and Scarless Skin Regeneration,” Technology, vol 1: 1-8, 2013

21    Yarmush, M.L, Golberg,A, Sersa,G, Kotnik,T, Miklavcic,D “Electroporation Based Technologies for Medicine: Principles, Applications, and Challenges.” Accepted to Annual Reviews of Biomedical Engineering 2014.

22    Deipolyi, AR, Golberg, A, Yarmush,ML, Arellano,RS, Oklu,R, “Irreversible electroporation: evolution of a laboratory technique to interventional oncology,” Accepted to Diagnostic and Interventional Radiology.

Books and Book Chapters:

 

23    Golberg,A  Y. Fischer, and B. Rubinsky. The Use of Irreversible Electroporation in Food Preservation.  In Irreversible Electroporation, B. Rubinsky, Ed.: Springer Berlin Heidelberg, 2009, pp. 273-312

24    Golberg,A.  Bioelectrochemical phenomena: electrolysis and electroporation.  Scholar’s press, 228 pages.  2013. ISBN-10: 3639510690.

25    Golberg A., Rubinsky B.  Mass Transfer phenomena in Electroporation. In Transport in Biological Media. S.Becker, Ed.: Academic Press, Elsevier.  2013, pp 455-492.

 

Submitted:

1       Konry,T, Golberg,A, Yarmush,M.L, “Live individual cell functional phenotyping in droplet reactor.”

2       Golberg, A*,  Linshiz, G*, Kravets, I, Stawski, N, Hillson, N, Yarmush ML,Marks, RS, Konry, T,” Cloud-enabled microscopy and droplet microfluidic platform for specific detection of Escherichia coli in water.” * Equal contribution.

 

Conference Presentations, Abstracts, Posters and Major Seminars:

 

1       Golberg A. M. Belkin and B. Rubinsky, Irreversible Electroporation for Microbial Control of Drugs in Solution, Electroporation Based Technologies and Treatments 2009. Lubiana, Slovenia. Invited speaker.

2       Golberg, A. Macro Algae as a sustainable biomass source for chemicals and biofuels, Cleantech Open

National  Investor Conference,2011,l San Jose, CA.

3       Golberg,A. Irreversible electroporation in medicine and biotechnology, Invited seminar at AntiCancer Inc., San Diego,CA, 2011

4       Golberg, A. Electrolyses and electroporation in biotechnology, Harvard Medical School, Boston, 2011

5       Golberg,A. Distributed Biorefineries for developing countries, MIT Energy Initiative, Energy Club seminar 2012.

6       Golberg,A. Distributed Biorefineries thermodynamic analyses and optimization, Technion, Mechanical Engineering Faculty, Seminar, Sep 5, 2012.

7       Golberg, A.Microbial Load control by Intermittently delivered pulsed electric fields, Bio and Food Electrotechnologies, Solerno, Italy, Sep 26-28, 2012, presentation. Conference travel award

8       Golberg, A. Distributed marine biorefineries for developing economies, FONA FORUM for sustainable development,  Berlin, Oct 20-24, Germany, 2012, poster. Conference travel award

9       Golberg, A, Irreversible electroporation in medicine, UIC, Department of Biomedical Engineering, Chicago, Nov.5, 2012. Invited seminar.

10    Golberg, A, Linshiz,G, M. Koudritsky, Chemodanov,A, Hillson,N.J . Distributed marine biorefineries for developing economies, ASME Congress and Exhibition, Houston, Nov 9-15, TX, 2012, presentation.

11    Golberg, A, Linshiz,G, M. Koudritsky, Chemodanov,A, Hillson,N.J . Distributed marine biorefineries for developing economies, Eilot-Eilat Renewable energy conference, Eilat, Nov 28-30, Israel, 2012, poster.

12    Golberg, A, Broelsch, G.F, Bohr,S, Mihm, M.C, Austen, W.G, Albadawi,H, Watkins,M.T, Yarmush, M, Non-thermal, irreversible electroporation (IRE) allows for controlled ablation of cellular compartments followed by scarless regeneration of skin in a rat model, Harvard Surgery Day, 2013, poster.

13    Golberg, A, Broelsch, G.F, Bohr,S, Mihm, M.C, Austen, W.G, Albadawi,H, Watkins,M.T, Yarmush, M, Towards tissue regeneration using irreversible electroporation, Gordon Research Seminar. Invited Speaker. June 2013.

14    Vitkin,E, Linshiz,G , Golberg, A, Hillson, N.J, Yarmush,M.L, Keasling J., Yakhini Z. Computationl modeling of two-step bioethanol production:marin macroalgae Ulva Lactuca study. Poster and presentation. IBS13 conference. Beer-Sheva, Israel, June 2013.

15    Brölsch, GF, Golberg, A, Bohr,S, Mihm,MC Jr., Albadawi,H,  Watkins,MT,  Yarmush, ML, Austen WG Jr. LOP35: Scarless regeneration of rat skin following ablation by non-thermal irreversible electroporation. Plastic and Reconstructive Surgery. vol. 132(2): 108.

16    Khan S, Golberg,A, Brölsch, GF,  Bohr S, Mihm,MC Jr., Albadawi,H, Watkins MT, Austen,WG,  Jr., Yarmush, ML ,Non-Thermal, Irreversible Electroporation: A Novel Tool for Scarless Skin Regeneration.   Abstract accepted by the Massachusetts Chapter of the American College of Surgeons 2013 Massachusetts Chapter of the American College of Surgeons Poster Presentation

17    Golberg, A, Vitkin,E, Linshiz,G, AhmaKhan,S, Hillson, N.J, Yakhini Z, Yarmush,M.L,” Proposed Design of Distributed Marine Biorefineries: Thermodynamics, Technology, and Sustainability Implications for Developing economies,” ISES Abraham Kogan Session Lecture, October 7, 2013. Technion Israel.

18    Golberg, A, Khan, S,  Broelsch, G.F, Bohr,S, Mihm, M.C, Austen, W.G, Albadawi,H, Watkins,M.T, Yarmush, M, “Non-Thermal, Pulsed Electric Field Cell Ablation: A Novel Tool for Regenerative Medicine and Scarless Skin Regeneration,” Galil Biomedicine IV. October 8, 2013. Khiryat Shmona, Israel.

Patents

1       Rubinsky,B, Belkin,M,Golberg A, Sverdlik A. WIPO Patent Application WO/2010/113150. An apparatus, system and method for preventing biological contamination to materials during storage using pulsed electric energy.

2       Golberg A, Rubinsky B., United States Application 20130197425. Current cage for reduction of non-target tissue exposure to electric fields in electroporation based treatment.

Business competitions

1  Global Clean Tech Open Business Competition. Led the team, developed the techno-economical analyses for small   scale biorefineries for the production of carbon neutral fuels and zero emission electricity from macro algae. The team passed to semi-finals in California regional competition.  October 2011.

2  Berkeley B-Plan competition. Led the team, wrote a business plan with techno-economical analyses for the production of chemicals and fuels from algae. The team passed to the competition finals. April 2011.

3  Made for China, Global competition of sustainable technologies for China, USA finalist, October 2011. Proposal “Small scale biorefineries for rural China biofuel production”.

 

Media releases

 

Boiled potato battery project

Reuters: http://www.reuters.com/news/video/story?videoId=127046608

Al-Jaseera: http://www.youtube.com/watch?v=lZfs2keZnw4

Russian First channel: http://www.1tv.ru/news/other/158559

Project implementation in the developing countries:

http://www.scidev.net/en/new-technologies/news/potato-and-plantain-batteries-show-promise-1.html

Marine Biorefineries

http://www.scidev.net/en/climate-change-and-energy/renewable-energy/news/small-seaweed-refineries-could-meet-transport-needs-1.html

SERVICE     Reviewer:      Scientific Reports (Nature), Biotechnology and Bioengineering, Biomedical Engineering online,  J. Membrane Biology, IEEE Transactions on Plasma Science, Process Biochemistry, Chemical Engineering Research Communication, Journal of Vascular and Interventional Radiology

                       Conferences: ASME 2012 Topic organizer.

 

 

MEMBERSHIPS         NYACS 2011-, ASME 2013

FUNDING    Angiodynamics Inc. gift

$60,000 1/2011-12/2011, PI: Rubinsky, role: Co-I

                      

                       ECOR Postdoctoral Fellowship Award from the MGH Fund for Medical Discovery

$40,000    9/2012-8/2013,   role:  PI

Shriners Foundation Small Grant

$120,000  1/2013-12/2014 , PI: Yarmush , role: Co-I.

 

AWARDS AND HONORS

1997             First place in regional Olympiad in astronomy and cosmic physics, Kursk, Russia

2002             IDF, Platoon Award for Excellence in service, Israel.

2003             HAAS award for excellence in studies and community work, Israel and USA

2004-2006    Dean Award, Technion Food Eng. for excellence in studies, Israel

2007             BSc Cum laude in Biotechnology and Food Engineering, Israel

2008             Electroporation based technologies and treatments, Travel Award, November 15. Ljubljana, Slovenia.

2010             Extensive report and coverage by Nature, Reuters, Al-Jazzera, Russian 1^st and Israel news

channels for the   “biological battery invention”

http://www.reuters.com/video/2010/07/28/potato-battery-new-and-improved?videoId=127046608

2011             Regional finalist in California, Clean Tech Open competition, USA

2012             ECOR Postdoctoral Fellowship Award from the MGH Fund for Medical Discovery, Massachusetts General

Hospital, USA. (9 awardees from 88 applications)

2012             Bio and Food Electrotechnologies. Travel award. Solerno, Italy, Sep 26-28, 2012

2012             Green Talents 25 World High Potentials in Sustainable Development Award. German Federal Ministry of Education and   Research. (25 awardees from 403 applications, 69 countries) http://www.greentalents.de/890.php , Germany.

2013             Gordon Research Seminar on Tissue Repair and Regeneration. Travel Award. Invited speaker. June 15-18, USA.

2013             ISES Abraham Kogan Session Lecture Award on Renewable Energy. October 7. Israel.

 

TEACHING EXPERIENCE

Hebrew University (2009-2010) group leader, under Prof. Boris Rubinsky, trainee supervisor.

J.Kandel (2009) – today PhD student at PENN, B.Elkin (2009) today scientist at Halotechnics.

UC Berkeley (2011) group leader, under Prof. Boris Rubinsky, trainee supervisor.

X.Garcia(UC Berkeley) , F.Fernand (Polytech Marseille,France), M-J Antonini (ENSAM, France)

      

NPO for education promotion (1998-2005).

Developed and taught courses for multicultural interaction tolerance. Group dynamics development.

Israel Defense Forces Software Implementation (2001-2003)

Developed courses and exams. Trained class instructors. Performed frontal lectures and individual training on a complicated software.

 

Israel National Museum of Science (2004-2005)

Developed educational programs and performed basic scientific experiments for schools.

 

 

PROFESSIONAL EXPERIENCE

                                          

Consultant                         Toppik Technologies and Investments Ltd, (2006-2010)

Professional consulting services in agro and food engineering. Engagements:

• Initiated an establishing pomegranate processing factory. Client : Amit PomegTech, Gujarat,India
• Initiated a pomegranate farm. Client: Agricola de San Climente, Chille.
• Organized a pot flowers farm. Client: UMC Green Technologies, India
• Assisted in to a large agriculture company from India to find and implement new technologies.  Client : Ekta Farms, India

R&D engineer                             Life Technologies (Invitrogen), (2005-2010)

R&D research engineer  

Co-developed the following products:

Novex reversible protein stain:

https://products.invitrogen.com/ivgn/product/IB7710?ICID=search-product

iBlot (7 min Western Blot Procedure): http://www.invitrogen.com/site/us/en/home/brands/Product-Brand/iBlot-Dry-Blotting-System.html

iBase (dry gel electrophoreses):

http://products.invitrogen.com/ivgn/product/4466604?ICID=search-product

 

Military service in Israel Air Defense Network. (2000-2003)

ADN combat soldier. First Sergeant.

Responsible for ERP product. Performed requirement definition phase, development, and implementation. 

Management of software implementation team (8-10 software instructors).

PROFESSIONAL TRAINING

Illuminating the body. Optical Coherence Tomography.

Harvard Medical School, Boston, 2013

Introduction to Translational Medicine.

Harvard Medical School, Boston, 2012-2013

 

Responsible Conduct in Research (NIH-NSF training requirement).

University of California, Berkeley, 2011

 

Industrial Bio Processing course. QB3/GE

University of California, San Francisco, 2011

 

ADDITIONAL

Volunteered as an instructor in Haifa Municipal School. Taught mathematics in the basic school (2004-2005).

Volunteered in Haifa geriatric home. Community work (2005).

From 2006 to 2007 participated in Technion entrepreneurship club.

LANGUAGES

English- Fluent.

Hebrew- Fluent

Russian- Fluent