Patents in Immune Oncology – Inventor Yoram Reiter, PhD
Reporter: Aviva Lev- Ari, PhD, RN
Selected patents for generating TCRLs against Neoantigens and attaching a Toxin on the TCRL: For Linking a Toxin to TCRL
Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
CA 2474782 A1
ABSTRACT
An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 nanomolar, to a human major histocompatibility complex (MHC) class I being complexed with a HLA-restricted antigen and optionally further comprises an identifiable or therapeutic moiety conjugated to the antibody.
For Generating Any TCRL against any neoantigen
Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer
CA 2451353 A1
ABSTRACT
An immuno-molecule which comprises a soluble human MHC class I effector domain; and an antibody targeting domain which is linked to the soluble human MHC class I effector domain, methods of making same and uses thereof.
Single chain class i major histo-compatibility complexes, constructs encoding same and methods of generating same
CA 2404489 A1
Single chain class i major histocompatibility complexes, constructs encoding same and methods of generating same
US 20090258393 A1
ABSTRACT
Methods of generating a functional mammalian single chain MHC class I complex in prokaryotic expression systems and a functional human single chain MHC
class I complex in eukaryotic or prokaryotic expression systems, which complexes are capable of presenting specific antigenic peptides restricted to specific CTL clones.
Mhc-peptide complex binding ligands
Publication number, EP1485075 A4. Publication type, Application. Application number, EP20030742843. PCT number, PCT/US2003/005128.
Electrode
An electrode comprises a non-biological surface having unique surface electrical properties that vary over its extent, the electrical properties …
Artificial receptors
Antibodies are provided. For as example, an antibody capable of binding an artificial receptor which comprises a hydroquinone monolayer and …
Antibodies, methods and kits for diagnosing and treating melanoma
A method of diagnosing melanoma and antibodies capable of same are disclosed. The method comprises contacting a cell of the subject with …
Protease-activatable pseudomonas exotoxin a-like proproteins
This invention provides protease-activatable Pseudomonas exotoxin A-like (‘PE-like’) proproteins. The proproteins comprise (1) a cell …
High affinity antibody having a tcr-like specificity and use in …
An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 …
Antigen-presenting complex-binding compositions and uses thereof
A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an …
T cell subpopulations capable of treating cancer
A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing a frequency of tumor infiltrating …
An antibody fragment capable of modulating multidrug resistance and …
An antibody fragment and methods of utilizing same are provided. The antibody fragment includes an antigen binding region capable of …
Single chain class i major histo-compatibility complexes, constructs …
Methods of generating a functional mammalian single chain MHC class I complex in prokaryotic expression systems and a functional human single chain MHC …
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