Patents in Immune Oncology – Inventor Yoram Reiter, PhD
Reporter: Aviva Lev- Ari, PhD, RN
Selected patents for generating TCRLs against Neoantigens and attaching a Toxin on the TCRL: For Linking a Toxin to TCRL
Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
CA 2474782 A1
ABSTRACT
An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 nanomolar, to a human major histocompatibility complex (MHC) class I being complexed with a HLA-restricted antigen and optionally further comprises an identifiable or therapeutic moiety conjugated to the antibody.
For Generating Any TCRL against any neoantigen
Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer
CA 2451353 A1
ABSTRACT
An immuno-molecule which comprises a soluble human MHC class I effector domain; and an antibody targeting domain which is linked to the soluble human MHC class I effector domain, methods of making same and uses thereof.
Single chain class i major histo-compatibility complexes, constructs encoding same and methods of generating same
CA 2404489 A1
Single chain class i major histocompatibility complexes, constructs encoding same and methods of generating same
US 20090258393 A1
ABSTRACT
Methods of generating a functional mammalian single chain MHC class I complex in prokaryotic expression systems and a functional human single chain MHC
class I complex in eukaryotic or prokaryotic expression systems, which complexes are capable of presenting specific antigenic peptides restricted to specific CTL clones.
Mhc-peptide complex binding ligands
Publication number, EP1485075 A4. Publication type, Application. Application number, EP20030742843. PCT number, PCT/US2003/005128.
Electrode
An electrode comprises a non-biological surface having unique surface electrical properties that vary over its extent, the electrical properties …
Artificial receptors
Antibodies are provided. For as example, an antibody capable of binding an artificial receptor which comprises a hydroquinone monolayer and …
Antibodies, methods and kits for diagnosing and treating melanoma
A method of diagnosing melanoma and antibodies capable of same are disclosed. The method comprises contacting a cell of the subject with …
Protease-activatable pseudomonas exotoxin a-like proproteins
This invention provides protease-activatable Pseudomonas exotoxin A-like (‘PE-like’) proproteins. The proproteins comprise (1) a cell …
High affinity antibody having a tcr-like specificity and use in …
An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 …
Antigen-presenting complex-binding compositions and uses thereof
A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an …
T cell subpopulations capable of treating cancer
A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing a frequency of tumor infiltrating …
An antibody fragment capable of modulating multidrug resistance and …
An antibody fragment and methods of utilizing same are provided. The antibody fragment includes an antigen binding region capable of …
Single chain class i major histo-compatibility complexes, constructs …
Methods of generating a functional mammalian single chain MHC class I complex in prokaryotic expression systems and a functional human single chain MHC …
Isolated high affinity entities with t-cell receptor like …
Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD …
Antibodies with t-cell receptor like specificity towards native …
Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated autoantigenic …
Antibodies and their uses for diagnosis and treatment of …
Anti CMV antibodies are provided. Thus an antibody of the present invention comprises …
Fusion proteins, uses thereof and processes for producing same
This invention provides fusion proteins comprising consecutive amino acids which beginning at …
Antibodies, methods and kits for diagnosing and treating melanoma
The present invention relates to a method of identifying if a subject is suitable for TCRL-based epitope directed therapy, comprising determining …
Antibodies for selective apoptosis of cells
A recombinant isolated antibody and a pharmaceutical composition containing same, capable of specifically recognizing an MHC-peptide …
Antibodies which bind soluble t-cell receptor ligands
Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand …
Mhc-peptide complex binding ligands
Disclosed are protein ligands comprising an immunoglobulin heavy chain variable (VH) domain and an immunoglobulin light chain variable (VL) domain, …
Antikörper mit einer T-Zellenrezeptoren-ähnlichen Spezifizität, aber …
Isolierter Antikörper, der spezifisch mit einer Bindungsaffinität von unter 10 Nanomolar an einen menschlichen …
Methods and pharmaceutical compositions for immune deception, …
An immuno-molecule which comprises a soluble human MHC class I effector domain; and an antibody targeting domain which is linked to the …
Single chain class I major histo-compatibility complexes
A recombinant polypeptide and nucleic acid constructs capable of expressing the recombinant polypeptide are provided. The recombinant …
Single chain class i major histocompatibility complexes, constructs …
Provided are methods of generating a functional mammalian single chain MHC class I complex in prokaryotic expression systems and a host …
Method of predicting responsiveness to autologous adoptive cell …
A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing …
T cell subpopulations capable of treating cancer
Previous page. Next page. Claims(3). A method of determining responsiveness to adoptive cell transfer therapy …
Antibody having a T-cell receptor-like specificity, yet higher …
An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 …
Antibody having a t-cell receptor-like specificity, yet higher …
An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 …
Protease-activatable pseudomonas exotoxin a-like proproteins
This invention provides protease-activatable Pseudomonas exotoxin A-like (‘PE-like’) proproteins. The proproteins comprise (1) a cell …
Antibodies for selective apoptosis of cells
A recombinant isolated antibody and a pharmaceutical composition containing same, capable of specifically recognizing an MHC-peptide …
Anti human immunodeficiency antibodies and uses thereof
Provided are antibodies comprising an antigen recognition domain capable of binding an MHC molecule being complexed with a human …
Antibodies with t-cell receptor like specificity towards native …
Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated autoantigenic …
Anticorps antigrippe et leurs utilisations
L’invention porte sur des anticorps comprenant un domaine de reconnaissance d’antigène capable de se lier à une molécule MHC qui est …
Antibodies with t-cell receptor like specificity towards native …
Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated autoantigenic …
Anticorps antigrippe et leurs utilisations
L’invention porte sur des anticorps comprenant un domaine de reconnaissance d’antigène capable de se lier à une molécule MHC qui est …
Antibodies which bind soluble t-cell receptor ligands
Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand …
MHC-peptide complex binding ligands
Disclosed are protein ligands comprising an immunoglobulin heavy chain variable (VH) domain and an immunoglobulin light chain variable …
Antibodies, methods and kits for diagnosing and treating melanoma
A method of diagnosing melanoma and antibodies capable of same are disclosed. The method comprises contacting a cell of …
Fusionsproteine, ihre verwendung und verfahren zu ihrer herstellung
Fusionsprotein, umfassend aufeinanderfolgende Aminosäuren, welche, beginnend am Amino-Terminus des Proteins, aufeinanderfolgenden …
Electrode
The electrode or array of any of claims 1 – 7, wherein the electrode further comprises a structure having a plurality of layers, wherein said …
Antikörper mit t-zell-rezeptor-artiger spezifität, aber höherer …
Isolierter Antikörper, der spezifisch mit einer Bindungsaffinität von unter 20 Nanomolar an ein menschliches Haupthistokompatibilitätskomplex …
Antikörperfragment als multidrugresistenz-modulator sowie …
An antibody fragment and methods of utilizing same are provided. The antibody fragment includes an antigen binding region capable of …
Search Results
Entités isolées à affinité élevée dotées d’une spécificité telle que …
La présente invention concerne des complexes isolés comprenant un complexe majeur d’histocompatibilité (CMH) de classe II et un peptide …
Procedes et compositions pharmaceutiques permettant la falsification …
L’invention concerne une immuno-molécule comprenant un domaine effecteur humain MHC soluble de classe I; et un domaine de ciblage …
Anticorps, procédés et kits de diagnostic et de traitement de mélanomes
L’invention concerne un procédé de diagnostic de mélanomes et des anticorps pouvant agir de même. Le procédé comprend la mise en …
Anticorps présentant une spécificité de type récepteur des …
Claims(12). Anticorps …
Methods and pharmaceutical compositions for immune deception, …
A molecule consisting of consecutive amino acids present in the following consecutive segments, beginning at the amino terminus of the …
Einkettige haupthistokompatibilitätskomplexe der klasse i (mhc-i), …
Isolierte Zusammensetzung, umfassend eine Mehrzahl von Komplexen, die jeweils aus einem Antigenpeptid, das zum Binden einer humanen …
Fusion proteins, uses thereof and processes for producing same
This invention provides fusion proteins comprising consecutive amino acids which beginning at the amino terminus of the protein correspond to …
An antibody fragment capable of modulating multidrug resistance and …
An antibody fragment and methods of utilizing same are provided. The antibody fragment includes an antigen binding region capable of …
Antibody fragment capable of modulating multidrug resistance and …
An antibody fragment and methods of utilizing same are provided. The antibody fragment includes an antigen binding region …
Single chain class I major histocompatibility complexes
A recombinant polypeptide and nucleic acid constructs capable of expressing the recombinant polypeptide are provided. The recombinant …
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