Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia
Reporter: Aviva Lev-Ari, PhD, RN
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Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeabil…
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Cyclosporin A is a cyclic nonribosomal peptide of eleven amino acids;
- an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient’s immune system, and therefore the risk of organ rejection. Also
- causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. It has a role as
- an antifungal agent,
- an antirheumatic drug,
- a dermatologic drug,
- an immunosuppressive agent,
- a metabolite,
- a carcinogenic agent,
- an anti-asthmatic drug,
- an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor,
- an anticoronaviral agent and
- a geroprotector.
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