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Adipocyte Differentiation: The Effects of Hormones and Differentiation Factors

Reporters: Irina Robu, PhD and Aviva Lev-Ari, PhD, RN

 

 

Hormones and Differentiation Factors influencing Adipocyte Differentiation

 

Agent	Effect	Comment	References
Insulin	+	Accelerates lipid accumulation	43, 57, 106, 154, 160
IGF-1	+	Stimulates adipocyte differentiation	132, 154, 170
Glucocorticoids	+	Stimulates adipocyte differentiation	49, 57, 106, 160, 179
Growth hormone	+/-	Induces adipogenesis in preadipose cell lines	46, 60, 170, 171
		Inhibits adipogenesis in primary cultures
Retinoic acid	+/-	Concentration dependent	143, 144
Thyroid hormone	+/no effect	Inducing effect on adipogenesis restricted to a Preadipose cell line	57, 146, 148, 160 175
Prostaglandins	+/-	Varied effects depending on model system	103, 110, 136, 167
EGF, TGF-alpha	–	Inhibit adipocyte differentiation	58, 98, 146, 167
TGF-beta	–	Potent inhibitor of adipogenesis	127, 149, 155, 167
aFGF, bFGF	+/-	Conflicting results	58, 79, 146, 148, 167
IL-1, interferon-gamma, TNF-alpha	–	Inhibit adipocyte differentiation	50, 119, 126
PDGF	+/-	Conflicting results	58, 61, 146
cAMP	+	Induces adipocyte diffferentiation	137, 175, 180
Vatimin D	+/-	Conflicting results	10, 80, 88, 169
Oestrogen, progesterone	+/no effect		56, 139

Abbreviations: IGF-1, insulin-like growth factor 1; EGF, epidermal growth factor; TGF, transforming growth factor; FGF, fibroblast growth factor; IL-1, interleukin-1; TNF-α, tumor necrosis factor-α; PDGF, platelet- derived growth factor; cAMP, cyclic adenosine monophosphate.

TABLE SOURCE

Table 1. on Page 9 in Adipose Tissue and Adipocyte Differentiation: Molecular and Cellular Aspects and Tissue Engineering Applications

1. Niemelä*, S. Miettinen, J.R. Sarkanen and N. Ashammakhi

http://www.oulu.fi/spareparts/ebook_topics_in_t_e_vol4/abstracts/niemela.pdf

Topics in Tissue Engineering, Vol. 4. Eds. N Ashammakhi, R Reis, & F Chiellini © 2008.

Niemelä et al. Adipose tissue factor 1- and sterol regulatory element-binding protein-responsive gene. J Biol Chem

1997; 272: 7298-7305.

 

Wosnitza et al. (2007) have shown that both preadipocytes and endothelial cells share a common progenitor cell type demonstrating endothelial and adipogenic maturation potential. Furthermore their result reveals that even some mature cells of mesenchymal origin have a remarkable potency to perform transdifferentiation between endothelium and adipose tissue.177 Boquest et al. (2006), have, however, shown that despite limited upregulation of endothelium related marker surface proteins CD31 and CD144 expression after endothelial differentiation stimulation, adipose tissue derived stem cells have a limited commitment to the endothelial lineage in vitro.14

Conclusions

Resent advances in bioengineering and cell biology of fat tissue have led to innovative and new therapeutic potentials for regenerative medicine. Autologous human adipose tissue- derived stem cells could have clinical applicability for cell-based therapies and tissue engineering purposes. Promising results suggest that adipose tissue will be a useful tool in biotechnology.

 

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Adipose Tissue and Adipocyte Differentiation: Molecular and Cellular Aspects and Tissue Engineering Applications

1. Niemelä*, S. Miettinen, J.R. Sarkanen and N. Ashammakhi

http://www.oulu.fi/spareparts/ebook_topics_in_t_e_vol4/abstracts/niemela.pdf