Device to Support Mitral Valve rather than Replace it: Boston Scientific gave $15 million Loan to Israeli Heart Valve Maker Mvalve in deal for a $200 million Buyout Option
Reporter: Aviva Lev-Ari, PhD, RN
See MValve Three Patent Claims, below
Israeli heart valve maker Mvalve reportedly pulls in a $15 million investment from Boston Scientific in a deal that includes a $200 million buyout option.
Boston Scientific (NYSE:BSX) reportedly put down a $15 million investment in Israeli heart valve developer Mvalve Technologies that includes a $200 million buyout option.
Mvalve is developing technology to treat mitral valve regurgitation, according to its LinkedIn profile. Co-founder & CEO Assif Stoffman is an executive vice president with Israeli venture capital fund XT Hitech, which is the sole investor in Mvalve, according to Globes.
SOURCE
http://www.biospace.com/News/stealthy-mvalve-raises-15-million-from-boston/339068
Stealthy Mvalve raises $15M from Boston Scientific
July 7, 2014 by Brad Perriello
Israeli heart valve maker Mvalve reportedly pulls in a $15 million investment from Boston Scientific in a deal that includes a $200 million buyout option.
Boston Scientific (NYSE:BSX) reportedly put down a $15 million investment in Israeli heart valve developer Mvalve Technologies that includes a $200 million buyout option.
Mvalve is developing technology to treat mitral valve regurgitation, according to its LinkedIn profile. Co-founder & CEO Assif Stoffman is an executive vice president with Israeli venture capital fund XT Hitech, which is the sole investor in Mvalve, according to Globes.
The Boston Scientific investment is a $15 million convertible debt offering, according to the newspaper, which cited unnamed sources.
Mvalve has filed 3 patent applications, 2 covering “Cardiac Valve Support Structure” and another covering “Cardiac Valve Modification Device,” according to PatentBuddy.
MValve: Three Patents and their Claims
2014/0005,778 CARDIAC VALVE SUPPORT STRUCTUREMar 08, 13Jan 02, 14[A61F]
US Family Size | International Coverage |
Abstract
Cardiac valve supports and their methods of use.
Abstract Image is not Available
First Claim
1. A cardiac valve support adapted for endovascular delivery to a cardiac valve, comprising:first and second support elements each having a collapsed delivery configuration and a deployed configuration;and wherein at least two bridging members extend from the first support element to the second support element, said bridging members having a delivery configuration and a deployed configuration, wherein said bridging members extend radially inward from the first and second support elements in the deployed configuration.
2. A cardiac valve support adapted for endovascular delivery to a cardiac valve, comprising: first and second support elements each having a collapsed delivery configuration and a deployed configuration; and wherein at least two bridging members extend from the first support element to the second support element, said bridging members having a delivery configuration and a deployed configuration, wherein said bridging members extend longitudinally, and without any appreciable radial curvature, between first and second support elements in the deployed configuration. |
3. The cardiac valve support of claim 1 or claim 2, wherein the first and second bridging members extend from the first and second support elements about 180 degrees from one another. |
4. The cardiac valve support of claim 1 or claim 2, wherein at least one of the first and second support elements has an annular shape. |
5. The cardiac valve support of claim 1 or claim 2, wherein at least one of the first and second support elements has an outer perimeter that is entirely rigid. |
6. The cardiac valve support of claim 1 or claim 2, wherein at least one portion of the inner perimeter of at least one of the support elements is elastically deformable in a radial direction. |
7. The cardiac valve support of claim 1 or claim 2, wherein at least one of the support elements in its deployed configuration has the form of a flat annular ring, and wherein the difference (Rd) between the outer radius and the inner radius of said annular ring is in the range of 1-14 mm. |
8. The cardiac valve support of claim 7, wherein the ratio between Rd and the thickness of the flat annular ring is between 10:1 and 20:1. |
9. The cardiac valve support of claim 7, wherein the inner diameter of the flat annular ring is in the range of 23-29 mm and the outer diameter thereof is in the range of 30-50 mm. |
10. The cardiac valve support of claim 7, wherein the thickness of the flat annular ring is in the range of 0.25-0.6 mm. |
11. The cardiac valve support of claim 1 or claim 2, wherein said support device further comprises one or more extensions, attached to the bridging members or to one or both support elements, such that portion(s) of said one or more such extensions form a guidance element that is capable of centering a wire that is passed through the center of said support device. |
12. The cardiac valve support of claim 1 or claim 2, wherein the bridging members and/or the support elements are fitted with heart tissue anchoring means adapted to securely anchor said support elements to the heart wall. |
13. The cardiac valve support of claim 1 or claim 2, further comprising one or more intra-ventricular and/or intra-atrial stabilizing elements. |
14. The cardiac valve support according to claim 13, wherein the stabilizing elements are selected from the group consisting of complete ring structures, partial rings, curved arms or wings, and elongate arms or wings. |
15. The cardiac valve support of claim 1 or claim 2, comprising only two bridging members. |
16. A system adapted for endovascular delivery or transapical delivery to replace a mitral valve, comprising: a cardiac valve support according to any one of the previous claims; and a replacement heart valve comprising an expandable anchor and a plurality of leaflets adapted to be secured to the cardiac valve support. |
17. The system of claim 16, wherein the replacement heart valve is a prosthetic aortic valve. |
18. A method of replacing a patient’s mitral valve, comprising the steps of: (a) delivering a valve support to a location near a subject’s mitral valve, the valve support comprising a first support element, a second support element, and at least two bridging members extending from the first and second support elements; (b) allowing the first support element to unfold from a collapsed configuration to a deployed configuration secured against cardiac tissue in the area of the mitral valve annulus; (c) allowing the bridge members to unfold from their delivery configuration to their deployed configuration positioned in general alignment with the coaptation points of the native mitral valve leaflets; and (d) allowing the second support element to unfold from a collapsed configuration to a deployed configuration secured against cardiac tissue in the area of the mitral valve annulus. |
19. The method of claim 18, wherein native cardiac valve leaflet function is maintained throughout the procedure. |
20. The method of claim 18, wherein the valve support is delivered either endovascularly or by the transapical route. |
21. The method of claim 18, further comprising the step of causing anchoring and/or stabilizing means fitted to the support elements and/or bridging members to come into contact with cardiac tissue. |
22. The method of claim 18 further comprising securing a prosthetic cardiac valve to the valve support. |
23. The method of claim 22 wherein securing the prosthetic valve to the valve support comprises expanding said valve with a balloon. |
24. The method of claim 22 wherein securing the prosthetic valve to the valve support comprises allowing said valve to self-expand. |
25. The method of claim 22, wherein the prosthetic valve is delivered by the same route as the valve support. |
26. The method of claim 22, wherein the prosthetic valve and the valve support are delivered by different routes. |
27. The method of claim 22, wherein the prosthetic cardiac valve is a prosthetic aortic valve. |
SOURCE
– See more at: http://www.patentbuddy.com/Patent/20140005778#sthash.ZTTVCo0G.dpuf
2013/0304,197 CARDIAC VALVE MODIFICATION DEVICEFeb 27, 13Nov 14, 13[A61F]
– See more at: http://www.patentbuddy.com/Patent/20130304197#sthash.bkkEnilX.dpuf
2012/0059,458 Cardiac Valve Support StructureSep 01, 11Mar 08, 12[A61F]
1. A cardiac valve support adapted for endovascular delivery to a cardiac valve, comprising:a first support element with a collapsed delivery configuration and a deployed configuration;a second support element with a collapsed delivery configuration and a deployed configuration;a first bridging member extending from the first support element to the second support element, wherein the first bridging member has a delivery configuration and a deployed configuration; anda second bridging member extending from the first support element to the second support element, wherein the first bridging member has a delivery configuration and a deployed configuration;wherein the first and second bridging members extend radially inward from the first and second support elements in the deployed configurations.
2. The cardiac valve support of claim 1 wherein the first and second bridging members extend from first and second discrete locations around the first and second support elements. |
3. The cardiac valve support of claim 2 wherein the first and second bridging members symmetrically extend from the first and second support elements. |
4. The cardiac valve support of claim 2 wherein the first and second bridging members extend from the first and second support elements about 180 degrees from one another. |
5. The cardiac valve support of claim 1 wherein at least one of the first and second support elements has an annular shape. |
6. The cardiac valve support of claim 1 wherein the first and second bridging members each have a replacement valve engagement portion adapted to securely engage a replacement heart valve. |
7. The cardiac valve support of claim 6 wherein the engagements portions each have a locking element adapted to securely lock with a portion of a replacement heart valve. |
8. The cardiac valve support of claim 1 wherein the first and second support elements are adapted to preferentially bend at least one location. |
9. The cardiac valve support of claim 1 wherein the first and second support elements each have a curved portion in their deployed configurations, wherein the curved portions are adapted to assume a tighter curved configuration in the collapsed delivery configurations. |
10. The cardiac valve support of claim 1 wherein the first and second bridging members are generally C-shaped in their deployed configurations. |
11. The cardiac valve support of claim 1 wherein the first support element has at least one coupling element adapted to reversibly couple to a delivery system. |
12. The cardiac valve support of claim 10 wherein the at least one coupling element is a threaded bore. |
13. The cardiac valve support of claim 1 wherein the second support element has a dimension in the deployed configuration that is larger than a dimension of the first support element in the deployed configuration. |
14. A system adapted for endovascular delivery to replace a mitral valve, comprising: a cardiac valve support comprising a first support element with a collapsed delivery configuration and a deployed configuration; a second support element with a collapsed delivery configuration and a deployed configuration; a first bridging member extending from the first support element to the second support element, wherein the first bridging member has a delivery configuration and a deployed configuration; and a second bridging member extending from the first support element to the second support element, wherein the first bridging member has a delivery configuration and a deployed configuration; wherein the first and second bridging members extend radially inward from the first and second support elements in the deployed configurations; and a replacement heart valve comprising an expandable anchor and a plurality of leaflets adapted to be secured to the cardiac valve support. |
15. The system of claim 14 wherein the bridging members are adapted to securingly engage the replacement heart valve. |
16. A method of replacing a patient’s mitral valve, comprising: endovascularly delivering a valve support to a location near a subject’s mitral valve, the valve support comprising a first support element, a second support element, and first and second bridging members extending from the first and second support elements; expanding the first support element from a collapsed configuration to a deployed configuration secured against cardiac tissue below the plane of the mitral valve annulus; expanding the bridge members from delivery configurations to deployed configurations positioned in general alignment with the coaptation points of the native mitral valve leaflets; and expanding the second support element from a collapsed configuration to a deployed configuration secured against left atrial tissue above the plane of the mitral valve annulus. |
17. The method of claim 16 wherein expanding the first support element comprises allowing the first support element to self-expand against cardiac tissue. |
18. The method of claim 16 wherein expanding each of the bridge members comprises allowing the bridge members to assume a deployed configuration in which they extend radially inward from the first and second support elements. |
19. The method of claim 16 wherein expanding the second support element against left atrial tissue comprises allowing the second support element to self-expand. |
20. The method of claim 16 wherein expanding the first support element comprises expanding the first support element towards a generally annularly shaped deployed configuration. |
21. The method of claim 16 wherein expanding the first support element comprises expanding the first support element secured against papillary tendons. |
22. The method of claim 21 wherein expanding the first support element comprises expanding the first support element secured against papillary tendons without displacing them. |
23. The method of claim 16 wherein native leaflets function after expanding the second support element. |
24. The method of claim 16 wherein expanding the first support element occurs before expanding the second support element. |
25. The method of claim 16 wherein expanding the bridge members comprises allowing the bridge members to symmetrically extend from the first support element to the second support element. |
26. The method of claim 16 wherein expanding the bridge members comprises allowing the bridge members to extend from the first and second support elements about 180 degrees from one another. |
27. The method of claim 16 wherein expanding the second support element comprises expanding the second support element to the deployed configuration in which the second support element has a dimension larger than a dimension of the first support element in the deployed configuration. |
28. The method of claim 16 further comprising securing a replacement mitral valve to the valve support. |
29. The method of claim 28 wherein securing the replacement mitral valve to the valve support comprises expanding the replacement mitral valve from a collapsed delivery configuration to an expanded configuration. |
30. The method of claim 29 wherein expanding the replacement mitral valve comprises expanding the replacement mitral valve with a balloon. |
31. The method of claim 29 wherein expanding the replacement mitral valve comprises allowing the replacement mitral valve to self-expand. |
32. The method of claim 28 wherein securing a replacement mitral valve to the valve support comprises securing the replacement mitral valve radially within the valve support. |
33. The method of claim 28 wherein securing a replacement mitral valve to the valve support comprises locking a replacement mitral valve element with a valve support element to lock the replacement mitral valve to the valve support. |
34. The method of claim 33 wherein the bridge members each comprise a bridge lock element and the replacement mitral valve comprises a plurality of lock elements, and the locking step comprises locking one of the plurality of lock elements with one of the bridge lock elements and locking a second of the plurality of lock elements with the other of the bridge lock elements. |
– See more at: http://www.patentbuddy.com/Company/Profile/MVALVE-TECHNOLOGIES-LTD./5066825#sthash.PrSC4bIS.dpuf
SIMILAR ENTRIES
Stealthy Mvalve has a single-page website listing only its name, an owner login and the slogan “A paradigm shift in the treatment of mitral regurgitation.” Its device is designed to support the mitral valve rather than replace it, according to Globes.[link broken]
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