This is part of a continuing discussion now in progress, and may continue into an analysis covering the proteins, isoforms, enzyme catalysts, isoenzymes, substrate affinities, and signaling effects published in over 100 publications related to carcinogenesis and cell regulatory control of gluconeogenesis, glycolysis, and the ubiquitin pathway
Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?
Author: Larry H. Bernstein, MD, FCAP
A Critical Review
What is the Warburg effect?
“Warburg Effect” describes the preference of glycolysis and lactate fermentation rather than oxidative phosphorylation for energy production in cancer cells. Mitochondrial metabolism is an important and necessary component in the functioning and maintenance of the organelle, and accumulating evidence suggests that dysfunction of mitochondrial metabolism plays a role in cancer. Progress has demonstrated the mechanisms of the mitochondrial metabolism-to-glycolysis switch in cancer development and how to target this metabolic switch.
In vertebrates, food is digested and supplied to cells mainly in the form of glucose. Glucose is broken down further to make Adenosine Triphosphate (ATP) by two pathways. One is via anaerobic metabolism occurring in the cytoplasm, also known as glycolysis. The major physiological significance of glycolysis lies in making ATP…
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Larry is this an UPDATE to you famous article with same name?
If yes, then you need to go to the original paper on the Journal,
Write on top UPDATED on today date, bold red
Start to type NEW Content.
Thank you
The reader will have in same place everything you wished to publish on this topic.
This needs more time, and when Jose finishes with the World Cup, he’ll be sending me more. Then I can have a Part 1 and Part 2. I’ll have to get help from RR Coifman for the analysis, which might be impossible, but even in the Table I have only begun, it looks like the focus needs a new tool for chemotherapy. It hasn’t been unlocked – which I think, is the reason for so many failures.
On Sat, Jun 21, 2014 at 9:57 AM, Pharmaceutical Intelligence wrote:
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