Posts Tagged ‘Regenerative’

Liver tissues free of tumors found in newly discovered cells

Reported by: Irina Robu, PhD

Researchers at University of San Diego, School of Medicine discovered a new population of liver cells that are better at regenerating liver tissues than original liver cells, hepatocytes. The article published in August 13 in cells were identified as hybrid hepatocytes and are able to regenerate liver tissue without giving rise to cancer. Of all major organs, the liver has the highest capacity to regenerate—that’s why many liver diseases, including cirrhosis and hepatitis, can often be cured by transplanting a piece of liver from a healthy donor.

A study done recently by Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology, researchers traced the cells responsible for replenishing hepatocytes following chronic liver injury induced by exposure to carbon tetrachloride.They found a unique population of hepatocytes located in the portal triad which undergo extensive proliferation and replenish liver mass after chronic liver injuries. Since the cells are similar to normal hepatocytes, but express low levels of bile duct cell-specific genes, the researchers called them “hybrid hepatocytes.”

“Hybrid hepatocytes represent not only the most effective way to repair a diseased liver, but also the safest way to prevent fatal liver failure by cell transplantation,” Karin said.



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