Feeds:
Posts
Comments

Posts Tagged ‘Florida State University’

Reporter and Curator: Aviva Lev-Ari, PhD, RN

Oldest picture

http://th.physik.uni-frankfurt.de/~jr/physpiceinstein.html

my favorite picture of Albert Eistein

http://www.google.com/search?q=albert+einstein+pictures&hl=en&tbo=u&tbm=isch&source=univ&sa=X&ei=sXKyUI6RJ4j-0gG7m4DIDA&sqi=2&ved=0CDUQsAQ&biw=779&bih=776

http://www.albert-einstein.org/

A new study on the neuroanatomy of Albert Einstein was

Released: 11/15/2012 10:00 AM EST
Embargo expired: 11/15/2012 7:00 PM EST
Source: Florida State University

Portions of Albert Einstein’s brain have been found to be unlike those of most people and could be related to his extraordinary cognitive abilities, according to a new study led by Florida State University evolutionary anthropologist Dean Falk.

Brain

Uncommon Features of Einstein’s Brain Might Explain His Remarkable Cognitive Abilities

Released: 11/15/2012 10:00 AM EST
Embargo expired: 11/15/2012 7:00 PM EST
Source: Florida State University

Newswise — TALLAHASSEE, Fla. ⎯ Portions of Albert Einstein’s brain have been found to be unlike those of most people and could be related to his extraordinary cognitive abilities, according to a new study led by Florida State University evolutionary anthropologist Dean Falk.

Falk, along with colleagues Frederick E. Lepore of the Robert Wood Johnson Medical School and Adrianne Noe, director of the National Museum of Health and Medicine, describe for the first time the entire cerebral cortex of Einstein’s brain from an examination of 14 recently discovered photographs. The researchers compared Einstein’s brain to 85 “normal” human brains and, in light of current functional imaging studies, interpreted its unusual features.

“Although the overall size and asymmetrical shape of Einstein’s brain were normal, the prefrontal, somatosensory, primary motor, parietal, temporal and occipital cortices were extraordinary,” said Falk, the Hale G. Smith Professor of Anthropology at Florida State. “These may have provided the neurological underpinnings for some of his visuospatial and mathematical abilities, for instance.”

The study, “The Cerebral Cortex of Albert Einstein: A Description and Preliminary Analysis of Unpublished Photographs,” will be published Nov. 16 in the journal Brain.

Upon Einstein’s death in 1955, his brain was removed and photographed from multiple angles with the permission of his family. Furthermore, it was sectioned into 240 blocks from which histological slides were prepared. Unfortunately, a great majority of the photographs, blocks and slides were lost from public sight for more than 55 years. The 14 photographs used by the researchers now are held by the National Museum of Health and Medicine.

The paper also publishes the “roadmap” to Einstein’s brain prepared in 1955 by Dr. Thomas Harvey to illustrate the locations within Einstein’s previously whole brain of 240 dissected blocks of tissue, which provides a key to locating the origins within the brain of the newly emerged histological slides.

SOURCE:

http://www.newswise.com/articles/uncommon-features-of-einstein-s-brain-might-explain-his-remarkable-cognitive-abilities

Albert Einstein died 50 years ago Monday. While that day marked the end of his life, it was only the beginning of a long, strange journey for his brain.

Thomas Harvey, a doctor at the hospital where Einstein died, removed the famous scientist’s brain and kept it with him over the next four decades. Harvey wanted to know what made Einstein a genius.

As Brian Burrell writes in his new book Postcards from the Brain Museum, Harvey wasn’t alone.

Scientists have long sought to understand the nature of genius and before computers and imaging technology, they had few options other than studying the actual brain.

Burrell discusses the long, strange journey of Einstein’s brain.

The Long, Strange Journey of Einstein’s Brain

April 18, 2005

Albert Einstein’s Brain May Provide Clues To His Genius, Study Says

By  Posted: 11/17/2012 12:08 am EST Updated: 11/19/2012 6:26 pm EST

http://www.huffingtonpost.com/2012/11/17/albert-einstein-brain-study-genius_n_2144865.html

ORIGINAL PAPER  in BRAIN, A JOURNAL OF NEUROLOGY, OCCASIONAL PAPER – November 16, 2012

The cerebral cortex of Albert Einstein: a description and preliminary analysis of unpublished

photographs

http://www.oxfordjournals.org/our_journals/brainj/press_releases/prpaper.pdf

Paper Authors’ Affiliations:

Dean Falk,1,2 Frederick E. Lepore3,4 and Adrianne Noe5

1 Department of Anthropology, Florida State University, Tallahassee, FL 32306-7772, USA

2 School for Advanced Research, Santa Fe, NM 87505, USA

3 Department of Neurology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA

4 Department of Ophthalmology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA

5 National Museum of Health and Medicine, Silver Spring, MD 20910, USA

Correspondence to:

Dean Falk,

School for Advanced Research,

660 Garcia Street,

Santa Fe, NM 87505, USA

E-mail: dfalk@fsu.edu or falk@sarsf.org

Summary and conclusions

Quote from Brain, 2012, November 16, 2012, green color added

Einstein’s brain is of unexceptional size and its combination of a relatively wide and forward-projecting right frontal lobe with a relatively wide and posteriorly protruding left occipital lobe is the most prevalent pattern seen in right-handed adult males.

We have identified the sulci that delimit expansions of cortex (gyri or convolutions) on the external surfaces of all of the lobes of the brain and on the medial surfaces of both hemispheres. The morphology 25 in some parts of Einstein’s cerebral cortex is highly unusual compared with 25 (Ono et al., 1990) and 60 (Connolly, 1950) human brains for which sulcal patterns have been thoroughly described. To the extent possible, the blocks of brain from particularly interesting areas are identified on the ‘roadmap’ that was prepared when Einstein’s brain was sectioned, as a guide for researchers who may wish to explore the histological correlates of Einstein’s gross cortical morphology.

Contrary to earlier reports, newly available photographs reveal that Einstein’s brain is not spherical in shape. The surface area of Einstein’s inferior parietal lobule is larger on the left than the right side, whereas that of his superior parietal lobule appears markedly larger in the right hemisphere. The photographs also suggest that the primary somatosensory and motor cortices representing the face and tongue are differentially expanded in the left hemisphere, that the posterior ascending limb of the Sylvian fissure is separate from (rather than confluent with) the postcentral inferior sulcus,and that parietal opercula are present. Nevertheless, our findings are concordant with the earlier suggestion that unusual morphology in Einstein’s parietal lobes may have provided neurological substrates for his visuospatial and mathematical abilities (Witelson  et al., 1999a, b).

Our results also suggest that Einstein had relatively expanded prefrontal cortices, which may have provided underpinnings for some of his extraordinary cognitive abilities, including his productive use of thought experiments. From an evolutionary perspective, the specific parts of Einstein’s prefrontal cortex that appear to be differentially expanded are of interest because recent findings indicate that these same areas increased differentially in size and became neurologically reorganized at microanatomical levels during hominin evolution in association with the emergence of higher cognitive abilities (Semendeferi et al., 2011).

It would be interesting therefore to investigate the histological correlates of these (as well as parietal) regions of Einstein’s brain from the newly available slides. We hope that future research on comparative primate neuroanatomy, paleoneurology and functional neuroanatomy will provide insight about some of the unusually convoluted parts of Einstein’s brain that we have described with little, if any, interpretation (e.g. the external neuroanatomy of the occipital lobes, posterolateral temporal cortex, and inferior temporal gyri). 

Figure 12 The remainder of the original ‘road map’ to the 240 blocks sectioned from Einstein’s brain. A–D correspond with Fig. 8.

The figure is reproduced with permission from the National Museum of Health and Medicine.

| Brain 2012: Page 22 of 24 D. Falk et al.

Acknowledgements

The authors thank the estate of Thomas S. Harvey, MD, for

donating the materials that form the basis for this article to the

National Museum of Health and Medicine, Elizabeth Lockett and

5 Emily Wilson for help in accessing materials, and Jessica Calzada

for preparation of figures. Kurt Rockenstein is thanked for extensive

technical support. We also received help from Eric Boyle, Tim

Clarke, Jr., Laura Cutter, Elizabeth Eubanks, Albert Galaburda, Lois

Hawkes, Sam Huckaba and Micah Vandegrift. The National

Museum of Health and Medicine is acknowledged for permission

to reproduce the 12 images that appear in this article. The views

expressed are those of the authors and do not reflect the official

policy or position of the Department of Defense or the United

States Government.

Individuals who are interested in studying the newly emerged

Harvey Collection should contact medicalmuseum@amedd

.army.mil.

Funding

Publication costs were provided by the College of Arts and

20 Sciences at Florida State University, and travel support for DF

was provided by the School for Advanced Research in Santa Fe,

New Mexico.

REFERENCES

Abraham C. Possessing genius. New York: St. Martin’s Press; 2002.

25 Allen JS, Bruss J, Damasio H. Looking for the lunate sulcus: a magnetic

resonance imaging study in modern humans. Anat Rec A Discov Mol

Cell Evol Biol 2006; 288: 867–76.

Allman JM, Tetreault NA, Hakeem AY, Manaye KF, Semendeferi K,

Erwin JM, et al. The von Economo neurons in frontoinsular and an-

 terior cingulate cortex in great apes and humans. Brain Struct Funct

2010; 214: 495–517.

Amunts K, Schleicher A, Burgel U, Mohlberg H, Uylings HB, Zilles K.

Broca’s region revisited: cytoarchitecture and intersubject variability.

J Comp Neurol 1999; 412: 319–41.

Amunts K, Schleicher A, Ditterich A, Zilles K. Broca’s region: cytoarchitectonic

asymmetry and developmental changes. J Comp Neurol 2003;

465: 72–89.

Anderson B, Harvey T. Alterations in cortical thickness and neuronal

density in the frontal cortex of Albert Einstein. Neurosci Lett 1996;

210: 161–4.

Bailey P, Von Bonin G. The isocortex of man. Urbana, IL: University of

Illinois Press; 1951.

Bangert M, Schlaug G. Specialization of the specialized in features of

external human brain morphology. Eur J Neurosci 2006; 24: 1832–4.

Broca P. Remarques sur le sie´ ge de la faculte´ du langage articule´ , suivies

d’une observation d’aphe´ mie (Perte de la Parole). Bulletin de la Socie´ te´

Anatomique de Paris 1861; 6: 330–57.

Clark GM, Mackay CE, Davidson ME, Iversen SD, Collinson SL,

James AC, et al. Paracingulate sulcus asymmetry; sex difference, cor-

relation with semantic fluency and change over time in adolescent

onset psychosis. Psychiatry Res 2010; 184: 10–15.

Cole MW, Yeung N, Freiwald WA, Botvinick M. Conflict over cingulate

cortex: between-species differences in cingulate may support

enhanced cognitive flexibility in humans. Brain Behav Evol 2010; 75:

239–40.

Colombo JA, Reisin HD, Miguel-Hidalgo JJ, Rajkowska G. Cerebral cortex

astroglia and the brain of a genius: a propos of A. Einstein’s. Brain Res

Rev 2006; 52: 257–63.

Connolly JC. External morphology of the primate brain. Springfield, IL: C.

C. Thomas; 1950. 60

Courchesne E, Chisum HJ, Townsend J, Cowles A, Covington J, Egaas B,

et al. Normal brain development and aging: quantitative analysis at

in vivo MR imaging in healthy volunteers. Radiology 2000; 216:

672–82.

Dehaene S. Reading in the Brain. New York: Viking; 2009. 65

Diamond MC, Scheibel AB, Murphy GM Jr, Harvey T. On the brain of a

scientist: Albert Einstein. Exp Neurol 1985; 88: 198–204.

Duvernoy HM, Bourqouin P, Cabanis EA, Cattin F, Maeder P. The

human brain: surface, blood supply, and three-dimensional sectional

anatomy. 2nd edn. New York: Springer-Verlag; 1999. 70

Falk D. New information about Albert Einstein’s brain. Front Evol

Neurosci 2009; 1: 3.

Falk D. Hominin paleoneurology: where are we now? In: Hofman MA,

Falk D, editors Evolution of the primate brain: from neuron to behav-

ior. London: Elsevier; 2012. p. 255–72. 75

Filosa A, Paixao S, Honsek SD, Carmona MA, Becker L, Feddersen B,

et al. Neuron-glia communication via EphA4/ephrin-A3 modulates

LTP through glial glutamate transport. Nat Neurosci 2009; 12:

1285–92.

Finlay BL, Darlington RB. Linked regularities in the development and 80

evolution of mammalian brains. Science 1995; 268: 1578–84.

Galaburda AM. [Broca’s region: anatomic remarks made a century

after the death of its discoverer]. Rev Neurol (Paris) 1980; 136:

609–16.

Galaburda AM. Albert Einstein’s brain. Lancet 1999; 354: 1821. 85

Galaburda AM, Geschwind N. Anatomical asymmetries in the adult and

developing brain and their implications for function. Adv Pediatr 1981;

28: 271–92.

Galaburda AM, Kosslyn SM, Christen Y. The Languages of the brain.

Cambridge, MA: Harvard University Press; 2002. 90

Galaburda AM, LeMay M, Kemper TL, Geschwind N. Right-left asymmetrics

in the brain. Science 1978; 199: 852–6.

Geschwind N, Levitsky W. Human brain: left-right asymmetries in temporal

speech region. Science 1968; 161: 186–7.

Gilbert DT, Wilson TD. Prospection: experiencing the future. Science 95

2007; 317: 1351–4.

Hadamard J. The psychology of invention in the mathematical field.

Princeton, NJ: Dover Publications; 1945.

Hines T. Further on Einstein’s brain. Exp Neurol 1998; 150: 343–4.

Hofman MA. Design principles of the human brain: an evolutionary 100

perspective. In: Hofman MA, Falk D, editors. Evolution of the primate

brain: from neuron to behavior. London: Elsevier; 2012.

p. 373–90.

Iaria G, Petrides M. Occipital sulci of the human brain: variability and

probability maps. J Comp Neurol 2007; 501: 243–59. 105

Isaacson W. Einstein, his life and universe. New York: Simon and

Schuster; 2007.

Jerison HJ. Evolution of the brain and intelligence. New York: Academic

Press; 1973.

Keller SS, Crow T, Foundas A, Amunts K, Roberts N. Broca’s area: no- 110

menclature, anatomy, typology and asymmetry. Brain Lang 2009; 109:

29–48.

Keller SS, Highley JR, Garcia-Finana M, Sluming V, Rezaie R, Roberts N.

Sulcal variability, stereological measurement and asymmetry of Broca’s

area on MR images. J Anat 2007; 211: 534–55. 115

Kigar DL, Witelson SF, Glezer II, Harvey T. Estimates of cell number in

temporal neocortex in the brain of Albert Einstein. Soc Neurosci Abst

1997; 23: 89.9.

Knops A, Thirion B, Hubbard EM, Michel V, Dehaene S. Recruitment of

an area involved in eye movements during mental arithmetic. Science 120

2009; 324: 1583–5.

Kosslyn SM, Ganis G, Thompson WL. Neural foundations of imagery.

Nat Rev Neurosci 2001; 2: 635–42.

The brain of Albert Einstein Brain 2012: Page 23 of 24 | 23

Kosslyn SM, Thompson WL, Kim IJ, Alpert NM. Topographical representations

of mental images in primary visual cortex. Nature 1995; 378:

496–8.

LeMay M. Morphological cerebral asymmetries of modern man,

5 fossil man, and nonhuman primate. Ann N Y Acad Sci 1976; 280:

349–66.

LeMay M. Asymmetries of the skull and handedness. Phrenology revisited.

J Neurol Sci 1977; 32: 243–53.

LeMay M. Left-right dissymmetry, handedness. Am J Neuroradiol 1992;

10 13: 493–504.

Lepore FE. Dissecting genius—Einstein’s brain and the search for the

neural basis of intellect. Vol. 3. Cerebrum: The Dana Forum on

Brain Science; 2001. p. 11–26.

Magnotta VA, Andreasen NC, Schultz SK, Harris G, Cizadlo T, Heckel D,

15 et al. Quantitative in vivo measurement of gyrification in the

human brain: changes associated with aging. Cereb Cortex 1999; 9:

151–60.

Ono M, Kubik S, Abernathy CD. Atlas of the Cerebral Sulci. New York:

Thieme Medical Publishers, Inc.; 1990.

20 Penfield W, Rasmussen T. The cerebral cortex of man: a clinical study of

localization of function. New York: Hafner Publishing Company; 1968.

Posner MI, Rothbart MK, Sheese BE, Tang Y. The anterior cingulate

gyrus and the mechanism of self-regulation. Cogn Affect Behav

Neurosci 2007; 7: 391–5.

25 Sack AT, Sperling JM, Prvulovic D, Formisano E, Goebel R, Di Salle F,

et al. Tracking the mind’s image in the brain II: transcranial magnetic

stimulation reveals parietal asymmetry in visuospatial imagery. Neuron

2002; 35: 195–204.

Schenker NM, Buxhoeveden DP, Blackmon WL, Amunts K, Zilles K,

30 Semendeferi K. A comparative quantitative analysis of cytoarchitecture

and minicolumnar organization in Broca’s area in humans and great

apes. J Comp Neurol 2008; 510: 117–28.

Semendeferi K, Teffer K, Buxhoeveden DP, Park MS, Bludau S,

Amunts K, et al. Spatial organization of neurons in the frontal pole

35 sets humans apart from great apes. Cereb Cortex 2011; 21: 1485–97.

Smith GE. The fossil anthropoid ape from Taungs. Nature 1925; 115:

235.

Smith GE. The morphology of the occipital region of the cerebral hemisphere

in man and the apes. Anatomisher Anzeiger 1904; 24: 436–51.

Teffer K, Semendeferi K. Human prefrontal cortex: evolution, develop- 40

ment, and pathology. In: Hofman MA, Falk D, editors. Evolution of

the primate brain: from neuron to behavior. London: Elsevier; 2012.

p. 191–218.

Toga AW, Narr KL, Thompson PM, Luders E. Brain asymmetry: evolu-

tion. Encyclopedia Neurosci 2009; 2: 303–11. 45

Tu¨ re U, Yasargil DC, Al-Mefty O, Yasargil MG. Topographic anatomy of

the insular region. J Neurosurg 1999; 90: 720–33.

Van Essen DC. A tension-based theory of morphogenesis and

compact wiring in the central nervous system. Nature 1997; 385:

313–18. 50

Van Essen DC. Cerebral cortical folding patterns in primates: why they

vary and what they signify. In: Kass JH, Preuss TM, editors. Evolution

of nervous systems. Vol. 4. London: Elsevier; 2007. p. 267–89.

Vein AA, Maat-Schieman ML. Famous Russian brains: historical attempts

to understand intelligence. Brain 2008; 131: 583–90. 55

Watkins KE, Paus T, Lerch JP, Zijdenbos A, Collins DL, Neelin P, et al.

Structural asymmetries in the human brain: a voxel-based statistical

analysis of 142 MRI scans. Cereb Cortex 2001; 11: 868–77.

Witelson SF, Kigar DL, Harvey T. Authors’ reply. Lancet 1999a; 354:

1822. 60

Witelson SF, Kigar DL, Harvey T. The exceptional brain of Albert

Einstein. Lancet 1999b; 353: 2149–53.

Yu¨ cel M, Stuart GW, Maruff P, Velakoulis D, Crowe SF, Savage G, et al.

Hemispheric and gender-related differences in the gross morphology

of the anterior cingulate/paracingulate cortex in normal volunteers: an 65

MRI morphometric study. Cereb Cortex 2001; 11: 17–25.

Zilles K, Dabringhaus A, Geyer S, Amunts K, Qu M, Schleicher A, et al.

Structural asymmetries in the human forebrain and the forebrain of

non-human primates and rats. Neurosci Biobehav Rev 1996; 20:

593–605. 70

Read Full Post »