Roles at http://pharmaceuticalintelligence.com
Co-Editor, Cancer Volume One and Volume Two e-Book
Research Categories OWNER:
- Bone Disease and Musculoskeletal Disease
- Liver & Digestive Diseases Research
- Chemical Biology and its relations to Metabolic Disease
- Disease Biology, Small Molecules in Development of Therapeutic Drugs
Ritu Saxena, PhD
ritu.uab@gmail.com
Updated on 2/18/2019
Analytics Team Leader & Senior Data Scientist
Phone: (+1) 309 – 226 – 3580
Scottsdale, AZ 85254
Analytical Skills
- Statistical Modeling
- Predictive Analytics
- Text Mining
- Social Media Analytics
- Marketing Analytics
- Business Intelligence
- Reporting
- Project Leadership
- Data to Business Value
- Data Visualization
- Time Series & Forecasting
Analytical Tools & Platforms
- SAS (base and EG)
- R Programming
- Python
- mySQL
- Tableau
- Teradata
- Hadoop, hive
- Microsoft Azure
- Microsoft Excel
- Sysomos
- Palisade@Risk
Education
Master of Science (2018)
Predictive Analytics
Northwestern University
Doctor of Philosophy (2009)
Cell Biology
The University of Alabama at Birmingham, Birmingham, AL
Master of Science (2004)
Life Sciences
Jawaharlal Nehru University, New Delhi, India
Bachelor of Science (2002)
Industrial Microbiology
Dr. B.R. Ambedkar University, India
P R O F I L E
Innovative analytics professional with 8+ years of diverse experience in advanced analytics, statistical modeling, pharmaceutical business intelligence, molecular biology research and project leadership. Passionate about providing actionable insights to the business using data analytics.
E X P E R I E N C E
Cybersecurity Analytics Lead (Apr 2018 – Current)
American Express, Phoenix, AZ
Leverage security and work with key stakeholders to identify use cases and provide relevant data solutions in the form of interactive visualizations, insights and predictive models. Developed a risk scoring unsupervised model for application risk and collaborated to have it the model and dashboard created in production.
Analytics & Business Intelligence Manager (Mar 2017 – Mar 2018)
Discover Financial Services, Phoenix, AZ
Leverage operations data; develop business intelligence and analytical solutions for business partners. Engage with sponsors & stakeholders across business units regarding project progress, requirements, expectations and deliverables.
Marketing Analytics Team Leader (Dec 2014 – Mar 2017)
Information Analytics, Caterpillar Inc., Peoria, IL
Lead cross-functional teams of data scientists, visualization and marketing professionals on analytics projects for creation, application and validation of statistical models and visualizations. Mentor and train incoming analysts and manage multiple projects on tight deadlines.
- Identified $42M of lost opportunity on part sales. Led a team, extracted customer data using Hadoop platform (Hive), developed algorithms to track lost part sales.
- Identified over $6M of lost revenue opportunity due to patent infringement on Cat parts. Developed a schema-based model with a single weighted index by combining multiple techniques such as cross-correlation, regression modeling, time series analysis and econometric modeling.
- Developed a reporting tool to track and quantify rental business risk to dealers. Performed regression modeling and ROI analysis to identify key variables affecting risk derived from multiple data sources (industrial, macroeconomic, financial and operational data).
- Identified valuable insights as common themes, and word networks from customer surveys. Used R, SAS Enterprise Miner and python-based sentiment analysis tools to mine comments and provided key actionable recommendations.
- Compared impact of marketing campaigns of traditional and non-traditional competitors using social media listening tools, Radian6 and Sysomos.
Expert Author, Communicator and Co-editor (2012-2014)
Leaders in Pharmaceutical Business Intelligence (LPBI) Group
- Scientific writing and reporting of cutting-edge technologies, cancer indications, drug targets and therapies
- Market research to identify emerging trends in drug discovery & medical technologies
- Published 5 Books on metabolic diseases and pharmacology, genomics and cancer biology on Amazon
Post-doctoral Research Associate,
Department of Cancer Biology and Pharmacology
University of Illinois College of Medicine, Peoria, IL (2010 – 2011)
- Developed an effective combinatorial strategy to restrict the growth of brain cancer cells
- Performed hypothesis testing and validated the effectiveness of combinatorial strategy by several cell growth assays
- Identified major molecular players demonstrating anti-cancerous effects that could serve as drug targets for glioblastoma therapy
S E L E C T E D P U B L I C A T I O N S
eBook and Book Chapters
- Baker M, Barliya T, Sarkar S, Saxena R, Williams SJ. Perspectives on Nitric Oxide in Disease Mechanisms (Biomed e-Books Book 1). Kindle edition. 2013 http://pharmaceuticalintelligence.com/biomed-e-books/series-a-e-books-on-cardiovascular-diseases/perspectives-on-nitric-oxide-in-disease-mechanisms-v2/ Accessed June 23, 2014.
- Triple Negative Breast Cancer: a clinical review (scheduled to be published in New Medicine Oncology Knowledge Base, 2015)
- Leukemia (invited book chapter) , Disease Prevention and Treatment Book (new edition scheduled to be published in 2015)
Technical reports (white papers)
- Saxena R, Non-small Cell Lung Cancer Drugs – where does the future lie?
- Saxena R, Personalized medicine-based cure for cancer might not be far away: Interview with Dr. Apostolia Tsimberidou
Peer-reviewed journal articles
- Saxena R, Pan G, Dohm ED, McDonald JM. Modeled microgravity and hindlimb unloading sensitize osteoclast precursors to RANKL mediated osteoclastogenesis. J Bone Miner Metab. 2011 Jan;29(1):111-22.
- Hurst DR, Xie Y, Vaidya KS, Mehta A, Moore BP, Accavitti-Loper MA, Samant RS, Saxena R, Silveira AC, Welch DR. Alterations of breast cancer metastasis suppressor 1:AT rich interactive domain 4A interaction modify gene expression but still suppress metastasis in human breast cancer cells. J Biol Chem. 2008 Mar 21;283(12):7438-44.
- Saxena R, Pan G, McDonald JM. Osteoblast and Osteoclast Differentiation in Modeled Microgravity. Ann N Y Acad Sci. 2007 Nov;1116:494-8.
H O N O R S & A W A R D S
- Competent Communicator Award, Toastmasters International, 2012
- Top Young Investigator Award, New York Academy of Sciences, 2007
- 3rd place in oral presentations at the ‘UAB Graduate Student Research Day’, 2007
- Junior Research Fellowship, Council of Scientific and Industrial Research, India, 2003
OLD VERSIONS
Personal Bio
I have a background in life sciences, and an extensive research extensive research experience in the field of Cancer and Bone Biology. My PhD project was aimed at elucidating the underlying molecular mechanisms of microgravity induced bone loss. I was successful in establishing and characterizing a novel in vitro simulated microgravity system that enabled the response of osteoclast or the bone resorbing cells to low gravity conditions. The findings were further elaborated and then used to test osteoporotic drugs in the in vivo mouse hindlimb unloading system leading to important conclusions about both microgravity-induced osteopenia and disuse osteoporosis induced bone loss.
Postdoctoral work at the Washington University in St. Louis was focused on molecular mechanisms involved in mechanical loading induced bone formation. My research experiences in cancer include studying breast cancer metastasis and Glioblastoma multiforme research at the University of Illinois College of Medicine. Research highlights include establishing stable cell lines with deletion mutants of breast cancer metastasis gene, BRMS1; and understanding the combinatorial effects of silencing matrix metalloproteinases and radiation on the proliferation, invasion, migration and angiogenesis of Glioblastoma multiforme cells, subsequently determining the role of integrin mediated signaling.
I am motivated and hard working; and have acquired diverse skills during my research endeavors including medical writing, project management, and pharmaceutical intelligence. I am pursuing my interest in scientific writing as an author, reporter and curator in the Pharmaceutical Business Intelligence venture by authoring posts on diverse areas including but not limited to bone, cancer, mitochondrial research. I am open to new opportunities, both laboratory-based and writing, where I would be able to utilize my skills to contribute and benefit the institution or company as an employee.
Ritu Saxena, Ph.D.
ritu.uab@gmail.com
PUBLICATIONS with Leaders in Pharmaceutical Business Intelligence
- Series C: e-Books on Cancer & Oncology
Sr. Editor: Stephen J Williams, PhD
Editors: Ritu Saxena, PhD, Tilda Barliya, PhD
Volume 2: Immunotherapy in Cancer & Radiation Oncology
Sr. Editor: Itshak Golan, PhD
Editors: Stephen J Williams, PhD, Dror Nir, PhD and Tilda Barliya, PhD, Ritu Saxena, PhD
RECENT PUBLICATIONS in Genomics, Cell Biology and Cancer as a Complex Disease
Genomics
Saxena, R. 3/4/2013. Genomics-based cure for diabetes on-the-way. http://pharmaceuticalintelligence.com/2013/03/04/genomics-based-cure-for-diabetes-on-the-way/
Saxena, R. 9/26/2012. ENCODE: the key to unlocking the secrets of complex genetic diseases
Saxena, R. 8/14/2012. Mitochondrial mutation analysis might be “1-step” away http://pharmaceuticalintelligence.com/2012/08/14/mitochondrial-mutation-analysis-might-be-1-step-away/
Cancer Biology
Saxena, R. 5/27/2013. Personalized medicine-based diagnostic test for NSCLC
Saxena, R. 6/24/2013. In Focus: Circulating Tumor Cells http://pharmaceuticalintelligence.com/2013/03/22/in-focus-identity-of-cancer-stem-cells/
Saxena, R. 4/10/2013. Hypervascular Hepatocellular Carcinoma: Important clues from Gadoxetic acid-based MRI imaging http://pharmaceuticalintelligence.com/2013/04/10/hypervascular-hepatocellular-carcinoma-important-clues-from-gadoxetic-acid-based-mri-imaging/
Saxena, R. 3/27/2013. In Focus: Targeting of Cancer Stem Cells http://pharmaceuticalintelligence.com/2013/03/27/in-focus-targeting-of-cancer-stem-cells/
Saxena, R. 3/22/2013. In Focus: Identity of Cancer Stem Cells
http://pharmaceuticalintelligence.com/2013/06/24/in-focus-circulating-tumor-cells/
Saxena, R. 3/8/2013. In Focus: Melanoma therapeutics http://pharmaceuticalintelligence.com/2013/03/08/in-focus-melanoma-therapeutics/
Saxena, R. 1/29/2013. In focus: Triple Negative Breast Cancer http://pharmaceuticalintelligence.com/2013/01/29/in-focus-triple-negative-breast-cancer/
Saxena, R. 1/15/2013. Exploring the role of vitamin C in Cancer therapy http://pharmaceuticalintelligence.com/2013/01/15/exploring-the-role-of-vitamin-c-in-cancer-therapy/
Saxena, R. 1/7/2013. Personalized medicine gearing up to tackle cancer
http://pharmaceuticalintelligence.com/2013/01/07/personalized-medicine-gearing-up-to-tackle-cancer/
Saxena, R. 12/13/2012. Tumor Imaging and Targeting: Predicting Tumor Response to Treatment: Where we stand?
Saxena, R. 12/4/2012. Judging ‘Tumor response’-there is more food for thought
Saxena, R. 11/20/2012. Personalized medicine-based cure for cancer might not be far away
Saxena, R. 11/6/2012. Non-small Cell Lung Cancer drugs – where does the Future lie? http://pharmaceuticalintelligence.com/2012/11/06/non-small-cell-lung-cancer-drugs-where-does-the-future-lie/
Saxena, R. 10/22/2012. Blood-vessels-generating stem cells discovered http://pharmaceuticalintelligence.com/2012/10/22/blood-vessel-generating-stem-cells-discovered/
Saxena, R. 10/16/2012. Crucial role of Nitric Oxide in Cancer http://pharmaceuticalintelligence.com/2012/10/16/crucial-role-of-nitric-oxide-in-cancer/
Saxena, R. 9/17/2012. Scientists use natural agents for prostate cancer bone metastasis treatment
Saxena, R. 9/10/2012. β Integrin emerges as an important player in mitochondrial dysfunction associated Gastric Cancer
Saxena, R. 9/1/2012. Mitochondria and Cancer: An overview of mechanisms http://pharmaceuticalintelligence.com/2012/09/01/mitochondria-and-cancer-an-overview/
Saxena, R. 6/19/2012. Cancer and Bone: low magnitude vibrations help mitigate bone loss
Saxena, R. 5/21/2012. Battle of Steve Jobs and Ralph Steinman with Pancreatic cancer: How we lost
Saxena, R. 5/14/2012. Usp9x: Promising therapeutic target for pancreatic cancer http://pharmaceuticalintelligence.com/2012/05/14/promising-therapeutic-target-discovered-for-pancreatic-cancer/
Cell Biology
Saxena, R. 9/1/2012. Mitochondria and Cancer: An overview of mechanisms http://pharmaceuticalintelligence.com/2012/09/01/mitochondria-and-cancer-an-overview/
Saxena, R. 6/30/2012. A Protease for ‘Middle-down’ Proteomics http://pharmaceuticalintelligence.com/2012/06/30/a-protease-for-middle-down-proteomics/
HIGHLIGHTS
• Top Young Investigator Award at the 2nd Skeletal Biology Conference, Annals of New York Academy of
Sciences
• 6 + years of experience in Cell and Molecular Biology in vitro techniques
• Highly motivated researcher with an extensive experience in the fields of Câncer and Bone Biology
research
• Excellent communication skills along with a rich experience in working with multi-disciplinary teams on
challenging research projects
WORK EXPERIENCE
Editor, New Medicine Oncology KnowledgeBase Inc, Los Angeles, CA. March 2013 till March 2014
Edited, summarized and updated information on clinical trials of various cancer drugs. The summary included information from clinicaltrial.gov <http://clinicaltrial.gov> , phase, trail details, results and published updates (if available). Extracted and summarized latest information (preclinical and clinical) on cancer drugs published in prestigious cancer conferences including AACR and ASCO. Edited, wrote and compiled the Future Oncology newsletter reports.
Post Doctoral Research Associate: Department of Cancer Biology and Pharmacology April 2010 till December 2010
University of Illinois College of Medicine at Peoria, Peoria, IL
Post Doctoral Research Associate: Department of Orthopedic Surgery September 2009 till April 2010
Washington University in St. Louis, St. Louis, MO
EDUCATION
Doctor of Philosophy (December 2009)
Major: Cell Biology
University of Alabama at Birmingham, Birmingham, AL.
Master of Science (December 2004)
Major: Life Sciences
Jawaharlal Nehru University, New Delhi, India
Bachelor of Science (May 2002)
Major: Industrial Microbiology, Botany and Chemistry.
Dr. B.R. Ambedkar University, India
HONORS & AWARDS
• Top Young Investigator Award, New York Academy of Sciences – April 2007
• 3rd place in oral presentations at the ‘UAB Graduate Student Research Day’- March 2007
• Travel award, 29th Annual Meeting, ASBMR, Honolulu, Hawaii – September 2007
• Awarded the Junior Research Fellowship (JRF) and Lectureship (NET), through the National level scholarship examination by the Council of Scientific and Industrial Research (CSIR), India – December 2003
• Awarded for highest GPA during all the three years in the undergraduate department of Industrial Microbiology 1999-2002.
• ‘Certificate of qualification’ for the national level Mathematics Olympiad Contest organized by the Delhi Association of Mathematics Teachers – 1996
PUBLICATIONS
• Saxena R, Pan G, Dohm ED, McDonald JM. Modeled microgravity and hindlimb unloading sensitize osteoclast precursors to RANKL mediated osteoclastogenesis. Journal of Bone and Mineral Metabolism 2010 Jun 30.
• Hurst DR, Xie Y, Vaidya KS, Mehta A, Moore BP, Accavitti-Loper MA, Samant RS, Saxena R, Silveira AC, Welch DR. Alterations of breast cancer metastasis suppressor 1:AT rich interactive domain 4A interaction modify gene expression but still suppress metastasis in human breast cancer cells. Journal of Biological Chemistry 283:7438-7444, 2008.
• Saxena R, Pan G, McDonald JM. Osteoblast and Osteoclast Differentiation in Modeled Microgravity. Annals of the New York Academy of Sciences 1116: 494-498, 2007.
PRESENTATIONS
• Saxena R, Pan G, McDonald JM. Modeled Microgravity stimulates RANKL mediated Osteoclastogenesis, 30th Annual Meeting of the ASBMR, Montreal, Canada, September 15-18, 2008.
• Saxena R, Pan G, McDonald JM. Microgravity and Bone: Effects of Modeled Microgravity on Osteoclast Differentiation, 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR), Honolulu, Hawaii, September 16-19, 2007.
• Saxena R, Pan G, McDonald JM. Osteoblast and Osteoclast Differentiation in Modeled Microgravity, Skeletal Biology and Medicine conference, The New York Academy of Sciences, Mount Sinai School of Medicine, New York, April 25-28, 2007.
• Saxena R, Pan G, McDonald JM. Molecular Mechanisms of Microgravity induced Bone Loss, NASA Human
Research Program Investigator’s Workshop, League City, Texas -February 12-14, 2007.
MEMBERSHIP AND EXTERNAL ACTIVITIES
• Vice President of Public Relations of Prairieland Toastmasters club, Peoria, IL (2011-12)
• Served in the Peoria Art Guild Committee, Peoria, IL – Organized the Junction City Art Fair (May 2010) and Fine Art Fair (September 2010).
• Member
• American Medical Writers association (AMWA) (2011-12)
• Phi Beta Delta (2008-09)
• New York Academy of Sciences (NYAS) (2007-08)
• American Society for Bone and Mineral Research (ASBMR) (2007-09)
• Center for Metabolic Bone Diseases (CMBD), University of Alabama at Birmingham, AL (2007-09)
• Served as the UAB International Mentor, a university representative for helping the incoming International Students in the University of Alabama at Birmingham, Birmingham, AL. (August 2008- August 2009)
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