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DISCUSSION – Genomics-driven personalized medicine for Pancreatic Cancer Reporter: Aviva Lev-Ari, PhD, RN [bold face added, ALA] Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer –>>> Personalized Tumor Models Could Help Identify Combination Therapies for Hard-to-Treat Cancers   Original article Pancreatic Cancer – Genomics-driven personalized medicine   PDAC has a particularly poor prognosis, […]

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Tumor Genome Profiling Technology and Genomics Research Services from Mount Sinai Services: Offering of Personalis Reporter: Aviva Lev-Ari, PhD, RN Personalis, Mount Sinai Services to Offer Tumor Genome Profiling Technology Personalis announced today that it has signed a letter of intent to offer its next-generation tumor sequencing and interpretation technology in Canada through a collaboration […]

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Basic Research in Immune Oncology and Molecular Genomics: Methods to Stimulate Immunity by Alteration of Tumor Antigens Reporter: Aviva Lev-Ari, PhD, RN   I covered in Real Time the great event organized by Partners HealthCare Innovations Real Time Coverage and eProceedings of 2016 World Medical Innovation Forum: CANCER, April 25-27, 2016, Westin Hotel, Boston https://pharmaceuticalintelligence.com/2016/04/28/real-time-coverage-and-eproceedings-of-2016-world-medical-innovation-forum-cancer-april-25-27-2016-westin-hotel-boston/   […]

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Schizophrenia genomics Larry H. Bernstein, MD, FCAP, Curator LPBI   Histone Methylation at H3K9; Evidence for a Restrictive Epigenome in Schizophrenia Kayla A. Chase,1David P. Gavin,1Alessandro Guidotti,1 and Rajiv P. Sharma1 Schizophr Res. 2013 Sep; 149(0): 15–20.      doi:  10.1016/j.schres.2013.06.021 Epigenetic changes are stable and long-lasting chromatin modifications that regulate genomewide and local gene activity. […]

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Triglycerides: Is it a Risk Factor or a Risk Marker for Atherosclerosis and Cardiovascular Disease ? The Impact of Genetic Mutations on (ANGPTL4) Gene, encoder of (angiopoietin-like 4) Protein, inhibitor of Lipoprotein Lipase   Reporters, Curators and Authors: Aviva Lev-Ari, PhD, RN and Larry H. Bernstein, MD, FCAP Introduction The role for triglycerides as a […]

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Correspondence on Leadership in Genomics and other Gene Curations: Dr. Williams with Dr. Lev-Ari Authors: Stephen J Williams, PhD and Aviva Lev-Ari, PhD, RN     RE: Leadership in Genomics: VarElect – Variants in Disease and UCSC Genome Technology Center Reporter: Aviva Lev-Ari, PhD, RN Innovative Genomics Initiative (IGI)  2016 CRISPR WORKSHOP: PRACTICAL ASPECTS OF […]

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Serpins: A Review Reporter: Stephen J. Williams, Ph.D. Update of the human and mouse SERPIN gene superfamily Claire Heit,1 Brian C Jackson,1 Monica McAndrews,2 Mathew W Wright,3 David C Thompson,4 Gary A Silverman,5 Daniel W Nebert,6 and Vasilis Vasiliou1 Author information ► Article notes ► Copyright and License information ► This article has been cited […]

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Anatomy of a $105M Deal for Joint R&D in Genomics: CRISPR Therapeutics & Vertex Pharmaceuticals Reporter: Aviva Lev-Ari, PhD, RN Under the terms of the agreement: the partners will also evaluate an enumerated but undisclosed number of targets. Vertex will provide CRISPR Therapeutics with a $75 million up-front cash payment as well as a $30 […]

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UPDATED – Medical Interpretation of the Genomics Frontier – CRISPR – Cas9:  Gene Editing Technology for New Therapeutics Authors and Curators: Larry H Bernstein, MD, FCAP and Stephen J Williams, PhD and Curator: Aviva Lev-Ari, PhD, RN   UPDATED on 3/17/2015 Status “Interference — Initial memorandum” – CRISPR/Cas9 – The Biotech Patent Fight of the Century: UC, […]

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UNDERSTANDING CANCER AT THE GENETIC LEVEL: STANFORD GENETICS AND GENOMICS CERTIFICATE Reporter: Aviva Lev-Ari, PhD, RN     UNDERSTANDING CANCER AT THE GENETIC LEVEL VIEW VIDEO http://online.stanford.edu/course/understanding-cancer-genetic-level     Date: Wednesday, January 14, 2015 Go to Course Course topic: Medicine & Health COURSE DESCRIPTION Genetic research has been instrumental in developing leading methods used to […]

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