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Final Improvement Team (FIT) Members Contribute to Opportunities Map & Define LPBI Uniqueness   Opportunities Map in the Acquisition Arena Financial Valuation of Three Health Care Intellectual Property (IP) Content Asset Classes – WORK-in-PROGRESS, one part of forthcoming Positioning document We have put together all the view points made by each FIT Member into a TEAM generated […]

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New avenues for research in membrane biology reveals the mobility of protein at work Curator and Reporter: Dr. Premalata Pati, Ph.D., Postdoc Membrane proteins (MPs) are proteins that exist in the plasma membrane and conduct a variety of biological functions such as ion transport, substrate transport, and signal transduction. MPs undergo function-related conformational changes on […]

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Diarrheas – Bacterial and Nonbacterial Writer and Curator: Larry H. Bernstein, MD, FCAP    Introduction Diarrheas are one of the common problems of societies worldwide. However, the prevalence of cause of the diarrhea may be different depending on location, water quality, food source, age, and psychological stress factors. Microbial and Parasitic Diseases A Systematic Review […]

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Optogenetics: The Promise for development of Biological Alternatives to the Electronic Pacemaker: Pacing and Resynchronizing Heartbeat by Activating Light-sensitive Proteins: ion-channel ChR2, overexpressed in Excitable cells in Heart Muscle Cells to modulate their Electrical Activity Reporter: Aviva Lev-Ari, PhD, RN Optogenetics for in vivo cardiac pacing and resynchronization therapies Udi Nussinovitch & Lior Gepstein Affiliations Contributions […]

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Larry H. Bernstein, MD, FCAP, Interviewer, Curator Leaders in Pharmaceutical Intelligence Biochemical Insights of Dr. Jose Eduardo de Salles Roselino http://pharmaceuticalintelligence.com/12/24/2014/larryhbern/Biochemical_ Insights_of_Dr._Jose_Eduardo_de_Salles_Roselino/ Biochemical Insights of Dr. Jose Eduardo de Salles Roselino How is it that developments late in the 20th century diverted the attention of biological processes from a dynamic construct involving interacting chemical reactions under rapidly changing external conditions effecting tissues and cell function to a rigid construct that is determined unilaterally by the genome construct, diverting attention from mechanisms essential for seeing the complete cellular construct? Larry, I assume that in case you read the article titled Neo – Darwinism, The Modern Synthesis and Selfish Genes that bares no relationship with Physiology with Molecular Biology J. Physiol 2011; 589(5): 1007-11 by Denis Noble, you might find that it was the key factor required in order to understand the dislodgment of physiology as a foundation of medical reasoning. In the near unilateral emphasis of genomic activity as a determinant of cellular activity all of the required general support for the understanding of my reasoning. The DNA to protein link goes from triplet sequence to amino acid sequence. That is the realm of genetics. Further, protein conformation, activity and function requires that environmental and micro-environmental factors should be considered (Biochemistry). If that were not the case, we have no way to bridge the gap between the genetic code and the evolution of cells, tissues, organs, and organisms. Consider this example of hormonal function. I would like to stress in the cAMP dependent hormonal response, the transfer of information that occurs through conformation changes after protein interactions. This mechanism therefore, requires that proteins must not have their conformation determined by sequence alone. Regulatory protein conformation is determined by its sequence plus the interaction it has in its micro-environment. For instance, if your scheme takes into account what happens inside the membrane and that occurs before cAMP, then production is increased by hormone action. A dynamic scheme  will show an effect initially, over hormone receptor (hormone binding causing change in its conformation) followed by GTPase change in conformation caused by receptor interaction and […]

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Need for Protophysiology? Larry H. Bernstein, MD, FCAP, Curator LPBI     Comparison of fundamental physical properties of the model cells (protocells) and the living cells reveals the need in protophysiology V.V. Matveev International Journal of Astrobiology 2016. pp1-8.   http://dx.doi.org:/10.1017/S1473550415000476 A hypothesis is proposed about potassium ponds being the cradles of life enriches the […]

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Open Data Science Conference, Virtual and In-Person | October 27th – 30th, 2020, Natural Language Processing Track Virtual and In-Person | October 27th – 30th, 2020 Natural Language Processing Track Learn the latest models, advancements, and trends from the top practitioners and researchers behind NLP Conference Website AGENDA https://live.odsc.com/ Thursday – 10/29/2020 09:00 AM – […]

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Series A: e-Books on Cardiovascular Diseases Series A Content Consultant: Justin D Pearlman, MD, PhD, FACC VOLUME TWO  Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation The Art of Scientific & Medical Curation  http://www.amazon.com/dp/B018Q5MCN8 Justin D Pearlman, MD, PhD, FACC Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN Introduction to Volume Two […]

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Targeting Neuronal Cell Growth Larry H. Bernstein, MD, FCAP, Curator LPBI   Remote Mind Control Using chemogenetic tools to spur the brain into action By Kelly Rae Chi | November 1, 2015     http://www.the-scientist.com//?articles.view/articleNo/44321/title/Remote-Mind-Control/ http://www.the-scientist.com/November2015/LT_2_opener.jpg A MATTER OF TIME: Optogenetics methods, which work on the millisecond timescale, allow for the finest level of temporal control […]

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LIVE 11:45AM – 2:40PM US-India BioPharma & Healthcare Summit, June 2, 2016, Marriott Cambridge, MA   ANNOUNCEMENT Leaders in Pharmaceutical Business Intelligence (LPBI) Group will cover in Real Time using Social Media the 10th US-India BioPharma & Healthcare Summit, June 2, 2016 Aviva Lev-Ari, PhD, RN will be streaming LIVE from the  Marriott Cambridge, MA […]

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