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Optimization of CRISPR Gene Editing with Gold Nanoparticles Reporter: Irina Robu, PhD The CRISPR-Cas9 gene editing system has been welcomed as a hopeful solution to a range of genetic diseases, but the expertise has proven hard to deliver into cells. One plan is to open the cell membrane using an electric shock, but that can […]

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Breakthrough in Gene Editing CRISPR–Cas systems: First example of a fully programmable, RNA-guided integrase and lays the foundation for genomic manipulations that obviate the requirements for double-strand breaks and homology-directed repair.   Reporter: Aviva Lev-Ari, PhD, RN   CRISPR alternatives for editing genes without cutting: CRISPR 12, 12a, 13, 14 – Alternative Techniques to CRISPR/Cas9 […]

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Laboratory for Genomics Research (LGR) to be established by GSK ($67M investment in 5 years) at UC, Berkeley/UCSF to be lead by Prof. Jennifer Doudna focusing on immunology, oncology, and neuroscience disease-causing gene mutations and development of new technologies using CRISPR to accelerate new drug discovery   Reporter: Aviva Lev-Ari, PhD, RN   GlaxoSmithKline, UC’s […]

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Alternative to CRISPR/Cas9 – CAST (CRISPR-associated transposase) – A New Gene-editing Approach for Insertion of Large DNA Sequences into a Genome developed @BroadInstitute @MIT @Harvard Reporter: Aviva Lev-Ari, PhD, RN   A new gene-editing CAST member In Science, a team led by Jonathan Strecker, Alim Ladha, and core institute member Feng Zhang reports a new gene-editing approach that […]

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Top 10 CRISPR Podcasts Every Scientist (& Non-Scientist) by Synthego.com Reporter: Aviva Lev-Ari, PhD, RN     On 3/12/2015 – Dr. Williams posted Podcast Review: Quiet Innovation Podcast on Obtaining $ for Your Startup Reporter: Stephen J. Williams, Ph.D. https://pharmaceuticalintelligence.com/2015/03/12/podcast-review-quiet-innovation-podcast-on-obtaining-for-your-startup/   On 1/25/2016 – I posted Launching LPBI’s, Fourth Line of Business (D): FIVE Podcast – Audio […]

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Opportunities and Ethics of Editing Genomes: A CRISPR-Inspired Conversation, Prof. Jennifer Doudna’s Lecture at Stanford University, JANUARY 24, 2019 – 7:00PM TO 8:30PM, CEMEX AUDITORIUM, GRADUATE SCHOOL OF BUSINESS Reporter: Aviva Lev-Ari, PhD, RN   Opportunities and Ethics of Editing Genomes: A CRISPR-Inspired Conversation JANUARY 24, 2019 – 7:00PM TO 8:30PM EVENT SERIES: ARROW LECTURES EVENT SPONSOR: CENTER […]

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Will the Supreme Court accept a UC Berkeley Appeal of the Sep. 10th, US Court of Appeals for the Federal Circuit decision to uphold the patent filed by the Broad Institute on CRISPR/Cas9 gene editing? Reporter: Aviva Lev-Ari, PhD, RN   UPDATED on June 6, 2019 Several companies were founded on the initial CRISPR IP rights granted […]

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Sickle Cell and Beta Thalassemia chosen for first human trial of the gene editing technology, CRISPR by sponsoring companies CRISPR Therapeutics and Vertex Pharmaceuticals, trial at a single site in Germany,   Reporter: Aviva Lev-Ari, PhD, RN UPDATED on 3/09/2019 CRISPR Therapeutics share up on announcement of first dosing in the joint Vertex sponsored trial for […]

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Reporter and Curator: Dr. Sudipta Saha, Ph.D.   Researchers have embraced CRISPR gene-editing as a method for altering genomes, but some have reported that unwanted DNA changes may slip by undetected. The tool can cause large DNA deletions and rearrangements near its target site on the genome. Such alterations can confuse the interpretation of experimental […]

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New CRISPR Approach Transforms Skin Cells into Pluripotent Stem Cells Reporter: Irina Robu, PhD Dr. Timo Otonkoski, University of Helsinki and Dr.Juha Kere, King’s College London succeeded on reprograming skin cells into pluripotent stem cells by activating cell’s own genes using gene editing technology, CRISPR-Cas9-based gene activation (CRISPRa) that can be used to activate genes. […]

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