Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Sharada Kittur, Research Assistant 1, Synthetic Biology in Drug Discovery

Academic Mentor: Prof. Stephen J. Williams, PhD

Roles @LPBI Group – The plan for Academic Internship for 2023/2024 with potential continuation to 2024/2025:

Project #1: Study two methods for Medical Text Analysis with Machine Learning Algorithms:

Method A: Wolfram Language for Biological Sciences and LPBI Workflow of Eight Steps

WORKFLOW for a Eight-Steps Medical Text Analysis Operation using NLP on LPBI Medical and Life Sciences Content

https://pharmaceuticalintelligence.com/2021/07/15/workflow-for-a-ten-steps-medical-text-analysis-operation-using-nlp-on-lpbi-medical-and-life-sciences-content/

Method B:

ChatGPT + Wolfram PlugIn

Medicine with GPT-4 & ChatGPT

BioGPT

Completion of training and application of Project #1 are leading to a verifiable Certificate in Medical Text Analysis with NLP and GPT

The Pilot Study for Medical Text Analysis will access:

1. Data Set #1: 74 Text Podcasts
2. Data Set #2: 74 Text Galectins Articles

• We wish to experiment with

A. Wolfram Plug-In for ChatGPT for 1 & 2, above

B. BioGPT for 1 & 2, above

C. We wish to compare the results of A1 with B1

D. We wish to compare the results of A2 with B2

	Wolfram’s PlugIn for ChatGPT-4 A	BioGPT   B
74 Text Podcasts	Expected better performance
2. 74 Text Galectins Articles		Expected better performance

Project #2: Synthetic Biology in Drug Discovery

Application of knowledge and skills

• from Project #1, above
• from Software programs on Synthetic Biology in Drug Discovery
• to drug discovery of inhibitors of Galectins in the discovery of innovative Cancer therapeutics – drug discovery in-Silicon [Guidance by Prof. Williams]

Completion of training and application of Project #1 are leading to a verifiable Certificate in Synthetic Biology in Drug Discovery [Cancer/Oncology]

Proposal beyond the Plan

may be assigned for collaboration with another Intern 

• to drug discovery of Galectins as potentiators of angiogenesis in the discovery of innovative cardiovascular therapeutics – drug discovery in-Silicon [Guidance by Dr. Pearlman, MD, PhD, FACC and Aviva Lev-Ari, PhD, RN]

Completion of training and application of Project #1 are leading to a verifiable Certificate in Synthetic Biology in Drug Discovery [Cardiovascular]

 

12 categories of research of strong interest and intent to pursue expansion of knowledge, include the following:

1. Mid Range IR spectroscopy
2. Drug development using Multi Organ Chip
3. Alzheimer’s Disease
4. AI in medicine
5. BioIT: Informatics
6. Cancer Informatics
7. Computational Biology
8. Computational Histopathology
9. Pharmaceutical R&D informatics
10. Programmable Sensors
11. Biodegradable Drug-Eluting Material
12. Deep learning in Pathology

BIO

Sharada Kittur

Fremont, California, United States

    sharadasameerk@gmail.com

669 216 9744

   linkedin.com/in/sharada-kittur-53b28a286

Summary

• Almost 2 years of wet lab experience, trained in NMR, UV-Vis, and FTIR spectroscopies, Thin-layer Chromatography, Cell Culture, and Scanning Electron Microscope
• Analyzed a 176kB file containing the HTT gene using R and Python, to diagnose patient
• Presented at ACS National Meeting August 13-17, with a poster presentation “Correlating catalyst efficiency, stereoelectronics, and spectroscopic properties of novel CoII(salen) complexes as carbene transfer catalysts”
• First author on abstract titled, “Designing a Green Synthesis route and a green solvent to exfoliate Graphene for cost-efficient supercapacitors”, accepted to American Vacuum Society 68th International Conference (11/8/2022)

RESEARCH EXPERIENCE 

Leaders in Pharmaceutical Business Intelligence (LPBI) Group

September 2023 to Present

• Research Assistant 1, Synthetic Biology in Drug Discovery
• See Roles @LPBI Group, Above

Student Researcher

• Aspiring Scholars Directed Research Program (ASDRP)

Jan 2023 – Present (9 months)

• Researching a fully synthetic route to the Sporovexin compounds, originally isolated from Sporormiella vexans in the Njoo Lab in Organic Chemistry. Only group of high schoolers without university affiliation that present at the ACS national meetings inthe history of ACS.
• Presented at Loyola Marymount University’s West Coast Biological Sciences Undergraduate
• Conference (WCBSURC) on 4/22/2023 with a poster presentation “DNA-binding coordinate complexes of transition metals.” and “Towards a concise total synthesis and structural verification of SporovexinA, B, and C through a stereocontrolled aldol”
• Presenting at ACS National Meeting August 13-17, with a poster presentation “Correlating catalyst efficiency, stereoelectronics, and spectroscopic properties of novel CoII(salen) complexes as carbene transfer catalysts”

Bioinformatics Student

• Amgen X Shooting Stars Foundation

Jul 2023 – Jul 2023 (1 month)

Analyzed a 176kB file containing the HTT gene, determined that patient would have adult onset Huntington’s disease

• Attended presentations on biology, bioinformatics, and computer science

 Student Researcher

• Aspiring Scholars Directed Research Program (ASDRP)

Jan 2022 – Jan 2023 (1 year 1 month)

Researched an efficient way to synthesize graphene in the Sangeneni Lab in materials science.

First author on abstract titled, “Designing a Green Synthesis route and a green solvent to exfoliate

Graphene for cost-efficient supercapacitors”, accepted to American Vacuum Society 68th International Conference (11/8/2022).

Second author on abstract titled, “Modification of Surface Tension of a Green Solvent and Surfactants

to Enhance Graphene Synthesis”, accepted to Materials Research Society International Meeting (11/27/2022 – 12/2/2022)

 

Research Associate

• Nanospan

Apr 2022 – Jul 2022 (4 months)

Calculated carbon savings of product based on previous experimental data

Created graphics, brochures, and pamphlets about how company’s product (cement additive) revolutionized construction

Presented our results in the 2022 Annual TechCrunch Conference at UC Berkeley (6/14/2022)

 

EDUCATION 

 Washington High School

High School Diploma

Aug 2021 – Jun 2025

 

Ohlone College

Jun 2023 – Present

CHEM-108

LS-101

BIOT-105

 

SKILLS 

• R (Programming Language)   •   Data Analysis   •   Scanning Electron Microscopy (SEM)   •   NMR Spectroscopy Liquid Chromatography-Mass Spectrometry (LC-MS) •   Column Chromatography   •   Thin-Layer •  Chromatography (TLC)   •   Cell Culture   •   Cyclic Voltammetry   •   UV/Vis Spectroscopy