David Orchard-Webb, PhD, MTS: Scientist II – DrugDiscovery @LPBI Group, Cancer Indication
Roles @LPBI Group
A. Expert, Author, Writer on the following declared 12 domains of interest and expertise
- Anticancer Resistance
- Autoimmune Inflammatory Diseases
- Biomarkers & Medical Diagnostics
- Cancer and Therapeutics
- CANCER BIOLOGY & Innovations in Cancer Therapy
- Cancer Prevention: Research & Programs
- Cancer Screening
- Childhood cancer
- Immunotherapy
- Next Generation Sequencing (NGS)
- Clinical Trials and IRB related issues
- Pharmaceutical R&D Investment
B. MTS: Scientist II – DrugDiscovery @LPBI Group, Cancer Indications
David Orchard-Webb, PhD
Montréal, Canada
d.orchard-webb@bath.edu
+1 438 823 0338
https://davidorchardwebb.wordpress.com/
Languages: English (native), French (professional working proficiency)
| Email: | biosci.resources@gmail.com |
| Website: | https://biosci-rc.com/ |
| Phone: | +1 438 823 0338 |
Goal: to facilitate the research and development of therapeutics especially in the biologics sector.
Specialties: innovation, analytics, cancer biology, pancreatic disorders, biologics, process development, molecular and cellular biology.
Education
November 2007 – 2011 University of Leeds – PhD – The cancer cell biology of the integral membrane protein CUB Domain Containing Protein 1 (CDCP1). Supervised by Professor Eric G. Blair and Dr. Graham P. Cook.
October 2003 – June 2007 University of Bath – Master of Molecular & Cellular Biology (MCB) Degree Classification: 2(i)
Work Experience
November 2016 – Present: Research Assistant – Athla LLC/ HealthLabs/ MedStar Institutes for Innovation at MedStar Health in Washington (Remote)
“Smart medical data” bioinformatic project coordinated by Michael Gillam, MD. I assist Dr. Gillam with writing papers based on anonymous medical statistics from 6 hospitals in the Washington DC area.
May 2016 – Present: Research Assistant – McGill University- Department of Bioengineering
I assist professor Kamen with grant proposals and paper editing. In addition I am involved in BSL-2 bioengineering laboratory based vaccine characterization and cell culture development projects.
March 2016 – Present: MTS: Scientist II – DrugDiscovery @LPBI Group
DrugDiscovery @LPBI Group is a biotechnology pre-startup. Current responsibilities include establishing an IP position and developing an R&D program focused on the innovation of novel nano-oncolytic-immunotherapeutic technologies for cancer patients with high unmet medical need.
https://pharmaceuticalintelligence.com/drugdiscovery-lpbi-group/
January 2015 – present: Independent Consultant – Montréal
Bioscience Resources Consulting: Personal consulting website which provides biotech updates with a focus on pancreatic cancer. Scientific writing services are provided. Whitepapers available. Bioscience enquiries welcome.
Propel(x): Participated in evaluating an investment opportunity on the Propel(x) platform – addressed investor questions and shared insights on the fundraising company’s breakthrough science & technology, market size, and competitive landscape. Propel(x) is an angel investment platform exclusively focused on funding ‘deep technology’ startups – companies founded on a scientific discovery or meaningful engineering innovation.
VIE-TECH Consultants: I delivered a report concerning discovery and preclinical biologic development.
December 2013 – December 2014: Visiting Research Fellow: University of Leeds.
Achievements included the publishing of a first author research paper and a review article.
January 2012 – November 2013: Research Fellow: University of Leeds. Project title: Development of novel oncolytic adenoviruses for pancreatic cancer therapy.
Achievements included:
- Managed cell culture facility. Received and shipped cell lines according to MTAs.
- Constructed oncolytic adenovirus vectors that target pancreatic cancer.
- Monitored adenovirus infections via hexon flow cytometry assay.
- Developed an organotypic pancreatic cancer cell culture model, which involved teamwork and a high pressure environment.
- Developed, wrote and maintained protocols and SOPs
- Supervised, organised and trained masters and undergraduates in the Blair lab.
- Taught and examined undergraduates – The cell cycle – interactive seminar course.
- Liaised with external suppliers such as Starlab.
- Presented findings at national and international meetings.
April 2011 – December 2011: Research Fellow: University of Leeds. Project title: Defining the role of polyomavirus-encoded oncoproteins in the immune response to Merkel cell carcinoma.
- Identified upregulated and down-regulated cell surface proteins from an NGS dataset of a Merkel cell carcinoma that contained an integrated Merkel Cell Polyomavirus.
- Cloned a novel variant of the Merkel Cell Polyomavirus large T identified in the tumour material.
- Demonstrated that the large T variant had an altered cellular localisation compared to that found in the non-integrated virus by immunofluorescence microscopy.
- Concluded that truncated large T did not alter the cell surface expression of CD200 in primary keratinocyte cells by flow cytometry.
November 2007- February 2011: PhD: University of Leeds. The cancer cell biology of the integral membrane protein CUB Domain Containing Protein 1 (CDCP1). Supervised by Professor Eric G. Blair and Dr. Graham P. Cook.
I was employed as a research fellow with laboratory management responsibilities. In addition I undertook a PhD exploring the role of the protein CDCP1 in cancer. This work included published cellular functional assays resulting from CDCP1 knockdown by siRNA [3].
- Led team of 5 PhD candidates in the BBSRC Biotechnology Young Entrepreneurs Scheme (Biotechnology YES) competition. We were awarded best initial pitch.
- Successful completion of thesis and defence
- Presented my findings at national and European conferences
4th July 2007 – 31st August 2007: Research Assistant: University of Bath.
I developed a cell culture system for studying neuromuscular junctions (NMJs) using established cell lines under the supervision of Dr. Vasanta Subramanian.
August 2005 – August 2006: Sabbatical Scholar: Webb-Waring Institute for Cancer, Aging, and Antioxidant Research. Affiliated with the University of Colorado, Denver, Colorado U.S.A.
I finished in the top 10% of my first year undergraduate and therefore qualified to undertake the undergraduate Masters course which involved a year in industry/research laboratory.
I developed a new model of epithelial to mesenchymal transition (EMT). This model was used to determine a role for xanthine oxidoreductase in cancer cells.
Volunteer Experience & Causes
January 2014 – February 2014: English as a Second Language Teaching Assistant: Maison de l’amitié, Montréal
- I prepared and aided in the teaching of a weekly 3 hour English class for new Canadian immigrants.
Awards
July 2012: Yorkshire Cancer Research Travel Grant to give talk at the international DNA Tumour Virus Meeting, Montreal, Canada.
July 2010: Yorkshire Cancer Research Travel Grant to present a poster at the 21st meeting of the European Association for Cancer Research, Oslo, Norway.
Publications
- Orchard-Webb D. 2016. Progress Toward Commercial Scale and Efficiency in Cell Therapy Bioprocessing. BioProcess International. October Supplement. http://www.bioprocessintl.com/manufacturing/cell-therapies/manufacturing-cell-therapies-commercial-scale-efficiency/
- Orchard-Webb D. 2015. Future Directions in Pancreatic Cancer Therapy. JOP. Journal of the Pancreas 16:249-255.
- Orchard-Webb D.J., Lee T.C., Cook G.P., Blair G.E. 2014. CUB Domain Containing Protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells. BMC Cancer. 14:754.
- Orchard-Webb D; Fox N; Elghazawy RM; Speirs V; Smith AM; Lodge JPA; Melcher AA; Verbeke CS; Blair GE. 2012. Development of a Chimaeric Oncolytic Adenovirus Vector for Pancreatic Cancer Biotherapy. Journal of pathology. 228: S18-S18.
- Elghazawy RM; Fox N; Orchard-Webb D; Speirs V; Smith AM; Lodge JPA; Verbeke CS; Blair GE. 2012. An Ex-Vivo Model of Human Pancreatic Cancer. Journal of pathology. 228: S19-S19.
- Orchard-Webb, D. 2011. The cancer cell biology of the integral membrane protein CUB domain containing protein 1 (CDCP1). University of Leeds. Thesis.
- Orchard-Webb, D. J., Cook, G. P., and Blair, G. E. 2010. Poster 482: Characterising the role of the metastasis associated cell surface glycoprotein CDCP1 in cancer cell lines – possible roles in cell adhesion and survival. EJC Supplements 8: 123.
- Fini, M.A., Orchard-Webb, D., Kosmider, B., Amon, J.D., Kelland, R., Shibao, G., and Wright, R.M. 2008. Migratory Activity of Human Breast Cancer Cells is Modulated by Differential Expression of Xanthine Oxidoreductase. J. Cell. Biochem. 105: 1008-1026.
