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New studies link cell cycle proteins to immunosurveillance of premalignant cells Curator: Stephen J. Williams, Ph.D. The following is from a Perspectives article in the journal Science by Virinder Reen and Jesus Gil called “Clearing Stressed Cells: Cell cycle arrest produces a p21-dependent secretome that initaites immunosurveillance of premalignant cells”. This is a synopsis of […]

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Live Conference Coverage @Medcitynews Converge 2018 Philadelphia:Liquid Biopsy and Gene Testing vs Reimbursement Hurdles 9:25- 10:15 Liquid Biopsy and Gene Testing vs. Reimbursement Hurdles Genetic testing, whether broad-scale or single gene-testing, is being ordered by an increasing number of oncologists, but in many cases, patients are left to pay for these expensive tests themselves. How can […]

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Cancer-free after immunotherapy treatment: Treating advanced colon cancer – targeting KRAS gene mutation by tumor-infiltrating lymphocytes (TILs) and Killer T-cells (NK) Reporter: Aviva Lev-Ari, PhD, RN   Based on By DENISE GRADY DEC. 7, 2016 Continue reading the main story http://www.nytimes.com/2016/12/07/health/cancer-immunotherapy.html?_r=0 The research involves cancer-fighting immune cells called tumor-infiltrating lymphocytes, or TILs. These are white blood […]

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Systems Biology analysis of Transcription Networks, Artificial Intelligence, and High-End Computing Coming to Fruition in Personalized Oncology Curator: Stephen J. Williams, Ph.D. In the June 2020 issue of the journal Science, writer Roxanne Khamsi has an interesting article “Computing Cancer’s Weak Spots; An algorithm to unmask tumors’ molecular linchpins is tested in patients”[1], describing some […]

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Live Notes, Real Time Conference Coverage 2020 AACR Virtual Meeting April 28, 2020 Session on Evaluating Cancer Genomics from Normal Tissues Through Metastatic Disease 3:50 PM Reporter: Stephen J. Williams, PhD  Minisymposium: Evaluating Cancer Genomics from Normal Tissues through Evolution to Metastatic Disease Oncologic therapy shapes the fitness landscape of clonal hematopoiesis April 28, 2020, 4:10 […]

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Reporter: Danielle Smolyar, Research Assistant 3 – Text Analysis for 2.0 LPBI Group’s TNS #1 – 2020/2021 Academic Internship in Medical Text Analysis (MTA) Recently, researchers at Mount Sinai were able to develop a therapeutic agent that shows high levels of effectiveness in Vitro disrupting a biological pathway that allow cancer to survive. This finding […]

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Double Mutant PI3KA Found to Lead to Higher Oncogenic Signaling in Cancer Cells Curator: Stephen J. Williams, PhD PIK3CA (Phosphatidylinsitol 4,5-bisphosphate (PIP2) 3-kinase catalytic subunit α) is one of the most frequently mutated oncogenes in various tumor types ([1] and http://www.sanger.ac.uk/genetics/CGP/cosmic). Oncogenic mutations leading to the overactivation of PIK3CA, especially in context in of inactivating […]

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Live Notes, Real Time Conference Coverage 2020 AACR Virtual Meeting April 27, 2020 Minisymposium on AACR Project Genie & Bioinformatics 4:00 PM – 6:00 PM SESSION VMS.MD01.01 – Advancing Cancer Research through an International Cancer Registry: AACR Project GENIE Use Cases   Reporter: Stephen J. Williams, PhD April 27, 2020, 4:00 PM – 6:00 PM Virtual […]

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Machine Learning (ML) in cancer prognosis prediction helps the researcher to identify multiple known as well as candidate cancer diver genes Curator and Reporter: Dr. Premalata Pati, Ph.D., Postdoc Cancer has been characterized as a heterogeneous disease consisting of many different subtypes. The early diagnosis and prognosis of a cancer type have become a necessity […]

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Renal tumor macrophages linked to recurrence are identified using single-cell protein activity analysis Curator and Reporter: Dr. Premalata Pati, Ph.D., Postdoc When malignancy returns after a period of remission, it is called a cancer recurrence. After the initial or primary cancer has been treated, this can happen weeks, months, or even years later. The possibility […]

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