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New studies link cell cycle proteins to immunosurveillance of premalignant cells

Posted in Apoptosis, Biological Networks, Biological Networks, Gene Regulation and Evolution, Cancer - General, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer-Immune Interactions, Cell Biology, Signaling & Cell Circuits, Circulating Tumor Cells (CTC), Disease Biology, DNA repair, Efficacy of Anti-Tumor T Cells, Exosomes, Exosomes: Natural Carriers for siRNA Delivery, Immune Modulatory, Immuno-Oncology & Genomics, Immunology, KRAS Mutation, Modulating Macrophages in Cancer Immunotherapy, NK Cell-Based Cancer Immunotherapy, TP53 - Germline mutations, tagged CDKI, cell cycle, cell cycle arrest, cell cycle protein, cellular senescence, DNA repair or transcription factor genes, Immunology, immunosuppression, immunosurveillance, NF-kB, p21, p53, premalignant, transcriptional, transcriptional regulation, tumor suppressors on December 16, 2021| Leave a Comment »

New studies link cell cycle proteins to immunosurveillance of premalignant cells Curator: Stephen J. Williams, Ph.D. The following is from a Perspectives article in the journal Science by Virinder Reen and Jesus Gil called “Clearing Stressed Cells: Cell cycle arrest produces a p21-dependent secretome that initaites immunosurveillance of premalignant cells”. This is a synopsis of […]

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Live Conference Coverage @Medcitynews Converge 2018 Philadelphia:Liquid Biopsy and Gene Testing vs Reimbursement Hurdles

Posted in Big Data & Analytics, BioBanking, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Screening, Circulating Tumor Cells (CTC), Clinical Genomics, Diagnostics and Lab Tests, FDA, Health Economics and Outcomes Research, Healthcare costs and reimbursement, KRAS Mutation, Liquid Biopsy Chip detects an array of metastatic cancer cell markers in blood, Liquid Biopsy: Circulating Tumor Cells in Urine and Blood, Patient-centered Medicine, Personalized and Precision Medicine & Genomic Research, Scientific & Biotech Conferences: Press Coverage, Uncategorized, tagged biomarker panels, circulating cancer cells, circulating DNA, ctDNA Liquid Biopsy, healthcare reimbursement, liquid biopsy, therapeutic monitoring on July 12, 2018| Leave a Comment »

Live Conference Coverage @Medcitynews Converge 2018 Philadelphia:Liquid Biopsy and Gene Testing vs Reimbursement Hurdles 9:25- 10:15 Liquid Biopsy and Gene Testing vs. Reimbursement Hurdles Genetic testing, whether broad-scale or single gene-testing, is being ordered by an increasing number of oncologists, but in many cases, patients are left to pay for these expensive tests themselves. How can […]

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Cancer-free after immunotherapy treatment: Treating advanced colon cancer – targeting KRAS gene mutation by tumor-infiltrating lymphocytes (TILs) and Killer T-cells (NK)

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, KRAS Mutation on December 8, 2016| Leave a Comment »

Cancer-free after immunotherapy treatment: Treating advanced colon cancer – targeting KRAS gene mutation by tumor-infiltrating lymphocytes (TILs) and Killer T-cells (NK) Reporter: Aviva Lev-Ari, PhD, RN Based on By DENISE GRADY DEC. 7, 2016 Continue reading the main story http://www.nytimes.com/2016/12/07/health/cancer-immunotherapy.html?_r=0 The research involves cancer-fighting immune cells called tumor-infiltrating lymphocytes, or TILs. These are white blood […]

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Systems Biology Analysis of Transcription Networks, Artificial Intelligence, and High-End Computing Coming to Fruition in Personalized Oncology

Posted in Artificial Intelligence in CANCER, Artificial Intelligence in Health Care - Tools & Innovations, Artificial Intelligence in Medicine - Applications in Therapeutics, Big Data, BioIT: BioInformatics, BioIT: BioInformatics, NGS, Clinical & Translational, Pharmaceutical R&D Informatics, Clinical Genomics, Cancer Informatics, Biological Networks, Biological Networks, Gene Regulation and Evolution, Cancer - General, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, Cell Biology, Cell Biology, Signaling & Cell Circuits, Clinical & Translational, Clinical Genomics, Genomic Expression, Intelligent Information Systems, tagged activation of transcription factors, Artificial intelligence, Artificial Intelligence & Clinical Trials, Biological Networks, Columbia University Medical Center, DarwinHealth, mutational analysis, RNA-Seq, transcription control on July 14, 2020| Leave a Comment »

Systems Biology analysis of Transcription Networks, Artificial Intelligence, and High-End Computing Coming to Fruition in Personalized Oncology Curator: Stephen J. Williams, Ph.D. In the June 2020 issue of the journal Science, writer Roxanne Khamsi has an interesting article “Computing Cancer’s Weak Spots; An algorithm to unmask tumors’ molecular linchpins is tested in patients”[1], describing some […]

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Live Notes, Real Time Conference Coverage 2020 AACR Virtual Meeting April 28, 2020 Session on Evaluating Cancer Genomics from Normal Tissues Through Metastatic Disease 3:50 PM

Posted in BioIT: BioInformatics, BioIT: BioInformatics, NGS, Clinical & Translational, Pharmaceutical R&D Informatics, Clinical Genomics, Cancer Informatics, Biological Networks, Biological Networks, Gene Regulation and Evolution, Cancer - General, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, Cancer Screening, Gene Regulation and Evolution, Genetics & Innovations in Treatment, Genome Biology, Genomic Expression, Genomic Testing: Methodology for Diagnosis, interventional oncology, Variation in human protein-coding regions, tagged AACR, American Association for Cancer Research, breast cancer, Cancer Genomics, cancer genomics and therapy, cancer metastasis, Clonal evolution, Curation, curation communities, Glioma, gliomas, mutational burden, mutational spectrum, myeloid dysplatic syndrome, myeloma, spliceosome, tumor heterogeneity on April 28, 2020| Leave a Comment »

Live Notes, Real Time Conference Coverage 2020 AACR Virtual Meeting April 28, 2020 Session on Evaluating Cancer Genomics from Normal Tissues Through Metastatic Disease 3:50 PM Reporter: Stephen J. Williams, PhD Minisymposium: Evaluating Cancer Genomics from Normal Tissues through Evolution to Metastatic Disease Oncologic therapy shapes the fitness landscape of clonal hematopoiesis April 28, 2020, 4:10 […]

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Researchers develop novel therapy that could be effective in many cancers

Posted in Cancer - General, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Genomic Expression, Loss of function gene, therapeutics, tagged Akt, Cancer - General, Clinical trial, Drug discovery, health, medicine, Mount Sinai, MS21, novel therapeutic approach, Novella Clinical, research, therapeutics on July 29, 2021| Leave a Comment »

Reporter: Danielle Smolyar, Research Assistant 3 – Text Analysis for 2.0 LPBI Group’s TNS #1 – 2020/2021 Academic Internship in Medical Text Analysis (MTA) Recently, researchers at Mount Sinai were able to develop a therapeutic agent that shows high levels of effectiveness in Vitro disrupting a biological pathway that allow cancer to survive. This finding […]

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Double Mutant PI3KA Found to Lead to Higher Oncogenic Signaling in Cancer Cells

Posted in Apoptosis, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, Cell Biology, Cell Biology, Signaling & Cell Circuits, Childhood cancer, Computational Biology/Systems and Bioinformatics, Genetics & Pharmaceutical, Genome Biology, Genomic Expression, Pharmaceutical Drug Discovery, tumor microenvironment, tagged alpelsib, breast cancer, metastatic disease, mutation, PI3 kinase, PI3K/AKT pathway, PIK3CA inhibitor, tumorigenesis on September 24, 2020| Leave a Comment »

Double Mutant PI3KA Found to Lead to Higher Oncogenic Signaling in Cancer Cells Curator: Stephen J. Williams, PhD PIK3CA (Phosphatidylinsitol 4,5-bisphosphate (PIP2) 3-kinase catalytic subunit α) is one of the most frequently mutated oncogenes in various tumor types ([1] and http://www.sanger.ac.uk/genetics/CGP/cosmic). Oncogenic mutations leading to the overactivation of PIK3CA, especially in context in of inactivating […]

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Live Notes, Real Time Conference Coverage 2020 AACR Virtual Meeting April 27, 2020 Minisymposium on AACR Project Genie & Bioinformatics 4:00 PM – 6:00 PM

Posted in Big Data, BioBanking, BioIT: BioInformatics, BioIT: BioInformatics, NGS, Clinical & Translational, Pharmaceutical R&D Informatics, Clinical Genomics, Cancer Informatics, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Informatics, Conference Coverage with Social Media, REAL TIME Conference Coverage Twitter's Hashtags and Handles per Presentation/session, tagged AACR, American Association for Cancer Research, bioinformatic methodogies, bioinformatic tools, cancer conference, Cancer Genomics, Cancer research, Conference Coverage with Social Media, real time conference coverage, Transcriptomics, Twitter on April 27, 2020| Leave a Comment »

Live Notes, Real Time Conference Coverage 2020 AACR Virtual Meeting April 27, 2020 Minisymposium on AACR Project Genie & Bioinformatics 4:00 PM – 6:00 PM SESSION VMS.MD01.01 – Advancing Cancer Research through an International Cancer Registry: AACR Project GENIE Use Cases Reporter: Stephen J. Williams, PhD April 27, 2020, 4:00 PM – 6:00 PM Virtual […]

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Machine Learning (ML) in cancer prognosis prediction helps the researcher to identify multiple known as well as candidate cancer diver genes

Posted in Artificial Intelligence in CANCER, Cancer - General, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, Cancer Screening, Clinical Genomics, CRISPR/Cas9 & Gene Editing, Genetics & Innovations in Treatment, Machine Learning, Mutant Gene Expression, Personalized and Precision Medicine & Genomic Research, Precision Cancer Medicine, tagged Artificial intelligence, Cancer, Cancer prognosis prediction, cancer progression, computational algorithm, driver gene, Machine Learning on May 4, 2021| 2 Comments »

Machine Learning (ML) in cancer prognosis prediction helps the researcher to identify multiple known as well as candidate cancer diver genes Curator and Reporter: Dr. Premalata Pati, Ph.D., Postdoc Cancer has been characterized as a heterogeneous disease consisting of many different subtypes. The early diagnosis and prognosis of a cancer type have become a necessity […]

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Renal tumor macrophages linked to recurrence are identified using single-cell protein activity analysis

Posted in Artificial Intelligence in CANCER, Cancer - General, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, Immuno-Oncology & Genomics, Metastasis Process, RNA Biology, Cancer and Therapeutics, Single-cell sequencing, tumor microenvironment, tagged cancer metastasis, cancer recurrence, immune cells, learning algorithms, renal cell carcinoma, single-cell RNA sequencing, tumor associated macrophage on May 27, 2021| 2 Comments »

Renal tumor macrophages linked to recurrence are identified using single-cell protein activity analysis Curator and Reporter: Dr. Premalata Pati, Ph.D., Postdoc When malignancy returns after a period of remission, it is called a cancer recurrence. After the initial or primary cancer has been treated, this can happen weeks, months, or even years later. The possibility […]