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Search Results for 'monoclonal antibody'


A new mechanism of action to attack in the treatment of coronary artery disease (CAD), Novartis developed Ilaris (canakinumab), a human monoclonal antibody targeting the interleukin-1beta innate immunity pathway Reporter: Aviva Lev-Ari, PhD, RN   Speaking at an ESC press briefing, Ridker said, “This is what personalized predictive medicine is all about.” Once a patient has […]

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Monoclonal antibody treatment of Multiple Myeloma Larry H. Bernstein, MD, FCAP, Curator LPBI     Elotuzumab by DR ANTHONY MELVIN CRASTO Ph.D   Elotuzumab A SLAMF7-directed immunostimulatory antibody used to treat multiple myeloma. (Empliciti®) HuLuc-63;BMS-901608   http://media4.asco.org/156/9449/107994/107994_video_pvhr.jpg   Elotuzumab (brand name Empliciti, previously known as HuLuc63) is ahumanized monoclonal antibody used in relapsed multiple myeloma.[1] […]

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Monoclonal Antibody Drug Immunogenicity Larry H. Bernstein, MD, FCAP, Curator LPBI   Immunogenicity assessment of monoclonal antibodies Category: Abstracted Scientific Content Author(s): GaBI Journal Editor   Michelle Derbyshire, PhD, GaBI Online Editor GaBI 2015; 4(4).  http://gabi-journal.net/immunogenicity-assessment-of-monoclonal-antibodies.html The most critical safety concern relating to biologicals (including biosimilars) is immunogenicity. This is especially important for monoclonal antibody (mAb) biologicals, which […]

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MabVax’s HuMab 5B1 antibody (“5B1”) we are referring to an antibody produced by an actual human in response to a vaccine constructed to elicit an antibody response to a specific cancer antigen.   Recently, a series of successful studies were conducted on 5B1 and presented at the 2015 World Molecular Imaging Conference (WMIC) in September. These experiments showed theremarkable utility of this antibody and what […]

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Monoclonal Antibody Therapy and Market Demet Sag, PhD, CRA, GCP    Monoclonal Antibody treatment means a biological therapy where monoclonal antibodies is used to initiate development of specific antibodies (protein molecules produced by the B cells as a primary immune defense), so that they can fight against antigens (substances that are capable of inducing a […]

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                                Monoclonal Antibody Therapy: What is in the name or clear description? Curator: Demet Sag, PhD, CRA, GCP  What is in the name? Nomenclature is important part of the scientific community so we can stay on the same page in […]

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Antibody-bound Viral Antigens Reporter: Larry H. Bernstein, MD, FCAP   The following presentations are closely related to other similar pieces, except that this uniquely envisions the release and presentation of antibody-bound VIRAL antigens in targeting cancer cells.  The approach compares the lifelong immunity conferred by immunity to herpesvirus to immunosuppression of cancer targets by high […]

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Antibody drug conjugates (ADCs) Larry H. Bernstein, MD, FCAP, Curator LPBI   Processes for Constructing Homogeneous Antibody Drug Conjugates by DR ANTHONY MELVIN CRASTO Ph.D Processes for Constructing Homogeneous Antibody Drug Conjugates David Y. Jackson*† † Igenica Biotherapeutics, 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States Org. Process Res. Dev., Article ASAP http://dx.doi.org:/10.1021/acs.oprd.6b00067    […]

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GlaxoSmithKline is partnering up with Canadian biotherapeutics maker Zymeworks Inc. in order to develop Fc-engineered monoclonal and bi-specific antibody therapies. Sourced through Scoop.it from: http://www.european-biotechnology-news.com See on Scoop.it – Cardiovascular Disease: PHARMACO-THERAPY

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Novel antibody–antibiotic conjugate Larry H. Bernstein, MD, FCAP, Curator LPBI   Brief: On Wednesday, Roche researchers published a paper in Nature online entitled, “Novel antibody–antibiotic conjugate eliminates intracellular S. aureus.“ The major point of the paper is that by using antibiotic-armed antibodies, researchers were able to kill Staphylococcus aureus (S. aureus) in mice, despite the fact that […]

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