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Search Results for 'mitochondria'

Mitochondria Replacement Therapy

Posted in Cell Biology, Cell Biology, Signaling & Cell Circuits, cell-based therapy, Developmental biology, Embryology, Gene Therapy & Gene Editing Development, Preimplantation Genetic Diagnosis and Reproductive Genomics, Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, Reproductive Biology & Bio Instrumentation, Signaling & Cell Circuits, Single Cell Genomics, stem cell biology and patient-specific, tagged , , , , on April 14, 2019| Leave a Comment »


Reporter and Curator: Dr. Sudipta Saha, Ph.D.   Leigh syndrome is one of the hundreds of so-called mitochondrial diseases, which are caused by defects in the mitochondria that produce 90 percent of the body’s energy. These disorders are rare; about 1,000 to 4,000 babies in the United States are born with one every year. But they are devastating and […]

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The Three Parent Technique to Avoid Mitochondrial Disease in Embryo

Posted in Cell Biology, Developmental biology, Disease Biology, DNA repair, Gene Regulation, Genetics & Innovations in Treatment, Genomic Testing: Methodology for Diagnosis, Innovations, Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, tagged , , , , , on October 7, 2016| Leave a Comment »


Reporter and Curator: Dr. Sudipta Saha, Ph.D.   Mitochondrial disease   Mitochondria are present in almost all human cells, and vary in number from a few tens to many thousands. They generate the majority of a cell’s energy supply which powers every part of our body. Mitochondria have their own separate DNA, which carries just […]

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Drugs that activate this novel stress response pathway, which they call the mitochondrial-to-cytosolic stress response, protected both nematodes and cultured human cells with Huntington´s disease from protein-folding damage.

Posted in Innovations in Neurophysiology & Neuropsychology on September 24, 2016| Leave a Comment »


Drugs that activate this novel stress response pathway, which they call the mitochondrial-to-cytosolic stress response, protected both nematodes and cultured human cells with Huntington´s disease from protein-folding damage. Reporter: Aviva Lev-Ari, PhD, RN   “Maybe there is a way to use one drug to alter the mitochondrial signal and another drug to alter the communciation […]

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Effect of mitochondrial stress on epigenetic modifiers

Posted in Biochemical pathways, Biological Networks, Cell Biology, Signaling & Cell Circuits, Cell death pathways, Chemical Biology and its relations to Metabolic Disease, Curation, Cytokines, Disease Biology, Epigenetics and Environmental Factors, Gene Regulation, Human aging, Metabolism, Metabolomics, Proteins, Proteolysis, Proteomics, RNA Biology, Signaling, Signaling & Cell Circuits, tagged , , , , , , , , , , , , on May 7, 2016| Leave a Comment »


Effect of mitochondrial stress on epigenetic modifiers Larry H. Bernstein, MD, FCAP, Curator LPBI   Early Mitochondrial Stress Alters Epigenetics, Secures Lifelong Health Benefits GEN 5/3/2016  http://www.genengnews.com/gen-news-highlights/early-mitochondrial-stress-alters-epigenetics-secures-lifelong-health-benefits/81252685/ A little adversity builds character, or so the saying goes. True or not, the saying does seem an apt description of a developmental phenomenon that shapes gene expression. […]

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New Insights into mtDNA, mitochondrial proteins, aging, and metabolic control

Posted in Biochemical pathways, Biological Networks, Gene Regulation and Evolution, Cell Biology, Signaling & Cell Circuits, Cerebrovascular and Neurodegenerative Diseases, Chemical Biology and its relations to Metabolic Disease, Clinical & Translational, Clinical Diagnostics, Clinical Genomics, Diagnostics and Lab Tests, Disease Biology, Small Molecules in Development of Therapeutic Drugs, DNA repair, FDA Regulatory Affairs, Gene Regulation and Evolution, Genetics & Pharmaceutical, Genome Biology, Human aging, Human Immune System in Health and in Disease, Metabolism, Metabolomics, Neurodegenerative Diseases, Neurological Diseases, Proteins, Proteomics, tagged , , , , , , , on April 20, 2016| 1 Comment »


New Insights into mtDNA, mitochondrial proteins, aging, and metabolic control Larry H. Bernstein, MD, FCAP, Curator LPBI   Newly discovered proteins may protect against age-related illnesses   The proteins could play a key role in the aging process and the onset of diseases linked to older age BY Beth Newcomb   APRIL 13, 2016 http://news.usc.edu/98412/newly-discovered-proteins-may-protect-against-agings-illnesses/ http://news.usc.edu/files/2016/04/20160208_PinchasCohen_web-824×549.jpg […]

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Stem Cell Transplants Can Trigger Immune Reaction to Cell’s Mitochondria

Posted in Cell Biology, Signaling & Cell Circuits, Embryology, Regenerative Biology and Medicine, tagged , , , , , on November 21, 2015| Leave a Comment »


Previously unseen immune reaction identified for stem cell transplants. Reporter: Stephen J. Williams, Ph.D. Reposted from Healthinnovations at http://health-innovations.org/2014/11/21/previously-unseen-immune-reaction-identified-in-stem-cell-transplants/   Mouse cells and tissues created through nuclear transfer can be rejected by the body because of a previously unknown immune response to the cell’s mitochondria, according to an international study in mice by researchers at the […]

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EMBRACE-STEMI: Drug targeting mitochondria does not reduce infarct size – Healio

Posted in Uncategorized on April 21, 2015| Leave a Comment »


SAN DIEGO — The novel drug Bendavia did not meet any of its primary or secondary endpoints in a trial assessing its use prior to primary PCI in patients with STEMI, according to data presented at the American College of Cardiology Scientific Sessions.Patients… Source: http://www.healio.com See on Scoop.it – Cardiovascular Disease: PHARMACO-THERAPY

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Mitochondrial Pyridine Nucleotides and Electron Transport Chain -2.1.5

Posted in Academic Publishing, Anaerobic Glycolysis, Biochemical pathways, Chemical Biology and its relations to Metabolic Disease, Computational Biology/Systems and Bioinformatics, Curation, Disease Biology, Metabolism, Metabolomics, Oxidative phosphorylation, Pyridine nucleotides, Translational Science, Warburg effect, tagged , , , , , , on April 3, 2015| 3 Comments »


Mitochondrial Pyridine Nucleotides and Electron Transport Chain Larry H Bernstein, MD, FCAP, writer and curator http://pharmaceuticalinnovation.com/2015/04/03/larryhbern/Mitochondrial_Pyridine_Nucleotides_and_Electron_Transport_Chain 2.1.5 Mitochondrial Pyridine Nucleotides and Electron Transport Chain 2.1.5.1 Mitochondrial function in vivo evaluated by NADH fluorescence Mayevsky A1, Rogatsky GG. Am J Physiol Cell Physiol. 2007 Feb; 292(2):C615-40 http://dx.doi.org:/10.1152/ajpcell.00249.2006 Normal mitochondrial function is a critical factor in maintaining […]

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Mitochondrial Isocitrate Dehydrogenase and Variants

Posted in Acute lymphocytic leukemia, Acute myelocytic leukemia, Anaerobic Glycolysis, Biochemical pathways, Biological Networks, Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Clinical Diagnostics, Curation, Dehydrogenase, Developmental biology, Disease Biology, Enzyme Induction, Enzymes and isoenzymes, Genome Biology, Genomic Expression, Hematopoiesis, Innovations, Lipid metabolism, Metabolism, Metabolomics, Methylation, Mutant Gene Expression, Myelodysplasia, Open Access Journals, Personalized and Precision Medicine & Genomic Research, Pharmaceutical Drug Discovery, Phosphorylation, Proteins, Proteomics, Pyridine nucleotide transhydrogenase, Pyridine nucleotides, Signaling, Signaling & Cell Circuits, Small Molecules in Development of Therapeutic Drugs, tagged , , , , , , on April 2, 2015| Leave a Comment »


Mitochondrial Isocitrate Dehydrogenase and Variants Writer and Curator: Larry H. Bernstein, MD, FCAP  2.1.4      Mitochondrial Isocitrate Dehydrogenase (IDH) and variants 2.1.4.1 Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression of IDH-mutated low grade gliomas Juratli TA, Peitzsch M, Geiger K, Schackert G, Eisenhofer G, Krex D. Neuro Oncol. 2013 Jun;15(6):682-90 http://dx.doi.org:/10.1093/neuonc/not006 Low-grade […]

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Warburg Effect and Mitochondrial Regulation- 2.1.3

Posted in Academic Publishing, Amino acids, Anaerobic Glycolysis, Biochemical pathways, Biological Networks, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Chemical Biology and its relations to Metabolic Disease, Clinical Diagnostics, Curation, Cytoskeleton, Developmental biology, Disease Biology, Enzyme Induction, Enzymes and isoenzymes, Fatty acids, Gene Regulation, Genomic Expression, Hexokinase, Inosine nucleotides, Lipid metabolism, Lipids, Liver & Digestive Diseases Research, Loss of function gene, Metabolism, Metabolomics, Methods, mtDNA, Oxidative phosphorylation, Phosphorylation, Proteins, Proteomics, Pyridine nucleotides, Pyruvate Kinase, Signaling, Signaling & Cell Circuits, Small Molecules in Development of Therapeutic Drugs, Warburg effect, tagged , , , , , , , , , , on April 1, 2015| 2 Comments »


Warburg Effect and Mitochondrial Regulation -2.1.3 Writer and Curator: Larry H Bernstein, MD, FCAP  2.1.3 Warburg Effect and Mitochondrial Regulation 2.1.3.1 Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier NM Vacanti, AS Divakaruni, CR Green, SJ Parker, RR Henry, TP Ciaraldi, et a.. Molec Cell 6 Nov 2014; 56(3):425–435 http://dx.doi.org/10.1016/j.molcel.2014.09.024 Highlights Oxidation of fatty […]

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