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Mitochondria Replacement Therapy

Posted in Cell Biology, Cell Biology, Signaling & Cell Circuits, cell-based therapy, Developmental biology, Embryology, Gene Therapy & Gene Editing Development, Preimplantation Genetic Diagnosis and Reproductive Genomics, Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, Reproductive Biology & Bio Instrumentation, Signaling & Cell Circuits, Single Cell Genomics, stem cell biology and patient-specific, tagged genetic engineering, IVF, Leigh syndrome, mitochondria, Replacement on April 14, 2019| Leave a Comment »

Reporter and Curator: Dr. Sudipta Saha, Ph.D. Leigh syndrome is one of the hundreds of so-called mitochondrial diseases, which are caused by defects in the mitochondria that produce 90 percent of the body’s energy. These disorders are rare; about 1,000 to 4,000 babies in the United States are born with one every year. But they are devastating and […]

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Energy dysfunction detected in skin cells a possible additional explanation of the Alzheimer’s disease’s hallmark Dementia

Posted in Alzheimer's Disease, Apoptosis, Bio Instrumentation in Experimental Life Sciences Research, Cancer - General, cancer metabolism, Cell Biology, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, Etiology, Signaling, Signaling & Cell Circuits on February 13, 2018| Leave a Comment »

Energy dysfunction detected in skin cells a possible additional explanation of the Alzheimer’s disease’s hallmark Dementia Reporter: Aviva Lev-Ari, PhD, RN A team at Harvard-affiliated McLean Hospital tested the cells of late-onset Alzheimer’s patients and found malfunctions in their energy production, including problems with the health of their mitochondria, the cellular power plants that provide most of their […]

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The Three Parent Technique to Avoid Mitochondrial Disease in Embryo

Posted in Cell Biology, Developmental biology, Disease Biology, DNA repair, Gene Regulation, Genetics & Innovations in Treatment, Genomic Testing: Methodology for Diagnosis, Innovations, Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, tagged IVF, Maternal Spindle Transfer, Mitochondria Donation, Mitochondrial DNA, Pro-nuclear Transfer, Three Parent Technique on October 7, 2016| Leave a Comment »

Reporter and Curator: Dr. Sudipta Saha, Ph.D. Mitochondrial disease Mitochondria are present in almost all human cells, and vary in number from a few tens to many thousands. They generate the majority of a cell’s energy supply which powers every part of our body. Mitochondria have their own separate DNA, which carries just […]

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Paraoxonase 2 (PON2) appears to play a cardioprotective role in both human and experimental heart failure: Cardiologist Wai Hong Wilson Tang, MD, Director of Cleveland Clinic Lerner Research Institute’s Center for Clinical Genomics.

Posted in Frontiers in Cardiology and Cardiovascular Disorders, Heart Failure (HF), inflammation independent of lipid levels, tagged Paraoxonase 2 (PON2) on January 1, 2019| Leave a Comment »

Paraoxonase 2 (PON2) appears to play a cardioprotective role in both human and experimental heart failure: Cardiologist Wai Hong Wilson Tang, MD, Director of Cleveland Clinic Lerner Research Institute’s Center for Clinical Genomics. Reporter: Aviva Lev-Ari, PhD, RN Enzyme Protects Heart Against Stress and Could Potentially Lead to New Heart Failure Treatments https://consultqd.clevelandclinic.org/enzyme-protects-heart-against-stress-and-could-potentially-lead-to-new-heart-failure-treatments/amp/?__twitter_impression=true Categories: Basic Research, Heart & Vascular, Research […]

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Live Notes, Real Time Conference Coverage AACR 2020 #AACR20: Tuesday June 23, 2020 Noon-2:45 Educational Sessions

Posted in AI-assisted Cardiac MRI, Anaerobic Glycolysis, Artificial Intelligence - Breakthroughs in Theories and Technologies, Artificial Intelligence - General, Artificial Intelligence Applications in Health Care, Big Data, Big Data & Analytics, BioBanking, Biochemical pathways, Biological Networks, Gene Regulation and Evolution, Breast Cancer - impalpable breast lesions, Cancer - General, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, Cancer Informatics, cancer metabolism, Cancer Prevention: Research & Programs, Curation, Data Science, Deep Learning in Pathology, Intelligent Information Systems, Metabolic Immuno-Oncology, Metabolism, Oxidative phosphorylation, Phosphorylation, REAL TIME Conference Coverage Twitter's Hashtags and Handles per Presentation/session, Scientific & Biotech Conferences: Press Coverage, Scientific Publishing, Scientist: Career considerations, Signaling, Transformative Technologies in Healthcare, tumor microenvironment, tagged #AACR20, AACR, AI, Artificial intelligence, breast cancer, cancer conference, Cancer Genomics, Cancer immunology, cancer immunotherapeutics, cancer metabolic pathways, cancer metabolism, cancer metastasis, Cancer research, cancer researcy funding, cancerinformatics, checkpoint inhibitors, Conference Coverage with Social Media, deep learning, deep learning in drug discovery, Digital pathology, early onset cancer, health disparities, immune checkpoint, Natural killer cell, real time conference coverage, RNASeq, RNASeq Data Analysis on June 23, 2020| 1 Comment »

Live Notes, Real Time Conference Coverage AACR 2020: Tuesday June 23, 2020 Noon-2:45 Educational Sessions Reporter: Stephen J. Williams, PhD Follow Live in Real Time using #AACR20 @pharma_BI @AACR Register for FREE at https://www.aacr.org/ Presidential Address Elaine R Mardis, William N Hait DETAILS Welcome and introduction William N Hait Improving diagnostic yield in pediatric cancer precision […]

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The Philosopher’s Stone?

Posted in Autophagy, Biological Networks, Cell Biology, Chemical Biology and its relations to Metabolic Disease, Curation, Developmental biology, Disease Biology, DNA repair, Human aging, tagged Aging, mitochondria on February 7, 2016| Leave a Comment »

The Philosopher’s Stone? Larry H. Bernstein, MD, FCAP, Curator LPBI Mitochondria trigger cell aging, researchers discover How to rejuvenate or prevent aging in human and mice cells February 5, 2016 http://www.kurzweilai.net/mitochondria-shown-to-trigger-cell-ageing http://www.kurzweilai.net/images/mitochondria-clearing.jpg Preventing aging and rejuvenating human and mice cells in the lab (credit: Clara Correia‐Melo et al./EMBO Journal) An international team of scientists […]

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Agios Pharmaceuticals target the metabolism of cancer cells for making drugs that essentially try to repair cancer cells

Posted in Anaerobic Glycolysis, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, cancer metabolism, Metabolic Immuno-Oncology, Pyruvate Kinase, Warburg effect on August 4, 2017| Leave a Comment »

Agios Pharmaceuticals target the metabolism of cancer cells for making drugs that essentially try to repair cancer cells Reporter: Aviva Lev-Ari, PhD, RN A small biotech behind a groundbreaking approach to tackling cancer just got its first drug approved Lydia Ramsey, Aug. 1, 2017, 11:47 AM http://www.businessinsider.com/fda-approves-agios-pharmaceuticals-drug-targeting-cancer-cell-metabolism-2017-8 See Cancer Metabolism http://www.agios.com/research/cancer-metabolism/ Metabolic Immuno-Oncology http://www.agios.com/research/metabolic-immuno-oncology/ […]

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Blood test uses DNA strands of dying cells

Posted in Cancer - General, CANCER BIOLOGY & Innovations in Cancer Therapy, Chemical Biology and its relations to Metabolic Disease, Clinical Diagnostics, Curation, Diagnostics and Lab Tests, Genomic Expression, Neurodegenerative Diseases, Neurological Diseases, Population Health Management, Genetics & Pharmaceutical, tagged Amino acids, Anaplerosis, Biosynthesis, Cancer - General, circulating DNA, Diagnosis, lipogenesis, Methylation, mitochondria, nucleotides on April 9, 2016| Leave a Comment »

Blood test uses DNA strands of dying cells Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN LPBI Hadassah-Developed Blood Test Detects Multiple Sclerosis, Cancer & Brain Damage http://www.hadassah.org/news-stories/blood-test-detects-neurodegenerative-disease.html A new blood test that uses the DNA strands of dying cells to detect diabetes, cancer, traumatic brain injury, and neurodegenerative disease has […]

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Sudipta Saha, PhD, Expert, Author, Writer, Co-Editor, Series D, Volume 2: Infectious Diseases and Co-Editor, Series D, Volume 4: Human Reproduction System

Posted in on August 17, 2020|

Sudipta Saha, PhD, Expert, Author, Writer, Co-Editor, Series D, Volume 2: Infectious Diseases and Co-Editor, Series D, Volume 4: Human Reproduction System Dr. Sudipta Saha, PhD Assistant Professor (III), Amity Institute of Physiology and Allied Sciences (AIPAS), Amity University, Noida, Uttar Pradesh, Sector-125, Noida – 201313 Mobile: +91 9830079019, +91 9810349961 E-Mail: sudiptasaha49@yahoo.co.in, sudiptasaha1977@gmail.com, ssaha2@amity.edu […]

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Effect of mitochondrial stress on epigenetic modifiers

Posted in Biochemical pathways, Biological Networks, Cell Biology, Signaling & Cell Circuits, Cell death pathways, Chemical Biology and its relations to Metabolic Disease, Curation, Cytokines, Disease Biology, Epigenetics and Environmental Factors, Gene Regulation, Human aging, Metabolism, Metabolomics, Proteins, Proteolysis, Proteomics, RNA Biology, Signaling, Signaling & Cell Circuits, tagged Aging, Chromatin, enzymes, Epigenetics, Histone demethylase, histone H3K9 di-methylation marks, histone methyltransferase met-2, hypothalamus, lifespan, lin-65, metabolic stress, mitochondria, Protein folding on May 7, 2016| Leave a Comment »

Effect of mitochondrial stress on epigenetic modifiers Larry H. Bernstein, MD, FCAP, Curator LPBI Early Mitochondrial Stress Alters Epigenetics, Secures Lifelong Health Benefits GEN 5/3/2016 http://www.genengnews.com/gen-news-highlights/early-mitochondrial-stress-alters-epigenetics-secures-lifelong-health-benefits/81252685/ A little adversity builds character, or so the saying goes. True or not, the saying does seem an apt description of a developmental phenomenon that shapes gene expression. […]