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A Mechanism of Cancer Metastasis

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, tagged , , , , , , , , , , on May 1, 2016| Leave a Comment »


A Mechanism of Cancer Metastasis Larry H. Bernstein, MD, FCAP, Curator LPBI   A Protein that Spreads Cancer Nils Halberg at the University of Bergen has identified a protein that makes it possible for cancer cells to spread http://www.technologynetworks.com/Proteomics/news.aspx?ID=190563 The cells inside a tumour differ a lot. While some remains “good” and do not cause […]

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How cancer metastasis occurs

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, tagged , , , , , , , , , , on April 30, 2016| 1 Comment »


How cancer metastasis occurs Larry H. Bernstein, MD, FCAP, Curator LPBI   How Cancer Cells Slide along Narrow Path to Metastasis http://www.genengnews.com/gen-news-highlights/how-cancer-cells-slide-along-narrow-path-to-metastasis/81252674/ In tumors, abnormal protein-fiber environments and genetic perturbations conspire to give rise to metastatic behavior. In this looking-glass world, cells that bump into each other do not halt and reverse direction, as they […]

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Prognostic biomarker for NSCLC and Cancer Metastasis

Posted in Cancer and Current Therapeutics, Immunodiagnostics, Lung and pulmonology, tagged , , , , , , , , , , , , on March 24, 2016| Leave a Comment »


Prognostic biomarker for NSCLC and Cancer Metastasis Larry H. Bernstein, MD, FCAP, Curator LPBI   Membranous CD24 expression as detected by the monoclonal antibody SWA11 is a prognostic marker in non-small cell lung cancer patients Michael Majores, Anne Schindler, Angela Fuchs, Johannes Stein, Lukas Heukamp, Peter Altevogt and Glen Kristiansen BMC Clinical Pathology201515:19   http://dx.doi.org:/10.1186/s12907-015-0019-z Background    Lung cancer is one of the most common malignant neoplasms worldwide and […]

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Curbing Cancer Cell Growth & Metastasis-on-a-Chip’ Models Cancer’s Spread

Posted in 3D Plotting Scaffolds, Anaerobic Glycolysis, BioIT: BioInformatics, NGS, Clinical & Translational, Pharmaceutical R&D Informatics, Clinical Genomics, Cancer Informatics, Biological Networks, BioPrinting in Regenerative Medicine, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Clinical & Translational, Clinical Genomics, Drug Development using MultiOrgan Chip, MicroEngineering Cell-Tissue & Systems, Oxidative phosphorylation, Warburg effect, tagged , , , , , , , , , , , , , , , , , , , , , , , on March 19, 2016| Leave a Comment »


Curbing Cancer Cell Growth & Metastasis-on-a-Chip’ Models Cancer’s Spread Curator: Larry H. Bernstein, MD, FCAP   New Approach to Curbing Cancer Cell Growth http://www.technologynetworks.com/Metabolomics/news.aspx?ID=189342 Using a new approach, scientists at The Scripps Research Institute (TSRI) and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung […]

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Lymphatic Cancer Metastasis Model

Posted in Cancer - General, CANCER BIOLOGY & Innovations in Cancer Therapy, Disease Biology, tagged , , , , , , , , , on March 2, 2016| 1 Comment »


Lymphatic Cancer Metastasis Model Larry H. Bernstein, MD, FCAP, Curator LPBI   How Stress Affects Cancer’s Spread A mouse study reveals how chronic stress remodels lymphatic vasculature to facilitate the spread of tumor cells. By Catherine Offord | March 1, 2016 http://www.the-scientist.com/?articles.view/articleNo/45476/title/How-Stress-Affects-Cancer-s-Spread http://www.the-scientist.com/images/News/March2016/lymph.gif Green fluorescently-tagged nanospheres flow through a lymph vessel from an unstressed mouse […]

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Driver of Cancer Metastasis

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, tagged , on February 20, 2016| Leave a Comment »


Driver of Cancer Metastasis Larry H. Bernstein, MD, FCAP, Curator LPBI   Suicide Cells in Tumor Environment Can Drive Metastasis   GEN News Highlights   Feb 19, 2016   http://www.genengnews.com/gen-news-highlights/suicide-cells-in-tumor-environment-can-drive-metastasis/81252386/   http://www.genengnews.com/Media/images/GENHighlight/Feb19_2016_MassGenHosp_MetastasizedTumors8113718617.jpg These images show tumors that have metastasized to the lungs (b) and bones (d) in mice that had cancer-associated fibroblasts eliminated after 10 days. [Biju […]

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Genetic association for breast cancer metastasis

Posted in Biological Networks, Gene Regulation and Evolution, Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, tagged , , , on February 12, 2016| Leave a Comment »


Genetic association for breast cancer metastasis Larry H. Bernstein, MD, FCAP, Curator LPBI   Gene Found in Brain Turns Out to be Key Driver of Breast Cancer    GEN News Highlights  http://www.genengnews.com/gen-news-highlights/gene-found-in-brain-turns-out-to-be-key-driver-of-breast-cancer/81252361/ Researchers from the Wistar Institute report that a gene that was once thought to be found only in the brain is also expressed in […]

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Alkalinizing to block tumor metastasis

Posted in Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Warburg effect, tagged , , on February 5, 2016| Leave a Comment »


Alkalinizing to block tumor metastasis Larry H. Bernstein, MD, FCAP, Curator LPBI   Novel nanoparticle may help keep tumor growth at bay Beth Miller, Washington University   http://www.rdmag.com/news/2016/02/novel-nanoparticle-may-help-keep-tumor-growth-bay Engineers at Washington University in St. Louis found a way to keep a cancerous tumor from growing by using nanoparticles of the main ingredient in common antacid tablets. […]

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Preclinical study identifies ‘master’ proto-oncogene that regulates stress-induced ovarian cancer metastasis | MD Anderson Cancer Center

Posted in Uncategorized on August 15, 2014| Leave a Comment »


Scientists have discovered the signaling pathway whereby a master regulator of cancer cell proteins – known as Src – leads to ovarian cancer progression when exposed to stress hormones. Source: http://www.mdanderson.org See on Scoop.it – Cardiovascular Disease: PHARMACO-THERAPY

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Liver metastasis_treatments

Posted in Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Drug Delivery Platform Technology, Liver & Digestive Diseases Research, Personalized and Precision Medicine & Genomic Research, Regulated Clinical Trials: Design, Methods, Components and IRB related issues, tagged , , , , , , , , , , , , , , , on August 10, 2013| 6 Comments »


Author Tilda Barliya PhD Hepatic metastatic disease from colorectal cancer (CRC) is a significant clinical problem. The liver is the dominant metastatic site for patients with CRC, and although two-thirds of affected patients have extrahepatic spread, some have disease that is isolated to the liver. For patients with isolated liver metastases, regional treatment approaches may […]

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