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Complex rearrangements and oncogene amplification revealed by long-read DNA and RNA sequencing of a breast cancer cell line Reporter: Stephen J. Williams, PhD In a Genome Research report by Marie Nattestad et al. [1], the SK-BR-3 breast cancer cell line was sequenced using a long read single molecule sequencing protocol in order to develop one […]

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First Cost-Effectiveness Study of Multi-Gene Panel Sequencing in Advanced Non-Small Cell Lung Cancer Shows Moderate Cost-Effectiveness, Exposes Crucial Practice Gap WASHINGTON (June 27, 2019) — The results of the first economic modeling study to estimate the cost-effectiveness of “multi-gene panel sequencing” (MGPS) as compared to standard-of-care, single-gene tests for patients with advanced non-small cell lung […]

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CSHL, UCLA & Einstein to Lead Roundtable Discussions on Single-Cell Sequencing Interactive discussions on three of the key questions researchers are facing when considering single-cell analysis will be held on the second day of the Single-Cell Sequencing Conference at Next Generation Dx Summit, taking place August 20-21, 2014 in Washington, DC. For full program details […]

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US Personalized Cancer Genome Sequencing Market Outlook 2018 Reporter: Aviva lev-Ari, PhD, RN Published: March 2014 | Pages: 65 | Format: PDF  The whole genome sequencing technology, over the past decade, has developed at an unprecedented rate. There has been a rapid progression from targeted gene sequencing to targeted whole genome sequencing coupled with bioinformatics […]

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Reporter: Aviva Lev-Ari, PhD, RN   Researchers Report on Mutational Patterns in Adenoid Cystic Carcinoma May 20, 2013 By a GenomeWeb staff reporter NEW YORK (GenomeWeb News) – A Memorial Sloan-Kettering Cancer Center-led team has taken an exome- and genome-sequencing centered look at the mutations that may be found in the salivary gland cancer adenoid cystic […]

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing[1] Curator and Reporter: Stephen J. Williams, Ph.D. Genomic instability is considered a hallmark and necessary for generating the mutations which drive tumorigenesis. Multiple studies had suggested that there may be multiple driver mutations and a plethora of passenger mutations driving a single tumor.  This diversity of […]

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Curator:  Aviva Lev-Ari, PhD,RN Cancer Diagnostics by Genomic Sequencing: ‘No’ to Sequencing Patient’s DNA, ‘No’ to Sequencing Patient’s Tumor, ‘Yes’ to focus on Gene Mutation Aberration & Analysis of Gene Abnormalities How to Tailor Cancer Therapy to the particular Genetics of a patient’s Cancer THIS IS A SERIES OF FOUR POINTS OF VIEW IN SUPPORT […]

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Reporter: Aviva Lev-Ari, PhD, RN presented from our Research Category on  Interviews with Scientific Leaders   Inspiration From Dr. Maureen Cronin’s Achievements in Applying Genomic Sequencing to Cancer Diagnostics Posted by: Patrick Terry on October 18, 2011 Related to: Healthcare Trends, In Vitro Diagnostics     The Tale of Two Tests “It was the best of times, it was the […]

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Deep Learning extracts Histopathological Patterns and accurately discriminates 28 Cancer and 14 Normal Tissue Types: Pan-cancer Computational Histopathology Analysis Reporter: Aviva Lev-Ari, PhD, RN Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis Yu Fu1, Alexander W Jung1, Ramon Viñas Torne1, Santiago Gonzalez1,2, Harald Vöhringer1, Mercedes Jimenez-Linan3, Luiza Moore3,4, and Moritz Gerstung#1,5 # to whom […]

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Cancer Genomics: Multiomic Analysis of Single Cells and Tumor Heterogeneity Curator: Stephen J. Williams, PhD   scTrio-seq identifies colon cancer lineages Single-cell multiomics sequencing and analyses of human colorectal cancer. Shuhui Bian et al. Science  30 Nov 2018:Vol. 362, Issue 6418, pp. 1060-1063 To better design treatments for cancer, it is important to understand the […]

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