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Deep Learning extracts Histopathological Patterns and accurately discriminates 28 Cancer and 14 Normal Tissue Types: Pan-cancer Computational Histopathology Analysis

Posted in Artificial Intelligence Applications in Health Care, Artificial Intelligence in CANCER, Artificial Intelligence in Health Care - Tools & Innovations, Artificial Intelligence in Medicine - Application for Diagnosis, CANCER BIOLOGY & Innovations in Cancer Therapy, Computational Biology/Systems and Bioinformatics, Computational Histopathology, Deep Learning in Pathology, Genome Biology, Meta-analysis of transcriptome data on October 28, 2019| Leave a Comment »


Deep Learning extracts Histopathological Patterns and accurately discriminates 28 Cancer and 14 Normal Tissue Types: Pan-cancer Computational Histopathology Analysis Reporter: Aviva Lev-Ari, PhD, RN Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis Yu Fu1, Alexander W Jung1, Ramon Viñas Torne1, Santiago Gonzalez1,2, Harald Vöhringer1, Mercedes Jimenez-Linan3, Luiza Moore3,4, and Moritz Gerstung#1,5 # to whom […]

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CancerBase.org – The Global HUB for Diagnoses, Genomes, Pathology Images: A Real-time Diagnosis and Therapy Mapping Service for Cancer Patients – Anonymized Medical Records accessible to

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Computational Biology/Systems and Bioinformatics, Genetics & Innovations in Treatment, Genetics & Pharmaceutical, Genome Biology, Imaging-based Cancer Patient Management on July 28, 2016| Leave a Comment »


CancerBase.org – The Global HUB for Diagnoses, Genomes, Pathology Images: A Real-time Diagnosis and Therapy Mapping Service for Cancer Patients – Anonymized Medical Records accessible to anyone on Earth Reporter: Aviva Lev-Ari, PhD, RN   UPDATED on 10/29/2019 Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis Yu Fu1, Alexander W Jung1, Ramon Viñas Torne1, […]

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Pathology Reports

Posted in Cancer - General, Cancer and Current Therapeutics, Clinical & Translational, Clinical Diagnostics, Curation, tagged , , on February 20, 2016| Leave a Comment »


Pathology Reports Larry H. Bernstein, MD, FCAP, Curator LPBI   Complete Pathology Reports and Clinical Decision Making Posted by Michael Doyle on Jan 15, 2015   http://www.softworksgroup.com/blog/complete-pathology-reports (Synoptic Reporting) Pathology reports provide care teams with crucial diagnostic and prognostic data. For population-level research and quality assurance initiatives, it’s important that reports are consistently complete. But report […]

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Identifying Another Piece in the Parkinson’s Disease Pathology Puzzle

Posted in Biomarkers & Medical Diagnostics, Uncategorized, tagged on February 2, 2016| Leave a Comment »


Press release on January 29,2016 International Consortium Identifies and Validates Cellular Role of Priority Parkinson’s Disease Drug Target, LRRK2 Kinase An international public-private consortium MARTINSRIED, GERMANY; DUNDEE, UNITED KINGDOM; NEW YORK, has identified and validated a cellular role of a primary Parkinson’s disease drug target, LRRK2 kinase. This finding was published in the online open […]

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Pathology Insights

Posted in Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Screening, Clinical Diagnostics, Clinical Genomics, Curation, Genomic Testing: Methodology for Diagnosis, Human Immune System in Health and in Disease, Innovations, Lung and pulmonology, Personalized and Precision Medicine & Genomic Research, RNA Biology, Cancer and Therapeutics, tagged , , , , , on October 28, 2015| Leave a Comment »


Pathology Insights Larry H Bernstein, MD, FCAP, Curator LPBI   Translational Lung Cancer Research Predicting the Prognosis of Lung Cancer: The Evolution of Tumor, Node and Metastasis in the Molecular Age—Challenges and Opportunities Ramón Rami-Porta; Hisao Asamura; Peter Goldstraw Transl Lung Cancer Res. 2015;4(4):415-423. http://www.medscape.com/viewarticle/852315   Abstract and Introduction Origin and Evolution of the TNM Classification […]

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Topics in Pathology

Posted in Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Clinical & Translational, Genomic Expression, tagged , , , , , on October 1, 2015| Leave a Comment »


Topics in Pathology Larry H Bernstein, MD, FCAP, Curator LPBI Special Issues from Medscape Pathology Journal of Clinical Pathology Hospital Autopsy: Endangered or Extinct? Angus Turnbull; Michael Osborn; Nick Nicholas Disclosures J Clin Pathol. 2015;68(8):601-604. Abstract Aim To determine the hospital autopsy rate for the UK in 2013. Methods A study of data from a ‘Freedom of Information’ […]

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Outstanding Achievement in Pathology

Posted in BioIT: BioInformatics, Biological Networks, Biomarkers & Medical Diagnostics, Bone Disease and Musculoskeletal Disease, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Screening, Cardiac and Cardiovascular Surgical Procedures, Cell Biology, Cerebrovascular and Neurodegenerative Diseases, Peripheral Arterial Disease & Peripheral Vascular Surgery, tagged , , , , , , , on September 26, 2015| Leave a Comment »


Outstanding Achievement in Pathology Curator: Larry H Bernstein, MD, FCAP   Olympus America Honors Outstanding Pathologists During First Annual “Unsung Heroes” Awards Melville, Ny—Tracey Corey Handy, M.D., Chief Medical Examiner of Kentucky, and Matthew Zarka, M.D., affiliated with the University of Vermont and the Fletcher Allen Health Center, were recognized as the 1999 winners of […]

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Complete Pathology Reports

Posted in Clinical Diagnostics, Health Law & Patient Safety, HealthCare IT, tagged , , , , on January 16, 2015| Leave a Comment »


Larry Bernstein, MD, FCAP, Reporter https://pharmaceuticalintelligence.com/1/16/2015/Complete-Pathology-Reports Complete Pathology Reports and Their Importance for Clinical Decision Making Posted by Michael Doyle on Jan 15, 2015 10:17:00 AM Pathology reports provide care teams with crucial diagnostic and prognostic data. For population-level research and quality assurance initiatives, it’s important that reports are consistently complete. But report consistency can also be important for the medical outcomes of a single person. Today, I’ll discuss the unique experience of a friend of mine, and I’ll explain how his isolated incident is connected to large-scale initiatives in pathology reporting quality assurance. Incomplete Pathology Reports A friend of mine has particularly fair skin, and is at thus at increased risk for skin cancers. His family physician has recommended he have various moles removed to prevent the development of possible skin cancers. Over time, my friend and his family physician became troubled by the inconsistencies they found in comparing the pathology reports from his five different biopsies. Five out of five reports identified that the moles were dysplastic— irregular and potentially cancerous. Yet only three reports identified that this dysplasia was in his skin’s basal cells as opposed to squamous cells or melanocytes. The the type of skin cells exhibiting dysplasia is important to clinical decision making: dysplasia affecting melanocytes is the basis for melanomas, the most serious forms of skin cancer. Lacking this information makes it more difficult for care teams to develop the comprehensive understanding of an individual’s medical history that guides clinical decision making. In response to the incompleteness of the pathology reports, the family physician remarked, “I rarely have to query a pathologist about what’s in a report. It’s usually about what’s left out.” And it’s not just one physician who’s seeking better reports. Synoptic Reporting for Complete Consistency in Pathology For over 20 years, the College of American Pathologists (CAP) has been developing protocols and templates to standardize pathology reporting, substantially improving the completeness and consistency of pathology reports through the use of the synoptic— i.e. structured—format. Synoptic reporting uses coded data templates to produce standardized reports that are more complete and consistent than reports generated using narrative methods. Since 2014, the use of synoptic reporting has been among the CAP Laboratory Accreditation Program requirements. Cancer Care Ontario introduced synoptic reporting for pathologist across the province—the largest jurisdiction to do so. Clinicians have shown over- whelming support for this initiative, finding that synoptic reports have facilitated consistent intepretation of diagnostic and prognostic data. The Canadian Partnership Against Cancer is building on Ontario’s success to help implement synoptic pathology reporting across Canada, strengthening provincial cancer registries and fostering […]

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Pathology Emergence in the 21st Century

Posted in Bio Instrumentation in Experimental Life Sciences Research, Biological Networks, Gene Regulation and Evolution, Biomarkers & Medical Diagnostics, Biomedical Measurement Science, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Cerebrovascular and Neurodegenerative Diseases, Chemical Biology and its relations to Metabolic Disease, Clinical Diagnostics, Computational Biology/Systems and Bioinformatics, Curation, Developmental biology, Experimental validation, Explanatory, Gene Regulation, Genomic Expression, Methylation, Oxidative phosphorylation, Technology Advance Assessment of, Warburg effect, tagged , , , , on August 3, 2014| 5 Comments »


Pathology Emergence in the 21st Century Author and Curator: Larry Bernstein, MD, FCAP    This discussion follows the series on DNA and its replication, the code of life, and immediately follows a an up to date survey of RNA, it’s many discovered forms, their function, and the transcription of RNA, intermediate to protein synthesis.  This […]

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Molecular Pathology: Advanced Topics

Posted in Biological Networks, Gene Regulation and Evolution, Genome Biology on February 26, 2014| Leave a Comment »


Molecular Pathology: Advanced Topics Reporter: Aviva Lev-Ari, PhD, RN About this Digital Course: VIEW VIDEO – Latest Advances in Molecular Pathology   This course is designed to educate practicing pathologists on the current molecular diagnostics technologies. This three part course is produced in collaboration between Cambridge Healthtech Institute and the College of American Pathologists. Agenda at […]

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