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Search Results for 'Mitochondria'


Reporter and Curator: Dr. Sudipta Saha, Ph.D.   Leigh syndrome is one of the hundreds of so-called mitochondrial diseases, which are caused by defects in the mitochondria that produce 90 percent of the body’s energy. These disorders are rare; about 1,000 to 4,000 babies in the United States are born with one every year. But they are devastating and […]

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Reporter and Curator: Dr. Sudipta Saha, Ph.D.   Mitochondrial disease   Mitochondria are present in almost all human cells, and vary in number from a few tens to many thousands. They generate the majority of a cell’s energy supply which powers every part of our body. Mitochondria have their own separate DNA, which carries just […]

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Drugs that activate this novel stress response pathway, which they call the mitochondrial-to-cytosolic stress response, protected both nematodes and cultured human cells with Huntington´s disease from protein-folding damage. Reporter: Aviva Lev-Ari, PhD, RN   “Maybe there is a way to use one drug to alter the mitochondrial signal and another drug to alter the communciation […]

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Effect of mitochondrial stress on epigenetic modifiers Larry H. Bernstein, MD, FCAP, Curator LPBI   Early Mitochondrial Stress Alters Epigenetics, Secures Lifelong Health Benefits GEN 5/3/2016  http://www.genengnews.com/gen-news-highlights/early-mitochondrial-stress-alters-epigenetics-secures-lifelong-health-benefits/81252685/ A little adversity builds character, or so the saying goes. True or not, the saying does seem an apt description of a developmental phenomenon that shapes gene expression. […]

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New Insights into mtDNA, mitochondrial proteins, aging, and metabolic control Larry H. Bernstein, MD, FCAP, Curator LPBI   Newly discovered proteins may protect against age-related illnesses   The proteins could play a key role in the aging process and the onset of diseases linked to older age BY Beth Newcomb   APRIL 13, 2016 http://news.usc.edu/98412/newly-discovered-proteins-may-protect-against-agings-illnesses/ http://news.usc.edu/files/2016/04/20160208_PinchasCohen_web-824×549.jpg […]

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Previously unseen immune reaction identified for stem cell transplants. Reporter: Stephen J. Williams, Ph.D. Reposted from Healthinnovations at http://health-innovations.org/2014/11/21/previously-unseen-immune-reaction-identified-in-stem-cell-transplants/   Mouse cells and tissues created through nuclear transfer can be rejected by the body because of a previously unknown immune response to the cell’s mitochondria, according to an international study in mice by researchers at the […]

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SAN DIEGO — The novel drug Bendavia did not meet any of its primary or secondary endpoints in a trial assessing its use prior to primary PCI in patients with STEMI, according to data presented at the American College of Cardiology Scientific Sessions.Patients… Source: http://www.healio.com See on Scoop.it – Cardiovascular Disease: PHARMACO-THERAPY

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Mitochondrial Pyridine Nucleotides and Electron Transport Chain Larry H Bernstein, MD, FCAP, writer and curator http://pharmaceuticalinnovation.com/2015/04/03/larryhbern/Mitochondrial_Pyridine_Nucleotides_and_Electron_Transport_Chain 2.1.5 Mitochondrial Pyridine Nucleotides and Electron Transport Chain 2.1.5.1 Mitochondrial function in vivo evaluated by NADH fluorescence Mayevsky A1, Rogatsky GG. Am J Physiol Cell Physiol. 2007 Feb; 292(2):C615-40 http://dx.doi.org:/10.1152/ajpcell.00249.2006 Normal mitochondrial function is a critical factor in maintaining […]

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Mitochondrial Isocitrate Dehydrogenase and Variants Writer and Curator: Larry H. Bernstein, MD, FCAP  2.1.4      Mitochondrial Isocitrate Dehydrogenase (IDH) and variants 2.1.4.1 Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression of IDH-mutated low grade gliomas Juratli TA, Peitzsch M, Geiger K, Schackert G, Eisenhofer G, Krex D. Neuro Oncol. 2013 Jun;15(6):682-90 http://dx.doi.org:/10.1093/neuonc/not006 Low-grade […]

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Warburg Effect and Mitochondrial Regulation -2.1.3 Writer and Curator: Larry H Bernstein, MD, FCAP  2.1.3 Warburg Effect and Mitochondrial Regulation 2.1.3.1 Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier NM Vacanti, AS Divakaruni, CR Green, SJ Parker, RR Henry, TP Ciaraldi, et a.. Molec Cell 6 Nov 2014; 56(3):425–435 http://dx.doi.org/10.1016/j.molcel.2014.09.024 Highlights Oxidation of fatty […]

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