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Cancer treatment using CRISPR-based Genome Editing System  Reporter: Irina Robu, PhD CRISPR, stands for “clusters of regularly interspaced short palindromic repeats” is one of the biggest accomplishments in science of this decade and it is the simplest tool for altering DNA sequences and modifying gene functions. The technology is adapted form the natural defense mechanism […]

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Renal tumor macrophages linked to recurrence are identified using single-cell protein activity analysis Curator and Reporter: Dr. Premalata Pati, Ph.D., Postdoc When malignancy returns after a period of remission, it is called a cancer recurrence. After the initial or primary cancer has been treated, this can happen weeks, months, or even years later. The possibility […]

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Live Notes, Real Time Conference Coverage 2020 AACR Virtual Meeting April 28, 2020 Session on Evaluating Cancer Genomics from Normal Tissues Through Metastatic Disease 3:50 PM Reporter: Stephen J. Williams, PhD  Minisymposium: Evaluating Cancer Genomics from Normal Tissues through Evolution to Metastatic Disease Oncologic therapy shapes the fitness landscape of clonal hematopoiesis April 28, 2020, 4:10 […]

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Live Notes, Real Time Conference Coverage AACR 2020 #AACR20: Tuesday June 23, 2020 Noon-2:45 Educational Sessions

Live Notes, Real Time Conference Coverage AACR 2020: Tuesday June 23, 2020 Noon-2:45 Educational Sessions Reporter: Stephen J. Williams, PhD Follow Live in Real Time using #AACR20 @pharma_BI @AACR Register for FREE at https://www.aacr.org/   Presidential Address Elaine R Mardis, William N Hait DETAILS Welcome and introduction William N Hait   Improving diagnostic yield in pediatric cancer precision […]

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Lesson 5 Cell Signaling And Motility: Cytoskeleton & Actin: Curations and Articles of reference as supplemental information: #TUBiol3373 Curator: Stephen J. Williams, Ph.D. Cell motility or migration is an essential cellular process for a variety of biological events. In embryonic development, cells migrate to appropriate locations for the morphogenesis of tissues and organs. Cells need to migrate […]

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Systems Biology analysis of Transcription Networks, Artificial Intelligence, and High-End Computing Coming to Fruition in Personalized Oncology Curator: Stephen J. Williams, Ph.D. In the June 2020 issue of the journal Science, writer Roxanne Khamsi has an interesting article “Computing Cancer’s Weak Spots; An algorithm to unmask tumors’ molecular linchpins is tested in patients”[1], describing some […]

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Engineered Bacteria used as Trojan Horse for Cancer Immunotherapy Reporter: Irina Robu, PhD Researchers are using synthetic biology— design and construction of new biological entities such as enzymes, genetic circuits, and cells or the redesign of existing biological systems—is changing medicine leading to innovative solution in molecular-based therapeutics. To address the issue of designing therapies that can induce a […]

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AI System Used to Detect Lung Cancer Reporter: Irina Robu, PhD 3.3.13   AI System Used to Detect Lung Cancer, Volume 2 (Volume Two: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS and BioInformatics, Simulations and the Genome Ontology), Part 2: CRISPR for Gene Editing and DNA Repair Lung cancer is characterized by uncontrolled cell […]

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Cancer Genomics: Multiomic Analysis of Single Cells and Tumor Heterogeneity Curator: Stephen J. Williams, PhD 4.3.7 Cancer Genomics: Multiomic Analysis of Single Cells and Tumor Heterogeneity, Volume 2 (Volume Two: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS and BioInformatics, Simulations and the Genome Ontology), Part 4: Single Cell Genomics scTrio-seq identifies colon cancer lineages Single-cell […]

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Papers citing PharmaceuticalIntelligence.com Reporter: Stephen J. Williams, PhD (10 papers, 5 peer reviewed, 2 web page, 2 teaching lectures, 1 preprint) Search from years 2012 – 2018 Summary Peer Reviewed Yan-Fang Guan, Gai-Rui Li, Rong-Jiao Wang, Yu-Ting Yi, Ling Yang, Dan Jiang, Xiao-Ping Zhang, and Yin Peng. Application of next-generation sequencing in clinical oncology to […]

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